{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T09:39:40Z","timestamp":1788514780176,"version":"build-2803163510"},"reference-count":73,"publisher":"Springer Science and Business Media LLC","issue":"7","license":[{"start":{"date-parts":[[2023,3,11]],"date-time":"2023-03-11T00:00:00Z","timestamp":1678492800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2023,3,11]],"date-time":"2023-03-11T00:00:00Z","timestamp":1678492800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/501100003196","name":"Ministero della Salute","doi-asserted-by":"publisher","award":["RC-2773803"],"award-info":[{"award-number":["RC-2773803"]}],"id":[{"id":"10.13039\/501100003196","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Neurol"],"published-print":{"date-parts":[[2023,7]]},"DOI":"10.1007\/s00415-023-11655-9","type":"journal-article","created":{"date-parts":[[2023,3,11]],"date-time":"2023-03-11T07:02:55Z","timestamp":1678518175000},"page":"3377-3390","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Sleep counts! Role and impact of sleep in the multimodal management of multiple sclerosis"],"prefix":"10.1007","volume":"270","author":[{"given":"Maria P.","family":"Mogavero","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giuseppe","family":"Lanza","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oliviero","family":"Bruni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lourdes M.","family":"DelRosso","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raffaele","family":"Ferri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2867-5424","authenticated-orcid":false,"given":"Luigi","family":"Ferini-Strambi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2023,3,11]]},"reference":[{"key":"11655_CR1","doi-asserted-by":"publisher","first-page":"269","DOI":"10.1016\/S1474-4422(18)30443-5","volume":"18","author":"G. B. D. Multiple Sclerosis Collaborators","year":"2019","unstructured":"G. B. D. Multiple Sclerosis Collaborators (2019) Global, regional, and national burden of multiple sclerosis 1990\u20132016: a systematic analysis for the Global Burden of Disease Study 2016. The Lancet Neurology. 18:269\u2013285","journal-title":"The Lancet Neurology."},{"key":"11655_CR2","first-page":"988","volume":"28","author":"M Ward","year":"2022","unstructured":"Ward M, Goldman MD (2022) Epidemiology and pathophysiology of multiple sclerosis. Continuum 28:988\u20131005","journal-title":"Continuum"},{"key":"11655_CR3","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1038\/s41579-022-00770-5","volume":"21","author":"SS Soldan","year":"2023","unstructured":"Soldan SS, Lieberman PM (2023) Epstein-Barr virus and multiple sclerosis. Nat Rev Microbiol 21:51\u201364","journal-title":"Nat Rev Microbiol"},{"key":"11655_CR4","doi-asserted-by":"publisher","first-page":"612","DOI":"10.1177\/0883073819855592","volume":"34","author":"LB Krupp","year":"2019","unstructured":"Krupp LB, Vieira MC, Toledano H, Peneva D, Druyts E, Wu P et al (2019) A Review of available treatments, clinical evidence, and guidelines for diagnosis and treatment of pediatric multiple sclerosis in the United States. J Child Neurol 34:612\u2013620","journal-title":"J Child Neurol"},{"key":"11655_CR5","doi-asserted-by":"publisher","first-page":"17","DOI":"10.2147\/PHMT.S140765","volume":"9","author":"EM Sikes","year":"2018","unstructured":"Sikes EM, Motl RW, Ness JM (2018) Pediatric multiple sclerosis: current perspectives on health behaviors. Pediatr Health Med Ther 9:17\u201325","journal-title":"Pediatr Health Med Ther"},{"issue":"11","key":"11655_CR6","doi-asserted-by":"publisher","first-page":"146","DOI":"10.3390\/children5110146","volume":"5","author":"J Petrin","year":"2018","unstructured":"Petrin J, Fiander M, Doss P, Yeh EA (2018) A scoping review of modifiable risk factors in pediatric onset multiple sclerosis: building for the future. Children 5(11):146","journal-title":"Children"},{"key":"11655_CR7","doi-asserted-by":"publisher","first-page":"1039","DOI":"10.1111\/dmcn.14212","volume":"61","author":"S Duignan","year":"2019","unstructured":"Duignan S, Brownlee W, Wassmer E, Hemingway C, Lim M, Ciccarelli O et al (2019) Paediatric multiple sclerosis: a new era in diagnosis and treatment. Dev Med Child Neurol 61:1039\u20131049","journal-title":"Dev Med Child Neurol"},{"key":"11655_CR8","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2022.853096","volume":"12","author":"MR Zielinski","year":"2022","unstructured":"Zielinski MR, Gibbons AJ (2022) Neuroinflammation, sleep, and circadian rhythms. Front Cell Infect Microbiol 12:853096","journal-title":"Front Cell Infect Microbiol"},{"key":"11655_CR9","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1186\/1742-2094-11-51","volume":"11","author":"IA Clark","year":"2014","unstructured":"Clark IA, Vissel B (2014) Inflammation-sleep interface in brain disease: TNF, insulin, orexin. J Neuroinflammation 11:51","journal-title":"J Neuroinflammation"},{"issue":"11","key":"11655_CR10","doi-asserted-by":"publisher","first-page":"2612","DOI":"10.3390\/cancers13112612","volume":"13","author":"MP Mogavero","year":"2021","unstructured":"Mogavero MP, Silvani A, DelRosso LM, Salemi M, Ferri R (2021) Focus on the complex interconnection between cancer, narcolepsy and other neurodegenerative diseases: a possible case of orexin-dependent inverse comorbidity. Cancers 13(11):2612","journal-title":"Cancers"},{"key":"11655_CR11","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1016\/B978-0-12-819410-2.00004-7","volume":"184","author":"G Lanza","year":"2022","unstructured":"Lanza G, DelRosso LM, Ferri R (2022) Sleep and homeostatic control of plasticity. Handb Clin Neurol 184:53\u201372","journal-title":"Handb Clin Neurol"},{"issue":"2","key":"11655_CR12","doi-asserted-by":"publisher","first-page":"253","DOI":"10.5664\/jcsm.10304","volume":"19","author":"Y Zhang","year":"2022","unstructured":"Zhang Y, Ren R, Yang L, Zhang H, Shi Y, Vitiello MV et al (2022) Sleep in multiple sclerosis: a systematic review and meta-analysis of polysomnographic findings. J Clin Sleep Med 19(2):253\u2013265","journal-title":"J Clin Sleep Med"},{"key":"11655_CR13","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1177\/1352458516664034","volume":"23","author":"G Lanza","year":"2017","unstructured":"Lanza G, Ferri R, Bella R, Ferini-Strambi L (2017) The impact of drugs for multiple sclerosis on sleep. Mult Scler 23:5\u201313","journal-title":"Mult Scler"},{"key":"11655_CR14","doi-asserted-by":"publisher","first-page":"193","DOI":"10.1016\/0165-1781(89)90047-4","volume":"28","author":"DJ Buysse","year":"1989","unstructured":"Buysse DJ, Reynolds CF 3rd, Monk TH, Berman SR, Kupfer DJ (1989) The Pittsburgh Sleep Quality Index: a new instrument for psychiatric practice and research. Psychiatry Res 28:193\u2013213","journal-title":"Psychiatry Res"},{"key":"11655_CR15","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0049996","volume":"7","author":"HM Boe Lunde","year":"2012","unstructured":"Boe Lunde HM, Aae TF, Indrevag W, Aarseth J, Bjorvatn B, Myhr KM et al (2012) Poor sleep in patients with multiple sclerosis. PLoS ONE 7:e49996","journal-title":"PLoS ONE"},{"key":"11655_CR16","doi-asserted-by":"publisher","first-page":"540","DOI":"10.1093\/sleep\/14.6.540","volume":"14","author":"MW Johns","year":"1991","unstructured":"Johns MW (1991) A new method for measuring daytime sleepiness: the Epworth sleepiness scale. Sleep 14:540\u2013545","journal-title":"Sleep"},{"key":"11655_CR17","doi-asserted-by":"publisher","first-page":"309","DOI":"10.5114\/ninp.2012.30261","volume":"46","author":"B Labuz-Roszak","year":"2012","unstructured":"Labuz-Roszak B, Kubicka-Baczyk K, Pierzchala K, Machowska-Majchrzak A, Skrzypek M (2012) Fatigue and its association with sleep disorders, depressive symptoms and anxiety in patients with multiple sclerosis. Neurol Neurochir Pol 46:309\u2013317","journal-title":"Neurol Neurochir Pol"},{"key":"11655_CR18","doi-asserted-by":"publisher","first-page":"1291","DOI":"10.1007\/s10072-012-1229-0","volume":"34","author":"A Pokryszko-Dragan","year":"2013","unstructured":"Pokryszko-Dragan A, Bilinska M, Gruszka E, Biel L, Kaminska K, Konieczna K (2013) Sleep disturbances in patients with multiple sclerosis. Neurol Sci 34:1291\u20131296","journal-title":"Neurol Sci"},{"key":"11655_CR19","doi-asserted-by":"publisher","first-page":"1138","DOI":"10.1177\/1352458507078685","volume":"13","author":"T Kumpfel","year":"2007","unstructured":"Kumpfel T, Schwan M, Pollmacher T, Yassouridis A, Uhr M, Trenkwalder C et al (2007) Time of interferon-beta 1a injection and duration of treatment affect clinical side effects and acute changes of plasma hormone and cytokine levels in multiple sclerosis patients. Mult Scler 13:1138\u20131145","journal-title":"Mult Scler"},{"key":"11655_CR20","doi-asserted-by":"publisher","first-page":"316","DOI":"10.1016\/j.clineuro.2010.12.013","volume":"113","author":"Y Nadjar","year":"2011","unstructured":"Nadjar Y, Coutelas E, Prouteau P, Panzer F, Paquet D, Saint-Val C et al (2011) Injection of interferon-beta in the morning decreases flu-like syndrome in many patients with multiple sclerosis. Clin Neurol Neurosurg 113:316\u2013322","journal-title":"Clin Neurol Neurosurg"},{"key":"11655_CR21","doi-asserted-by":"publisher","first-page":"123","DOI":"10.1186\/s12883-018-1113-5","volume":"18","author":"S Kotterba","year":"2018","unstructured":"Kotterba S, Neusser T, Norenberg C, Bussfeld P, Glaser T, Dorner M et al (2018) Sleep quality, daytime sleepiness, fatigue, and quality of life in patients with multiple sclerosis treated with interferon beta-1b: results from a prospective observational cohort study. BMC Neurol 18:123","journal-title":"BMC Neurol"},{"key":"11655_CR22","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1016\/j.jns.2011.11.003","volume":"314","author":"L Melamud","year":"2012","unstructured":"Melamud L, Golan D, Luboshitzky R, Lavi I, Miller A (2012) Melatonin dysregulation, sleep disturbances and fatigue in multiple sclerosis. J Neurol Sci 314:37\u201340","journal-title":"J Neurol Sci"},{"key":"11655_CR23","doi-asserted-by":"publisher","first-page":"525","DOI":"10.1001\/archneur.61.4.525","volume":"61","author":"HP Attarian","year":"2004","unstructured":"Attarian HP, Brown KM, Duntley SP, Carter JD, Cross AH (2004) The relationship of sleep disturbances and fatigue in multiple sclerosis. Arch Neurol 61:525\u2013528","journal-title":"Arch Neurol"},{"key":"11655_CR24","doi-asserted-by":"publisher","first-page":"238","DOI":"10.1177\/1352458509354551","volume":"16","author":"L Mendozzi","year":"2010","unstructured":"Mendozzi L, Tronci F, Garegnani M, Pugnetti L (2010) Sleep disturbance and fatigue in mild relapsing remitting multiple sclerosis patients on chronic immunomodulant therapy: an actigraphic study. Mult Scler 16:238\u2013247","journal-title":"Mult Scler"},{"key":"11655_CR25","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1159\/000335076","volume":"68","author":"JP Neau","year":"2012","unstructured":"Neau JP, Paquereau J, Auche V, Mathis S, Godeneche G, Ciron J et al (2012) Sleep disorders and multiple sclerosis: a clinical and polysomnography study. Eur Neurol 68:8\u201315","journal-title":"Eur Neurol"},{"key":"11655_CR26","doi-asserted-by":"publisher","first-page":"744","DOI":"10.1080\/01616412.2020.1773629","volume":"42","author":"C Rocchi","year":"2020","unstructured":"Rocchi C, Pulcini A, Vesprini C, Totaro V, Viticchi G, Falsetti L et al (2020) Sleep in multiple sclerosis patients treated with interferon beta: an actigraphic study. Neurol Res 42:744\u2013748","journal-title":"Neurol Res"},{"key":"11655_CR27","doi-asserted-by":"publisher","DOI":"10.2174\/1871527321666220513121138","author":"C Rocchi","year":"2022","unstructured":"Rocchi C, Lombardi L, Broggi S, Danni MC, Lattanzi S, Viticchi G et al (2022) Impact of dimethylfumarate on sleep in multiple sclerosis patients: an actigraphic study. CNS Neurol Disord Drug Targets. https:\/\/doi.org\/10.2174\/1871527321666220513121138","journal-title":"CNS Neurol Disord Drug Targets"},{"key":"11655_CR28","doi-asserted-by":"publisher","first-page":"e58643","DOI":"10.1371\/journal.pone.0058643","volume":"8","author":"A Svenningsson","year":"2013","unstructured":"Svenningsson A, Falk E, Celius EG, Fuchs S, Schreiber K, Berko S et al (2013) Natalizumab treatment reduces fatigue in multiple sclerosis. Results from the TYNERGY trial; a study in the real life setting. PLoS ONE 8:e58643","journal-title":"PLoS ONE"},{"key":"11655_CR29","doi-asserted-by":"publisher","first-page":"18","DOI":"10.3389\/fneur.2015.00018","volume":"6","author":"IK Penner","year":"2015","unstructured":"Penner IK, Sivertsdotter EC, Celius EG, Fuchs S, Schreiber K, Berko S et al (2015) Improvement in fatigue during natalizumab treatment is linked to improvement in depression and day-time sleepiness. Front Neurol 6:18","journal-title":"Front Neurol"},{"key":"11655_CR30","doi-asserted-by":"publisher","first-page":"177","DOI":"10.7224\/1537-2073.2015-033","volume":"18","author":"RA Sater","year":"2016","unstructured":"Sater RA, Gudesblatt M, Kresa-Reahl K, Brandes DW, Sater P (2016) NAPS-MS: natalizumab effects on parameters of sleep in patients with multiple sclerosis. Int J MS Care 18:177\u2013182","journal-title":"Int J MS Care"},{"key":"11655_CR31","first-page":"205521732110046","volume":"7","author":"CM Hersh","year":"2021","unstructured":"Hersh CM, Kieseier B, de Moor C, Miller DM, Campagnolo D, Williams JR et al (2021) Impact of natalizumab on quality of life in a real-world cohort of patients with multiple sclerosis: results from MS PATHS. Mult Scler J Exp Transl Clin 7:20552173211004630","journal-title":"Mult Scler J Exp Transl Clin"},{"key":"11655_CR32","doi-asserted-by":"publisher","first-page":"1194","DOI":"10.1016\/j.psyneuen.2010.02.005","volume":"35","author":"M Dresler","year":"2010","unstructured":"Dresler M, Genzel L, Kluge M, Schussler P, Weber F, Rosenhagen M et al (2010) Off-line memory consolidation impairments in multiple sclerosis patients receiving high-dose corticosteroid treatment mirror consolidation impairments in depression. Psychoneuroendocrinology 35:1194\u20131202","journal-title":"Psychoneuroendocrinology"},{"key":"11655_CR33","doi-asserted-by":"publisher","first-page":"613","DOI":"10.1177\/1352458510393772","volume":"17","author":"C Veauthier","year":"2011","unstructured":"Veauthier C, Radbruch H, Gaede G, Pfueller CF, Dorr J, Bellmann-Strobl J et al (2011) Fatigue in multiple sclerosis is closely related to sleep disorders: a polysomnographic cross-sectional study. Mult Scler 17:613\u2013622","journal-title":"Mult Scler"},{"key":"11655_CR34","doi-asserted-by":"publisher","first-page":"1826","DOI":"10.1016\/j.clineuro.2013.05.018","volume":"115","author":"C Veauthier","year":"2013","unstructured":"Veauthier C, Gaede G, Radbruch H, Gottschalk S, Wernecke KD, Paul F (2013) Treatment of sleep disorders may improve fatigue in multiple sclerosis. Clin Neurol Neurosurg 115:1826\u20131830","journal-title":"Clin Neurol Neurosurg"},{"key":"11655_CR35","doi-asserted-by":"publisher","DOI":"10.1016\/j.msard.2022.103837","volume":"63","author":"SA Glasmacher","year":"2022","unstructured":"Glasmacher SA, Kearns PK, Hassan Z, Connick P, Tauber S, Reetz K et al (2022) The influence of disease-modifying therapy on hidden disability burden in people with newly diagnosed relapsing-remitting multiple sclerosis. Mult Scler Relat Disord 63:103837","journal-title":"Mult Scler Relat Disord"},{"key":"11655_CR36","doi-asserted-by":"publisher","first-page":"607","DOI":"10.1007\/s40261-019-00793-6","volume":"39","author":"M Yeganeh Salehpour","year":"2019","unstructured":"Yeganeh Salehpour M, Mollica A, Momtaz S, Sanadgol N, Farzaei MH (2019) Melatonin and multiple sclerosis: from plausible neuropharmacological mechanisms of action to experimental and clinical evidence. Clin Drug Investig 39:607\u2013624","journal-title":"Clin Drug Investig"},{"key":"11655_CR37","doi-asserted-by":"publisher","first-page":"769","DOI":"10.1007\/s10072-019-04137-2","volume":"41","author":"C Skarlis","year":"2020","unstructured":"Skarlis C, Anagnostouli M (2020) The role of melatonin in multiple sclerosis. Neurol Sci 41:769\u2013781","journal-title":"Neurol Sci"},{"key":"11655_CR38","doi-asserted-by":"publisher","first-page":"132","DOI":"10.1016\/0022-510X(93)90215-K","volume":"115","author":"RA Cohen","year":"1993","unstructured":"Cohen RA, Kessler HR, Fischer M (1993) The Extended Disability Status Scale (EDSS) as a predictor of impairments of functional activities of daily living in multiple sclerosis. J Neurol Sci 115:132\u2013135","journal-title":"J Neurol Sci"},{"key":"11655_CR39","first-page":"543","volume":"65","author":"M Adamczyk-Sowa","year":"2014","unstructured":"Adamczyk-Sowa M, Pierzchala K, Sowa P, Polaniak R, Kukla M, Hartel M (2014) Influence of melatonin supplementation on serum antioxidative properties and impact of the quality of life in multiple sclerosis patients. J Physiol Pharmacol 65:543\u2013550","journal-title":"J Physiol Pharmacol"},{"key":"11655_CR40","doi-asserted-by":"publisher","first-page":"588","DOI":"10.1207\/s15327752jpa6703_13","volume":"67","author":"AT Beck","year":"1996","unstructured":"Beck AT, Steer RA, Ball R, Ranieri W (1996) Comparison of beck depression inventories -IA and -II in psychiatric outpatients. J Pers Assess 67:588\u2013597","journal-title":"J Pers Assess"},{"key":"11655_CR41","doi-asserted-by":"publisher","first-page":"1585","DOI":"10.1007\/s11064-014-1347-6","volume":"39","author":"M Adamczyk-Sowa","year":"2014","unstructured":"Adamczyk-Sowa M, Pierzchala K, Sowa P, Mucha S, Sadowska-Bartosz I, Adamczyk J et al (2014) Melatonin acts as antioxidant and improves sleep in MS patients. Neurochem Res 39:1585\u20131593","journal-title":"Neurochem Res"},{"key":"11655_CR42","doi-asserted-by":"publisher","first-page":"107","DOI":"10.1186\/s12883-018-1114-4","volume":"18","author":"MJ Drake","year":"2018","unstructured":"Drake MJ, Canham L, Cotterill N, Delgado D, Homewood J, Inglis K et al (2018) Results of a randomized, double blind, placebo controlled, crossover trial of melatonin for treatment of Nocturia in adults with multiple sclerosis (MeNiMS). BMC Neurol 18:107","journal-title":"BMC Neurol"},{"key":"11655_CR43","first-page":"205521732110487","volume":"7","author":"WY Hsu","year":"2021","unstructured":"Hsu WY, Anderson A, Rowles W, Peters KE, Li V, Stone KL et al (2021) Effects of melatonin on sleep disturbances in multiple sclerosis: a randomized, controlled pilot study. Mult Scler J Exp Transl Clin 7:20552173211048756","journal-title":"Mult Scler J Exp Transl Clin"},{"key":"11655_CR44","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1097\/JNN.0000000000000409","volume":"51","author":"P Newland","year":"2019","unstructured":"Newland P, Lorenz RA, Smith JM, Dean E, Newland J, Cavazos P (2019) The relationship among multiple sclerosis-related symptoms, sleep quality, and sleep hygiene behaviors. J Neurosci Nurs 51:37\u201342","journal-title":"J Neurosci Nurs"},{"key":"11655_CR45","doi-asserted-by":"publisher","DOI":"10.1016\/j.msard.2020.101958","volume":"40","author":"CF Siengsukon","year":"2020","unstructured":"Siengsukon CF, Alshehri M, Williams C, Drerup M, Lynch S (2020) Feasibility and treatment effect of cognitive behavioral therapy for insomnia in individuals with multiple sclerosis: a pilot randomized controlled trial. Mult Scler Relat Disord 40:101958","journal-title":"Mult Scler Relat Disord"},{"key":"11655_CR46","doi-asserted-by":"publisher","first-page":"1865","DOI":"10.2147\/NSS.S324879","volume":"13","author":"C Williams-Cooke","year":"2021","unstructured":"Williams-Cooke C, LeSuer L, Drerup M, Siengsukon C (2021) The impact of cognitive behavioral therapy for insomnia on sleep log and actigraphy outcomes in people with multiple sclerosis: a secondary analysis. Nat Sci Sleep 13:1865\u20131874","journal-title":"Nat Sci Sleep"},{"key":"11655_CR47","first-page":"7110582","volume":"2022","author":"D Turkowitch","year":"2022","unstructured":"Turkowitch D, Ludwig R, Nelson E, Drerup M, Siengsukon CF (2022) Telehealth-delivered cognitive behavioral therapy for insomnia in individuals with multiple sclerosis: a pilot study. Mult Scler Int 2022:7110582","journal-title":"Mult Scler Int"},{"issue":"12","key":"11655_CR48","doi-asserted-by":"publisher","first-page":"2216","DOI":"10.3390\/jcm8122216","volume":"8","author":"L Tonetti","year":"2019","unstructured":"Tonetti L, Camilli F, Giovagnoli S, Natale V, Lugaresi A (2019) Circadian activity rhythm in early relapsing-remitting multiple sclerosis. J Clin Med 8(12):2216","journal-title":"J Clin Med"},{"issue":"1","key":"11655_CR49","doi-asserted-by":"publisher","first-page":"310","DOI":"10.3390\/ijms23010310","volume":"23","author":"C Scapoli","year":"2021","unstructured":"Scapoli C, Ziliotto N, Lunghi B, Menegatti E, Salvi F, Zamboni P et al (2021) Combination of genomic and transcriptomic approaches highlights vascular and circadian clock components in multiple sclerosis. Inte J Mol Sci. 23(1):310","journal-title":"Inte J Mol Sci."},{"key":"11655_CR50","doi-asserted-by":"publisher","first-page":"287","DOI":"10.1038\/s41573-020-00109-w","volume":"20","author":"W Ruan","year":"2021","unstructured":"Ruan W, Yuan X, Eltzschig HK (2021) Circadian rhythm as a therapeutic target. Nat Rev Drug Discovery 20:287\u2013307","journal-title":"Nat Rev Drug Discovery"},{"key":"11655_CR51","doi-asserted-by":"publisher","first-page":"886","DOI":"10.1136\/jnnp.2006.104000","volume":"78","author":"L Glass-Marmor","year":"2007","unstructured":"Glass-Marmor L, Paperna T, Ben-Yosef Y, Miller A (2007) Chronotherapy using corticosteroids for multiple sclerosis relapses. J Neurol Neurosurg Psychiatry 78:886\u2013888","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"11655_CR52","doi-asserted-by":"publisher","first-page":"124","DOI":"10.1016\/j.jneuroim.2009.03.004","volume":"210","author":"L Glass-Marmor","year":"2009","unstructured":"Glass-Marmor L, Paperna T, Galboiz Y, Miller A (2009) Immunomodulation by chronobiologically-based glucocorticoids treatment for multiple sclerosis relapses. J Neuroimmunol 210:124\u2013127","journal-title":"J Neuroimmunol"},{"key":"11655_CR53","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1016\/j.neubiorev.2018.03.011","volume":"88","author":"E De Somma","year":"2018","unstructured":"De Somma E, Jain RW, Poon KWC, Tresidder KA, Segal JP, Ghasemlou N (2018) Chronobiological regulation of psychosocial and physiological outcomes in multiple sclerosis. Neurosci Biobehav Rev 88:73\u201383","journal-title":"Neurosci Biobehav Rev"},{"key":"11655_CR54","doi-asserted-by":"publisher","first-page":"145","DOI":"10.1016\/j.msard.2018.12.029","volume":"28","author":"MA Chalah","year":"2019","unstructured":"Chalah MA, Kauv P, Creange A, Hodel J, Lefaucheur JP, Ayache SS (2019) Neurophysiological, radiological and neuropsychological evaluation of fatigue in multiple sclerosis. Mult Scler Relat Disord 28:145\u2013152","journal-title":"Mult Scler Relat Disord"},{"key":"11655_CR55","doi-asserted-by":"publisher","DOI":"10.3389\/fnagi.2022.995000","volume":"14","author":"G Lanza","year":"2022","unstructured":"Lanza G, Fisicaro F, Dubbioso R, Ranieri F, Chistyakov AV, Cantone M et al (2022) A comprehensive review of transcranial magnetic stimulation in secondary dementia. Front Aging Neurosci 14:995000","journal-title":"Front Aging Neurosci"},{"key":"11655_CR56","doi-asserted-by":"publisher","DOI":"10.1016\/j.smrv.2022.101735","volume":"67","author":"G Lanza","year":"2023","unstructured":"Lanza G, Fisicaro F, Cantone M, Pennisi M, Cosentino FII, Lanuzza B et al (2023) Repetitive transcranial magnetic stimulation in primary sleep disorders. Sleep Med Rev 67:101735","journal-title":"Sleep Med Rev"},{"key":"11655_CR57","doi-asserted-by":"publisher","first-page":"28","DOI":"10.1016\/j.neucli.2021.12.001","volume":"52","author":"MA Chalah","year":"2022","unstructured":"Chalah MA, Grigorescu C, Kumpfel T, Lefaucheur JP, Padberg F, Palm U et al (2022) The effects of transcranial direct current stimulation on sleep in patients with multiple sclerosis-a pilot study. Clin Neurophysiol 52:28\u201332","journal-title":"Clin Neurophysiol"},{"key":"11655_CR58","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0174872","volume":"12","author":"Y Xiang","year":"2017","unstructured":"Xiang Y, Lu L, Chen X, Wen Z (2017) Does Tai Chi relieve fatigue? A systematic review and meta-analysis of randomized controlled trials. PLoS ONE 12:e0174872","journal-title":"PLoS ONE"},{"key":"11655_CR59","doi-asserted-by":"publisher","first-page":"176","DOI":"10.1016\/j.ctcp.2008.03.001","volume":"14","author":"L Esmonde","year":"2008","unstructured":"Esmonde L, Long AF (2008) Complementary therapy use by persons with multiple sclerosis: benefits and research priorities. Complement Ther Clin Pract 14:176\u2013184","journal-title":"Complement Ther Clin Pract"},{"key":"11655_CR60","doi-asserted-by":"publisher","first-page":"317","DOI":"10.1007\/s40272-021-00451-5","volume":"23","author":"C Fernandez-Carbonell","year":"2021","unstructured":"Fernandez-Carbonell C, Charvet LE, Krupp LB (2021) Enhancing mood, cognition, and quality of life in pediatric multiple sclerosis. Paediatr Drugs 23:317\u2013329","journal-title":"Paediatr Drugs"},{"key":"11655_CR61","doi-asserted-by":"publisher","first-page":"481","DOI":"10.1177\/1352458511424307","volume":"18","author":"AB Zafar","year":"2012","unstructured":"Zafar AB, Ness J, Dowdy S, Avis K, Bashir K (2012) Examining sleep, fatigue, and daytime sleepiness in pediatric multiple sclerosis patients. Mult Scler 18:481\u2013488","journal-title":"Mult Scler"},{"key":"11655_CR62","doi-asserted-by":"publisher","first-page":"70","DOI":"10.1016\/j.ejpn.2018.10.006","volume":"23","author":"S Carroll","year":"2019","unstructured":"Carroll S, Chalder T, Hemingway C, Heyman I, Bear H, Sweeney L et al (2019) Adolescent and parent factors related to fatigue in paediatric multiple sclerosis and chronic fatigue syndrome: a comparative study. Eur J Paediatr Neurol 23:70\u201380","journal-title":"Eur J Paediatr Neurol"},{"key":"11655_CR63","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1007\/s11910-015-0546-0","volume":"15","author":"C Veauthier","year":"2015","unstructured":"Veauthier C (2015) Sleep disorders in multiple sclerosis. Rev Curr Neurol Neurosci Rep 15:21","journal-title":"Rev Curr Neurol Neurosci Rep"},{"issue":"13","key":"11655_CR64","doi-asserted-by":"publisher","first-page":"4217","DOI":"10.3390\/molecules27134217","volume":"27","author":"GG Ortiz","year":"2022","unstructured":"Ortiz GG, Briones-Torres AL, Benitez-King G, Gonzalez-Ortiz LJ, Palacios-Magana CV, Pacheco-Moises FP (2022) Beneficial effect of melatonin alone or in combination with glatiramer acetate and interferon beta-1b on experimental autoimmune encephalomyelitis. Molecules 27(13):4217","journal-title":"Molecules"},{"key":"11655_CR65","doi-asserted-by":"publisher","first-page":"5613","DOI":"10.1002\/jcp.27391","volume":"234","author":"B Farhood","year":"2019","unstructured":"Farhood B, Goradel NH, Mortezaee K, Khanlarkhani N, Najafi M, Sahebkar A (2019) Melatonin and cancer: from the promotion of genomic stability to use in cancer treatment. J Cell Physiol 234:5613\u20135627","journal-title":"J Cell Physiol"},{"key":"11655_CR66","doi-asserted-by":"publisher","first-page":"221","DOI":"10.1007\/s00415-012-6622-3","volume":"260","author":"P Wipfler","year":"2013","unstructured":"Wipfler P, Heikkinen A, Harrer A, Pilz G, Kunz A, Golaszewski SM et al (2013) Circadian rhythmicity of inflammatory serum parameters: a neglected issue in the search of biomarkers in multiple sclerosis. J Neurol 260:221\u2013227","journal-title":"J Neurol"},{"key":"11655_CR67","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0190601","volume":"13","author":"P Lavtar","year":"2018","unstructured":"Lavtar P, Rudolf G, Maver A, Hodzic A, Starcevic Cizmarevic N, Zivkovic M et al (2018) Association of circadian rhythm genes ARNTL\/BMAL1 and CLOCK with multiple sclerosis. PLoS ONE 13:e0190601","journal-title":"PLoS ONE"},{"key":"11655_CR68","doi-asserted-by":"publisher","first-page":"209","DOI":"10.1007\/s00281-022-00919-7","volume":"44","author":"KJ Gray","year":"2022","unstructured":"Gray KJ, Gibbs JE (2022) Adaptive immunity, chronic inflammation and the clock. Semin Immunopathol 44:209\u2013224","journal-title":"Semin Immunopathol"},{"key":"11655_CR69","doi-asserted-by":"publisher","first-page":"268","DOI":"10.1111\/imm.13167","volume":"161","author":"P Downton","year":"2020","unstructured":"Downton P, Early JO, Gibbs JE (2020) Circadian rhythms in adaptive immunity. Immunology 161:268\u2013277","journal-title":"Immunology"},{"issue":"10","key":"11655_CR70","doi-asserted-by":"publisher","first-page":"2168","DOI":"10.3390\/ijms18102168","volume":"18","author":"N Ozturk","year":"2017","unstructured":"Ozturk N, Ozturk D, Kavakli IH, Okyar A (2017) Molecular aspects of circadian pharmacology and relevance for cancer chronotherapy. Int J Mol Sci 18(10):2168","journal-title":"Int J Mol Sci"},{"key":"11655_CR71","doi-asserted-by":"publisher","first-page":"349","DOI":"10.1038\/nrrheum.2015.31","volume":"11","author":"F Buttgereit","year":"2015","unstructured":"Buttgereit F, Smolen JS, Coogan AN, Cajochen C (2015) Clocking in: chronobiology in rheumatoid arthritis. Nat Rev Rheumatol 11:349\u2013356","journal-title":"Nat Rev Rheumatol"},{"issue":"2","key":"11655_CR72","first-page":"00549","volume":"14","author":"GR Swanson","year":"2022","unstructured":"Swanson GR, Biglin M, Raff H, Chouhan V, Jochum S, Shaikh M et al (2022) Impact of chronotherapy on 6-mercaptopurine metabolites in inflammatory bowel disease: a pilot crossover trial. Clin Transl Gastroenterol 14(2):00549","journal-title":"Clin Transl Gastroenterol"},{"key":"11655_CR73","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.n71","volume":"372","author":"MJ Page","year":"2021","unstructured":"Page MJ, McKenzie JE, Bossuyt PM, Boutron I, Hoffmann TC, Mulrow CD et al (2021) The PRISMA 2020 statement: an updated guideline for reporting systematic reviews. BMJ 372:n71","journal-title":"BMJ"}],"container-title":["Journal of Neurology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00415-023-11655-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00415-023-11655-9\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00415-023-11655-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,6,14]],"date-time":"2023-06-14T16:02:20Z","timestamp":1686758540000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00415-023-11655-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,3,11]]},"references-count":73,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2023,7]]}},"alternative-id":["11655"],"URL":"https:\/\/doi.org\/10.1007\/s00415-023-11655-9","relation":{},"ISSN":["0340-5354","1432-1459"],"issn-type":[{"value":"0340-5354","type":"print"},{"value":"1432-1459","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,3,11]]},"assertion":[{"value":"23 January 2023","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"27 February 2023","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"28 February 2023","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"11 March 2023","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors have no financial conflicts of interest to disclose.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflicts of interest"}}]}}