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This study aims to measure cognitive function in patients diagnosed with AE.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods<\/jats:title>\n            <jats:p>This case\u2013control study included AE patients (<jats:italic>n<\/jats:italic>\u2009=\u200911) with antibodies against NMDA receptor (NMDAR) (<jats:italic>n<\/jats:italic>\u2009=\u20094), VGKC (<jats:italic>n<\/jats:italic>\u2009=\u20093), GAD (3), and one antibody-negative patient. The control group contained 12 pneumococcal meningo-encephalitis patients (PC). Subgroup analyses compared AE patients with and without NMDAR antibodies. Neurocognitive tests were performed to evaluate verbal and visual memory, face recognition, attentional capacity, incidental learning capacity, and overall cognitive function (Montreal cognitive assessment, MoCA). Limbic structural involvement was assessed through magnetic resonance imaging (MRI). Statistical analyses investigated correlations between antibody status, results of neurocognitive tests, and MRI findings.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results<\/jats:title>\n            <jats:p>Follow-up (AE vs. PC) was 33 (11\u201395) vs. 96 (26\u2013132) months after diagnosis. Neurocognitive functions were normal in both AE and PC groups in all tests except face recognition, which was pathological in both groups. The overall\/recognition\/long-delay visual memory (<jats:italic>p<\/jats:italic>\u2009=\u20090.009\/0.008\/0.005) and incidental learning (<jats:italic>p<\/jats:italic>\u2009=\u20090.017) scores were significantly higher in NMDAR patients compared to non-NMDAR patients. Non-NMDAR patients with right-sided limbic MRI pathologies had significantly lower overall\/recognition\/long-delay visual memory (<jats:italic>p<\/jats:italic>\u2009=\u20090.006\/0.044\/0.024) and incidental learning (<jats:italic>p<\/jats:italic>\u2009=\u20090.009) scores compared to NMDAR patients.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p>We observed mainly normal neurocognitive functions after autoimmune and bacterial encephalitis. However, compared to NMDAR patients, patients with non-NMDAR autoimmune encephalitis showed a significant and material-specific association between a right-sided hippocampal lesion and limitations in figural-mnestic and incidental learning capacities. Neurocognitive functions in AE patients should be further evaluated prospectively and in more detail.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1007\/s00415-024-12742-1","type":"journal-article","created":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T14:54:20Z","timestamp":1738421660000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Hippocampal dysfunction after autoimmune encephalitis depending on the antibody type"],"prefix":"10.1007","volume":"272","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9300-1130","authenticated-orcid":false,"given":"Martin","family":"H\u00e4nsel","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Heinz","family":"Reichmann","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antje","family":"Haehner","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Henning","family":"Schmitz-Peiffer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9641-0922","authenticated-orcid":false,"given":"Hauke","family":"Schneider","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2025,2,1]]},"reference":[{"issue":"9","key":"12742_CR1","doi-asserted-by":"publisher","first-page":"727","DOI":"10.1016\/j.biopsych.2015.02.024","volume":"79","author":"C Finke","year":"2016","unstructured":"Finke C, Kopp UA, Pajkert A, Behrens JR, Leypoldt F, Wuerfel JT, Ploner CJ, Pr\u00fcss H, Paul F (2016) Structural hippocampal damage following anti-N-Methyl-D-aspartate receptor encephalitis. 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