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We assessed frequency of anxiety, depression, and general distress in CMT.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>We administered online the Hospital Anxiety-Depression Scale (HADS) to CMT patients of the Italian registry and controls. HADS-A and HADS-D scores\u2009\u2265\u200911 defined the presence of anxiety\/depression and HADS total score (HADS-T)\u2009\u2265\u200922 of general distress. We analysed correlation with disease severity and clinical characteristics, use of anxiolytics\/antidepressants and analgesic\/anti-inflammatory drugs.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>We collected data from 252 CMT patients (137 females) and 56 controls. CMT patient scores for anxiety (mean\u2009\u00b1\u2009standard deviation, 6.7\u2009\u00b1\u20094.8), depression (4.5\u2009\u00b1\u20094.0), and general distress (11.5\u2009\u00b1\u20098.1) did not differ from controls and the Italian population. However, compared to controls, the percentages of subjects with depression (10% vs 2%) and general distress (14% vs 4%) were significantly higher in CMT patients. We found no association between HADS scores and disease duration or CMT type. Patients with general distress showed more severe disease and higher rate of positive sensory symptoms. Depressed patients also had more severe disease. Nineteen percent of CMT patients took antidepressants\/anxiolytics (12% daily) and 70% analgesic\/anti-inflammatory drugs. Patients with anxiety, depression, and distress reported higher consumption of anxiolytics\/antidepressants. About 50% of patients with depression and\/or general distress did not receive any specific pharmacological treatment.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusions<\/jats:title>\n                <jats:p>An appreciable proportion of CMT patients shows general distress and depression. Both correlated with disease severity and consumption of antidepressants\/anxiolytics, suggesting that the disease itself is contributing to general distress and depression.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1007\/s00415-022-11365-8","type":"journal-article","created":{"date-parts":[[2022,9,16]],"date-time":"2022-09-16T16:03:10Z","timestamp":1663344190000},"page":"394-401","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Anxiety and depression in Charcot-Marie-Tooth disease: data from the Italian CMT national 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MB, AB, IT, FM. AS, LS, TC, SCP, IA, LP, CP. DC, PS, AQ, PV, ST, LG, MR, AM, SP, CP report no disclosure.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflicts of interest"}},{"value":"The study was approved by the Ethics Committee of the Fondazione IRCCS Istituto Neurologico Carlo Besta, Milan (no. 52\/2016 Date: April 2, 2014), and then by the Ethics Committees of all the other eight participating centres. It conforms with World Medical Association Declaration of Helsinki.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical standard statement"}}]}}