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Non-financial Interests: S.J. Pittock has provided consultation to Alexion Pharmaceuticals and MedImmune but has received no personal fees or personal compensation for these consulting activities. A. McKeon has consulted for MedImmune, LLC, Grifols and Euroimmun but has not received personal compensation for these activities. E. St. Louis has consulted for Axovant, Inc., but has not received personal compensation for these activities. Financial Interests: S. J. Pittock has received research support from Alexion Pharmaceuticals, MedImmune and Grifols. W. O. Tobin receives research support from the National Institute of Neurological Disorders and Stroke, the National Institute of Allergy and Infectious Diseases, Alexion Pharmaceuticals, Sanofi US Services Inc., and UCB Biosciences. A. McKeon receives research support from MedImmune, LLC. E. 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