{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T16:29:29Z","timestamp":1785774569620,"version":"3.56.0"},"reference-count":30,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2022,11,29]],"date-time":"2022-11-29T00:00:00Z","timestamp":1669680000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2022,11,29]],"date-time":"2022-11-29T00:00:00Z","timestamp":1669680000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100016359","name":"Zhongnan Hospital of Wuhan University","doi-asserted-by":"publisher","award":["ZNJC201924"],"award-info":[{"award-number":["ZNJC201924"]}],"id":[{"id":"10.13039\/501100016359","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Bureau of Science and Technology of Qingxiu District","award":["2019041"],"award-info":[{"award-number":["2019041"]}]},{"name":"Guangxi Zhuang Autonomous Region Health Care Commission","award":["Z20201417"],"award-info":[{"award-number":["Z20201417"]}]},{"name":"Department of Science and Technology of Hubei Province","award":["2020ZYYD014"],"award-info":[{"award-number":["2020ZYYD014"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Neurol"],"published-print":{"date-parts":[[2023,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Objective<\/jats:title>\n                <jats:p>To investigate whether hyperdense middle cerebral artery sign (HMCAS) on pretreatment no-contrast CT (NCCT) is associated with hemorrhagic transformation (HT) after endovascular thrombectomy (EVT).<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>Patients with acute middle cerebral artery (MCA) occlusion who received EVT in three comprehensive hospitals were retrospectively evaluated. They were divided into four groups based on the presence or absence of HMCAS and corresponding CTA findings, among whom differences were compared. Univariate and multivariate logistic regression analyses were performed to investigate the association between HMCAS and HT and its subtypes.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>318 patients were included, among whom 149 (46.9%) had HMCAS. Patients in the proximal positive HMCAS group had higher National Institute of Health Stroke Scale scores and lower Alberta Stroke Program Early CT Scores (ASPECTS) than those in the proximal negative HMCAS group. The rate of HT was higher in the proximal positive HMCAS group than that in the proximal negative HMCAS group. In multivariate logistic regression analysis, the proximal HMCAS were independently associated with HT (adjusted OR\u2009=\u20092.073, 95% CI 1.211\u20133.551, <jats:italic>p<\/jats:italic>\u2009=\u20090.008) and aHT (adjusted OR\u2009=\u20092.271, 95% CI 1.294\u20133.986, <jats:italic>p<\/jats:italic>\u2009=\u20090.004), but not with sHT. Patients who developed HT, including aHT and sHT, had a lower rate of good outcome.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusion<\/jats:title>\n                <jats:p>Proximal HMCAS on initial NCCT was independently associated with aHT in patients who received EVT for acute MCA occlusion. Both aHT and sHT had a detrimental effect on clinical outcome.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1007\/s00415-022-11500-5","type":"journal-article","created":{"date-parts":[[2022,11,29]],"date-time":"2022-11-29T22:09:04Z","timestamp":1669759744000},"page":"1587-1599","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Proximal hyperdense middle cerebral artery sign is associated with increased risk of asymptomatic hemorrhagic transformation after endovascular thrombectomy: a multicenter retrospective study"],"prefix":"10.1007","volume":"270","author":[{"given":"Zhiming","family":"Kang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lishuo","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dong","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gang","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiangbo","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Han","family":"Qiu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0433-799X","authenticated-orcid":false,"given":"Bin","family":"Mei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junjian","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2022,11,29]]},"reference":[{"key":"11500_CR1","doi-asserted-by":"publisher","first-page":"1723","DOI":"10.1016\/s0140-6736(16)00163-x","volume":"387","author":"M Goyal","year":"2016","unstructured":"Goyal M, Menon BK, van Zwam WH, Dippel DW, Mitchell PJ, Demchuk AM, D\u00e1valos A, Majoie CB, van der Lugt A, de Miquel MA, Donnan GA, Roos YB, Bonafe A, Jahan R, Diener HC, van den Berg LA, Levy EI, Berkhemer OA, Pereira VM, Rempel J, Mill\u00e1n M, Davis SM, Roy D, Thornton J, Rom\u00e1n LS, Rib\u00f3 M, Beumer D, Stouch B, Brown S, Campbell BC, van Oostenbrugge RJ, Saver JL, Hill MD, Jovin TG (2016) Endovascular thrombectomy after large-vessel ischaemic stroke: a meta-analysis of individual patient data from five randomised trials. Lancet 387:1723\u20131731. https:\/\/doi.org\/10.1016\/s0140-6736(16)00163-x","journal-title":"Lancet"},{"key":"11500_CR2","doi-asserted-by":"publisher","first-page":"e344","DOI":"10.1161\/str.0000000000000211","volume":"50","author":"WJ Powers","year":"2019","unstructured":"Powers WJ, Rabinstein AA, Ackerson T, Adeoye OM, Bambakidis NC, Becker K, Biller J, Brown M, Demaerschalk BM, Hoh B, Jauch EC, Kidwell CS, Leslie-Mazwi TM, Ovbiagele B, Scott PA, Sheth KN, Southerland AM, Summers DV, Tirschwell DL (2019) Guidelines for the early management of patients with acute ischemic stroke: 2019 update to the 2018 guidelines for the early management of acute ischemic stroke: a guideline for healthcare professionals From the American Heart Association\/American Stroke Association. Stroke 50:e344\u2013e418. https:\/\/doi.org\/10.1161\/str.0000000000000211","journal-title":"Stroke"},{"key":"11500_CR3","doi-asserted-by":"publisher","first-page":"464","DOI":"10.1136\/neurintsurg-2018-014141","volume":"11","author":"KR van Kranendonk","year":"2019","unstructured":"van Kranendonk KR, Treurniet KM, Boers AMM, Berkhemer OA, van den Berg LA, Chalos V, Lingsma HF, van Zwam WH, van der Lugt A, van Oostenbrugge RJ, Dippel DWJ, Roos Y, Marquering HA, Majoie C (2019) Hemorrhagic transformation is associated with poor functional outcome in patients with acute ischemic stroke due to a large vessel occlusion. J Neurointerv Surg 11:464\u2013468. https:\/\/doi.org\/10.1136\/neurintsurg-2018-014141","journal-title":"J Neurointerv Surg"},{"key":"11500_CR4","doi-asserted-by":"publisher","first-page":"469","DOI":"10.1136\/neurintsurg-2018-014080","volume":"11","author":"YB Lee","year":"2019","unstructured":"Lee YB, Yoon W, Lee YY, Kim SK, Baek BH, Kim JT, Park MS (2019) Predictors and impact of hemorrhagic transformations after endovascular thrombectomy in patients with acute large vessel occlusions. J Neurointerv Surg 11:469\u2013473. https:\/\/doi.org\/10.1136\/neurintsurg-2018-014080","journal-title":"J Neurointerv Surg"},{"key":"11500_CR5","doi-asserted-by":"publisher","first-page":"1203","DOI":"10.1161\/strokeaha.116.016368","volume":"48","author":"Y Hao","year":"2017","unstructured":"Hao Y, Yang D, Wang H, Zi W, Zhang M, Geng Y, Zhou Z, Wang W, Xu H, Tian X, Lv P, Liu Y, Xiong Y, Liu X, Xu G (2017) Predictors for symptomatic intracranial hemorrhage after endovascular treatment of acute ischemic stroke. Stroke 48:1203\u20131209. https:\/\/doi.org\/10.1161\/strokeaha.116.016368","journal-title":"Stroke"},{"key":"11500_CR6","doi-asserted-by":"publisher","first-page":"229","DOI":"10.1111\/ene.14539","volume":"28","author":"P Constant Dit Beaufils","year":"2021","unstructured":"Constant Dit Beaufils P, Preterre C, De Gaalon S, Labreuche J, Mazighi M, Di Maria F, Sibon I, Marnat G, Gariel F, Blanc R, Gory B, Consoli A, Zhu F, Richard S, Fahed R, Desal H, Lapergue B, Guillon B, Bourcier R (2021) Prognosis and risk factors associated with asymptomatic intracranial hemorrhage after endovascular treatment of large vessel occlusion stroke: a prospective multicenter cohort study. Eur J Neurol 28:229\u2013237. https:\/\/doi.org\/10.1111\/ene.14539","journal-title":"Eur J Neurol"},{"key":"11500_CR7","doi-asserted-by":"publisher","first-page":"3470","DOI":"10.1007\/s00415-022-11046-6","volume":"269","author":"G Tang","year":"2022","unstructured":"Tang G, Cao Z, Luo Y, Wu S, Sun X (2022) Prognosis associated with asymptomatic intracranial hemorrhage after acute ischemic stroke: a systematic review and meta-analysis. J Neurol 269:3470\u20133481. https:\/\/doi.org\/10.1007\/s00415-022-11046-6","journal-title":"J Neurol"},{"key":"11500_CR8","doi-asserted-by":"publisher","DOI":"10.1136\/jnis-2022-019474","author":"W van der Steen","year":"2022","unstructured":"van der Steen W, van der Ende NAM, Luijten SPR, Rinkel LA, van Kranendonk KR, van Voorst H, Roosendaal SD, Beenen LFM, Coutinho JM, Emmer BJ, van Oostenbrugge RJ, Majoie C, Lingsma HF, van der Lugt A, Dippel DWJ, Roozenbeek B (2022) Type of intracranial hemorrhage after endovascular stroke treatment: association with functional outcome. J Neurointerv Surg. https:\/\/doi.org\/10.1136\/jnis-2022-019474","journal-title":"J Neurointerv Surg"},{"key":"11500_CR9","doi-asserted-by":"publisher","DOI":"10.1016\/j.clineuro.2022.107298","volume":"218","author":"Z Kang","year":"2022","unstructured":"Kang Z, Nie C, Ouyang K, Wu X, Yin J, Sun D, Mei B (2022) A Nomogram for predicting symptomatic intracranial hemorrhage after endovascular thrombectomy. Clin Neurol Neurosurg 218:107298. https:\/\/doi.org\/10.1016\/j.clineuro.2022.107298","journal-title":"Clin Neurol Neurosurg"},{"key":"11500_CR10","doi-asserted-by":"publisher","first-page":"294","DOI":"10.1159\/000460265","volume":"43","author":"J Kaesmacher","year":"2017","unstructured":"Kaesmacher J, Kaesmacher M, Maegerlein C, Zimmer C, Gersing AS, Wunderlich S, Friedrich B, Boeckh-Behrens T, Kleine JF (2017) Hemorrhagic transformations after thrombectomy: risk factors and clinical relevance. Cerebrovasc Dis 43:294\u2013304. https:\/\/doi.org\/10.1159\/000460265","journal-title":"Cerebrovasc Dis"},{"key":"11500_CR11","doi-asserted-by":"publisher","first-page":"102","DOI":"10.1161\/strokeaha.114.007036","volume":"46","author":"G Mair","year":"2015","unstructured":"Mair G, Boyd EV, Chappell FM, von Kummer R, Lindley RI, Sandercock P, Wardlaw JM (2015) Sensitivity and specificity of the hyperdense artery sign for arterial obstruction in acute ischemic stroke. Stroke 46:102\u2013107. https:\/\/doi.org\/10.1161\/strokeaha.114.007036","journal-title":"Stroke"},{"key":"11500_CR12","doi-asserted-by":"publisher","first-page":"769","DOI":"10.1161\/01.str.30.4.769","volume":"30","author":"C Manelfe","year":"1999","unstructured":"Manelfe C, Larrue V, von Kummer R, Bozzao L, Ringleb P, Bastianello S, Iweins F, Lesaffre E (1999) Association of hyperdense middle cerebral artery sign with clinical outcome in patients treated with tissue plasminogen activator. Stroke 30:769\u2013772. https:\/\/doi.org\/10.1161\/01.str.30.4.769","journal-title":"Stroke"},{"key":"11500_CR13","doi-asserted-by":"publisher","first-page":"239","DOI":"10.1159\/000329375","volume":"32","author":"M Paciaroni","year":"2011","unstructured":"Paciaroni M, Agnelli G, Floridi P, Alberti A, Acciarresi M, Venti M, Alagia MG, Fiacca A, Gallina MC, Guercini G, Pantaleoni R, Leone F, Pieroni A, Caso V (2011) Hyperdense middle cerebral and\/or internal carotid arteries in acute ischemic stroke: rate, predictive factors and influence on clinical outcome. Cerebrovasc Dis 32:239\u2013245. https:\/\/doi.org\/10.1159\/000329375","journal-title":"Cerebrovasc Dis"},{"key":"11500_CR14","doi-asserted-by":"publisher","DOI":"10.1002\/brb3.2116","volume":"11","author":"J Hou","year":"2021","unstructured":"Hou J, Sun Y, Duan Y, Zhang L, Xing D, Lee X, Yang B (2021) Hyperdense middle cerebral artery sign in large cerebral infarction. Brain Behav 11:e02116. https:\/\/doi.org\/10.1002\/brb3.2116","journal-title":"Brain Behav"},{"key":"11500_CR15","doi-asserted-by":"publisher","first-page":"984","DOI":"10.1016\/j.jocn.2012.10.013","volume":"20","author":"M Zou","year":"2013","unstructured":"Zou M, Churilov L, He A, Campbell B, Davis SM, Yan B (2013) Hyperdense middle cerebral artery sign is associated with increased risk of hemorrhagic transformation after intravenous thrombolysis for patients with acute ischaemic stroke. J Clin Neurosci 20:984\u2013987. https:\/\/doi.org\/10.1016\/j.jocn.2012.10.013","journal-title":"J Clin Neurosci"},{"key":"11500_CR16","doi-asserted-by":"publisher","first-page":"1670","DOI":"10.1016\/s0140-6736(00)02237-6","volume":"355","author":"PA Barber","year":"2000","unstructured":"Barber PA, Demchuk AM, Zhang J, Buchan AM (2000) Validity and reliability of a quantitative computed tomography score in predicting outcome of hyperacute stroke before thrombolytic therapy. ASPECTS Study Group. Alberta Stroke Programme Early CT Score. Lancet 355:1670\u20131674. https:\/\/doi.org\/10.1016\/s0140-6736(00)02237-6","journal-title":"Lancet"},{"key":"11500_CR17","doi-asserted-by":"publisher","first-page":"1317","DOI":"10.1056\/NEJMoa0804656","volume":"359","author":"W Hacke","year":"2008","unstructured":"Hacke W, Kaste M, Bluhmki E, Brozman M, D\u00e1valos A, Guidetti D, Larrue V, Lees KR, Medeghri Z, Machnig T, Schneider D, von Kummer R, Wahlgren N, Toni D (2008) Thrombolysis with alteplase 3\u20134.5 hours after acute ischemic stroke. N Engl J Med 359:1317\u20131329. https:\/\/doi.org\/10.1056\/NEJMoa0804656","journal-title":"N Engl J Med"},{"key":"11500_CR18","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1161\/01.str.24.1.35","volume":"24","author":"HP Adams Jr","year":"1993","unstructured":"Adams HP Jr, Bendixen BH, Kappelle LJ, Biller J, Love BB, Gordon DL, Marsh EE 3rd (1993) Classification of subtype of acute ischemic stroke. Definitions for use in a multicenter clinical trial. TOAST. Trial of Org 10172 in Acute Stroke Treatment. Stroke 24:35\u201341. https:\/\/doi.org\/10.1161\/01.str.24.1.35","journal-title":"Stroke"},{"key":"11500_CR19","doi-asserted-by":"publisher","first-page":"2450","DOI":"10.1007\/s00415-017-8655-0","volume":"264","author":"SK Kim","year":"2017","unstructured":"Kim SK, Baek BH, Lee YY, Yoon W (2017) Clinical implications of CT hyperdense artery sign in patients with acute middle cerebral artery occlusion in the era of modern mechanical thrombectomy. J Neurol 264:2450\u20132456. https:\/\/doi.org\/10.1007\/s00415-017-8655-0","journal-title":"J Neurol"},{"key":"11500_CR20","doi-asserted-by":"publisher","DOI":"10.1016\/j.jns.2021.117618","volume":"429","author":"A Mowla","year":"2021","unstructured":"Mowla A, Razavi SM, Lail NS, Mohammadi P, Shirani P, Kavak KS, Sawyer RN, Kamal H (2021) Hyperdense middle cerebral artery sign and response to combination of mechanical Thrombectomy plus intravenous thrombolysis in acute stroke patients. J Neurol Sci 429:117618. https:\/\/doi.org\/10.1016\/j.jns.2021.117618","journal-title":"J Neurol Sci"},{"key":"11500_CR21","doi-asserted-by":"publisher","first-page":"1138","DOI":"10.1016\/s1474-4422(16)30177-6","volume":"15","author":"S Bracard","year":"2016","unstructured":"Bracard S, Ducrocq X, Mas JL, Soudant M, Oppenheim C, Moulin T, Guillemin F (2016) Mechanical thrombectomy after intravenous alteplase versus alteplase alone after stroke (THRACE): a randomised controlled trial. Lancet Neurol 15:1138\u20131147. https:\/\/doi.org\/10.1016\/s1474-4422(16)30177-6","journal-title":"Lancet Neurol"},{"key":"11500_CR22","doi-asserted-by":"publisher","first-page":"2316","DOI":"10.1056\/NEJMoa2000120","volume":"382","author":"SO Martins","year":"2020","unstructured":"Martins SO, Mont\u2019Alverne F, Rebello LC, Abud DG, Silva GS, Lima FO, Parente BSM, Nakiri GS, Faria MB, Frudit ME, de Carvalho JJF, Waihrich E, Fiorot JA Jr, Cardoso FB, Hidalgo RCT, Z\u00e9tola VF, Carvalho FM, de Souza AC, Dias FA, Bandeira D, Miranda Alves M, Wagner MB, Carbonera LA, Oliveira-Filho J, Bezerra DC, Liebeskind DS, Broderick J, Molina CA, Fogolin Passos JE, Saver JL, Pontes-Neto OM, Nogueira RG (2020) Thrombectomy for stroke in the public health care system of Brazil. N Engl J Med 382:2316\u20132326. https:\/\/doi.org\/10.1056\/NEJMoa2000120","journal-title":"N Engl J Med"},{"key":"11500_CR23","doi-asserted-by":"publisher","first-page":"1797","DOI":"10.1161\/strokeaha.118.024286","volume":"50","author":"NH Petersen","year":"2019","unstructured":"Petersen NH, Ortega-Gutierrez S, Wang A, Lopez GV, Strander S, Kodali S, Silverman A, Zheng-Lin B, Dandapat S, Sansing LH, Schindler JL, Falcone GJ, Gilmore EJ, Amin H, Cord B, Hebert RM, Matouk C, Sheth KN (2019) Decreases in blood pressure during thrombectomy are associated with larger infarct volumes and worse functional outcome. Stroke 50:1797\u20131804. https:\/\/doi.org\/10.1161\/strokeaha.118.024286","journal-title":"Stroke"},{"key":"11500_CR24","doi-asserted-by":"publisher","first-page":"101","DOI":"10.1177\/1747493021991972","volume":"17","author":"KL Ume","year":"2022","unstructured":"Ume KL, Dandapat S, Weber MW, Zevallos CB, Fifer A, Levy A, Delfino K, Ortega-Gutierrez S, Siddiqui FM (2022) Absent hyperdense middle cerebral artery sign is associated with poor functional outcome after mechanical thrombectomy. Int J Stroke 17:101\u2013108. https:\/\/doi.org\/10.1177\/1747493021991972","journal-title":"Int J Stroke"},{"key":"11500_CR25","doi-asserted-by":"publisher","first-page":"977","DOI":"10.1007\/s00234-013-1191-4","volume":"55","author":"S Soize","year":"2013","unstructured":"Soize S, Barbe C, Kadziolka K, Estrade L, Serre I, Pierot L (2013) Predictive factors of outcome and hemorrhage after acute ischemic stroke treated by mechanical thrombectomy with a stent-retriever. Neuroradiology 55:977\u2013987. https:\/\/doi.org\/10.1007\/s00234-013-1191-4","journal-title":"Neuroradiology"},{"key":"11500_CR26","doi-asserted-by":"publisher","first-page":"1237","DOI":"10.1161\/strokeaha.110.605576","volume":"42","author":"DS Liebeskind","year":"2011","unstructured":"Liebeskind DS, Sanossian N, Yong WH, Starkman S, Tsang MP, Moya AL, Zheng DD, Abolian AM, Kim D, Ali LK, Shah SH, Towfighi A, Ovbiagele B, Kidwell CS, Tateshima S, Jahan R, Duckwiler GR, Vi\u00f1uela F, Salamon N, Villablanca JP, Vinters HV, Marder VJ, Saver JL (2011) CT and MRI early vessel signs reflect clot composition in acute stroke. Stroke 42:1237\u20131243. https:\/\/doi.org\/10.1161\/strokeaha.110.605576","journal-title":"Stroke"},{"key":"11500_CR27","doi-asserted-by":"publisher","first-page":"1756","DOI":"10.3174\/ajnr.A4402","volume":"36","author":"SK Kim","year":"2015","unstructured":"Kim SK, Yoon W, Kim TS, Kim HS, Heo TW, Park MS (2015) Histologic analysis of retrieved clots in acute ischemic stroke: correlation with stroke etiology and gradient-echo MRI. AJNR Am J Neuroradiol 36:1756\u20131762. https:\/\/doi.org\/10.3174\/ajnr.A4402","journal-title":"AJNR Am J Neuroradiol"},{"key":"11500_CR28","doi-asserted-by":"publisher","first-page":"599","DOI":"10.1136\/neurintsurg-2020-016005","volume":"13","author":"MH Mohammaden","year":"2021","unstructured":"Mohammaden MH, Haussen DC, Perry da Camara C, Pisani L, Olive Gadea M, Al-Bayati AR, Liberato B, Rangaraju S, Frankel MR, Nogueira RG (2021) Hyperdense vessel sign as a potential guide for the choice of stent retriever versus contact aspiration as first-line thrombectomy strategy. J Neurointerv Surg 13:599\u2013604. https:\/\/doi.org\/10.1136\/neurintsurg-2020-016005","journal-title":"J Neurointerv Surg"},{"key":"11500_CR29","doi-asserted-by":"publisher","first-page":"243","DOI":"10.1161\/strokeaha.112.674127","volume":"44","author":"P Moftakhar","year":"2013","unstructured":"Moftakhar P, English JD, Cooke DL, Kim WT, Stout C, Smith WS, Dowd CF, Higashida RT, Halbach VV, Hetts SW (2013) Density of thrombus on admission CT predicts revascularization efficacy in large vessel occlusion acute ischemic stroke. Stroke 44:243\u2013245. https:\/\/doi.org\/10.1161\/strokeaha.112.674127","journal-title":"Stroke"},{"key":"11500_CR30","doi-asserted-by":"publisher","first-page":"263","DOI":"10.1111\/jon.12115","volume":"25","author":"S Man","year":"2015","unstructured":"Man S, Hussain MS, Wisco D, Katzan IL, Aoki J, Tateishi Y, Cheng-Ching E, Hui FK, Masaryk TJ, Rasmussen PA, Uchino K (2015) The location of pretreatment hyperdense middle cerebral artery sign predicts the outcome of intraarterial thrombectomy for acute stroke. J Neuroimaging 25:263\u2013268. https:\/\/doi.org\/10.1111\/jon.12115","journal-title":"J Neuroimaging"}],"container-title":["Journal of Neurology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00415-022-11500-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00415-022-11500-5\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00415-022-11500-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,2,27]],"date-time":"2023-02-27T13:07:31Z","timestamp":1677503251000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00415-022-11500-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,11,29]]},"references-count":30,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2023,3]]}},"alternative-id":["11500"],"URL":"https:\/\/doi.org\/10.1007\/s00415-022-11500-5","relation":{},"ISSN":["0340-5354","1432-1459"],"issn-type":[{"value":"0340-5354","type":"print"},{"value":"1432-1459","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,11,29]]},"assertion":[{"value":"19 October 2022","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"20 November 2022","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"21 November 2022","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"29 November 2022","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors have no competing interests to declare.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflicts of interest"}},{"value":"This study was performed in accordance with the principles of the Declaration of Helsinki and was approved by the Medical Ethics Committee of Zhongnan Hospital of Wuhan University (Approval number: 2020198).","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval"}}]}}