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Here, we analyzed clinical data on pain in a large cohort of patients included into the German Network for Research in Autoimmune Encephalitis. Out of 102 patients in our cohort, pain was a frequent symptom (36% of all patients), often severe (63.6% of the patients with pain) and\/or even the major symptom (55.6% of the patients with pain). Pain phenotypes differed between patients. Cluster analysis revealed two major phenotypes including mostly distal-symmetric burning pain and widespread pain with myalgia and cramps. Almost all patients had IgG4 autoantibodies and some additional IgG1, 2, and\/or 3 autoantibodies, but IgG subclasses, titers, and presence or absence of intrathecal synthesis were not associated with the occurrence of pain. However, certain pre-existing risk factors for chronic pain like diabetes mellitus, peripheral neuropathy, or preexisting chronic back pain tended to occur more frequently in patients with anti-Caspr2 autoantibodies and pain. 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CG received speaker and consultancy fees or travel compensation from Alexion, Sobi, Argenx. His research including the submitted work is funded by the German Federal Ministry of Education and Research (BMBF) through a grant for the Forschungsverbund CONNECT-GENERATE, grant code 01GM2208E, and outside the submitted work by the German Research Foundation and the Schilling foundation. JL received speaker fees or travel compensation from Roche, Teva, the Movement Disorders Society and the Cure Huntington\u2019s Disease Initiative (CHDI). His institution has been reimbursed for his role as principal investigator in trials for SOM Biotech and CHDI. His research including the submitted work is funded by the German Federal Ministry of Education and Research (BMBF) through a grant for the Forschungsverbund CONNECT-GENERATE, grant code 01GM2208B, and outside the submitted work by the European Huntington\u2019s Disease Network (EHDN) and Ministry for Education and Research Baden-W\u00fcrttemberg. FvP reports personal fees and grants from Bial, Desitin Arzneimittel, Eisai, GW Pharmaceutical companies, Arvelle Therapeutics, Zogenix, and UCB Pharma. HR received consultancy fees from Orion and Gruenenthal.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflicts of interest"}},{"value":"Ethical approval for the inclusion of patient data to the GENERATE database was waived by the local Ethics Committees of all participating centers. 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