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Participants who met the inclusion criteria received active EA or sham EA for 60\u00a0min, three times a week for four weeks; CBZ (300\u00a0mg per day) or placebo for four weeks. The primary outcome was the change in visual analog scale (VAS) score from baseline to weeks 2, 4, 16, and 28. Secondary outcomes included quality of life and adverse events.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of 120 participants (75 females and 45 males; mean (SD) age, 58.5 (15.3) years) were included. The main effects of EA and CBZ were significant (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.001), and there was a significant interaction was identified between the interventions (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.041). Participants who received EA (mean difference [MD], \u22120.3 [95% CI, \u22120.40 to \u22120.20] at week 2; \u22121.6 [\u22121.70 to \u22121.50] at week 4; \u22121.1 [\u22121.31 to \u22120.89] at week 16; \u22120.8 [\u22121.01 to \u22120.59] at week 28), CBZ (MD, \u22120.6 [95% CI, \u22120.70 to \u22120.50] at week 2; \u22120.9 [\u22121.03 to \u22120.77] at week 4, \u22120.2 [\u22120.41 to 0.01] at week 16, 0.2 [\u22120.01 to 0.41] at week 28), and the combination of both (MD, \u22121.8 [95% CI, \u22121.90 to \u22121.70] at week 2; \u22123.7 [\u22123.83 to \u22123.57] at week 4, \u22123.4 [\u22123.61 to \u22123.19] at week 16, \u22122.9 [\u22123.11 to \u22122.69] at week 28) had a greater reduction in VAS score over the treatment phase than their respective control groups (sham EA, placebo, and sham EA plus placebo). EA-related adverse events (6\/59, 10.17%) were lower than that of CBZ (15\/59, 25.42%) during the whole phases.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>EA or CBZ alone are effective treatments for TN, while the combination of EA and low-dosage CBZ exerts a greater benefit. These findings in this trial demonstrate that the combination of EA and low-dosage CBZ may be clinically effective under certain circumstances.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Trial registration<\/jats:title>\n                    <jats:p>NCT03580317.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1007\/s00415-024-12433-x","type":"journal-article","created":{"date-parts":[[2024,5,30]],"date-time":"2024-05-30T23:42:28Z","timestamp":1717112548000},"page":"5122-5136","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":28,"title":["Electroacupuncture and carbamazepine for patients with trigeminal neuralgia: a randomized, controlled, 2\u2009\u00d7\u20092 factorial trial"],"prefix":"10.1007","volume":"271","clinical-trial-number":[{"clinical-trial-number":"nct03580317","registry":"10.18810\/clinical-trials-gov"}],"author":[{"given":"Rongrong","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaitao","family":"Luo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ning","family":"Luo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruohan","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feng","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yiyi","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yunfan","family":"Xia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoyu","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lifang","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruijie","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaomei","family":"Shao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Liang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianqiao","family":"Fang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,5,31]]},"reference":[{"issue":"2, Selected Top","key":"12433_CR1","first-page":"396","volume":"23","author":"G Cruccu","year":"2017","unstructured":"Cruccu G (2017) Trigeminal neuralgia. 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