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Neuromodulatory treatment by low-intensity noisy galvanic vestibular stimulation (nGVS) has indicated positive effects on postural instability in PD, which may possibly be conveyed to improvement of dynamic gait dysfunction.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Objective<\/jats:title>\n                <jats:p>To investigate the effects of individually tuned nGVS on normal and cognitively challenged walking in PD patients with mild-to-moderate gait dysfunction.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>Effects of nGVS of varying intensities (0\u20130.7\u00a0mA) on body sway were examined in 32 patients with PD (ON medication state, Hoehn and Yahr: 2.3\u2009\u00b1\u20090.5), who were standing with eyes closed on a posturographic force plate. Treatment response and optimal nGVS stimulation intensity were determined on an individual patient level. In a second step, the effects of optimal nGVS vs. sham treatment on walking with preferred speed and with a cognitive dual task were investigated by assessment of spatiotemporal gait parameters on a pressure-sensitive gait carpet.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>Evaluation of individual balance responses yielded that 59% of patients displayed a beneficial balance response to nGVS treatment with an average optimal improvement of 23%. However, optimal nGVS had no effects on gait parameters neither for the normal nor the cognitively challenged walking condition compared to sham stimulation irrespective of the nGVS responder status.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusions<\/jats:title>\n                <jats:p>Low-intensity nGVS seems to have differential treatment effects on static postural imbalance and continuous gait dysfunction in PD, which could be explained by a selective modulation of midbrain-thalamic circuits of balance control.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1007\/s00415-024-12504-z","type":"journal-article","created":{"date-parts":[[2024,6,17]],"date-time":"2024-06-17T11:06:13Z","timestamp":1718622373000},"page":"5489-5497","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["No evidence for effects of low-intensity vestibular noise stimulation on mild-to-moderate gait impairments in patients with Parkinson\u2019s disease"],"prefix":"10.1007","volume":"271","author":[{"given":"Daniela","family":"Peto","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Florian","family":"Schmidmeier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sabrina","family":"Katzdobler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Urban M.","family":"Fietzek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johannes","family":"Levin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5115-3777","authenticated-orcid":false,"given":"Max","family":"Wuehr","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas","family":"Zwergal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,6,17]]},"reference":[{"key":"12504_CR1","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/j.neuroscience.2012.07.054","volume":"223","author":"BR Aravamuthan","year":"2012","unstructured":"Aravamuthan BR, Angelaki DE (2012) Vestibular responses in the macaque pedunculopontine nucleus and central mesencephalic reticular formation. 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Kohlhammer GmbH medical publishers, non-financial support from Abbvie and compensation for duty as part-time CMO from MODAG, outside the submitted work. MW received funding from the neuroConn GmbH (DC stimulator). He serves as an associate editor for Frontiers in Neurology\u2014Section Neuro-otology and Section Translational Research in Rehabilitation. AZ reports speaker fees and research support from Dr. Willmar Schwabe GmbH. He serves as an associate editor for Frontiers in Neurology\u2014Section Neuro-otology and Section Translational Research in Rehabilitation.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"The ethics committee of the medical faculty of the Ludwig-Maximilians-University approved the study protocol (20-1137), which was conducted in accordance with the Declaration of Helsinki.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical standards"}}]}}