{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T19:38:05Z","timestamp":1790710685741,"version":"4.1.0"},"reference-count":69,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2022,12,13]],"date-time":"2022-12-13T00:00:00Z","timestamp":1670889600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2022,12,13]],"date-time":"2022-12-13T00:00:00Z","timestamp":1670889600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Neurol"],"published-print":{"date-parts":[[2023,4]]},"DOI":"10.1007\/s00415-022-11516-x","type":"journal-article","created":{"date-parts":[[2022,12,13]],"date-time":"2022-12-13T18:02:52Z","timestamp":1670954572000},"page":"1857-1879","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Cognition-oriented treatments and physical exercise on cognitive function in Huntington\u2019s disease: a systematic review"],"prefix":"10.1007","volume":"270","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7329-6725","authenticated-orcid":false,"given":"Katharine","family":"Huynh","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4163-6537","authenticated-orcid":false,"given":"Leila","family":"Nategh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7222-7181","authenticated-orcid":false,"given":"Sharna","family":"Jamadar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9637-8590","authenticated-orcid":false,"given":"Julie","family":"Stout","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0718-6760","authenticated-orcid":false,"given":"Nellie","family":"Georgiou-Karistianis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6522-8397","authenticated-orcid":false,"given":"Amit","family":"Lampit","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2022,12,13]]},"reference":[{"key":"11516_CR1","doi-asserted-by":"publisher","first-page":"24","DOI":"10.1111\/ene.13413","volume":"25","author":"P McColgan","year":"2018","unstructured":"McColgan P, Tabrizi SJ (2018) Huntington\u2019s disease: a clinical review. Eur J Neurol 25:24\u201334. https:\/\/doi.org\/10.1111\/ene.13413","journal-title":"Eur J Neurol"},{"key":"11516_CR2","doi-asserted-by":"publisher","first-page":"204","DOI":"10.1038\/nrneurol.2014.24","volume":"10","author":"CA Ross","year":"2014","unstructured":"Ross CA, Aylward EH, Wild EJ, Langbehn DR, Long JD, Warner JH, Scahill RI, Leavitt BR, Stout JC, Paulsen JS, Reilmann R, Unschuld PG, Wexler A, Margolis RL, Tabrizi SJ (2014) Huntington disease: natural history, biomarkers and prospects for therapeutics. Nat Rev Neurol 10:204\u2013216. https:\/\/doi.org\/10.1038\/nrneurol.2014.24","journal-title":"Nat Rev Neurol"},{"key":"11516_CR3","doi-asserted-by":"publisher","first-page":"500","DOI":"10.1212\/WNL.0b013e3181eccfa2","volume":"75","author":"K Duff","year":"2010","unstructured":"Duff K, Paulsen J, Mills J, Beglinger LJ, Moser DJ, Smith MM, Langbehn D, Stout J, Queller S, Harrington DL (2010) Mild cognitive impairment in prediagnosed Huntington disease. Neurology 75:500. https:\/\/doi.org\/10.1212\/WNL.0b013e3181eccfa2","journal-title":"Neurology"},{"key":"11516_CR4","doi-asserted-by":"publisher","DOI":"10.1016\/j.jns.2019.116523","volume":"408","author":"P Julayanont","year":"2020","unstructured":"Julayanont P, McFarland NR, Heilman KM (2020) Mild cognitive impairment and dementia in motor manifest Huntington\u2019s disease: classification and prevalence. J Neurol Sci 408:116523. https:\/\/doi.org\/10.1016\/j.jns.2019.116523","journal-title":"J Neurol Sci"},{"key":"11516_CR5","doi-asserted-by":"publisher","first-page":"395","DOI":"10.3233\/JHD-160228","volume":"15","author":"JA Simpson","year":"2016","unstructured":"Simpson JA, Lovecky D, Kogan J, Vetter LA, Yohrling GJ (2016) Survey of the Huntington\u2019s disease patient and caregiver community reveals most impactful symptoms and treatment needs. J Huntingtons Dis 15:395\u2013403. https:\/\/doi.org\/10.3233\/JHD-160228","journal-title":"J Huntingtons Dis"},{"key":"11516_CR6","doi-asserted-by":"publisher","first-page":"167","DOI":"10.1007\/s11065-020-09434-8","volume":"30","author":"HM Gavelin","year":"2020","unstructured":"Gavelin HM, Lampit A, Hallock H, Sabat\u00e9s J, Bahar-Fuchs A (2020) Cognition-oriented treatments for older adults: a systematic overview of systematic reviews. Neuropsychol Rev 30:167\u2013193. https:\/\/doi.org\/10.1007\/s11065-020-09434-8","journal-title":"Neuropsychol Rev"},{"key":"11516_CR7","doi-asserted-by":"publisher","first-page":"393","DOI":"10.1080\/13607863.2017.1423031","volume":"23","author":"O McDermott","year":"2019","unstructured":"McDermott O, Charlesworth G, Hogervorst E, Stoner C, Moniz-Cook E, Spector A, Csipke E, Orrell M (2019) Psychosocial interventions for people with dementia: a synthesis of systematic reviews. Aging Ment Health 23:393\u2013403. https:\/\/doi.org\/10.1080\/13607863.2017.1423031","journal-title":"Aging Ment Health"},{"key":"11516_CR8","doi-asserted-by":"publisher","first-page":"119","DOI":"10.1016\/j.neurobiolaging.2019.03.007","volume":"79","author":"RS Falck","year":"2019","unstructured":"Falck RS, Davis JC, Best JR, Crockett RA, Liu-Ambrose T (2019) Impact of exercise training on physical and cognitive function among older adults: a systematic review and meta-analysis. Neurobiol Aging 79:119\u2013130. https:\/\/doi.org\/10.1016\/j.neurobiolaging.2019.03.007","journal-title":"Neurobiol Aging"},{"key":"11516_CR9","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1016\/j.jphys.2019.11.014","volume":"66","author":"C-K Law","year":"2020","unstructured":"Law C-K, Lam FMH, Chung RCK, Pang MYC (2020) Physical exercise attenuates cognitive decline and reduces behavioural problems in people with mild cognitive impairment and dementia: a systematic review. J Physiother 66:9\u201318. https:\/\/doi.org\/10.1016\/j.jphys.2019.11.014","journal-title":"J Physiother"},{"key":"11516_CR10","doi-asserted-by":"publisher","first-page":"155","DOI":"10.1016\/j.ijnurstu.2018.01.002","volume":"79","author":"D Song","year":"2018","unstructured":"Song D, Yu DSF, Li PWC, Lei Y (2018) The effectiveness of physical exercise on cognitive and psychological outcomes in individuals with mild cognitive impairment: a systematic review and meta-analysis. Int J Nurs Stud 79:155\u2013164. https:\/\/doi.org\/10.1016\/j.ijnurstu.2018.01.002","journal-title":"Int J Nurs Stud"},{"key":"11516_CR11","doi-asserted-by":"publisher","DOI":"10.1016\/j.arr.2020.101113","volume":"62","author":"E Whitty","year":"2020","unstructured":"Whitty E, Mansour H, Aguirre E, Palomo M, Charlesworth G, Ramjee S, Poppe M, Brodaty H, Kales HC, Morgan-Trimmer S, Nyman SR, Lang I, Walters K, Petersen I, Wenborn J, Minihane AM, Ritchie K, Huntley J, Walker Z, Cooper C (2020) Efficacy of lifestyle and psychosocial interventions in reducing cognitive decline in older people: systematic review. Ageing Res Rev 62:101113. https:\/\/doi.org\/10.1016\/j.arr.2020.101113","journal-title":"Ageing Res Rev"},{"key":"11516_CR12","doi-asserted-by":"publisher","DOI":"10.1016\/j.arr.2020.101232","volume":"66","author":"HM Gavelin","year":"2021","unstructured":"Gavelin HM, Dong C, Minkov R, Bahar-Fuchs A, Ellis KA, Lautenschlager NT, Mellow ML, Wade AT, Smith AE, Finke C, Krohn S, Lampit A (2021) Combined physical and cognitive training for older adults with and without cognitive impairment: a systematic review and network meta-analysis of randomized controlled trials. Ageing Res Rev 66:101232. https:\/\/doi.org\/10.1016\/j.arr.2020.101232","journal-title":"Ageing Res Rev"},{"key":"11516_CR13","doi-asserted-by":"publisher","first-page":"1222","DOI":"10.1007\/s00415-019-09493-9","volume":"268","author":"MA-O Dauwan","year":"2019","unstructured":"Dauwan MA-O, Begemann MJH, Slot MIE, Lee EHM, Scheltens P, Sommer IEC (2019) Physical exercise improves quality of life, depressive symptoms, and cognition across chronic brain disorders: a transdiagnostic systematic review and meta-analysis of randomized controlled trials. J Neurol 268:1222\u20131246. https:\/\/doi.org\/10.1007\/s00415-019-09493-9","journal-title":"J Neurol"},{"key":"11516_CR14","doi-asserted-by":"publisher","first-page":"217","DOI":"10.3233\/JHD-170260","volume":"6","author":"NE Fritz","year":"2017","unstructured":"Fritz NE, Rao AK, Kegelmeyer D, Kloos A, Busse M, Hartel L, Carrier J, Quinn L (2017) Physical therapy and exercise interventions in Huntington\u2019s disease: a mixed methods systematic review. J Huntingtons Dis 6:217\u2013235. https:\/\/doi.org\/10.3233\/JHD-170260","journal-title":"J Huntingtons Dis"},{"key":"11516_CR15","doi-asserted-by":"publisher","first-page":"393","DOI":"10.3233\/JHD-190370","volume":"8","author":"AE Schwartz","year":"2019","unstructured":"Schwartz AE, van Walsem MR, Brean A, Frich JC (2019) Therapeutic use of music, dance, and rhythmic auditory cueing for patients with Huntington\u2019s Disease: a systematic review. J Huntingtons Dis 8:393\u2013420. https:\/\/doi.org\/10.3233\/JHD-190370","journal-title":"J Huntingtons Dis"},{"key":"11516_CR16","doi-asserted-by":"publisher","DOI":"10.7916\/tohm.v7910.7678.10.7916\/tohm.v0.678","author":"M Yu","year":"2019","unstructured":"Yu M, Bega D (2019) A review of the clinical evidence for complementary and alternative medicine in Huntington\u2019s disease. Tremor Other Hyperkinet Mov. https:\/\/doi.org\/10.7916\/tohm.v7910.7678.10.7916\/tohm.v0.678","journal-title":"Tremor Other Hyperkinet Mov"},{"key":"11516_CR17","doi-asserted-by":"publisher","first-page":"271","DOI":"10.1016\/j.apmr.2012.09.011","volume":"94","author":"DM Langenbahn","year":"2013","unstructured":"Langenbahn DM, Ashman T, Cantor J, Trott C (2013) An evidence-based review of cognitive rehabilitation in medical conditions affecting cognitive function. Arch Phys Med Rehabil 94:271\u2013286. https:\/\/doi.org\/10.1016\/j.apmr.2012.09.011","journal-title":"Arch Phys Med Rehabil"},{"key":"11516_CR18","doi-asserted-by":"publisher","DOI":"10.1080\/10833196.2021.1976019","author":"K Huynh","year":"2021","unstructured":"Huynh K, Nategh L, Jamadar S, Georgiou-Karistianis N, Lampit A (2021) Cognition-oriented treatments and physical exercise on cognitive function in Huntington\u2019s disease: protocol for systematic review. Phys Ther Rev. https:\/\/doi.org\/10.1080\/10833196.2021.1976019","journal-title":"Phys Ther Rev"},{"key":"11516_CR19","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.n71","volume":"372","author":"MJ Page","year":"2021","unstructured":"Page MJ, McKenzie JE, Bossuyt PM, Boutron I, Hoffmann TC, Mulrow CD, Shamseer L, Tetzlaff JM, Akl EA, Brennan SE, Chou R, Glanville J, Grimshaw JM, Hr\u00f3bjartsson A, Lalu MM, Li T, Loder EW, Mayo-Wilson E, McDonald S, McGuinness LA, Stewart LA, Thomas J, Tricco AC, Welch VA, Whiting P, Moher D (2021) The PRISMA 2020 statement: an updated guideline for reporting systematic reviews. BMJ 372:n71. https:\/\/doi.org\/10.1136\/bmj.n71","journal-title":"BMJ"},{"key":"11516_CR20","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.l4898","volume":"366","author":"JAC Sterne","year":"2019","unstructured":"Sterne JAC, Savovi\u0107 J, Page MJ, Elbers RG, Blencowe NS, Boutron I, Cates CJ, Cheng H-Y, Corbett MS, Eldridge SM, Emberson JR, Hern\u00e1n MA, Hopewell S, Hr\u00f3bjartsson A, Junqueira DR, J\u00fcni P, Kirkham JJ, Lasserson T, Li T, McAleenan A, Reeves BC, Shepperd S, Shrier I, Stewart LA, Tilling K, White IR, Whiting PF, Higgins JPT (2019) RoB 2: a revised tool for assessing risk of bias in randomised trials. BMJ 366:l4898. https:\/\/doi.org\/10.1136\/bmj.l4898","journal-title":"BMJ"},{"key":"11516_CR21","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.i4919","volume":"355","author":"JAC Sterne","year":"2016","unstructured":"Sterne JAC, Hern\u00e1n MA, Reeves BC, Savovi\u0107 J, Berkman ND, Viswanathan M, Henry D, Altman DG, Ansari MT, Boutron I, Carpenter JR, Chan A-W, Churchill R, Deeks JJ, Hr\u00f3bjartsson A, Kirkham J, J\u00fcni P, Loke YK, Pigott TD, Ramsay CR, Regidor D, Rothstein HR, Sandhu L, Santaguida PL, Sch\u00fcnemann HJ, Shea B, Shrier I, Tugwell P, Turner L, Valentine JC, Waddington H, Waters E, Wells GA, Whiting PF, Higgins JPT (2016) ROBINS-I: a tool for assessing risk of bias in non-randomised studies of interventions. BMJ 355:i4919. https:\/\/doi.org\/10.1136\/bmj.i4919","journal-title":"BMJ"},{"key":"11516_CR22","doi-asserted-by":"publisher","first-page":"203","DOI":"10.1037\/1082-989X.6.3.203","volume":"6","author":"LV Hedges","year":"2001","unstructured":"Hedges LV, Pigott TD (2001) The power of statistical tests in meta-analysis. Psychol Methods 6:203\u2013217. https:\/\/doi.org\/10.1037\/1082-989X.6.3.203","journal-title":"Psychol Methods"},{"key":"11516_CR23","doi-asserted-by":"publisher","first-page":"A46","DOI":"10.1136\/jnnp.2010.222695.1","volume":"81","author":"P Zinzi","year":"2010","unstructured":"Zinzi P, Jacopini G, Salmaso D, Zappata P, De Grandis R, Maceroni S, Basmagi L, Bentivoglio A, Frontali M (2010) Intensive multidisciplinary rehabilitation for Huntington\u2019s disease in Italy: results in a cohort of patients with consecutive treatments over 5 years. J Neurol Neurosurg Psychiatry 81:A46. https:\/\/doi.org\/10.1136\/jnnp.2010.222695.1","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"11516_CR24","doi-asserted-by":"publisher","first-page":"972","DOI":"10.1177\/0269215513487235","volume":"27","author":"AD Kloos","year":"2013","unstructured":"Kloos AD, Fritz NE, Kostyk SK, Young GS, Kegelmeyer DA (2013) Video game play (Dance Dance Revolution) as a potential exercise therapy in Huntington\u2019s disease: a controlled clinical trial. Clin Rehabil 27:972\u2013982. https:\/\/doi.org\/10.1177\/0269215513487235","journal-title":"Clin Rehabil"},{"key":"11516_CR25","doi-asserted-by":"publisher","first-page":"303","DOI":"10.3233\/JHD-200424","volume":"9","author":"C Casella","year":"2020","unstructured":"Casella C, Bourbon-Teles J, Parker GD, Metzler-Baddeley C, Bells S, Coulthard E, Jones DK, Rosser A (2020) Drumming motor sequence training induces apparent myelin remodelling in huntington\u2019s disease: a longitudinal diffusion MRI and quantitative magnetization transfer study. J Huntingtons Dis 9:303\u2013320. https:\/\/doi.org\/10.3233\/JHD-200424","journal-title":"J Huntingtons Dis"},{"key":"11516_CR26","doi-asserted-by":"publisher","first-page":"357","DOI":"10.1016\/j.jns.2019.10.1513","volume":"405","author":"K Ziora-Jakutowicz","year":"2019","unstructured":"Ziora-Jakutowicz K, Stepniak I, Krysa W, Sulek A, Rakowicz M, Witkowski G, Sienkiewicz-Jarosz H, Kruszynski M, Pawlisz M, Polak M, Lis D, Chabuda A (2019) Clinical evaluation of the effectiveness of teleneuroforma\u2014a home rehabilitation tool for patients with Huntington\u2019s disease. J Neurol Sci 405:357\u2013358. https:\/\/doi.org\/10.1016\/j.jns.2019.10.1513","journal-title":"J Neurol Sci"},{"key":"11516_CR27","doi-asserted-by":"publisher","first-page":"570","DOI":"10.1016\/j.rehab.2019.11.003","volume":"63","author":"DM Bartlett","year":"2020","unstructured":"Bartlett DM, Dann L, Poudel G, Maddison KJ, Eastwood PR, Lampit A, Lazar AS, Ziman MR, Cruickshank TM (2020) Effect of multidisciplinary rehabilitation on sleep outcomes in individuals with preclinical Huntington disease: an exploratory study. Ann Phys Rehabil Med 63:570\u2013573. https:\/\/doi.org\/10.1016\/j.rehab.2019.11.003","journal-title":"Ann Phys Rehabil Med"},{"key":"11516_CR28","doi-asserted-by":"publisher","DOI":"10.1016\/j.jns.2020.117022","author":"DM Bartlett","year":"2020","unstructured":"Bartlett DM, Govus A, Rankin T, Lampit A, Feindel K, Poudel G, Teo W-P, Lo J, Georgiou-Karistianis N, Ziman MR, Cruickshank TM (2020) The effects of multidisciplinary rehabilitation on neuroimaging, biological, cognitive and motor outcomes in individuals with premanifest Huntington\u2019s disease. J Neurol Sci. https:\/\/doi.org\/10.1016\/j.jns.2020.117022","journal-title":"J Neurol Sci"},{"key":"11516_CR29","doi-asserted-by":"publisher","DOI":"10.1016\/j.jns.2019.116522","volume":"408","author":"DM Bartlett","year":"2020","unstructured":"Bartlett DM, Rankin TJ, Dominguez DJF, Lazar AS, Kordsachia CC, Lo J, Govus AD, Power BD, Lampit A, Eastwood PR, Ziman MR, Cruickshank TM (2020) Multidisciplinary rehabilitation reduces hypothalamic grey matter volume loss in individuals with preclinical Huntington\u2019s disease: a nine-month pilot study. J Neurol Sci 408:116522. https:\/\/doi.org\/10.1016\/j.jns.2019.116522","journal-title":"J Neurol Sci"},{"key":"11516_CR30","doi-asserted-by":"publisher","DOI":"10.1016\/j.rehab.2020.06.006","author":"A Reyes","year":"2020","unstructured":"Reyes A, Bartlett D, Rankin T, Pulverenti TS, Georgiou-Karistianis N, Lampit A, Ziman M, Cruickshank T (2020) The effect of multidisciplinary therapy on dual task performance in preclinical Huntington\u2019s disease: an exploratory study. Ann Phys Rehabil Med. https:\/\/doi.org\/10.1016\/j.rehab.2020.06.006","journal-title":"Ann Phys Rehabil Med"},{"key":"11516_CR31","doi-asserted-by":"publisher","DOI":"10.1371\/currents.hd.9504af71e0d1f87830c25c394be47027","author":"A Piira","year":"2013","unstructured":"Piira A, van Walsem MR, Mikalsen G, Nilsen KH, Knutsen S, Frich JC (2013) Effects of a one year intensive multidisciplinary rehabilitation program for patients with Huntington\u2019s disease: a prospective intervention study. PLoS Curr. https:\/\/doi.org\/10.1371\/currents.hd.9504af71e0d1f87830c25c394be47027","journal-title":"PLoS Curr"},{"key":"11516_CR32","doi-asserted-by":"publisher","DOI":"10.1371\/currents.hd.2c56ceef7f9f8e239a59ecf2d94cddac","author":"A Piira","year":"2014","unstructured":"Piira A, van Walsem MR, Mikalsen G, Oie L, Frich JC, Knutsen S (2014) Effects of a two-year intensive multidisciplinary rehabilitation program for patients with Huntington\u2019s disease: a prospective intervention study. PLoS Curr. https:\/\/doi.org\/10.1371\/currents.hd.2c56ceef7f9f8e239a59ecf2d94cddac","journal-title":"PLoS Curr"},{"key":"11516_CR33","doi-asserted-by":"publisher","first-page":"379","DOI":"10.3233\/JHD-180294","volume":"7","author":"MR van Walsem","year":"2018","unstructured":"van Walsem MR, Piira A, Mikalsen G, Fossmo HL, Howe EI, Knutsen SF, Frich JC (2018) Cognitive performance after a one-year multidisciplinary intensive rehabilitation program for Huntington\u2019s disease: an observational study. J Huntingtons Dis 7:379\u2013389. https:\/\/doi.org\/10.3233\/JHD-180294","journal-title":"J Huntingtons Dis"},{"key":"11516_CR34","doi-asserted-by":"publisher","first-page":"603","DOI":"10.1177\/0269215507075495","volume":"21","author":"P Zinzi","year":"2007","unstructured":"Zinzi P, Jacopini G, De Grandis R, Graziani G, Maceroni S, Zappata P, Bentivoglio A, Frontali M, Salmaso D (2007) Effects of an intensive rehabilitation programme on patients with Huntington\u2019s disease: a pilot study. Clin Rehabil 21:603\u2013613. https:\/\/doi.org\/10.1177\/0269215507075495","journal-title":"Clin Rehabil"},{"key":"11516_CR35","doi-asserted-by":"publisher","first-page":"32","DOI":"10.1007\/s00415-016-8310-1","volume":"264","author":"S Frese","year":"2017","unstructured":"Frese S, Petersen JA, Ligon-Auer M, Mueller SM, Mihaylova V, Gehrig SM, Kana V, Rushing EJ, Unterburger E, Kagi G, Burgunder J-M, Toigo M, Jung HH (2017) Exercise effects in Huntington disease. J Neurol 264:32\u201339. https:\/\/doi.org\/10.1007\/s00415-016-8310-1","journal-title":"J Neurol"},{"key":"11516_CR36","doi-asserted-by":"publisher","first-page":"1325","DOI":"10.1111\/ene.12053","volume":"20","author":"JA Thompson","year":"2013","unstructured":"Thompson JA, Cruickshank TM, Penailillo LE, Lee JW, Newton RU, Barker RA, Ziman MR (2013) The effects of multidisciplinary rehabilitation in patients with early-to-middle-stage Huntington\u2019s disease: a pilot study. Eur J Neurol 20:1325\u20131329. https:\/\/doi.org\/10.1111\/ene.12053","journal-title":"Eur J Neurol"},{"key":"11516_CR37","doi-asserted-by":"publisher","first-page":"88","DOI":"10.1186\/s40814-020-00623-z","volume":"6","author":"E Yhnell","year":"2020","unstructured":"Yhnell E, Furby H, Lowe RS, Brookes-Howell LC, Drew CJG, Playle R, Watson G, Metzler-Baddeley C, Rosser AE, Busse ME (2020) A randomised feasibility study of computerised cognitive training as a therapeutic intervention for people with Huntington\u2019s disease (CogTrainHD). Pilot Feasibility Stud 6:88. https:\/\/doi.org\/10.1186\/s40814-020-00623-z","journal-title":"Pilot Feasibility Stud"},{"key":"11516_CR38","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1016\/j.parkreldis.2022.06.013","volume":"101","author":"L Quinn","year":"2022","unstructured":"Quinn L, Playle R, Drew CJG, Taiyari K, Williams-Thomas R, Muratori LM, Hamana K, Griffin BA, Kelson M, Schubert R, Friel C, Morgan-Jones P, Rosser A, Busse M, Montojo T, Ruiz Idiago JM, Hershberg J, Marder K, Bordelon Y, Reilmann R, Reetz K, Landwehrmeyer B (2022) Physical activity and exercise outcomes in Huntington\u2019s disease (PACE-HD): results of a 12-month trial-within-cohort feasibility study of a physical activity intervention in people with Huntington\u2019s disease. Parkinsonism Relat Disord 101:75\u201389. https:\/\/doi.org\/10.1016\/j.parkreldis.2022.06.013","journal-title":"Parkinsonism Relat Disord"},{"key":"11516_CR39","doi-asserted-by":"publisher","first-page":"136","DOI":"10.1002\/mds.870110204","volume":"11","author":"Huntington Study Group","year":"1996","unstructured":"Huntington Study Group (1996) Unified Huntington\u2019s Disease Rating Scale: reliability and consistency. Huntington Study Group. Mov Disord 11:136\u2013142. https:\/\/doi.org\/10.1002\/mds.870110204","journal-title":"Mov Disord"},{"key":"11516_CR40","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0176429","author":"M Sadeghi","year":"2017","unstructured":"Sadeghi M, Barlow-Krelina E, Gibbons C, Shaikh KT, Fung WLA, Meschino WS, Till C (2017) Feasibility of computerized working memory training in individuals with Huntington disease. PLoS\u00a0One. https:\/\/doi.org\/10.1371\/journal.pone.0176429","journal-title":"PLoS\u00a0One"},{"key":"11516_CR41","doi-asserted-by":"publisher","first-page":"273","DOI":"10.3233\/JHD-140113","volume":"3","author":"C Metzler-Baddeley","year":"2014","unstructured":"Metzler-Baddeley C, Cantera J, Coulthard E, Rosser A, Jones DK, Baddeley RJ (2014) Improved executive function and callosal white matter microstructure after rhythm exercise in Huntington\u2019s disease. J Huntingtons Dis 3:273\u2013283. https:\/\/doi.org\/10.3233\/JHD-140113","journal-title":"J Huntingtons Dis"},{"key":"11516_CR42","first-page":"6","volume":"2","author":"AS Aldine","year":"2021","unstructured":"Aldine AS, Ogilvie A, Wemmie J, Kent J, Schultz J, Long JD, Kamholz J, Sajjad H, Kline J, Shaw E, Voss M, Paulsen JS, Magnotta VA (2021) Moderate intensity exercise in pre-manifest Huntington\u2019s disease: results of a 6 months trial. SVOA Neurol 2:6\u201336","journal-title":"SVOA Neurol"},{"key":"11516_CR43","doi-asserted-by":"publisher","first-page":"149","DOI":"10.1097\/NPT.0000000000000016","volume":"37","author":"M Busse","year":"2013","unstructured":"Busse M, Quinn L, Debono K, Jones K, Collett J, Dawes H, Playle R, Kelly M, Simpson S, Backx K, Wasley D, Rosser A (2013) A randomized feasibility study of a 12-week community-based exercise program for people with Huntington\u2019s disease. J Neurol Phys Ther 37:149\u2013158. https:\/\/doi.org\/10.1097\/NPT.0000000000000016","journal-title":"J Neurol Phys Ther"},{"key":"11516_CR44","doi-asserted-by":"publisher","first-page":"46","DOI":"10.1016\/j.parkreldis.2016.06.023","volume":"31","author":"L Quinn","year":"2016","unstructured":"Quinn L, Hamana K, Kelson M, Dawes H, Collett J, Townson J, Roos R, van der Plas AA, Reilmann R, Frich JC, Rickards H, Rosser A, Busse M (2016) A randomized, controlled trial of a multi-modal exercise intervention in Huntington\u2019s disease. Parkinsonism Relat Disord 31:46\u201352. https:\/\/doi.org\/10.1016\/j.parkreldis.2016.06.023","journal-title":"Parkinsonism Relat Disord"},{"key":"11516_CR45","doi-asserted-by":"publisher","first-page":"97","DOI":"10.3233\/JHD-180315","volume":"8","author":"I Trinkler","year":"2019","unstructured":"Trinkler I, Chehere P, Salgues J, Monin M-L, Tezenas Du Montcel S, Khani S, Gargiulo M, Durr A (2019) Contemporary dance practice improves motor function and body representation in Huntington\u2019s disease: a pilot study. J Huntingtons Dis 8:97\u2013110. https:\/\/doi.org\/10.3233\/JHD-180315","journal-title":"J Huntingtons Dis"},{"key":"11516_CR46","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1002\/brb3.312","volume":"5","author":"TM Cruickshank","year":"2015","unstructured":"Cruickshank TM, Thompson JA, Reyes AP, Dominguez DJF, Georgiou-Karistianis N, Bynevelt M, Barker RA, Ziman MR (2015) The effect of multidisciplinary rehabilitation on brain structure and cognition in Huntington\u2019s disease: an exploratory study. Brain Behav 5:1\u201310. https:\/\/doi.org\/10.1002\/brb3.312","journal-title":"Brain Behav"},{"key":"11516_CR47","doi-asserted-by":"publisher","first-page":"1107","DOI":"10.1002\/mds.26203","volume":"30","author":"SN Wassef","year":"2015","unstructured":"Wassef SN, Wemmie J, Johnson CP, Johnson H, Paulsen JS, Long JD, Magnotta VA (2015) T1\u03c1 imaging in premanifest Huntington disease reveals changes associated with disease progression. Mov Disord 30:1107\u20131114. https:\/\/doi.org\/10.1002\/mds.26203","journal-title":"Mov Disord"},{"key":"11516_CR48","doi-asserted-by":"publisher","DOI":"10.1007\/s12264-022-00943-5","author":"J-J Xie","year":"2022","unstructured":"Xie J-J, Li X-Y, Dong Y, Chen C, Qu B-Y, Wang S, Xu H, Roe AW, Lai H-Y, Wu Z-Y (2022) Local and global abnormalities in pre-symptomatic Huntington\u2019s disease revealed by 7T resting-state functional MRI. Neurosci Bull. https:\/\/doi.org\/10.1007\/s12264-022-00943-5","journal-title":"Neurosci Bull"},{"key":"11516_CR49","doi-asserted-by":"publisher","first-page":"1843","DOI":"10.1212\/wnl.0000000000002145","volume":"85","author":"IH Leung","year":"2015","unstructured":"Leung IH, Walton CC, Hallock H, Lewis SJ, Valenzuela M, Lampit A (2015) Cognitive training in Parkinson disease: a systematic review and meta-analysis. Neurology 85:1843\u20131851. https:\/\/doi.org\/10.1212\/wnl.0000000000002145","journal-title":"Neurology"},{"key":"11516_CR50","doi-asserted-by":"publisher","first-page":"695","DOI":"10.1177\/1545968319860490","volume":"33","author":"A Lampit","year":"2019","unstructured":"Lampit A, Heine J, Finke C, Barnett MH, Valenzuela M, Wolf A, Leung IHK, Hill NTM (2019) Computerized cognitive training in multiple sclerosis: a systematic review and meta-analysis. Neurorehabil Neural Repair 33:695\u2013706. https:\/\/doi.org\/10.1177\/1545968319860490","journal-title":"Neurorehabil Neural Repair"},{"key":"11516_CR51","doi-asserted-by":"publisher","first-page":"245","DOI":"10.1007\/s41465-020-00188-y","volume":"5","author":"E Baykara","year":"2020","unstructured":"Baykara E, K\u00f6nen T, Unger K, Karbach J (2020) MRI predictors of cognitive training outcomes. J Cogn Enhanc 5:245\u2013258. https:\/\/doi.org\/10.1007\/s41465-020-00188-y","journal-title":"J Cogn Enhanc"},{"key":"11516_CR52","doi-asserted-by":"publisher","first-page":"601","DOI":"10.7916\/tm9j-f874","volume":"9","author":"SM Mueller","year":"2019","unstructured":"Mueller SM, Petersen JA, Jung HH (2019) Exercise in Huntington\u2019s disease: current state and clinical significance. Tremor Other Hyperkinet Mov 9:601\u2013601. https:\/\/doi.org\/10.7916\/tm9j-f874","journal-title":"Tremor Other Hyperkinet Mov"},{"key":"11516_CR53","doi-asserted-by":"publisher","first-page":"2308475","DOI":"10.1155\/2019\/2308475","volume":"2019","author":"X Li","year":"2019","unstructured":"Li X, Guo R, Wei Z, Jia J, Wei C (2019) Effectiveness of exercise programs on patients with dementia: a systematic review and meta-analysis of randomized controlled trials. BioMed Res Int 2019:2308475. https:\/\/doi.org\/10.1155\/2019\/2308475","journal-title":"BioMed Res Int"},{"key":"11516_CR54","doi-asserted-by":"publisher","first-page":"188","DOI":"10.1017\/BrImp.2017.6","volume":"18","author":"E Tsantali","year":"2017","unstructured":"Tsantali E, Economidis D, Rigopoulou S (2017) Testing the benefits of cognitive training vs. cognitive stimulation in miild Alzheimer\u2019s disease: a randomised controlled trial. Brain Impair 18:188\u2013196. https:\/\/doi.org\/10.1017\/BrImp.2017.6","journal-title":"Brain Impair"},{"key":"11516_CR55","doi-asserted-by":"publisher","first-page":"1349","DOI":"10.3233\/JAD-160810","volume":"56","author":"EL Kallio","year":"2017","unstructured":"Kallio EL, \u00d6hman H, Kautiainen H, Hietanen M, Pitk\u00e4l\u00e4 K (2017) Cognitive training interventions for patients with Alzheimer\u2019s disease: a systematic review. J Alzheimer\u2019s Dis 56:1349\u20131372. https:\/\/doi.org\/10.3233\/JAD-160810","journal-title":"J Alzheimer's Dis"},{"key":"11516_CR56","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1177\/0891988718813724","volume":"32","author":"S Germain","year":"2018","unstructured":"Germain S, Wojtasik V, Lekeu F, Quittre A, Olivier C, Godichard V, Salmon E (2018) Efficacy of cognitive rehabilitation in Alzheimer disease: a 1-year follow-up study. J Geriatr Psychiatry Neurol 32:16\u201323. https:\/\/doi.org\/10.1177\/0891988718813724","journal-title":"J Geriatr Psychiatry Neurol"},{"key":"11516_CR57","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.n532","volume":"372","author":"JA Watt","year":"2021","unstructured":"Watt JA, Goodarzi Z, Veroniki AA, Nincic V, Khan PA, Ghassemi M, Lai Y, Treister V, Thompson Y, Schneider R, Tricco AC, Straus SE (2021) Comparative efficacy of interventions for reducing symptoms of depression in people with dementia: systematic review and network meta-analysis. BMJ 372:n532. https:\/\/doi.org\/10.1136\/bmj.n532","journal-title":"BMJ"},{"key":"11516_CR58","doi-asserted-by":"publisher","first-page":"1058","DOI":"10.3389\/fneur.2018.01058","volume":"9","author":"C Zucchella","year":"2018","unstructured":"Zucchella C, Sinforiani E, Tamburin S, Federico A, Mantovani E, Bernini S, Casale R, Bartolo M (2018) The multidisciplinary approach to Alzheimer\u2019s disease and dementia. A narrative review of non-pharmacological treatment. Front Neurol 9:1058\u20131058. https:\/\/doi.org\/10.3389\/fneur.2018.01058","journal-title":"Front Neurol"},{"key":"11516_CR59","doi-asserted-by":"publisher","first-page":"121","DOI":"10.1016\/j.sleep.2021.05.022","volume":"84","author":"S Lee","year":"2021","unstructured":"Lee S, Kim JH, Chung JH (2021) The association between sleep quality and quality of life: a population-based study. Sleep Med 84:121\u2013126. https:\/\/doi.org\/10.1016\/j.sleep.2021.05.022","journal-title":"Sleep Med"},{"key":"11516_CR60","doi-asserted-by":"publisher","first-page":"363","DOI":"10.1093\/geronb\/gbv060","volume":"72","author":"JM Blaxton","year":"2021","unstructured":"Blaxton JM, Bergeman CS, Whitehead BR, Braun ME, Payne JD (2021) Relationships among nightly sleep quality, daily stress, and daily affect. J Gerontol B Psychol Sci Soc Sci 72:363\u2013372. https:\/\/doi.org\/10.1093\/geronb\/gbv060","journal-title":"J Gerontol B Psychol Sci Soc Sci"},{"key":"11516_CR61","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1007\/s11136-010-9717-2","volume":"20","author":"A Hawton","year":"2011","unstructured":"Hawton A, Green C, Dickens AP, Richards SH, Taylor RS, Edwards R, Greaves CJ, Campbell JL (2011) The impact of social isolation on the health status and health-related quality of life of older people. Qual Life Res 20:57\u201367. https:\/\/doi.org\/10.1007\/s11136-010-9717-2","journal-title":"Qual Life Res"},{"key":"11516_CR62","doi-asserted-by":"publisher","first-page":"5940","DOI":"10.3390\/jcm11195940","volume":"11","author":"F Wendel","year":"2022","unstructured":"Wendel F, Bauer A, Blotenberg I, Brettschneider C, Buchholz M, Czock D, D\u00f6hring J, Escales C, Frese T, Hoffmann W, Kaduszkiewicz H, K\u00f6nig H-H, L\u00f6bner M, Luppa M, Schwenker R, Thyrian JR, Wei\u00dfenborn M, Wiese B, Z\u00f6llinger I, Riedel-Heller SG, Gensichen J (2022) Social network and participation in elderly primary care patients in Germany and associations with depressive symptoms\u2014a cross-sectional analysis from the AgeWell.de study. J Clin Med 11:5940. https:\/\/doi.org\/10.3390\/jcm11195940","journal-title":"J Clin Med"},{"key":"11516_CR63","doi-asserted-by":"publisher","DOI":"10.1016\/j.arr.2019.100912","volume":"53","author":"L Nguyen","year":"2019","unstructured":"Nguyen L, Murphy K, Andrews G (2019) Cognitive and neural plasticity in old age: a systematic review of evidence from executive functions cognitive training. Ageing Res Rev 53:100912. https:\/\/doi.org\/10.1016\/j.arr.2019.100912","journal-title":"Ageing Res Rev"},{"key":"11516_CR64","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1186\/s11556-019-0217-2","volume":"16","author":"F Herold","year":"2019","unstructured":"Herold F, T\u00f6rpel A, Schega L, M\u00fcller NG (2019) Functional and\/or structural brain changes in response to resistance exercises and resistance training lead to cognitive improvements\u2014a systematic review. Eur Rev Aging Phys Act 16:10. https:\/\/doi.org\/10.1186\/s11556-019-0217-2","journal-title":"Eur Rev Aging Phys Act"},{"key":"11516_CR65","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0023175","volume":"6","author":"H Takeuchi","year":"2011","unstructured":"Takeuchi H, Taki Y, Sassa Y, Hashizume H, Sekiguchi A, Fukushima A, Kawashima R (2011) Working memory training using mental calculation impacts regional gray matter of the frontal and parietal regions. PLoS\u00a0One 6:e23175. https:\/\/doi.org\/10.1371\/journal.pone.0023175","journal-title":"PLoS\u00a0One"},{"key":"11516_CR66","doi-asserted-by":"publisher","first-page":"3878","DOI":"10.1016\/j.neuropsychologia","volume":"48","author":"M L\u00f6vd\u00e9n","year":"2010","unstructured":"L\u00f6vd\u00e9n M, Bodammer NC, K\u00fchn S, Kaufmann J, Sch\u00fctze H, Tempelmann C, Heinze HJ, D\u00fczel E, Schmiedek F, Lindenberger U (2010) Experience-dependent plasticity of white-matter microstructure extends into old age. Neuropsychologia 48:3878\u20133883. https:\/\/doi.org\/10.1016\/j.neuropsychologia","journal-title":"Neuropsychologia"},{"key":"11516_CR67","doi-asserted-by":"publisher","first-page":"230","DOI":"10.1016\/j.neurobiolaging.2021.01.025","volume":"101","author":"MA Gogniat","year":"2021","unstructured":"Gogniat MA, Robinson TL, Miller LS (2021) Exercise interventions do not impact brain volume change in older adults: a systematic review and meta-analysis. Neurobiol Aging 101:230\u2013246. https:\/\/doi.org\/10.1016\/j.neurobiolaging.2021.01.025","journal-title":"Neurobiol Aging"},{"key":"11516_CR68","doi-asserted-by":"publisher","DOI":"10.3389\/fnagi.2010.00032","author":"M Voss","year":"2010","unstructured":"Voss M, Prakash R, Erickson K, Basak C, Chaddock L, Kim J, Alves H, Heo S, Szabo A, White S, Wojcicki T, Mailey E, Gothe N, Olson E, McAuley E, Kramer A (2010) Plasticity of brain networks in a randomized intervention trial of exercise training in older adults. Front Aging Neurosci. https:\/\/doi.org\/10.3389\/fnagi.2010.00032","journal-title":"Front Aging Neurosci"},{"key":"11516_CR69","doi-asserted-by":"publisher","first-page":"14","DOI":"10.3389\/fnagi.2015.00014","volume":"7","author":"A Lampit","year":"2015","unstructured":"Lampit A, Hallock H, Suo C, Naismith SL, Valenzuela M (2015) Cognitive training-induced short-term functional and long-term structural plastic change is related to gains in global cognition in healthy older adults: a pilot study. Front Aging Neurosci 7:14\u201314. https:\/\/doi.org\/10.3389\/fnagi.2015.00014","journal-title":"Front Aging Neurosci"}],"container-title":["Journal of Neurology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00415-022-11516-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00415-022-11516-x\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00415-022-11516-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,3,27]],"date-time":"2023-03-27T01:46:11Z","timestamp":1679881571000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00415-022-11516-x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,12,13]]},"references-count":69,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2023,4]]}},"alternative-id":["11516"],"URL":"https:\/\/doi.org\/10.1007\/s00415-022-11516-x","relation":{},"ISSN":["0340-5354","1432-1459"],"issn-type":[{"value":"0340-5354","type":"print"},{"value":"1432-1459","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,12,13]]},"assertion":[{"value":"29 October 2022","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"2 December 2022","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"2 December 2022","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"13 December 2022","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors have no competing interests to declare that are relevant to the content of this article.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflicts of interest"}}]}}