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Alkhalifa reports no disclosures relevant to the manuscript. S. Chen reports no disclosures relevant to the manuscript. Z. I. Hasiloglu reports no disclosures relevant to the manuscript. M. Filosto reports no disclosures relevant to the manuscript. E. Cali reports no disclosures relevant to the manuscript. H. Houlden reports no disclosures relevant to the manuscript. P.V.S. de Souza reports no disclosures relevant to the manuscript. A. Alavi reports no disclosures relevant to the manuscript. C. Goizet reports no disclosures relevant to the manuscript. G. Stevanin reports a Biogen-Paris-Sciences Lettres contract unrelated to this work, and a grant support from the ASL-HSP-France Association (to GS) related to genetic studies in HSP patients. F. Taithe reports no disclosures relevant to the manuscript. F. Nicita is a member of the European Reference Network for Rare Neurological Diseases (ERN-RND). G. Vasco reports no disclosures relevant to the manuscript. S. Tozza has received personal fees for scientific events from Alnylam Pharmaceuticals and Amicus Therapeutics, travel grants to attend scientific meetings from Akcea Therapeutics. S. Cocozza has received research grants from Telethon and FISM, and fees for speaking from Amicus Therapeutics. N. Carboni reports no disclosures relevant to the manuscript. A. Figus reports no disclosures relevant to the manuscript. J. Wu reports no disclosures relevant to the manuscript. A. N. Basak reports no disclosures relevant to the manuscript. B. Brais reports no disclosures relevant to the manuscript. G. Rouleau reports no disclosures relevant to the manuscript.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflicts of interest"}},{"value":"The Institutional Review Boards of the participating institutions have approved the use of data for this retrospective study.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical standard"}}]}}