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Quantitative MRI provides effective means to characterize microstructural brain tissue changes both in lesions and normal-appearing brain tissue. However, the impact of the location of microstructural alterations in terms of neuronal pathways has not been thoroughly explored so far. Here, we study the extent and the location of tissue changes probed using quantitative MRI along white matter (WM) tracts extracted from a connectivity atlas.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We quantified voxel-wise T1 tissue alterations compared to normative values in a cohort of 99 MS patients. For each WM tract, we extracted metrics reflecting tissue alterations both in lesions and normal-appearing WM and correlated these with cross-sectional disability and disability evolution after 2\u00a0years.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>In early MS patients, T1 alterations in normal-appearing WM correlated better with disability evolution compared to cross-sectional disability. Further, the presence of lesions in supratentorial tracts was more strongly associated with cross-sectional disability, while microstructural alterations in infratentorial pathways yielded higher correlations with disability evolution. In progressive patients, all major WM pathways contributed similarly to explaining disability, and correlations with disability evolution were generally poor.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>We showed that microstructural changes evaluated in specific WM pathways contribute to explaining future disability in early MS, hence highlighting the potential of tract-wise analyses in monitoring disease progression. Further, the proposed technique allows to estimate WM tract-specific microstructural characteristics in clinically compatible acquisition times, without the need for advanced diffusion imaging.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1007\/s00415-023-12023-3","type":"journal-article","created":{"date-parts":[[2023,10,11]],"date-time":"2023-10-11T06:04:40Z","timestamp":1697004280000},"page":"631-641","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Tract-wise microstructural analysis informs on current and future disability in early multiple sclerosis"],"prefix":"10.1007","volume":"271","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1532-9664","authenticated-orcid":false,"given":"Veronica","family":"Ravano","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8449-6634","authenticated-orcid":false,"given":"Gian Franco","family":"Piredda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5605-8821","authenticated-orcid":false,"given":"Jan","family":"Krasensky","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3812-7483","authenticated-orcid":false,"given":"Michaela","family":"Andelova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3160-9022","authenticated-orcid":false,"given":"Tomas","family":"Uher","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8092-6625","authenticated-orcid":false,"given":"Barbora","family":"Srpova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9543-4359","authenticated-orcid":false,"given":"Eva Kubala","family":"Havrdova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0675-2866","authenticated-orcid":false,"given":"Karolina","family":"Vodehnalova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1915-0036","authenticated-orcid":false,"given":"Dana","family":"Horakova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4885-602X","authenticated-orcid":false,"given":"Petra","family":"Nytrova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2924-1866","authenticated-orcid":false,"given":"Jonathan A.","family":"Disselhorst","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8207-4908","authenticated-orcid":false,"given":"Tom","family":"Hilbert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7866-2854","authenticated-orcid":false,"given":"B\u00e9n\u00e9dicte","family":"Mar\u00e9chal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2938-9657","authenticated-orcid":false,"given":"Jean-Philippe","family":"Thiran","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7598-9456","authenticated-orcid":false,"given":"Tobias","family":"Kober","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6975-5634","authenticated-orcid":false,"given":"Jonas","family":"Richiardi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8784-7997","authenticated-orcid":false,"given":"Manuela","family":"Vaneckova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2023,10,11]]},"reference":[{"issue":"12","key":"12023_CR1","doi-asserted-by":"publisher","first-page":"1688","DOI":"10.3174\/ajnr.A7536","volume":"43","author":"M Tranfa","year":"2022","unstructured":"Tranfa M, Pontillo G, Petracca M et al (2022) Quantitative MRI in multiple sclerosis: from theory to application. 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Ravano, J-P. Thiran and J. Richiardi have no financial or proprietary interests in any material discussed in this article. G.F. Piredda, J.A. Disselhorst, T. Hilbert, B. Mar\u00e9chal and T. Kober are employed by Siemens Healthineers International AG, Switzerland. M. Vaneckova received compensation for speaker honoraria, travel and consultant fees from Biogen, Sanofi Genzyme, Novartis, Roche and Teva, as well as support for research activities from Biogen. J. Krasensky received financial support for research activities from Biogen Idec. M. Andelova received financial support for conference travel from Novartis, Genzyme, Merck Serono, Biogen Idec and Roche. T. Uher received financial support for conference travel from Biogen Idec, Novartis, Sanofi, Roche and Merck Serono and speaker honoraria from Biogen Idec, Novartis and Roche as well as support for research activities from Biogen Idec and Sanofi. B. Srpova received compensation for traveling and conference fees from Novartis, Sanofi Genzyme, Biogen Idec, Roche and Merck as well as support for research activities from Biogen Idec. E.K. Havrdova received speaker honoraria and consultant fees from Biogen Idec, Merck Serono, Novartis, Genzyme and Teva, as well as support for research activities from Biogen Idec and Merck Serono. K. Vodehnalova received compensation for traveling, conference fees and consulting fees from Merck, Teva, Sanofi Genzyme, Biogen Idec, Novartis, Roche. D. Horakova received compensation for travel, speaker honoraria, and consultant fees from Biogen Idec, Novartis, Merck, Bayer, Sanofi Genzyme, Roche and Teva, as well as support for research activities from Biogen Idec. She was also supported by the Czech Ministry of Education project Progress Q27\/LF1. P. Nytrova received speaker honoraria and consultant fees from Biogen, Novartis, Merck, Roche, and financial support for research activities from Roche and Merck.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflicts of interest"}},{"value":"The study was conducted according to the Declaration of Helsinki and The Ethics Committee of the General Teaching Hospital in Prague provided approval for the examination of both MS patients and for healthy individuals. All participants gave their written informed consent.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"Written informed consent was obtained from all patients in this study.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to participate"}},{"value":"Not applicable as no individual details are reported.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to publish"}}]}}