{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T06:09:26Z","timestamp":1788847766634,"version":"build-2803163510"},"reference-count":50,"publisher":"Springer Science and Business Media LLC","issue":"8","license":[{"start":{"date-parts":[[2023,5,10]],"date-time":"2023-05-10T00:00:00Z","timestamp":1683676800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2023,5,10]],"date-time":"2023-05-10T00:00:00Z","timestamp":1683676800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Neurol"],"published-print":{"date-parts":[[2023,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Background<\/jats:title>\n                <jats:p>Atrial fibrillation (AF) detection and treatment are key elements to reduce recurrence risk in cryptogenic stroke (CS) with underlying arrhythmia. The purpose of the present study was to assess the predictors of AF in CS and the utility of existing AF-predicting scores in The Nordic Atrial Fibrillation and Stroke (NOR-FIB) Study.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Method<\/jats:title>\n                <jats:p>The NOR-FIB study was an international prospective observational multicenter study designed to detect and quantify AF in CS and cryptogenic transient ischaemic attack (TIA) patients monitored by the insertable cardiac monitor (ICM), and to identify AF-predicting biomarkers. The utility of the following AF-predicting scores was tested: AS5F, Brown ESUS-AF, CHA<jats:sub>2<\/jats:sub>DS<jats:sub>2<\/jats:sub>-VASc, CHASE-LESS, HATCH, HAVOC, STAF and SURF.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>In univariate analyses increasing age, hypertension, left ventricle hypertrophy, dyslipidaemia, antiarrhythmic drugs usage, valvular heart disease, and neuroimaging findings of stroke due to intracranial vessel occlusions and previous ischemic lesions were associated with a higher likelihood of detected AF. In multivariate analysis, age was the only independent predictor of AF. All the AF-predicting scores showed significantly higher score levels for AF than non-AF patients. The STAF and the SURF scores provided the highest sensitivity and negative predictive values, while the AS5F and SURF reached an area under the receiver operating curve (AUC)\u2009&gt;\u20090.7.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusion<\/jats:title>\n                <jats:p>Clinical risk scores may guide a personalized evaluation approach in CS patients. Increasing awareness of the usage of available AF-predicting scores may optimize the arrhythmia detection pathway in stroke units.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1007\/s00415-023-11680-8","type":"journal-article","created":{"date-parts":[[2023,5,11]],"date-time":"2023-05-11T06:08:00Z","timestamp":1683785280000},"page":"4049-4059","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Prediction of underlying atrial fibrillation in patients with a cryptogenic stroke: results from the NOR-FIB Study"],"prefix":"10.1007","volume":"270","author":[{"given":"B.","family":"Ratajczak-Tretel","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. 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DA has received honoraria and consultation fees from Actelion, Amgen, AstraZeneca, BMS\/Pfizer, Bayer, Boehringer-Ingelheim, MSD, Novartis, Pharmacosmos, Roche Diagnostics, Sanofi, Takeda, and Vifor Pharma, and research funding (to the institution) from BMS\/Pfizer, Bayer, Roche Diagnostics and Medtronic. BRT and ATL have received travel funding from Medtronic.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflicts of interest"}},{"value":"The study was performed according to Helsinki Declaration and was approved by the Norwegian Regional Committee for Medical and Health Research Ethics (REK 2013\/2371) and local ethics committees in Denmark and Sweden. Written consent was obtained from all participants. Patients\u00b4 data were collected through the European Cerebrovascular Research Infrastructure (ECRI) and stored in the Services for Sensitive Data (TSD) at the University of Oslo. Study is registered at ClinicalTrials.gov (NCT02937077).","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}}]}}