{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,9]],"date-time":"2026-05-09T18:23:39Z","timestamp":1778351019709,"version":"3.51.4"},"reference-count":26,"publisher":"Springer Science and Business Media LLC","issue":"9","license":[{"start":{"date-parts":[[2023,6,8]],"date-time":"2023-06-08T00:00:00Z","timestamp":1686182400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2023,6,8]],"date-time":"2023-06-08T00:00:00Z","timestamp":1686182400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82172015"],"award-info":[{"award-number":["82172015"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82202217"],"award-info":[{"award-number":["82202217"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100021171","name":"Basic and Applied Basic Research Foundation of Guangdong Province","doi-asserted-by":"publisher","award":["2022A1515011264"],"award-info":[{"award-number":["2022A1515011264"]}],"id":[{"id":"10.13039\/501100021171","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100021171","name":"Basic and Applied Basic Research Foundation of Guangdong Province","doi-asserted-by":"publisher","award":["2021A1515012279"],"award-info":[{"award-number":["2021A1515012279"]}],"id":[{"id":"10.13039\/501100021171","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Science and Technology Program of Guangzhou,China","award":["202201011228"],"award-info":[{"award-number":["202201011228"]}]},{"name":"Science and Technology Program of Guangzhou,China","award":["202201011244"],"award-info":[{"award-number":["202201011244"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Neurol"],"published-print":{"date-parts":[[2023,9]]},"DOI":"10.1007\/s00415-023-11792-1","type":"journal-article","created":{"date-parts":[[2023,6,8]],"date-time":"2023-06-08T19:01:41Z","timestamp":1686250901000},"page":"4466-4477","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Analysis and hierarchical clustering of infratentorial morphological MRI identifies SCAs phenogroups"],"prefix":"10.1007","volume":"270","author":[{"given":"Jing","family":"Zhao","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wenting","family":"Zeng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaolong","family":"Huang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manshi","family":"Hu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kang","family":"Yuan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chao","family":"Wu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haishan","family":"Qiu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5483-2169","authenticated-orcid":false,"given":"Jianping","family":"Chu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2023,6,8]]},"reference":[{"key":"11792_CR1","doi-asserted-by":"publisher","DOI":"10.3390\/pharmaceutics13071018","author":"FV Borbolla-Jim\u00e9nez","year":"2021","unstructured":"Borbolla-Jim\u00e9nez FV, Del Prado-Audelo ML, Cisneros B, Caballero-Flor\u00e1n IH, Leyva-G\u00f3mez G, Maga\u00f1a JJ (2021) New perspectives of gene therapy on polyglutamine spinocerebellar ataxias: from molecular targets to novel nanovectors. Pharmaceutics. https:\/\/doi.org\/10.3390\/pharmaceutics13071018","journal-title":"Pharmaceutics"},{"issue":"2","key":"11792_CR2","doi-asserted-by":"publisher","first-page":"533","DOI":"10.1007\/s00415-018-9076-4","volume":"266","author":"R Sullivan","year":"2019","unstructured":"Sullivan R, Yau WY, O\u2019Connor E, Houlden H (2019) Spinocerebellar ataxia: an update. J Neurol 266(2):533\u2013544. https:\/\/doi.org\/10.1007\/s00415-018-9076-4","journal-title":"J Neurol"},{"issue":"2","key":"11792_CR3","doi-asserted-by":"publisher","first-page":"128","DOI":"10.1002\/acn3.504","volume":"5","author":"K Reetz","year":"2018","unstructured":"Reetz K, Rodr\u00edguez-Labrada R, Dogan I et al (2018) Brain atrophy measures in preclinical and manifest spinocerebellar ataxia type 2. Ann Clin Transl Neurol 5(2):128\u2013137. https:\/\/doi.org\/10.1002\/acn3.504","journal-title":"Ann Clin Transl Neurol"},{"issue":"10","key":"11792_CR4","doi-asserted-by":"publisher","first-page":"2273","DOI":"10.1002\/mds.28610","volume":"36","author":"J Faber","year":"2021","unstructured":"Faber J, Schaprian T, Berkan K et al (2021) Regional brain and spinal cord volume loss in spinocerebellar ataxia type 3. Mov Disord 36(10):2273\u20132281. https:\/\/doi.org\/10.1002\/mds.28610","journal-title":"Mov Disord"},{"issue":"3","key":"11792_CR5","doi-asserted-by":"publisher","first-page":"401","DOI":"10.1002\/ana.25297","volume":"84","author":"TJR Rezende","year":"2018","unstructured":"Rezende TJR, De Paiva JLR, Martinez ARM et al (2018) Structural signature of SCA3: from presymptomatic to late disease stages. Ann Neurol 84(3):401\u2013408. https:\/\/doi.org\/10.1002\/ana.25297","journal-title":"Ann Neurol"},{"issue":"1","key":"11792_CR6","doi-asserted-by":"publisher","first-page":"24","DOI":"10.1038\/s41572-019-0081-4","volume":"5","author":"T Klockgether","year":"2019","unstructured":"Klockgether T, Mariotti C, Paulson HL (2019) Spinocerebellar ataxia. Nat Rev Dis Primers 5(1):24. https:\/\/doi.org\/10.1038\/s41572-019-0081-4","journal-title":"Nat Rev Dis Primers"},{"issue":"1","key":"11792_CR7","doi-asserted-by":"publisher","first-page":"158","DOI":"10.1016\/j.neuroimage.2009.07.027","volume":"49","author":"JB Schulz","year":"2010","unstructured":"Schulz JB, Borkert J, Wolf S et al (2010) Visualization, quantification and correlation of brain atrophy with clinical symptoms in spinocerebellar ataxia types 1, 3 and 6. Neuroimage 49(1):158\u2013168. https:\/\/doi.org\/10.1016\/j.neuroimage.2009.07.027","journal-title":"Neuroimage"},{"issue":"1120","key":"11792_CR8","doi-asserted-by":"publisher","first-page":"20201353","DOI":"10.1259\/bjr.20201353","volume":"94","author":"MI Metwally","year":"2021","unstructured":"Metwally MI, Basha MA, Abdelhamid GA et al (2021) Neuroanatomical MRI study: reference values for the measurements of brainstem, cerebellar vermis, and peduncles. Br J Radiol 94(1120):20201353. https:\/\/doi.org\/10.1259\/bjr.20201353","journal-title":"Br J Radiol"},{"key":"11792_CR9","doi-asserted-by":"publisher","first-page":"187","DOI":"10.1016\/j.jns.2018.02.022","volume":"387","author":"M Higashi","year":"2018","unstructured":"Higashi M, Ozaki K, Hattori T et al (2018) A diagnostic decision tree for adult cerebellar ataxia based on pontine magnetic resonance imaging. J Neurol Sci 387:187\u2013195. https:\/\/doi.org\/10.1016\/j.jns.2018.02.022","journal-title":"J Neurol Sci"},{"issue":"1","key":"11792_CR10","doi-asserted-by":"publisher","first-page":"214","DOI":"10.1148\/radiol.2453061703","volume":"246","author":"A Quattrone","year":"2008","unstructured":"Quattrone A, Nicoletti G, Messina D et al (2008) MR imaging index for differentiation of progressive supranuclear palsy from Parkinson disease and the Parkinson variant of multiple system atrophy. Radiology 246(1):214\u2013221. https:\/\/doi.org\/10.1148\/radiol.2453061703","journal-title":"Radiology"},{"key":"11792_CR11","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2022.912592","volume":"13","author":"SA Sobana","year":"2022","unstructured":"Sobana SA, Huda F, Hermawan R et al (2022) Brain MRI volumetry analysis in an Indonesian family of SCA 3 patients: a case-based study. Front Neurol 13:912592. https:\/\/doi.org\/10.3389\/fneur.2022.912592","journal-title":"Front Neurol"},{"issue":"1","key":"11792_CR12","doi-asserted-by":"publisher","first-page":"524","DOI":"10.1186\/s12877-021-02471-9","volume":"21","author":"Y Su","year":"2021","unstructured":"Su Y, Dong J, Sun J et al (2021) Cognitive function assessed by Mini-mental state examination and risk of all-cause mortality: a community-based prospective cohort study[J]. BMC Geriatr 21(1):524. https:\/\/doi.org\/10.1186\/s12877-021-02471-9","journal-title":"BMC Geriatr"},{"issue":"4","key":"11792_CR13","doi-asserted-by":"publisher","first-page":"557","DOI":"10.1007\/s10072-015-2472-y","volume":"37","author":"Q Wei","year":"2016","unstructured":"Wei Q, Zheng Z, Guo X et al (2016) Association between depression and survival in Chinese amyotrophic lateral sclerosis patients. Neurol Sci 37(4):557\u2013563. https:\/\/doi.org\/10.1007\/s10072-015-2472-y","journal-title":"Neurol Sci"},{"key":"11792_CR14","doi-asserted-by":"publisher","DOI":"10.1016\/j.yebeh.2022.108628","volume":"129","author":"XR Zhu","year":"2022","unstructured":"Zhu XR, Zhu ZR, Wang LX et al (2022) Prevalence and risk factors for depression and anxiety in adult patients with epilepsy: Caregivers\u2019 anxiety and place of residence do mater. Epilepsy Behav 129:108628. https:\/\/doi.org\/10.1016\/j.yebeh.2022.108628","journal-title":"Epilepsy Behav"},{"key":"11792_CR15","first-page":"316","volume":"56","author":"T Wei","year":"2017","unstructured":"Wei T, Wei MT (2017) Package \u2018corrplot.\u2019 Statistician 56:316\u2013324","journal-title":"Statistician"},{"issue":"1","key":"11792_CR16","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1023\/A:1010933404324","volume":"45","author":"L Breiman","year":"2001","unstructured":"Breiman L (2001) Random forests. Mach Learn 45(1):5\u201332","journal-title":"Mach Learn"},{"key":"11792_CR17","doi-asserted-by":"publisher","first-page":"411","DOI":"10.3389\/fneur.2020.00411","volume":"11","author":"YW Park","year":"2020","unstructured":"Park YW, Joers JM, Guo B et al (2020) Assessment of cerebral and cerebellar white matter microstructure in spinocerebellar ataxias 1, 2, 3, and 6 using diffusion MRI. Front Neurol 11:411. https:\/\/doi.org\/10.3389\/fneur.2020.00411","journal-title":"Front Neurol"},{"key":"11792_CR18","doi-asserted-by":"publisher","first-page":"714","DOI":"10.3389\/fneur.2017.00714","volume":"8","author":"X Wu","year":"2017","unstructured":"Wu X, Liao X, Zhan Y et al (2017) Microstructural alterations in asymptomatic and symptomatic patients with spinocerebellar ataxia type 3: a tract-based spatial statistics study. Front Neurol 8:714. https:\/\/doi.org\/10.3389\/fneur.2017.00714","journal-title":"Front Neurol"},{"key":"11792_CR19","doi-asserted-by":"publisher","first-page":"1025","DOI":"10.3389\/fneur.2019.01025","volume":"10","author":"H Peng","year":"2019","unstructured":"Peng H, Liang X, Long Z et al (2019) Gene-related cerebellar neurodegeneration in SCA3\/MJD: a case-controlled imaging-genetic study. Front Neurol 10:1025. https:\/\/doi.org\/10.3389\/fneur.2019.01025","journal-title":"Front Neurol"},{"issue":"2","key":"11792_CR20","doi-asserted-by":"publisher","first-page":"128","DOI":"10.1007\/s12311-014-0619-7","volume":"14","author":"CN Fahl","year":"2015","unstructured":"Fahl CN, Branco LM, Bergo FP, D\u2019Abreu A, Lopes-Cendes I, Fran\u00e7a MC Jr (2015) Spinal cord damage in Machado-Joseph disease. Cerebellum 14(2):128\u2013132. https:\/\/doi.org\/10.1007\/s12311-014-0619-7","journal-title":"Cerebellum"},{"key":"11792_CR21","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2020.616419","volume":"11","author":"A Nigri","year":"2020","unstructured":"Nigri A, Sarro L, Mongelli A et al (2020) Progression of cerebellar atrophy in spinocerebellar ataxia type 2 gene carriers: a longitudinal MRI study in preclinical and early disease stages. Front Neurol 11:616419. https:\/\/doi.org\/10.3389\/fneur.2020.616419","journal-title":"Front Neurol"},{"issue":"6","key":"11792_CR22","doi-asserted-by":"publisher","first-page":"780","DOI":"10.1002\/mds.25757","volume":"29","author":"E Salvatore","year":"2014","unstructured":"Salvatore E, Tedeschi E, Mollica C et al (2014) Supratentorial and infratentorial damage in spinocerebellar ataxia 2: a diffusion-weighted MRI study. Mov Disord 29(6):780\u2013786. https:\/\/doi.org\/10.1002\/mds.25757","journal-title":"Mov Disord"},{"issue":"6","key":"11792_CR23","doi-asserted-by":"publisher","first-page":"1096","DOI":"10.3174\/ajnr.A4343","volume":"36","author":"M Mascalchi","year":"2015","unstructured":"Mascalchi M, Toschi N, Giannelli M et al (2015) Progression of microstructural damage in spinocerebellar ataxia type 2: a longitudinal DTI study. AJNR Am J Neuroradiol 36(6):1096\u20131101. https:\/\/doi.org\/10.3174\/ajnr.A4343","journal-title":"AJNR Am J Neuroradiol"},{"key":"11792_CR24","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21031020","author":"M Mascalchi","year":"2020","unstructured":"Mascalchi M, Vella A (2020) Neuroimaging biomarkers in SCA2 gene carriers. Int J Mol Sci. https:\/\/doi.org\/10.3390\/ijms21031020","journal-title":"Int J Mol Sci"},{"issue":"1","key":"11792_CR25","doi-asserted-by":"publisher","first-page":"133","DOI":"10.1007\/s12311-021-01285-0","volume":"21","author":"A Nigri","year":"2022","unstructured":"Nigri A, Sarro L, Mongelli A et al (2022) Spinocerebellar ataxia type 1: one-year longitudinal study to identify clinical and MRI measures of disease progression in patients and presymptomatic carriers. Cerebellum 21(1):133\u2013144. https:\/\/doi.org\/10.1007\/s12311-021-01285-0","journal-title":"Cerebellum"},{"issue":"3","key":"11792_CR26","doi-asserted-by":"publisher","first-page":"459","DOI":"10.1007\/s12311-020-01120-y","volume":"19","author":"Z Rentiya","year":"2020","unstructured":"Rentiya Z, Hutnik R, Mekkam YQ, Bae J (2020) The pathophysiology and clinical manifestations of spinocerebellar ataxia type 6. Cerebellum 19(3):459\u2013464. https:\/\/doi.org\/10.1007\/s12311-020-01120-y","journal-title":"Cerebellum"}],"container-title":["Journal of Neurology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00415-023-11792-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00415-023-11792-1\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00415-023-11792-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,11]],"date-time":"2023-08-11T12:08:31Z","timestamp":1691755711000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00415-023-11792-1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,6,8]]},"references-count":26,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2023,9]]}},"alternative-id":["11792"],"URL":"https:\/\/doi.org\/10.1007\/s00415-023-11792-1","relation":{},"ISSN":["0340-5354","1432-1459"],"issn-type":[{"value":"0340-5354","type":"print"},{"value":"1432-1459","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,6,8]]},"assertion":[{"value":"21 February 2023","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"20 May 2023","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"22 May 2023","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"8 June 2023","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors have no relevant financial or non-financial interests to disclose.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflicts of interest"}},{"value":"The research ethics committees of our hospital approved this protocol ([2020]507).","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical standard"}},{"value":"Informed consent was obtained from all participants included in the study, and the participants signed informed consent regarding publishing their data and photographs.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed consent"}}]}}