{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T16:17:15Z","timestamp":1791908235053,"version":"4.3.4"},"reference-count":48,"publisher":"Springer Science and Business Media LLC","issue":"10","license":[{"start":{"date-parts":[[2024,9,5]],"date-time":"2024-09-05T00:00:00Z","timestamp":1725494400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2024,9,5]],"date-time":"2024-09-05T00:00:00Z","timestamp":1725494400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/501100022720","name":"Fondazione Regionale per la Ricerca Biomedica","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100022720","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008530","name":"Fondo Europeo di Sviluppo Regionale","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100008530","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100003196","name":"Ministero della Salute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003196","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007601","name":"Horizon 2020","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007601","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003407","name":"Ministero dell\u2019Istruzione, dell\u2019Universit\u00e0 e della Ricerca","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003407","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Neurol"],"published-print":{"date-parts":[[2024,10]]},"DOI":"10.1007\/s00415-024-12658-w","type":"journal-article","created":{"date-parts":[[2024,9,5]],"date-time":"2024-09-05T07:05:36Z","timestamp":1725519936000},"page":"6944-6955","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Prevalence and motor-functional correlates of frontotemporal-spectrum disorders in a large cohort of non-demented ALS patients"],"prefix":"10.1007","volume":"271","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4398-2051","authenticated-orcid":false,"given":"Barbara","family":"Poletti","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edoardo Nicol\u00f2","family":"Aiello","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monica","family":"Consonni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barbara","family":"Iazzolino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvia","family":"Torre","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Federica","family":"Solca","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Veronica","family":"Faltracco","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandra","family":"Telesca","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesca","family":"Palumbo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eleonora","family":"Dalla Bella","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Enrica","family":"Bersano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nilo","family":"Riva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Federico","family":"Verde","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefano","family":"Messina","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alberto","family":"Doretti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessio","family":"Maranzano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudia","family":"Morelli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Calvo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vincenzo","family":"Silani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giuseppe","family":"Lauria","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adriano","family":"Chi\u00f2","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicola","family":"Ticozzi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,9,5]]},"reference":[{"key":"12658_CR1","doi-asserted-by":"publisher","first-page":"655","DOI":"10.1038\/s41582-023-00878-z","volume":"19","author":"S Abrahams","year":"2023","unstructured":"Abrahams S (2023) Neuropsychological impairment in amyotrophic lateral sclerosis\u2013frontotemporal-spectrum disorder. Nat Rev Neurol 19:655\u2013667","journal-title":"Nat Rev Neurol"},{"key":"12658_CR2","doi-asserted-by":"publisher","first-page":"153","DOI":"10.1080\/21678421.2016.1267768","volume":"18","author":"MJ Strong","year":"2017","unstructured":"Strong MJ, Abrahams S, Goldstein LH et al (2017) Amyotrophic lateral sclerosis-frontotemporal-spectrum disorder (ALS-FTSD): Revised diagnostic criteria. Amyotroph Lateral Scler Frontotemporal Degener 18:153\u2013174","journal-title":"Amyotroph Lateral Scler Frontotemporal Degener"},{"key":"12658_CR3","doi-asserted-by":"publisher","first-page":"27","DOI":"10.3109\/17482960802645008","volume":"11","author":"J Raaphorst","year":"2010","unstructured":"Raaphorst J, De Visser M, Linssen WH, De Haan RJ, Schmand B (2010) The cognitive profile of amyotrophic lateral sclerosis: a meta-analysis. Amyotroph Lateral Scler 11:27\u201337","journal-title":"Amyotroph Lateral Scler"},{"key":"12658_CR4","doi-asserted-by":"publisher","first-page":"611","DOI":"10.1136\/jnnp-2015-310734","volume":"87","author":"E Beeldman","year":"2016","unstructured":"Beeldman E, Raaphorst J, Twennaar MK, de Visser M, Schmand BA, de Haan RJ (2016) The cognitive profile of ALS: a systematic review and meta-analysis update. J Neurol Neurosurg Psychiatry 87:611\u2013619","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"12658_CR5","doi-asserted-by":"publisher","first-page":"2","DOI":"10.1080\/21678421.2022.2101379","volume":"24","author":"J Finsel","year":"2023","unstructured":"Finsel J, Uttner I, V\u00e1zquez Medrano CR, Ludolph AC, Lul\u00e9 D (2023) Cognition in the course of ALS\u2014a meta-analysis. Amyotroph Lateral Scler Frontotemporal Degener 24:2\u201313","journal-title":"Amyotroph Lateral Scler Frontotemporal Degener"},{"key":"12658_CR6","doi-asserted-by":"publisher","first-page":"493","DOI":"10.3109\/17482968.2012.656652","volume":"13","author":"J Raaphorst","year":"2012","unstructured":"Raaphorst J, Beeldman E, De Visser M, De Haan RJ, Schmand B (2012) A systematic review of behavioural changes in motor neuron disease. Amyotroph Lateral Scler 13:493\u2013501","journal-title":"Amyotroph Lateral Scler"},{"key":"12658_CR7","doi-asserted-by":"publisher","first-page":"14","DOI":"10.1080\/21678421.2022.2053721","volume":"24","author":"MA Kutlubaev","year":"2023","unstructured":"Kutlubaev MA, Caga J, Xu Y, Areprintseva DK, Pervushina EV, Kiernan MC (2023) Apathy in amyotrophic lateral sclerosis: systematic review and meta-analysis of frequency, correlates, and outcomes. Amyotroph Lateral Scler Frontotemporal Degener 24:14\u201323","journal-title":"Amyotroph Lateral Scler Frontotemporal Degener"},{"key":"12658_CR8","doi-asserted-by":"publisher","first-page":"324","DOI":"10.1080\/21678421.2020.1732424","volume":"21","author":"IK Gosselt","year":"2020","unstructured":"Gosselt IK, Nijboer TC, Van Es MA (2020) An overview of screening instruments for cognition and behaviour in patients with ALS: selecting the appropriate tool for clinical practice. Amyotroph Lateral Scler Frontotemporal Degener 21:324\u2013336","journal-title":"Amyotroph Lateral Scler Frontotemporal Degener"},{"key":"12658_CR9","doi-asserted-by":"publisher","first-page":"9","DOI":"10.3109\/21678421.2013.805784","volume":"15","author":"S Abrahams","year":"2014","unstructured":"Abrahams S, Newton J, Niven E, Foley J, Bak TH (2014) Screening for cognition and behaviour changes in ALS. Amyotroph Lateral Scler Frontotemporal Degener 15:9\u201314","journal-title":"Amyotroph Lateral Scler Frontotemporal Degener"},{"issue":"10","key":"12658_CR10","doi-asserted-by":"publisher","first-page":"e984","DOI":"10.1212\/WNL.0000000000008063","volume":"93","author":"A Chi\u00f2","year":"2019","unstructured":"Chi\u00f2 A, Moglia C, Canosa A, Manera U, Vasta R, Brunetti M et al (2019) Cognitive impairment across ALS clinical stages in a population-based cohort. Neurology 93(10):e984\u2013e994","journal-title":"Neurology"},{"key":"12658_CR11","doi-asserted-by":"publisher","first-page":"1182","DOI":"10.1016\/S1474-4422(16)30199-5","volume":"15","author":"A Al-Chalabi","year":"2016","unstructured":"Al-Chalabi A, Hardiman O, Kiernan MC, Chi\u00f2 A, Rix-Brooks B, van den Berg LH (2016) Amyotrophic lateral sclerosis: moving towards a new classification system. Lancet Neurol 15:1182\u20131194","journal-title":"Lancet Neurol"},{"key":"12658_CR12","doi-asserted-by":"publisher","first-page":"2456","DOI":"10.1093\/brain\/awr179","volume":"134","author":"K Rascovsky","year":"2011","unstructured":"Rascovsky K, Hodges JR, Knopman D et al (2011) Sensitivity of revised diagnostic criteria for the behavioural variant of frontotemporal dementia. Brain 134:2456\u20132477","journal-title":"Brain"},{"key":"12658_CR13","doi-asserted-by":"publisher","first-page":"1006","DOI":"10.1212\/WNL.0b013e31821103e6","volume":"76","author":"ML Gorno-Tempini","year":"2011","unstructured":"Gorno-Tempini ML, Hillis AE, Weintraub S et al (2011) Classification of primary progressive aphasia and its variants. Neurology 76:1006\u20131014","journal-title":"Neurology"},{"key":"12658_CR14","doi-asserted-by":"publisher","first-page":"489","DOI":"10.1080\/21678421.2016.1183679","volume":"17","author":"B Poletti","year":"2016","unstructured":"Poletti B, Solca F, Carelli L et al (2016) The validation of the Italian Edinburgh cognitive and behavioural ALS screen (ECAS). Amyotroph Lateral Scler Frontotemporal Degener 17:489\u2013498","journal-title":"Amyotroph Lateral Scler Frontotemporal Degener"},{"key":"12658_CR15","doi-asserted-by":"publisher","first-page":"941","DOI":"10.1007\/s10072-022-06505-x","volume":"44","author":"B Poletti","year":"2023","unstructured":"Poletti B, Aiello EN, Solca F et al (2023) Diagnostic properties of the Italian ECAS-Carer Interview (ECAS-CI). Neurol Sci 44:941\u2013946","journal-title":"Neurol Sci"},{"key":"12658_CR16","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0304593","volume":"19","author":"A Serian","year":"2024","unstructured":"Serian A, Finsel J, Ludolph AC, Uttner I, Lul\u00e9 D (2024) Screening instruments of cognition: The relation of the mini-mental state examination to the Edinburgh cognitive and behavioural ALS screen in amyotrophic lateral sclerosis. PLoS ONE 19:e0304593","journal-title":"PLoS ONE"},{"key":"12658_CR17","doi-asserted-by":"publisher","first-page":"139","DOI":"10.1097\/01.JGP.0000192478.82189.a8","volume":"14","author":"R Perneczky","year":"2006","unstructured":"Perneczky R, Wagenpfeil S, Komossa K, Grimmer T, Diehl J, Kurz A (2006) Mapping scores onto stages: mini-mental state examination and clinical dementia rating. Am J Geriatr Psychiatry 14:139\u2013144","journal-title":"Am J Geriatr Psychiatry"},{"key":"12658_CR18","doi-asserted-by":"crossref","unstructured":"Poletti B, Aiello EN, La Tona A, et al. Single task-level, 2SD-based cutoffs for the Italian version of the Edinburgh Cognitive and Behavioral ALS screen (ECAS). Amyotroph Lateral Scler Frontotemporal Degener. 2023:1\u20134.","DOI":"10.1080\/21678421.2023.2220746"},{"key":"12658_CR19","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1016\/S0022-510X(99)00210-5","volume":"169","author":"JM Cedarbaum","year":"1999","unstructured":"Cedarbaum JM, Stambler N, Malta E et al (1999) The ALSFRS-R: a revised ALS functional rating scale that incorporates assessments of respiratory function. J Neurol Sci 169:13\u201321","journal-title":"J Neurol Sci"},{"key":"12658_CR20","doi-asserted-by":"publisher","first-page":"265","DOI":"10.1212\/01.wnl.0000194316.91908.8a","volume":"66","author":"FC Kimura","year":"2006","unstructured":"Kimura FC, Fujimura C, Ishida S, Nakajima H, Furutama D, Uehara H et al (2006) Progression rate of ALSFRS-R at time of diagnosis predicts survival time in ALS. Neurology 66:265\u2013267","journal-title":"Neurology"},{"key":"12658_CR21","doi-asserted-by":"publisher","first-page":"847","DOI":"10.1093\/brain\/awr351","volume":"135","author":"JC Roche","year":"2012","unstructured":"Roche JC, Rojas-Garcia R, Scott KM, Scotton W, Ellis CE, Burman R et al (2012) A proposed staging system for amyotrophic lateral sclerosis. Brain 135:847\u2013852","journal-title":"Brain"},{"key":"12658_CR22","doi-asserted-by":"publisher","first-page":"38","DOI":"10.1136\/jnnp-2013-306589","volume":"86","author":"A Chi\u00f2","year":"2015","unstructured":"Chi\u00f2 A, Hammond ER, Mora G, Bonito V, Filippini G (2015) Development and evaluation of a clinical staging system for amyotrophic lateral sclerosis. J Neurol Neurosurg Psychiatry 86:38\u201344","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"12658_CR23","doi-asserted-by":"publisher","first-page":"159","DOI":"10.1080\/21678421.2018.1556696","volume":"20","author":"R Balendra","year":"2019","unstructured":"Balendra R, Al Khleifat A, Fang T, Al-Chalabi A (2019) A standard operating procedure for King\u2019s ALS clinical staging. Amyotroph Lateral Scler Frontotemporal Degener 20:159\u2013164","journal-title":"Amyotroph Lateral Scler Frontotemporal Degener"},{"key":"12658_CR24","doi-asserted-by":"publisher","first-page":"572","DOI":"10.1080\/21678421.2023.2236651","volume":"24","author":"S Ghaderi","year":"2023","unstructured":"Ghaderi S, Fatehi F, Kalra S, Batouli SA (2023) MRI biomarkers for memory-related impairment in amyotrophic lateral sclerosis: a systematic review. Amyotroph Lateral Scler Frontotemporal Degener 24:572\u2013588","journal-title":"Amyotroph Lateral Scler Frontotemporal Degener"},{"key":"12658_CR25","doi-asserted-by":"publisher","first-page":"e1370","DOI":"10.1212\/WNL.0000000000006317","volume":"91","author":"C Crockford","year":"2018","unstructured":"Crockford C, Newton J, Lonergan K, Chiwera T, Booth T, Chandran S et al (2018) ALS-specific cognitive and behaviour changes associated with advancing disease stage in ALS. Neurology 91:e1370\u2013e1380","journal-title":"Neurology"},{"issue":"4","key":"12658_CR26","first-page":"316","volume":"95","author":"CA McHutchison","year":"2024","unstructured":"McHutchison CA, Wuu J, McMillan CT, Rademakers R, Statland J, Wu G et al (2024) Temporal course of cognitive and behavioural changes in motor neuron diseases. J Neurol Neurosurg Psychiatry 95(4):316\u2013324","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"12658_CR27","doi-asserted-by":"publisher","first-page":"1590","DOI":"10.1212\/WNL.0b013e31828f18ac","volume":"80","author":"M Elamin","year":"2013","unstructured":"Elamin M, Bede P, Byrne S, Jordan N, Gallagher L, Wynne B et al (2013) Cognitive changes predict functional decline in ALS: a population-based longitudinal study. Neurology 80:1590\u20131597","journal-title":"Neurology"},{"key":"12658_CR28","doi-asserted-by":"publisher","first-page":"5397","DOI":"10.1007\/s10072-022-06157-x","volume":"43","author":"EN Aiello","year":"2022","unstructured":"Aiello EN, Pain D, Radici A, Aktipi KM, Sideri R, Appollonio I, Mora G (2022) Cognition and motor phenotypes in ALS: a retrospective study. Neurol Sci 43:5397\u20135402","journal-title":"Neurol Sci"},{"key":"12658_CR29","doi-asserted-by":"publisher","first-page":"373","DOI":"10.1080\/21678421.2020.1771732","volume":"21","author":"E Bersano","year":"2020","unstructured":"Bersano E, Sarnelli MF, Solara V, Iazzolino B, Peotta L, De Marchi F et al (2020) Decline of cognitive and behavioral functions in amyotrophic lateral sclerosis: a longitudinal study. Amyotroph Lateral Scler Frontotemporal Degener 21:373\u2013379","journal-title":"Amyotroph Lateral Scler Frontotemporal Degener"},{"key":"12658_CR30","doi-asserted-by":"publisher","first-page":"357","DOI":"10.1136\/jnnp-2020-323876","volume":"92","author":"A Canosa","year":"2021","unstructured":"Canosa A, Moglia C, Manera U, Vasta R, Torrieri MC, Arena V et al (2021) Metabolic brain changes across different levels of cognitive impairment in ALS: a 18F-FDG-PET study. J Neurol, Neurosurg Psychiatry 92:357\u2013363","journal-title":"J Neurol, Neurosurg Psychiatry"},{"key":"12658_CR31","doi-asserted-by":"publisher","first-page":"488","DOI":"10.1212\/CPJ.0000000000000397","volume":"7","author":"M Bock","year":"2017","unstructured":"Bock M, Duong YN, Kim A, Allen I, Murphy J, Lomen-Hoerth C (2017) Progression and effect of cognitive-behavioral changes in patients with amyotrophic lateral sclerosis. Neurol Clin Pract 7:488\u2013498","journal-title":"Neurol Clin Pract"},{"key":"12658_CR32","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0253279","volume":"16","author":"S Ye","year":"2021","unstructured":"Ye S, Jin P, Chen L, Zhang N, Fan D (2021) Prognosis of amyotrophic lateral sclerosis with cognitive and behavioural changes based on a sixty-month longitudinal follow-up. PLoS ONE 16:e0253279","journal-title":"PLoS ONE"},{"key":"12658_CR33","doi-asserted-by":"publisher","first-page":"387","DOI":"10.1080\/21678421.2018.1473443","volume":"19","author":"B Poletti","year":"2018","unstructured":"Poletti B, Solca F, Carelli L, Faini A, Madotto F, Lafronza A et al (2018) Cognitive-behavioral longitudinal assessment in ALS: the Italian Edinburgh Cognitive and Behavioral ALS screen (ECAS). Amyotroph Lateral Scler Frontotemporal Degener 19:387\u2013395","journal-title":"Amyotroph Lateral Scler Frontotemporal Degener"},{"key":"12658_CR34","doi-asserted-by":"publisher","first-page":"527","DOI":"10.1080\/21678421.2022.2051552","volume":"23","author":"EN Aiello","year":"2022","unstructured":"Aiello EN, Iazzolino B, Pain D, Peotta L, Palumbo F, Radici A et al (2022) The diagnostic value of the Italian version of the Edinburgh Cognitive and Behavioral ALS Screen (ECAS). Amyotroph Lateral Scler Frontotemporal Degener 23:527\u2013531","journal-title":"Amyotroph Lateral Scler Frontotemporal Degener"},{"key":"12658_CR35","doi-asserted-by":"publisher","first-page":"339","DOI":"10.1080\/21678421.2022.2134801","volume":"24","author":"EN Aiello","year":"2023","unstructured":"Aiello EN, Solca F, Torre S, Carelli L, Monti A, Ferrucci R et al (2023) Reliable change indices for the Italian Edinburgh cognitive and behavioral ALS screen (ECAS). Amyotroph Lateral Scler Frontotemporal Degener 24:339\u2013342","journal-title":"Amyotroph Lateral Scler Frontotemporal Degener"},{"key":"12658_CR36","doi-asserted-by":"publisher","first-page":"517","DOI":"10.1080\/21678421.2022.2039713","volume":"23","author":"CT McMillan","year":"2022","unstructured":"McMillan CT, Wuu J, Rascovsky K, Cosentino S, Grossman M, Elman L et al (2022) Defining cognitive impairment in amyotrophic lateral sclerosis: an evaluation of empirical approaches. Amyotroph Lateral Scler Frontotemporal Degener 23:517\u2013526","journal-title":"Amyotroph Lateral Scler Frontotemporal Degener"},{"key":"12658_CR37","doi-asserted-by":"publisher","first-page":"450","DOI":"10.3389\/fpsyg.2018.00450","volume":"9","author":"L Carelli","year":"2018","unstructured":"Carelli L, Solca F, Faini A, Madotto F, Lafronza A, Monti A et al (2018) The complex interplay between depression\/anxiety and executive functioning: insights from the ECAS in a large ALS population. Front Psychol 9:450","journal-title":"Front Psychol"},{"key":"12658_CR38","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1002\/mus.26475","volume":"60","author":"M Siciliano","year":"2019","unstructured":"Siciliano M, Trojano L, Trojsi F, Monsurro MR, Tedeschi G, Santangelo G (2019) Assessing anxiety and its correlates in amyotrophic lateral sclerosis: The state-trait anxiety inventory. Muscle Nerve 60:47\u201355","journal-title":"Muscle Nerve"},{"key":"12658_CR39","doi-asserted-by":"publisher","first-page":"552","DOI":"10.1016\/j.jocn.2011.07.042","volume":"19","author":"E Mioshi","year":"2012","unstructured":"Mioshi E, Lillo P, Kiernan M, Hodges J (2012) Activities of daily living in motor neuron disease: role of behavioural and motor changes. J Clin Neurosci 19:552\u2013556","journal-title":"J Clin Neurosci"},{"key":"12658_CR40","doi-asserted-by":"publisher","first-page":"1087","DOI":"10.1007\/s10072-023-07074-3","volume":"45","author":"EN Aiello","year":"2024","unstructured":"Aiello EN, Solca F, Torre S, Gentile F, Scheveger F, Olivero M et al (2024) Frontotemporal-spectrum disorders and functional independence in non-demented ALS patients. Neurol Sci 45:1087\u20131095","journal-title":"Neurol Sci"},{"key":"12658_CR41","doi-asserted-by":"publisher","first-page":"62","DOI":"10.1080\/21678421.2021.1924206","volume":"22","author":"JS Shah","year":"2021","unstructured":"Shah JS, Pedraza O, Festic E, Oskarsson B (2021) The relationship between ventilatory function and cognitive and behavioral impairment in ALS. Amyotroph Lateral Scler Frontotemporal Degener 22:62\u201367","journal-title":"Amyotroph Lateral Scler Frontotemporal Degener"},{"key":"12658_CR42","doi-asserted-by":"publisher","first-page":"4105","DOI":"10.1093\/brain\/awad129","volume":"146","author":"A Maranzano","year":"2023","unstructured":"Maranzano A, Verde F, Colombo E, Poletti B, Doretti A, Bonetti R et al (2023) Regional spreading pattern is associated with clinical phenotype in amyotrophic lateral sclerosis. Brain 146:4105\u20134116","journal-title":"Brain"},{"key":"12658_CR43","doi-asserted-by":"publisher","first-page":"1402","DOI":"10.1111\/ene.15243","volume":"29","author":"A Maranzano","year":"2022","unstructured":"Maranzano A, Poletti B, Solca F, Torre S, Colombo E, Far\u00e9 M et al (2022) Upper motor neuron dysfunction is associated with the presence of behavioural impairment in patients with amyotrophic lateral sclerosis. Eur J Neurol 29:1402\u20131409","journal-title":"Eur J Neurol"},{"key":"12658_CR44","doi-asserted-by":"crossref","unstructured":"Aiello EN, Solca F, Torre S, Patisso V, De Lorenzo A, Treddenti M, et al. Bulbar involvement and cognitive features in amyotrophic lateral sclerosis: a retrospective study on 347 patients. Front Aging Neurosci. 2023;15.","DOI":"10.3389\/fnagi.2023.1217080"},{"key":"12658_CR45","doi-asserted-by":"publisher","first-page":"688","DOI":"10.1136\/jnnp-2020-325701","volume":"92","author":"T Yang","year":"2021","unstructured":"Yang T, Hou Y, Li C, Cao B, Cheng Y, Wei Q, Zhang L et al (2021) Risk factors for cognitive impairment in amyotrophic lateral sclerosis: a systematic review and meta-analysis. J Neurol Neurosurg Psychiatry 92:688\u2013693","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"12658_CR46","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000208082","volume":"102","author":"C Moglia","year":"2024","unstructured":"Moglia C, Calvo A, Canosa A, Manera U, Vasta R, Di Pede F et al (2024) Cognitive and behavioral features of patients with Amyotrophic lateral sclerosis who are carriers of the TARDBP pathogenic variant. Neurology 102:e208082","journal-title":"Neurology"},{"key":"12658_CR47","doi-asserted-by":"publisher","first-page":"e2052","DOI":"10.1212\/WNL.0000000000201044","volume":"99","author":"E Dalla Bella","year":"2022","unstructured":"Dalla Bella E, Bersano E, Bruzzone MG, Gellera C, Pensato V, Lauria G et al (2022) Behavioral and cognitive phenotypes of patients with amyotrophic lateral sclerosis carrying SOD1 variants. Neurology 99:e2052\u2013e2062","journal-title":"Neurology"},{"key":"12658_CR48","doi-asserted-by":"publisher","first-page":"150","DOI":"10.1002\/ana.26928","volume":"96","author":"A Calvo","year":"2024","unstructured":"Calvo A, Moglia C, Canosa A, Manera U, Vasta R, Grassano M et al (2024) High Frequency of Cognitive and Behavioral Impairment in Amyotrophic Lateral Sclerosis Patients with SOD1 Pathogenic Variants. Ann Neurol 96:150\u2013158","journal-title":"Ann Neurol"}],"container-title":["Journal of Neurology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00415-024-12658-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00415-024-12658-w\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00415-024-12658-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,10,3]],"date-time":"2024-10-03T04:02:35Z","timestamp":1727928155000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00415-024-12658-w"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,9,5]]},"references-count":48,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2024,10]]}},"alternative-id":["12658"],"URL":"https:\/\/doi.org\/10.1007\/s00415-024-12658-w","relation":{},"ISSN":["0340-5354","1432-1459"],"issn-type":[{"value":"0340-5354","type":"print"},{"value":"1432-1459","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,9,5]]},"assertion":[{"value":"28 July 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"20 August 2024","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"20 August 2024","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"5 September 2024","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"V. S. received compensation for consulting services and\/or speaking activities from AveXis, Cytokinetics, Italfarmaco, Liquidweb S.r.l., and Novartis Pharma AG, receives or has received research supports from the Italian Ministry of Health, AriSLA, and E-Rare Joint Transnational Call. He is in the Editorial Board of <i>Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration<\/i>, <i>European Neurology<\/i>, <i>American Journal of Neurodegenerative Diseases<\/i>, <i>Frontiers in Neurology<\/i>. B.P. received compensation for consulting services and\/or speaking activities from Liquidweb S.r.l. B.P. is Associate Editor for <i>Frontier in Neuroscience<\/i>. N. T. received compensation for consulting services and\/or speaking fees from Amylyx Pharmaceuticals, Biogen, Italfarmaco, and Zambon Biotech SA. He is Associate Editor for <i>Frontiers in Aging Neuroscience<\/i>. F.V. is Associated Editor for <i>Journal of Alzheimer\u2019s Disease<\/i>. E.N.A. serves as an Editorial Board Member for <i>BMC Neurology<\/i>. A.Ch. is a member of the following Scientific Advisory Boards: Mitsubishi Tanabe, Roche, Biogen, Denali Pharma, Cytokinetics, Amylyx Pharmaceuticals, VectorY, and Ferrer and Zambon Biotech; he received a scientific grant from Biogen; he is a member of the following Drug Safety and Monitoring Boards: AB Science, Verge, Corcept and Eli Lilly; A. Ca. has received a research grant from Cytokinetics. The other authors have nothing to declare.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"Participants provided informed consent and data were treated according to current regulations. This study was approved by the Ethics Committee of IRCCS Istituto Auxologico Italiano (ID: 2013_06_25), by the Ethics Committee of Fondazione IRCCS Istituto Neurologico Carlo Besta (ID: 71\/2015; 2017\/06\/07, Excerpt 6\/41; 2020\/06\/17, Excerpt 01\/73; 2023\/01\/18, Excerpt 06\/11), and by the Ethics Committee of the ALS Expert Center of Torino, Azienda Ospedaliero Universitaria Citt\u00e0 della Salute e della Scienza (ID: #0038876).","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval"}},{"value":"Not applicable.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Patient consent for publication"}}]}}