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Depression is among the most common psychological difficulties in HD. People with HD encounter numerous stressors related to their diagnosis and the impact of HD on their daily lives. Understanding the relationship between HD-specific psychosocial stressors and depression symptoms is critical for optimising treatment and developing a holistic, disease-specific model of depression in HD.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>Fifty-seven adults with the HD gene expansion (33 pre-symptomatic, 24 symptomatic) completed a self-report depression questionnaire and rated how much stress they experienced in relation to 20 psychosocial challenges commonly associated with HD. We examined associations between depression symptoms and each stressor individually, and after clustering using principal components analysis.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>Depression symptoms were significantly associated with most of the psychosocial stressors assessed. Clustering with principal components analysis revealed that higher depression scores had significant independent associations with greater stress related to the future implications of HD (\u03b2\u2009=\u2009.44, <jats:italic>p<\/jats:italic>\u2009=\u2009.001) and sleep and psychological difficulties (\u03b2\u2009=\u2009.28, <jats:italic>p<\/jats:italic>\u2009=\u2009.005), but not with stress related to functional limitations (\u03b2\u2009=\u2009.11, <jats:italic>p<\/jats:italic>\u2009=\u2009.33) or interpersonal issues caused by HD (\u03b2\u2009=\u2009.15, <jats:italic>p<\/jats:italic>\u2009=\u2009.21).<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusions<\/jats:title>\n                <jats:p>Stressful experiences associated with HD constitute an important risk factor for depression in HD. Our findings support the use of more psychologically informed models of depression in HD and necessitate further research on tailored psychosocial interventions for HD patients with depression.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1007\/s00415-023-11982-x","type":"journal-article","created":{"date-parts":[[2023,9,11]],"date-time":"2023-09-11T10:02:10Z","timestamp":1694426530000},"page":"289-299","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["The relationship between disease-specific psychosocial stressors and depressive symptoms in Huntington\u2019s disease"],"prefix":"10.1007","volume":"271","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2458-865X","authenticated-orcid":false,"given":"Hiba","family":"Bilal","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ian H.","family":"Harding","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julie C.","family":"Stout","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2023,9,11]]},"reference":[{"key":"11982_CR1","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/nrdp.2015.5","volume":"1","author":"GP Bates","year":"2015","unstructured":"Bates GP, Dorsey R, Gusella JF, Hayden MR, Kay C, Leavitt BR, Nance M, Ross CA, Scahill RI, Wetzel R, Wild EJ, Tabrizi SJ (2015) Huntington disease. 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Although these ad boards were focused on HD, neither focused on depression, which is the topic of the current manuscript. Julie Stout also serves in an ongoing role as a director of the company Zindametrix, which provides services to pharmaceutical companies to facilitate the implementation of cognitive assessment in Huntington's disease clinical trials. Several of these trials have been ongoing throughout the time of the research reported in this paper, however, none of the trials are focused on depression in HD, and therefore are not considered a conflict of interest for the work reported in the manuscript. Julie Stout has provided paid consulting services to Sage Therapeutics related to HD but not directly related to the work presented in this paper. Finally, Julie Stout receives an annual honorarium for her services as the Chair of the Scientific Oversight Committee of the global Enroll-HD study. Again, this role is not in conflict with or related to the contents of the report.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"The Monash University Human Research Ethics Committee (MUHREC) approved this study (MUHREC ID: 23043). All participants provided written informed consent in accordance with the Declaration of Helsinki.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"Informed consent was obtained from all individual participants included in the study.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed consent"}}]}}