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We hypothesized that testing of memory-guided spatial navigation i.e., a highly hippocampus-dependent behaviour, might reveal behavioural correlates of hippocampal dysfunction in non-demented ALS patients.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>We conducted a prospective study of spatial cognition in 43 non-demented ALS outpatients (11f, 32\u00a0m, mean age 60.0\u00a0years, mean disease duration 27.0\u00a0months, mean ALSFRS-R score 40.0) and 43 healthy controls (14f, 29\u00a0m, mean age 57.0\u00a0years). Participants were tested with a virtual memory-guided navigation task derived from animal research (\u201cstarmaze\u201d) that has previously been used in studies of hippocampal function. Participants were further tested with neuropsychological tests of visuospatial memory (SPART, 10\/36 Spatial Recall Test), fluency (5PT, five-point test) and orientation (PTSOT, Perspective Taking\/Spatial Orientation Test).<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>Patients successfully learned and navigated the starmaze from memory, both in conditions that forced memory of landmarks (success: patients 50.7%, controls 47.7%, <jats:italic>p<\/jats:italic>\u2009=\u20090.786) and memory of path sequences (success: patients 96.5%, controls 94.0%, <jats:italic>p<\/jats:italic>\u2009=\u20090.937). Measures of navigational efficacy (latency, path error and navigational uncertainty) did not differ between groups (<jats:italic>p<\/jats:italic>\u2009\u2265\u20090.546). Likewise, SPART, 5PT and PTSOT scores did not differ between groups (<jats:italic>p<\/jats:italic>\u2009\u2265\u20090.238).<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusions<\/jats:title>\n                <jats:p>This study found no behavioural correlate for hippocampal dysfunction in non-demented ALS patients. These findings support the view that the individual cognitive phenotype of ALS may relate to distinct disease subtypes rather than being a variable expression of the same underlying condition.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1007\/s00415-023-11753-8","type":"journal-article","created":{"date-parts":[[2023,5,8]],"date-time":"2023-05-08T11:01:57Z","timestamp":1683543717000},"page":"4031-4040","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Memory-guided navigation in amyotrophic lateral sclerosis"],"prefix":"10.1007","volume":"270","author":[{"given":"Patrizia M.","family":"Maier","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deetje","family":"Iggena","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Meyer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carsten","family":"Finke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0983-4530","authenticated-orcid":false,"given":"Christoph J.","family":"Ploner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2023,5,8]]},"reference":[{"key":"11753_CR1","doi-asserted-by":"publisher","first-page":"2084","DOI":"10.1016\/S0140-6736(17)31287-4","volume":"390","author":"MA van Es","year":"2017","unstructured":"van Es MA, Hardiman O, Chi\u00f2 A et al (2017) Amyotrophic lateral sclerosis. 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