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Hertz og Hustru Inger Hertz Fond","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006088","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006197","name":"Fonden til L\u00e6gevidenskabens Fremme","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006197","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Region Midtjyllands Strategiske Forskningsmidler"},{"name":"The Aarhus County Research Initiative"},{"DOI":"10.13039\/100007605","name":"Aarhus Universitet","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100007605","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Neurol"],"published-print":{"date-parts":[[2024,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Background<\/jats:title>\n                <jats:p>Calcitonin gene-related peptide (CGRP) plays an important role in migraine pathophysiology, and post-traumatic headache (PTH) frequently presents with migraine-like features. Despite several clinical similarities, few studies have explored CGRP in PTH and concussion. This study investigates serum CGRP levels in patients with persistent post-concussion symptoms (PPCS), including PTH.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>This cohort study was based on serum samples from individuals aged 18\u201330\u00a0years with PPCS who participated in a previously published randomized controlled trial of a non-pharmacological intervention. The primary outcome was serum CGRP concentrations, determined at baseline before randomization and at follow-up 7\u00a0months later, using an enzyme-linked immunosorbent assay (ELISA). CGRP levels at baseline were compared with healthy anonymous blood donors in the same age group.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>Baseline serum samples were collected from 86 participants with PPCS. The participants were most often female (78%) and migraine-like headache was the most frequent headache phenotype (74%). Serum CGRP levels were higher in participants with PPCS than in 120 healthy individuals (median: 158.5\u00a0pg\/mL vs. 76.3\u00a0pg\/mL, p\u2009=\u20090.050). A stratified analysis revealed that females with PPCS had a fivefold higher median than healthy females (166.3\u00a0pg\/mL vs. 32.1\u00a0pg\/mL, p\u2009=\u20090.0006), while no differences were observed in males (p\u2009=\u20090.83). At follow-up, CGRP levels decreased with a median change of \u2009\u2013\u20091.3\u00a0pg\/mL (95% confidence interval: \u2009\u2013\u200917.6\u20130, p\u2009=\u20090.024).<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Discussion<\/jats:title>\n                <jats:p>Elevated serum levels of CGRP in patients with PPCS and a decrease over time suggest an involvement of CGRP in PTH\/PPCS. If confirmed in other studies, it could pave the way for CGRP-targeted therapies, which could have clinical significance.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1007\/s00415-024-12181-y","type":"journal-article","created":{"date-parts":[[2024,1,17]],"date-time":"2024-01-17T12:02:16Z","timestamp":1705492936000},"page":"2458-2472","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Serum calcitonin gene-related peptide in patients with persistent post-concussion symptoms, including headache: a cohort study"],"prefix":"10.1007","volume":"271","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3890-9976","authenticated-orcid":false,"given":"Peter Preben","family":"Eggertsen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5585-639X","authenticated-orcid":false,"given":"Johan","family":"Palmfeldt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6262-2986","authenticated-orcid":false,"given":"Henrik Winther","family":"Schytz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9558-5122","authenticated-orcid":false,"given":"Debbie","family":"Hay","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3470-5589","authenticated-orcid":false,"given":"Rikke Katrine Jentoft","family":"Olsen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5339-171X","authenticated-orcid":false,"given":"J\u00f8rgen Feldb\u00e6k","family":"Nielsen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,1,17]]},"reference":[{"issue":"10","key":"12181_CR1","doi-asserted-by":"publisher","first-page":"1683","DOI":"10.1007\/s00701-015-2512-7","volume":"157","author":"W Peeters","year":"2015","unstructured":"Peeters W, Van Den Brande R, Polinder S, Brazinova A, Steyerberg EW, Lingsma HF et al (2015) Epidemiology of traumatic brain injury in Europe. 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D.L.H. has received research support from AbbVie, and has acted as an advisor, speaker or consultant for Amgen, Teva and Eli Lilly in the past three years. P.P.E, J.P., R.K.O, and J.F.N. report no conflicts of interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflicts of interest"}},{"value":"The study was conducted in accordance with the Declaration of Helsinki, and was approved by the Committee of Health Research Ethics of the Central Denmark region (case no. 1-10-72-237-14). All PPCS participants provided written informed consent. Written informed consent was not required from the healthy individuals as it comprised of blood samples from anonymized Danish blood donors all of whom have consented to the use of their anonymized samples for research []. The previously published RCT study (GAIN 1.0) was registered on ClinicalTrials.gov (NCT02337101) in January 2015 and published in 2019 []. In February 2023, before measuring CGRP, we uploaded and registered the hypotheses and a statistical analysis plan for the primary outcome of this study (NCT05812742).","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and registrations"}}]}}