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MS was diagnosed using the 2017 McDonald criteria with a minimum observation time of two years from ON onset.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>20.5% of 44 MS-converters did <jats:italic>not<\/jats:italic> fulfil the 2017 McDonald criteria at ON onset. A doubling of cNfL was associated with 207% (74%\u2013514%) higher odds of MS (p\u2009=\u20090.00042, adjusted for age). Fulfilment of\u2009\u2265\u20091 MRI criterion for dissemination in space (DIS) and presence of brain contrast-enhancing lesions were associated with higher cNfL. Furthermore, cNfL correlated with inter-eye differences in retinal nerve fiber layer (RNFL) thickness (Spearman\u2019s \u03c1\u2009=\u20090.46, p\u2009=\u20098\u2009\u00d7\u200910<jats:sup>\u20135<\/jats:sup>). Incorporating cNfL\u2009\u2265\u2009906\u00a0pg\/mL as a substitute for either dissemination in time or one MRI criterion for DIS increased the sensitivity (90.9% vs. 79.6%) and accuracy (91.9% vs. 87.8%), but also reduced the specificity (93.3% vs. 100%) of the 2017 McDonald criteria.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusion<\/jats:title>\n                <jats:p>cNfL was related to MS diagnostic parameters and the degree of RNFL swelling. Clinical use of cNfL may aid in identification of ON patients with increased risk of MS until larger studies have elaborated on the potential loss of specificity if used diagnostically.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1007\/s00415-024-12587-8","type":"journal-article","created":{"date-parts":[[2024,7,25]],"date-time":"2024-07-25T07:03:04Z","timestamp":1721890984000},"page":"6127-6135","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Cerebrospinal fluid neurofilament light chain in acute optic neuritis and its predictive ability of multiple sclerosis"],"prefix":"10.1007","volume":"271","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2759-7903","authenticated-orcid":false,"given":"Moschoula","family":"Passali","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1268-5102","authenticated-orcid":false,"given":"Ian","family":"Galea","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0432-1488","authenticated-orcid":false,"given":"Maria H\u00f8jberg","family":"Knudsen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laurie Chi","family":"Lau","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2959-2161","authenticated-orcid":false,"given":"Stig Pr\u00e6stekj\u00e6r","family":"Cramer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1661-7438","authenticated-orcid":false,"given":"Jette Lautrup","family":"Frederiksen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,7,25]]},"reference":[{"key":"12587_CR1","doi-asserted-by":"publisher","first-page":"5382","DOI":"10.1007\/s00415-022-11193-w","volume":"269","author":"M Filippi","year":"2022","unstructured":"Filippi M, Amato MP, Centonze D, Gallo P, Gasperini C, Inglese M, Patti F, Pozzilli C, Preziosa P, Trojano M (2022) Early use of high-efficacy disease-modifying therapies makes the difference in people with multiple sclerosis: an expert opinion. 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Bosn J Basic Med Sci 22:699\u2013706. https:\/\/doi.org\/10.17305\/bjbms.2021.7326","journal-title":"Bosn J Basic Med Sci"}],"container-title":["Journal of Neurology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00415-024-12587-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00415-024-12587-8\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00415-024-12587-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,9,5]],"date-time":"2024-09-05T12:23:56Z","timestamp":1725539036000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00415-024-12587-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,7,25]]},"references-count":30,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2024,9]]}},"alternative-id":["12587"],"URL":"https:\/\/doi.org\/10.1007\/s00415-024-12587-8","relation":{},"ISSN":["0340-5354","1432-1459"],"issn-type":[{"value":"0340-5354","type":"print"},{"value":"1432-1459","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,7,25]]},"assertion":[{"value":"22 June 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"15 July 2024","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"16 July 2024","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"25 July 2024","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors have no conflicts of interest related to this study. M. Passali received funding from the Danish Multiple Sclerosis Society. I. Galea received funding from Merck-Serono, Novartis and The Binding Site. M.H. Knudsen received funding from Sanofi Genzyme and the Danish Multiple Sclerosis Society and non-financial support from Merck. S.P. Cramer received funding from Sanofi Genzyme and the Danish Multiple Sclerosis Society. J. Frederiksen served on scientific advisory boards for and received funding for travel related to these activities as well as honoraria from Merck Serono, Sanofi-Aventis, Roche, Novartis and Chiesi.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflicts of interest"}},{"value":"The study was conducted in accordance with the 1964 Declaration of Helsinki and its later amendments. Participants signed written informed consent form before study participation in the clinical trial with protocol number H-17019986 and our biomarker study with protocol number H-4\u20132014-095. Both protocols were approved by Copenhagen\u2019s Regional Committee on Health Research Ethics.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval"}}]}}