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Heterogeneous results have been found about the correlation between objective and subjective upper limb function. The aim of the present study is to perform a systematic review and meta-analysis of studies presenting data on the strength of association between the gold standard for 9-Hole Peg Test scores and Patient-Reported Outcome Measures (PROMs) of manual ability. Primary research studies including assessments of 9-Hole Peg Test scores and Patient-Reported Outcome Measures were searched in Scopus, Web of Science, and PubMed. Meta analytical calculations were performed using a random-effects model. We retrieved <jats:italic>n<\/jats:italic>\u2009=\u200927 studies including <jats:italic>n<\/jats:italic>\u2009=\u200975 distinct effect sizes (<jats:italic>N<\/jats:italic> of subjects\u2009=\u20093263). The central tendency analysis showed a strong correlation between 9-HPT scores and PROMs (<jats:italic>r<\/jats:italic>\u2009=\u20090.51, 95% CI [0.44, 0.58]). Moderator analysis showed the effect size to be significantly larger in studies with a mean or median EDSS level indicating severe disability. The publication bias hypothesis was not supported; instead, we noted that studies based on larger samples also tend to report stronger effect sizes. Results of the study indicate that the correlation between 9-HPT and PROMs is strong, although the constructs measured by these instrument does not fully overlap. The correlation between 9-HPT and PROMs was stronger in larger studies and when samples include a sizeable subgroup of PwMS with severe disability, pointing out the importance of sample diversity.<\/jats:p>","DOI":"10.1007\/s00415-023-11801-3","type":"journal-article","created":{"date-parts":[[2023,6,9]],"date-time":"2023-06-09T11:02:29Z","timestamp":1686308549000},"page":"4179-4191","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["The correlation between 9-HPT and patient-reported measures of upper limb function in multiple sclerosis: a systematic review and meta-analysis"],"prefix":"10.1007","volume":"270","author":[{"given":"Erica","family":"Grange","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudio","family":"Solaro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rachele","family":"Di Giovanni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7107-0810","authenticated-orcid":false,"given":"Davide","family":"Marengo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2023,6,9]]},"reference":[{"key":"11801_CR1","doi-asserted-by":"publisher","first-page":"287","DOI":"10.1016\/B978-0-443-07271-0.50008-2","volume-title":"McAlpine's multiple sclerosis","author":"I McDonald","year":"2006","unstructured":"McDonald I, Compston A (2006) The symptoms and signs of multiple sclerosis. 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