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The primary outcome was favorable [modified Rankin Scale (mRS) 0\u20131) at ninety days and the secondary outcome was hemorrhage events after anticoagulants. Factors affecting the outcomes were pooled into multivariate regression and ROC curve analysis.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>Of 234 eligible patients, there were 63 (26.9%) patients achieved a favorable outcome. The symptomatic intracranial hemorrhage (sICH), ICH, and systemic hemorrhage events after anticoagulants occurred in 8 (3.4%), 28 (12.0%), and 39 (16.7%) patients, severally. A longer EVT to anticoagulation time (<jats:italic>p<\/jats:italic>\u2009=\u20090.033) was associated with an unfavorable outcome (mRS 3\u20136). An earlier EVT to anticoagulation time was the independent risk factor of sICH (<jats:italic>p<\/jats:italic>\u2009=\u20090.043), ICH (<jats:italic>p<\/jats:italic>\u2009=\u20090.005), and systemic hemorrhage (<jats:italic>p<\/jats:italic>\u2009=\u20090.005). There was no significant difference in recurrent AIS\/ transient ischemic attack (TIA) or mortality among patients who started anticoagulation at \u2264\u20094\u00a0days, \u2265\u200915\u00a0days, or 4 to 15\u00a0days. The optimum cut-off for initiating anticoagulants to predict a favorable outcome and hemorrhage events was 4.5\u00a0days and 3.5\u00a0days after EVT, respectively.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusions<\/jats:title>\n                <jats:p>In AF-related AIS, the time of EVT to anticoagulation is an independent factor of the functional outcome and hemorrhage events after anticoagulation. The optimal initiate time of anticoagulant after EVT is 4.5\u00a0days.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>ClinicalTrialRegister<\/jats:title>\n                <jats:p>NCT03754738.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1007\/s00415-022-11515-y","type":"journal-article","created":{"date-parts":[[2023,1,3]],"date-time":"2023-01-03T17:03:32Z","timestamp":1672765412000},"page":"2084-2095","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["The optimum anticoagulation time after endovascular thrombectomy for atrial fibrillation-related large vessel occlusion stroke: a real-world study"],"prefix":"10.1007","volume":"270","author":[{"given":"Hongrui","family":"Ma","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruiwen","family":"Che","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qihan","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wantong","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Longfei","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenbo","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Di","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chuanjie","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xunming","family":"Ji","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2023,1,3]]},"reference":[{"key":"11515_CR1","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1007\/s40292-017-0237-9","volume":"25","author":"M Balaghi-Inalou","year":"2018","unstructured":"Balaghi-Inalou M, Parsa SA, Gachkar L et al (2018) Anticoagulant therapy in atrial fibrillation for stroke prevention: assessment of agreement between clinicians\u2019 decision and CHA2DS2-VASc and HAS-BLED scores. 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All enrolled AIS patients with AF receiving EVT had been approved by the Ethics Committee (NO. 2017030). The study was conducted according to the principles of the Declaration of Helsinki.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical standards"}}]}}