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Status epilepticus was diagnosed according to ILAE criteria. Additionally, we employed an alternative classification with more emphasis on the course of status epilepticus. We used data from three large control groups to compare NfL in status epilepticus versus neurologically healthy controls.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>We included 28 patients (mean age: 69.4\u00a0years, SD: 15\u00a0years) with a median status duration of 44\u00a0h (IQR: 80\u00a0h). Twenty-one patients (75%) suffered from convulsive status epilepticus and seven (25%) from non-convulsive status epilepticus. Six patients died (21%). Cerebrospinal fluid and serum NfL concentrations showed a high correlation (<jats:italic>r<\/jats:italic>\u2009=\u20090.73, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001, Pearson). The main determinant of NfL concentration was the status duration. NfL concentrations did not differ between convulsive status epilepticus and convulsive status epilepticus classified according to the ILAE or to the alternative classification without and with adjusting for status duration and time between status onset and sampling. We found no association of NfL concentration with death, treatment refractoriness, or prognostic scores.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusion<\/jats:title>\n                <jats:p>The results suggest that neurodestruction in status epilepticus measured by NfL is mainly determined by status duration, not status type nor therapy refractoriness. Therefore, our results suggest that regarding neurodestruction convulsive and non-convulsive status epilepticus are both neurological emergencies of comparable urgency.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1007\/s00415-022-11547-4","type":"journal-article","created":{"date-parts":[[2023,1,9]],"date-time":"2023-01-09T17:03:54Z","timestamp":1673283834000},"page":"2128-2138","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":29,"title":["Neurofilament light (NfL) as biomarker in serum and CSF in status epilepticus"],"prefix":"10.1007","volume":"270","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2197-1079","authenticated-orcid":false,"given":"Nils G.","family":"Margraf","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Justina","family":"Dargvainiene","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emily","family":"Theel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frank","family":"Leypoldt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wolfgang","family":"Lieb","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andre","family":"Franke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Klaus","family":"Berger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jens","family":"Kuhle","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gregor","family":"Kuhlenbaeumer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2023,1,9]]},"reference":[{"key":"11547_CR1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0132177","volume":"10","author":"F Al Nimer","year":"2015","unstructured":"Al Nimer F, Thelin E, Nystrom H, Dring AM, Svenningsson A, Piehl F, Nelson DW, Bellander BM (2015) Comparative assessment of the prognostic value of biomarkers in traumatic brain injury reveals an independent role for serum levels of neurofilament light. 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Lecture fees were given by Jazz Pharma and Angelini Pharma. Research support was granted by Jazz Pharma, Angelini Pharma, Eisai Pharma, UCB Pharma, LivaNova and Desitin Pharma. He also receives funding from the Ministry of Health (Schleswig\u2013Holstein) and the German Research Council (DFG). Non-financial interests: none. JD has no relevant financial or non-financial interests to disclose. ET has no relevant financial or non-financial interests to disclose. FL reports having received speaker\u2019s honoraria from Grifols, Biogen, Novartis, Roche, Alexion, serving on advisory boards for Roche and Biogen and receiving research funding from the German Ministry of Education and Research, the German Society for Laboratory Medicine (DGKL) and the German Research Council (DFG). He works for an academic institution offering commercial autoantibody testing. Non-financial interests: none. WL has no relevant financial or non-financial interests to disclose. AF has no relevant financial or non-financial interests to disclose. KB receives for the MEMO Study funding by the German Research Society (Deutsche Forschungsgemeinschaft DFG, grant: BE1996\/1-1). The measurement of NfL was done through funds from the Institute of Epidemiology and Social Medicine, University of Muenster. The BiDirect Study is supported by grants of the German Ministry of Research and Education (BMBF) to the University of Muenster (01ER0816 and 01ER1506). Non-financial interests: none. JK received speaker fees, research support, travel support, and\/or served on advisory boards\u00a0by Swiss MS Society, Swiss National Research Foundation (320030_189140\/1), University of Basel, Progressive MS Alliance, Bayer, Biogen, Bristol Myers Squibb, Celgene, Merck, Novartis, Octave\u00a0Bioscience, Roche, Sanofi. Non-financial interests: none. GK receives non-project-related financial support from the BMBF project CONNECT-GENERATE: Genetics of autoimmune encephalitis. Non-financial interests: none. The authors declare that they have no conflict of interest concerning this work.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflicts of interest"}},{"value":"The study was approved by the Ethics Committee of the Medical Faculty of the Christian-Albrechts-University, Kiel, Germany (D 480\/20). The study was conducted following the World Medical Association Declaration of Helsinki. The use of retrospective data was reviewed and confirmed by the Ethics Committee. The data protection guidelines were also observed. The identity of the subjects is protected.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical standards"}}]}}