{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,4]],"date-time":"2026-11-04T03:40:14Z","timestamp":1793763614066,"version":"4.6.1"},"reference-count":41,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2022,11,3]],"date-time":"2022-11-03T00:00:00Z","timestamp":1667433600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2022,11,3]],"date-time":"2022-11-03T00:00:00Z","timestamp":1667433600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Neurol"],"published-print":{"date-parts":[[2023,2]]},"DOI":"10.1007\/s00415-022-11450-y","type":"journal-article","created":{"date-parts":[[2022,11,3]],"date-time":"2022-11-03T17:11:04Z","timestamp":1667495464000},"page":"975-985","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":27,"title":["Drugs associated with posterior reversible encephalopathy syndrome, a worldwide signal detection study"],"prefix":"10.1007","volume":"270","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1686-0681","authenticated-orcid":false,"given":"Alexander","family":"Balcerac","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kevin","family":"Bihan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dimitri","family":"Psimaras","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B\u00e9n\u00e9dicte","family":"Lebrun-Vignes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joe-Elie","family":"Salem","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicolas","family":"Weiss","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2022,11,3]]},"reference":[{"issue":"4","key":"11450_CR1","doi-asserted-by":"publisher","first-page":"omx011","DOI":"10.1093\/omcr\/omx011","volume":"2017","author":"SR Sudulagunta","year":"2017","unstructured":"Sudulagunta SR, Sodalagunta MB, Kumbhat M, Settikere Nataraju A (2017) Posterior reversible encephalopathy syndrome(PRES). Oxf Med Case Rep 2017(4):omx011","journal-title":"Oxf Med Case Rep"},{"issue":"2","key":"11450_CR2","doi-asserted-by":"publisher","first-page":"205","DOI":"10.1001\/archneurol.2007.46","volume":"65","author":"VH Lee","year":"2008","unstructured":"Lee VH, Wijdicks EFM, Manno EM, Rabinstein AA (2008) Clinical spectrum of reversible posterior leukoencephalopathy syndrome. Arch Neurol 65(2):205\u2013210","journal-title":"Arch Neurol"},{"issue":"9","key":"11450_CR3","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0044534","volume":"7","author":"S Legriel","year":"2012","unstructured":"Legriel S, Schraub O, Azoulay E, Hantson P, Magalhaes E, Coquet I et al (2012) Determinants of recovery from severe posterior reversible encephalopathy syndrome. PLoS ONE 7(9):e44534","journal-title":"PLoS ONE"},{"issue":"1\u20132","key":"11450_CR4","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1016\/j.jns.2014.09.019","volume":"347","author":"LM Alhilali","year":"2014","unstructured":"Alhilali LM, Reynolds AR, Fakhran S (2014) A multi-disciplinary model of risk factors for fatal outcome in posterior reversible encephalopathy syndrome. J Neurol Sci 347(1\u20132):59\u201365","journal-title":"J Neurol Sci"},{"key":"11450_CR5","doi-asserted-by":"crossref","unstructured":"Legriel S, Lerner A, Wintermark M, Rykken JB, Gao B (2020) Editorial: posterior reversible encephalopathy syndrome and associated diseases. Front Neurol [Internet]. [cit\u00e9 16 janv 2022];11. Disponible sur: https:\/\/www.frontiersin.org\/article\/10.3389\/fneur.2020.00667","DOI":"10.3389\/fneur.2020.00667"},{"issue":"9","key":"11450_CR6","doi-asserted-by":"publisher","first-page":"851","DOI":"10.4065\/mcp.2011.0090","volume":"86","author":"SJ Wagner","year":"2011","unstructured":"Wagner SJ, Acquah LA, Lindell EP, Craici IM, Wingo MT, Rose CH et al (2011) Posterior reversible encephalopathy syndrome and eclampsia: pressing the case for more aggressive blood pressure control. Mayo Clin Proc 86(9):851\u2013856","journal-title":"Mayo Clin Proc"},{"key":"11450_CR7","doi-asserted-by":"publisher","DOI":"10.1136\/bcr-2016-216512","volume":"2016","author":"HMA Abdullah","year":"2016","unstructured":"Abdullah HMA, Ullah W, Ahmad E, Anwer F (2016) Posterior reversible encephalopathy syndrome in malignant hypertension secondary to focal segmental glomerulosclerosis. BMJ Case Rep 2016:bcr2016216512","journal-title":"BMJ Case Rep"},{"issue":"5","key":"11450_CR8","doi-asserted-by":"publisher","first-page":"924","DOI":"10.3174\/ajnr.A0960","volume":"29","author":"WS Bartynski","year":"2008","unstructured":"Bartynski WS, Tan HP, Boardman JF, Shapiro R, Marsh JW (2008) Posterior reversible encephalopathy syndrome after solid organ transplantation. Am J Neuroradiol 29(5):924\u2013930","journal-title":"Am J Neuroradiol"},{"issue":"5","key":"11450_CR9","doi-asserted-by":"publisher","first-page":"427","DOI":"10.4065\/mcp.2009.0590","volume":"85","author":"JE Fugate","year":"2010","unstructured":"Fugate JE, Claassen DO, Cloft HJ, Kallmes DF, Kozak OS, Rabinstein AA (2010) Posterior reversible encephalopathy syndrome: associated clinical and radiologic findings. Mayo Clin Proc 85(5):427\u2013432","journal-title":"Mayo Clin Proc"},{"key":"11450_CR10","doi-asserted-by":"publisher","DOI":"10.1136\/bcr-2018-225128","author":"O Garner","year":"2018","unstructured":"Garner O, Ramirez A, Iardino A (2018) A case of posterior reversible encephalopathy syndrome associated with sepsis. Case Rep. https:\/\/doi.org\/10.1136\/bcr-2018-225128","journal-title":"Case Rep"},{"issue":"2","key":"11450_CR11","doi-asserted-by":"publisher","first-page":"e329","DOI":"10.1016\/j.ijcard.2013.12.275","volume":"172","author":"R Lorusso","year":"2014","unstructured":"Lorusso R, Vizzardi E, Pinelli L, Gelsomino S (2014) Posterior reversible encephalopathy syndrome in a patient submitted to extracorporeal membrane oxygenation for acute fulminant myocarditis. Int J Cardiol 172(2):e329\u2013e330","journal-title":"Int J Cardiol"},{"issue":"1","key":"11450_CR12","doi-asserted-by":"publisher","first-page":"72","DOI":"10.1002\/ajh.20147","volume":"77","author":"CS Tam","year":"2004","unstructured":"Tam CS, Galanos J, Seymour JF, Pitman AG, Stark RJ, Prince HM (2004) Reversible posterior leukoencephalopathy syndrome complicating cytotoxic chemotherapy for hematologic malignancies. Am J Hematol 77(1):72\u201376","journal-title":"Am J Hematol"},{"issue":"9","key":"11450_CR13","doi-asserted-by":"publisher","first-page":"1327","DOI":"10.1023\/A:1012248800195","volume":"12","author":"MJ Edwards","year":"2001","unstructured":"Edwards MJ, Walker R, Vinnicombe S, Barlow C, MacCallum P, Foran JM (2001) Reversible posterior leukoencephalopathy syndrome following CHOP chemotherapy for diffuse large B-cell lymphoma. Ann Oncol Off J Eur Soc Med Oncol 12(9):1327\u20131329","journal-title":"Ann Oncol Off J Eur Soc Med Oncol"},{"issue":"4","key":"11450_CR14","doi-asserted-by":"publisher","first-page":"304","DOI":"10.1002\/ajh.20772","volume":"82","author":"B Saito","year":"2007","unstructured":"Saito B, Nakamaki T, Nakashima H, Usui T, Hattori N, Kawakami K et al (2007) Reversible posterior leukoencephalopathy syndrome after repeat intermediate-dose cytarabine chemotherapy in a patient with acute myeloid leukemia. Am J Hematol 82(4):304\u2013306","journal-title":"Am J Hematol"},{"issue":"10","key":"11450_CR15","doi-asserted-by":"publisher","first-page":"1475","DOI":"10.1001\/archneur.63.10.1475","volume":"63","author":"JA Allen","year":"2006","unstructured":"Allen JA, Adlakha A, Bergethon PR (2006) Reversible posterior leukoencephalopathy syndrome after bevacizumab\/FOLFIRI regimen for metastatic colon cancer. Arch Neurol 63(10):1475\u20131478","journal-title":"Arch Neurol"},{"key":"#cr-split#-11450_CR16.1","doi-asserted-by":"crossref","unstructured":"How J, Blattner M, Fowler S, Wang-Gillam A, Schindler SE (2016) Chemotherapy-associated Posterior Reversible Encephalopathy Syndrome [Internet]. Wolters Kluwer","DOI":"10.1097\/NRL.0000000000000105"},{"key":"#cr-split#-11450_CR16.2","unstructured":"[cit\u00e9 10 ao\u00fbt 2021]. Disponible sur: https:\/\/www.ingentaconnect.com\/content\/wk\/nrl\/2016\/00000021\/00000006\/art00009"},{"issue":"5","key":"11450_CR17","doi-asserted-by":"publisher","first-page":"409","DOI":"10.1177\/009286150804200501","volume":"42","author":"M Lindquist","year":"2008","unstructured":"Lindquist M (2008) VigiBase, the WHO global ICSR database system: basic facts. Drug Inf J 42(5):409\u2013419","journal-title":"Drug Inf J"},{"issue":"4","key":"11450_CR18","doi-asserted-by":"publisher","first-page":"473","DOI":"10.1016\/S0167-9473(99)00114-0","volume":"34","author":"R Orre","year":"2000","unstructured":"Orre R, Lansner A, Bate A, Lindquist M (2000) Bayesian neural networks with confidence estimations applied to data mining. Comput Stat Data Anal 34(4):473\u2013493","journal-title":"Comput Stat Data Anal"},{"issue":"1","key":"11450_CR19","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1177\/0962280211403604","volume":"22","author":"GN Nor\u00e9n","year":"2013","unstructured":"Nor\u00e9n GN, Hopstadius J, Bate A (2013) Shrinkage observed-to-expected ratios for robust and transparent large-scale pattern discovery. Stat Methods Med Res 22(1):57\u201369","journal-title":"Stat Methods Med Res"},{"issue":"4","key":"11450_CR20","doi-asserted-by":"publisher","first-page":"315","DOI":"10.1007\/s002280050466","volume":"54","author":"A Bate","year":"1998","unstructured":"Bate A, Lindquist M, Edwards IR, Olsson S, Orre R, Lansner A et al (1998) A Bayesian neural network method for adverse drug reaction signal generation. Eur J Clin Pharmacol 54(4):315\u2013321","journal-title":"Eur J Clin Pharmacol"},{"issue":"12","key":"11450_CR21","doi-asserted-by":"publisher","first-page":"1579","DOI":"10.1016\/S1470-2045(18)30608-9","volume":"19","author":"J-E Salem","year":"2018","unstructured":"Salem J-E, Manouchehri A, Moey M, Lebrun-Vignes B, Bastarache L, Pariente A et al (2018) Cardiovascular toxicities associated with immune checkpoint inhibitors: an observational, retrospective, pharmacovigilance study. Lancet Oncol 19(12):1579\u20131589","journal-title":"Lancet Oncol"},{"key":"11450_CR22","doi-asserted-by":"publisher","unstructured":"Salem J-E, Nguyen LS, Moslehi JJ, Ederhy S, Lebrun-Vignes B, Roden DM et al (2021) Anticancer drug-induced life-threatening ventricular arrhythmias: a World Health Organization pharmacovigilance study. Eur Heart J [Internet]. [cit\u00e9 3 oct 2021];(ehab362). Disponible sur: https:\/\/doi.org\/10.1093\/eurheartj\/ehab362","DOI":"10.1093\/eurheartj\/ehab362"},{"issue":"2","key":"11450_CR23","doi-asserted-by":"publisher","first-page":"179","DOI":"10.1016\/j.therap.2016.02.010","volume":"71","author":"G Miremont-Salam\u00e9","year":"2016","unstructured":"Miremont-Salam\u00e9 G, Th\u00e9ophile H, Haramburu F, B\u00e9gaud B (2016) Causality assessment in pharmacovigilance: The French method and its successive updates. Therapies 71(2):179\u2013186","journal-title":"Therapies"},{"issue":"11","key":"11450_CR24","first-page":"CR549","volume":"11","author":"P Striano","year":"2005","unstructured":"Striano P, Striano S, Tortora F, De Robertis E, Palumbo D, Elefante A et al (2005) Clinical spectrum and critical care management of Posterior Reversible Encephalopathy Syndrome (PRES). Med Sci Monit Int Med J Exp Clin Res 11(11):CR549-553","journal-title":"Med Sci Monit Int Med J Exp Clin Res"},{"key":"11450_CR25","doi-asserted-by":"publisher","first-page":"93","DOI":"10.1016\/j.brainresbull.2017.03.012","volume":"131","author":"Z Chen","year":"2017","unstructured":"Chen Z, Shen G-Q, Lerner A, Gao B (2017) Immune system activation in the pathogenesis of posterior reversible encephalopathy syndrome. Brain Res Bull 131:93\u201399","journal-title":"Brain Res Bull"},{"issue":"1","key":"11450_CR26","doi-asserted-by":"publisher","first-page":"27915","DOI":"10.1038\/srep27915","volume":"6","author":"R Rodrigues-Diez","year":"2016","unstructured":"Rodrigues-Diez R, Gonz\u00e1lez-Guerrero C, Oca\u00f1a-Salceda C, Rodrigues-Diez RR, Egido J, Ortiz A et al (2016) Calcineurin inhibitors cyclosporine A and tacrolimus induce vascular inflammation and endothelial activation through TLR4 signaling. Sci Rep 6(1):27915","journal-title":"Sci Rep"},{"key":"11450_CR27","doi-asserted-by":"crossref","unstructured":"Agarwala SS, Case S (2010). Everolimus (RAD001) in the treatment of advanced renal cell carcinoma: a review. The oncologist [Internet]. [cit\u00e9 10 ao\u00fbt 2021];15(3). Disponible sur: https:\/\/pubmed.ncbi.nlm.nih.gov\/20215359\/","DOI":"10.1634\/theoncologist.2009-0141"},{"issue":"7","key":"11450_CR28","doi-asserted-by":"publisher","first-page":"731","DOI":"10.1093\/oxfordjournals.annonc.a010723","volume":"7","author":"M Cwikiel","year":"1996","unstructured":"Cwikiel M, Eskilsson J, Albertsson M, Stavenow L (1996) The influence of 5-fluorouracil and methotrexate on vascular endothelium. An experimental study using endothelial cells in the culture. Ann Oncol 7(7):731\u2013737","journal-title":"Ann Oncol"},{"issue":"2","key":"11450_CR29","doi-asserted-by":"publisher","first-page":"356","DOI":"10.1016\/j.ajpath.2014.10.021","volume":"185","author":"B Ranchoux","year":"2015","unstructured":"Ranchoux B, G\u00fcnther S, Quarck R, Chaumais M-C, Dorfm\u00fcller P, Antigny F et al (2015) Chemotherapy-induced pulmonary hypertension: role of alkylating agents. Am J Pathol 185(2):356\u2013371","journal-title":"Am J Pathol"},{"issue":"16","key":"11450_CR30","doi-asserted-by":"publisher","first-page":"8999","DOI":"10.1039\/C7RA13014G","volume":"8","author":"NA Fletcher","year":"2018","unstructured":"Fletcher NA, Krebs MD (2018) Sustained delivery of anti-VEGF from injectable hydrogel systems provides a prolonged decrease of endothelial cell proliferation and angiogenesis in vitro. RSC Adv 8(16):8999\u20139005","journal-title":"RSC Adv"},{"key":"11450_CR31","doi-asserted-by":"publisher","first-page":"S122","DOI":"10.1016\/S0049-3848(12)70031-2","volume":"129","author":"AD Blann","year":"2012","unstructured":"Blann AD (2012) Endothelial cell activation markers in cancer. Thromb Res 129:S122\u2013S126","journal-title":"Thromb Res"},{"issue":"10","key":"11450_CR32","doi-asserted-by":"publisher","first-page":"3677","DOI":"10.1182\/blood-2003-09-3198","volume":"103","author":"S Rajagopalan","year":"2004","unstructured":"Rajagopalan S, Somers EC, Brook RD, Kehrer C, Pfenninger D, Lewis E et al (2004) Endothelial cell apoptosis in systemic lupus erythematosus: a common pathway for abnormal vascular function and thrombosis propensity. Blood 103(10):3677\u20133683","journal-title":"Blood"},{"issue":"1","key":"11450_CR33","doi-asserted-by":"publisher","first-page":"42","DOI":"10.1159\/000046673","volume":"22","author":"SH Jacobson","year":"2002","unstructured":"Jacobson SH, Egberg N, Hylander B, Lundahl J (2002) Correlation between soluble markers of endothelial dysfunction in patients with renal failure. Am J Nephrol 22(1):42\u201347","journal-title":"Am J Nephrol"},{"issue":"1","key":"11450_CR34","doi-asserted-by":"publisher","first-page":"155","DOI":"10.1007\/s00415-011-6152-4","volume":"259","author":"TG Liman","year":"2012","unstructured":"Liman TG, Bohner G, Heuschmann PU, Endres M, Siebert E (2012) The clinical and radiological spectrum of posterior reversible encephalopathy syndrome: the retrospective Berlin PRES study. J Neurol 259(1):155\u2013164","journal-title":"J Neurol"},{"issue":"sup1","key":"11450_CR35","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1080\/13697130601114917","volume":"10","author":"GMC Rosano","year":"2007","unstructured":"Rosano GMC, Vitale C, Marazzi G, Volterrani M (2007) Menopause and cardiovascular disease: the evidence. Climacteric 10(sup1):19\u201324","journal-title":"Climacteric"},{"issue":"6","key":"11450_CR36","doi-asserted-by":"publisher","first-page":"591","DOI":"10.1016\/j.therap.2020.02.022","volume":"75","author":"K Bihan","year":"2020","unstructured":"Bihan K, Lebrun-Vignes B, Funck-Brentano C, Salem J-E (2020) Uses of pharmacovigilance databases: an overview. Therapie d\u00e9c 75(6):591\u2013598","journal-title":"Therapie d\u00e9c"},{"issue":"25","key":"11450_CR37","doi-asserted-by":"publisher","first-page":"2443","DOI":"10.1161\/CIRCULATIONAHA.120.049210","volume":"142","author":"L Xiao","year":"2020","unstructured":"Xiao L, Salem J-E, Clauss S, Hanley A, Bapat A, Hulsmans M et al (2020) Ibrutinib-mediated atrial fibrillation attributable to inhibition of C-terminal Src kinase. Circulation 142(25):2443\u20132455","journal-title":"Circulation"},{"issue":"13","key":"11450_CR38","doi-asserted-by":"publisher","first-page":"1070","DOI":"10.1161\/CIRCULATIONAHA.119.040162","volume":"140","author":"J-E Salem","year":"2019","unstructured":"Salem J-E, Yang T, Moslehi JJ, Waintraub X, Gandjbakhch E, Bachelot A et al (2019) Androgenic effects on ventricular repolarization: a translational study from the international pharmacovigilance database to iPSC-cardiomyocytes. Circulation 140(13):1070\u20131080","journal-title":"Circulation"},{"key":"11450_CR39","doi-asserted-by":"publisher","first-page":"14","DOI":"10.1016\/j.jclinepi.2021.01.015","volume":"134","author":"C Khouri","year":"2021","unstructured":"Khouri C, Petit C, Tod M, Lepelley M, Revol B, Roustit M et al (2021) Adverse drug reaction risks obtained from meta-analyses and pharmacovigilance disproportionality analyses are correlated in most cases. J Clin Epidemiol 134:14\u201321","journal-title":"J Clin Epidemiol"},{"issue":"9","key":"11450_CR40","doi-asserted-by":"publisher","first-page":"1101","DOI":"10.1002\/ajh.26259","volume":"96","author":"C Dolladille","year":"2021","unstructured":"Dolladille C, Ederhy S, Ezine E, Choquet S, Nguyen LS, Alexandre J et al (2021) Chimeric antigen receptor T-cells safety: a pharmacovigilance and meta-analysis study. Am J Hematol 96(9):1101\u20131111","journal-title":"Am J Hematol"}],"container-title":["Journal of Neurology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00415-022-11450-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00415-022-11450-y\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00415-022-11450-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,1,30]],"date-time":"2023-01-30T05:15:24Z","timestamp":1675055724000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00415-022-11450-y"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,11,3]]},"references-count":41,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2023,2]]}},"alternative-id":["11450"],"URL":"https:\/\/doi.org\/10.1007\/s00415-022-11450-y","relation":{},"ISSN":["0340-5354","1432-1459"],"issn-type":[{"value":"0340-5354","type":"print"},{"value":"1432-1459","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,11,3]]},"assertion":[{"value":"22 August 2022","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"21 October 2022","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"22 October 2022","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"3 November 2022","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"All co-authors have seen and agree with the contents of the manuscript and there is no financial interest to report.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflicts of interest"}},{"value":"The supplied data came from a variety of sources. The likelihood of a causal relationship was not the same in all cases. The information does not represent the opinion of the World Health Organization.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical statement"}}]}}