{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T05:14:14Z","timestamp":1792818854455,"version":"4.5.0"},"reference-count":54,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2024,12,12]],"date-time":"2024-12-12T00:00:00Z","timestamp":1733961600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2024,12,12]],"date-time":"2024-12-12T00:00:00Z","timestamp":1733961600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"DOI":"10.13039\/501100010983","name":"Health Research Fund of Central Denmark Region","doi-asserted-by":"publisher","award":["A3520"],"award-info":[{"award-number":["A3520"]}],"id":[{"id":"10.13039\/501100010983","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008628","name":"Institut for Klinisk Medicin, Aarhus Universitet","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008628","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007606","name":"Aarhus Universitetshospital","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007606","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Neurol"],"published-print":{"date-parts":[[2025,1]]},"DOI":"10.1007\/s00415-024-12743-0","type":"journal-article","created":{"date-parts":[[2024,12,12]],"date-time":"2024-12-12T12:22:36Z","timestamp":1734006156000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":28,"title":["Incidence and mortality of ALS: a 42-year population-based nationwide study"],"prefix":"10.1007","volume":"272","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2210-6020","authenticated-orcid":false,"given":"Lotte Sahin","family":"Levison","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jakob Udby","family":"Blicher","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henning","family":"Andersen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,12,12]]},"reference":[{"issue":"10360","key":"12743_CR1","doi-asserted-by":"publisher","first-page":"1363","DOI":"10.1016\/s0140-6736(22)01272-7","volume":"400","author":"EL Feldman","year":"2022","unstructured":"Feldman EL, Goutman SA, Petri S et al (2022) Amyotrophic lateral sclerosis. Lancet 400(10360):1363\u20131380. https:\/\/doi.org\/10.1016\/s0140-6736(22)01272-7","journal-title":"Lancet"},{"issue":"5","key":"12743_CR2","doi-asserted-by":"publisher","first-page":"465","DOI":"10.1016\/s1474-4422(21)00414-2","volume":"21","author":"SA Goutman","year":"2022","unstructured":"Goutman SA, Hardiman O, Al-Chalabi A et al (2022) Emerging insights into the complex genetics and pathophysiology of amyotrophic lateral sclerosis. Lancet Neurol 21(5):465\u2013479. https:\/\/doi.org\/10.1016\/s1474-4422(21)00414-2","journal-title":"Lancet Neurol"},{"issue":"11","key":"12743_CR3","doi-asserted-by":"publisher","first-page":"617","DOI":"10.1038\/nrneurol.2013.203","volume":"9","author":"A Al-Chalabi","year":"2013","unstructured":"Al-Chalabi A, Hardiman O (2013) The epidemiology of ALS: a conspiracy of genes, environment and time. Nat Rev Neurol 9(11):617\u2013628. https:\/\/doi.org\/10.1038\/nrneurol.2013.203","journal-title":"Nat Rev Neurol"},{"key":"12743_CR4","doi-asserted-by":"publisher","first-page":"82","DOI":"10.1016\/j.envres.2017.07.048","volume":"159","author":"CE Cicero","year":"2017","unstructured":"Cicero CE, Mostile G, Vasta R et al (2017) Metals and neurodegenerative diseases. A systematic review. Environ Res 159:82\u201394. https:\/\/doi.org\/10.1016\/j.envres.2017.07.048","journal-title":"Environ Res"},{"issue":"2","key":"12743_CR5","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1136\/oemed-2016-103700","volume":"74","author":"TL Peters","year":"2017","unstructured":"Peters TL, Kamel F, Lundholm C et al (2017) Occupational exposures and the risk of amyotrophic lateral sclerosis. Occup Environ Med 74(2):87\u201392. https:\/\/doi.org\/10.1136\/oemed-2016-103700","journal-title":"Occup Environ Med"},{"key":"12743_CR6","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1016\/j.neubiorev.2016.04.007","volume":"66","author":"E Lacorte","year":"2016","unstructured":"Lacorte E, Ferrigno L, Leoncini E, Corbo M, Boccia S, Vanacore N (2016) Physical activity, and physical activity related to sports, leisure and occupational activity as risk factors for ALS: a systematic review. Neurosci Biobehav Rev 66:61\u201379. https:\/\/doi.org\/10.1016\/j.neubiorev.2016.04.007","journal-title":"Neurosci Biobehav Rev"},{"issue":"1","key":"12743_CR7","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1159\/000510987","volume":"55","author":"G Liu","year":"2021","unstructured":"Liu G, Ou S, Cui H et al (2021) Head Injury and amyotrophic lateral sclerosis: a meta-analysis. Neuroepidemiology 55(1):11\u201319. https:\/\/doi.org\/10.1159\/000510987","journal-title":"Neuroepidemiology"},{"issue":"12","key":"12743_CR8","doi-asserted-by":"publisher","first-page":"1283","DOI":"10.1212\/wnl.0000000000004390","volume":"89","author":"JPK Rooney","year":"2017","unstructured":"Rooney JPK, Visser AE, D\u2019Ovidio F et al (2017) A case-control study of hormonal exposures as etiologic factors for ALS in women: Euro-MOTOR. Neurology 89(12):1283\u20131290. https:\/\/doi.org\/10.1212\/wnl.0000000000004390","journal-title":"Neurology"},{"issue":"6","key":"12743_CR9","doi-asserted-by":"publisher","first-page":"e613","DOI":"10.1212\/wnl.0000000000207474","volume":"101","author":"C Wolfson","year":"2023","unstructured":"Wolfson C, Gauvin DE, Ishola F, Oskoui M (2023) Global prevalence and incidence of amyotrophic lateral sclerosis: a systematic review. Neurology 101(6):e613\u2013e623. https:\/\/doi.org\/10.1212\/wnl.0000000000207474","journal-title":"Neurology"},{"issue":"1","key":"12743_CR10","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1093\/ije\/dyw061","volume":"46","author":"B Marin","year":"2017","unstructured":"Marin B, Boum\u00e9diene F, Logroscino G et al (2017) Variation in worldwide incidence of amyotrophic lateral sclerosis: a meta-analysis. Int J Epidemiol 46(1):57\u201374. https:\/\/doi.org\/10.1093\/ije\/dyw061","journal-title":"Int J Epidemiol"},{"issue":"7\u20138","key":"12743_CR11","doi-asserted-by":"publisher","first-page":"528","DOI":"10.1080\/21678421.2018.1497065","volume":"19","author":"E Longinetti","year":"2018","unstructured":"Longinetti E, Regod\u00f3n Wallin A, Samuelsson K et al (2018) The Swedish motor neuron disease quality registry. Amyotroph Lateral Scler Frontotemporal Degener 19(7\u20138):528\u2013537. https:\/\/doi.org\/10.1080\/21678421.2018.1497065","journal-title":"Amyotroph Lateral Scler Frontotemporal Degener"},{"issue":"4","key":"12743_CR12","doi-asserted-by":"publisher","first-page":"817","DOI":"10.1007\/s00415-019-09190-7","volume":"266","author":"DJ Leighton","year":"2019","unstructured":"Leighton DJ, Newton J, Stephenson LJ et al (2019) Changing epidemiology of motor neurone disease in Scotland. J Neurol 266(4):817\u2013825. https:\/\/doi.org\/10.1007\/s00415-019-09190-7","journal-title":"J Neurol"},{"issue":"7\u20138","key":"12743_CR13","doi-asserted-by":"publisher","first-page":"522","DOI":"10.1080\/21678421.2018.1513534","volume":"19","author":"E Benjaminsen","year":"2018","unstructured":"Benjaminsen E, Alstadhaug KB, Gulsvik M, Baloch FK, Odeh F (2018) Amyotrophic lateral sclerosis in Nordland county, Norway, 2000\u20132015: prevalence, incidence, and clinical features. Amyotroph Lateral Scler Frontotemporal Degener 19(7\u20138):522\u2013527. https:\/\/doi.org\/10.1080\/21678421.2018.1513534","journal-title":"Amyotroph Lateral Scler Frontotemporal Degener"},{"issue":"1\u20132","key":"12743_CR14","doi-asserted-by":"publisher","first-page":"90","DOI":"10.1080\/21678421.2018.1511732","volume":"20","author":"F Palese","year":"2019","unstructured":"Palese F, Sartori A, Verriello L et al (2019) Epidemiology of amyotrophic lateral sclerosis in Friuli-Venezia Giulia, North-Eastern Italy, 2002\u20132014: a retrospective population-based study. Amyotroph Lateral Scler Frontotemporal Degener 20(1\u20132):90\u201399. https:\/\/doi.org\/10.1080\/21678421.2018.1511732","journal-title":"Amyotroph Lateral Scler Frontotemporal Degener"},{"key":"12743_CR15","unstructured":"Statistics Denmark. https:\/\/www.statbank.dk\/statbank5a\/default.asp?w=1536. Accessed Jan 4, 2024"},{"issue":"8","key":"12743_CR16","doi-asserted-by":"publisher","first-page":"541","DOI":"10.1007\/s10654-014-9930-3","volume":"29","author":"M Schmidt","year":"2014","unstructured":"Schmidt M, Pedersen L, S\u00f8rensen HT (2014) The Danish Civil Registration System as a tool in epidemiology. Eur J Epidemiol 29(8):541\u2013549. https:\/\/doi.org\/10.1007\/s10654-014-9930-3","journal-title":"Eur J Epidemiol"},{"key":"12743_CR17","doi-asserted-by":"publisher","first-page":"563","DOI":"10.2147\/clep.S179083","volume":"11","author":"M Schmidt","year":"2019","unstructured":"Schmidt M, Schmidt SAJ, Adelborg K et al (2019) The Danish health care system and epidemiological research: from health care contacts to database records. Clin Epidemiol 11:563\u2013591. https:\/\/doi.org\/10.2147\/clep.S179083","journal-title":"Clin Epidemiol"},{"key":"12743_CR18","doi-asserted-by":"publisher","first-page":"449","DOI":"10.2147\/clep.S91125","volume":"7","author":"M Schmidt","year":"2015","unstructured":"Schmidt M, Schmidt SA, Sandegaard JL, Ehrenstein V, Pedersen L, S\u00f8rensen HT (2015) The Danish National Patient Registry: a review of content, data quality, and research potential. Clin Epidemiol 7:449\u2013490. https:\/\/doi.org\/10.2147\/clep.S91125","journal-title":"Clin Epidemiol"},{"issue":"7 Suppl","key":"12743_CR19","doi-asserted-by":"publisher","first-page":"30","DOI":"10.1177\/1403494811401482","volume":"39","author":"E Lynge","year":"2011","unstructured":"Lynge E, Sandegaard JL, Rebolj M (2011) The Danish National Patient Register. Scand J Public Health 39(7 Suppl):30\u201333. https:\/\/doi.org\/10.1177\/1403494811401482","journal-title":"Scand J Public Health"},{"key":"12743_CR20","unstructured":"European Medicines Agency. https:\/\/www.ema.europa.eu\/en\/medicines\/human\/EPAR\/rilutek#authorisation-details-section. Accessed Aug 18, 2024"},{"issue":"3","key":"12743_CR21","doi-asserted-by":"publisher","first-page":"798","DOI":"10.1093\/ije\/dyw213","volume":"46","author":"A Potteg\u00e5rd","year":"2016","unstructured":"Potteg\u00e5rd A, Schmidt SAJ, Wallach-Kildemoes H, S\u00f8rensen HT, Hallas J, Schmidt M (2016) Data resource profile: The Danish National Prescription Registry. Int J Epidemiol 46(3):798\u2013798f. https:\/\/doi.org\/10.1093\/ije\/dyw213","journal-title":"Int J Epidemiol"},{"key":"12743_CR22","unstructured":"The Danish Ministry of Health. https:\/\/sum.dk\/Media\/C\/A\/Healthcare-in%20denmark%20an%20overview%20english-V16-dec.pdf. Accessed Feb 1, 2024"},{"issue":"3\u20134","key":"12743_CR23","doi-asserted-by":"publisher","first-page":"224","DOI":"10.3109\/21678421.2014.988161","volume":"16","author":"MA Kioumourtzoglou","year":"2015","unstructured":"Kioumourtzoglou MA, Seals RM, Himmerslev L, Gredal O, Hansen J, Weisskopf MG (2015) Comparison of diagnoses of amyotrophic lateral sclerosis by use of death certificates and hospital discharge data in the Danish population. Amyotroph Lateral Scler Frontotemporal Degener 16(3\u20134):224\u2013229. https:\/\/doi.org\/10.3109\/21678421.2014.988161","journal-title":"Amyotroph Lateral Scler Frontotemporal Degener"},{"key":"12743_CR24","doi-asserted-by":"publisher","first-page":"409","DOI":"10.2147\/CLEP.S458661","volume":"16","author":"LS Levison","year":"2024","unstructured":"Levison LS, Andersen H (2024) Registration of Amyotrophic Lateral Sclerosis: Validity in the Danish National Patient Registry. Clin Epidemiol 16:409\u2013415. https:\/\/doi.org\/10.2147\/CLEP.S458661","journal-title":"Clin Epidemiol"},{"issue":"5","key":"12743_CR25","doi-asserted-by":"publisher","first-page":"771","DOI":"10.1097\/wco.0000000000000730","volume":"32","author":"E Longinetti","year":"2019","unstructured":"Longinetti E, Fang F (2019) Epidemiology of amyotrophic lateral sclerosis: an update of recent literature. Curr Opin Neurol 32(5):771\u2013776. https:\/\/doi.org\/10.1097\/wco.0000000000000730","journal-title":"Curr Opin Neurol"},{"issue":"5\u20136","key":"12743_CR26","doi-asserted-by":"publisher","first-page":"436","DOI":"10.1080\/21678421.2023.2165947","volume":"24","author":"JD Berry","year":"2023","unstructured":"Berry JD, Blanchard M, Bonar K et al (2023) Epidemiology and economic burden of amyotrophic lateral sclerosis in the United States: a literature review. Amyotrop Lateral Scler Frontotemporal Degener 24(5\u20136):436\u2013448. https:\/\/doi.org\/10.1080\/21678421.2023.2165947","journal-title":"Amyotrop Lateral Scler Frontotemporal Degener"},{"issue":"8","key":"12743_CR27","doi-asserted-by":"publisher","first-page":"1","DOI":"10.15585\/mmwr.ss6508a1","volume":"65","author":"P Mehta","year":"2016","unstructured":"Mehta P, Kaye W, Bryan L et al (2016) Prevalence of amyotrophic lateral sclerosis\u2014United States, 2012\u20132013. MMWR Surveill Summ 65(8):1\u201312. https:\/\/doi.org\/10.15585\/mmwr.ss6508a1","journal-title":"MMWR Surveill Summ"},{"issue":"46","key":"12743_CR28","doi-asserted-by":"publisher","first-page":"1285","DOI":"10.15585\/mmwr.mm6746a1","volume":"67","author":"P Mehta","year":"2018","unstructured":"Mehta P, Kaye W, Raymond J et al (2018) Prevalence of amyotrophic lateral sclerosis\u2014United States, 2015. MMWR Morb Mortal Wkly Rep 67(46):1285\u20131289. https:\/\/doi.org\/10.15585\/mmwr.mm6746a1","journal-title":"MMWR Morb Mortal Wkly Rep"},{"issue":"7","key":"12743_CR29","doi-asserted-by":"publisher","first-page":"216","DOI":"10.15585\/mmwr.mm6707a3","volume":"67","author":"P Mehta","year":"2018","unstructured":"Mehta P, Kaye W, Raymond J et al (2018) Prevalence of amyotrophic lateral sclerosis\u2014United States, 2014. MMWR Morb Mortal Wkly Rep 67(7):216\u2013218. https:\/\/doi.org\/10.15585\/mmwr.mm6707a3","journal-title":"MMWR Morb Mortal Wkly Rep"},{"issue":"1\u20132","key":"12743_CR30","doi-asserted-by":"publisher","first-page":"123","DOI":"10.1080\/21678421.2019.1682614","volume":"21","author":"R Punjani","year":"2020","unstructured":"Punjani R, Wagner L, Horton K, Kaye W (2020) Atlanta metropolitan area amyotrophic lateral sclerosis (ALS) surveillance: incidence and prevalence 2009\u20132011 and survival characteristics through 2015. Amyotroph Lateral Scler Frontotemporal Degener 21(1\u20132):123\u2013130. https:\/\/doi.org\/10.1080\/21678421.2019.1682614","journal-title":"Amyotroph Lateral Scler Frontotemporal Degener"},{"issue":"10","key":"12743_CR31","doi-asserted-by":"publisher","first-page":"565","DOI":"10.1038\/s41582-019-0244-7","volume":"15","author":"Y Hou","year":"2019","unstructured":"Hou Y, Dan X, Babbar M et al (2019) Ageing as a risk factor for neurodegenerative disease. Nat Rev Neurol 15(10):565\u2013581. https:\/\/doi.org\/10.1038\/s41582-019-0244-7","journal-title":"Nat Rev Neurol"},{"issue":"4","key":"12743_CR32","doi-asserted-by":"publisher","first-page":"944","DOI":"10.1007\/s00415-019-09652-y","volume":"267","author":"L Xu","year":"2020","unstructured":"Xu L, Liu T, Liu L et al (2020) Global variation in prevalence and incidence of amyotrophic lateral sclerosis: a systematic review and meta-analysis. J Neurol 267(4):944\u2013953. https:\/\/doi.org\/10.1007\/s00415-019-09652-y","journal-title":"J Neurol"},{"issue":"12","key":"12743_CR33","doi-asserted-by":"publisher","first-page":"1083","DOI":"10.1016\/s1474-4422(18)30404-6","volume":"17","author":"G Logroscino","year":"2018","unstructured":"Logroscino G, Piccininni M, Marin B et al (2018) Global, regional, and national burden of motor neuron diseases 1990\u20132016: a systematic analysis for the Global Burden of Disease Study 2016. Lancet Neurol 17(12):1083\u20131097. https:\/\/doi.org\/10.1016\/s1474-4422(18)30404-6","journal-title":"Lancet Neurol"},{"issue":"3\u20134","key":"12743_CR34","doi-asserted-by":"publisher","first-page":"264","DOI":"10.1080\/21678421.2019.1587629","volume":"20","author":"A Gowland","year":"2019","unstructured":"Gowland A, Opie-Martin S, Scott KM et al (2019) Predicting the future of ALS: the impact of demographic change and potential new treatments on the prevalence of ALS in the United Kingdom, 2020\u20132116. Amyotrop Lateral Scler Frontotemporal Degener 20(3\u20134):264\u2013274. https:\/\/doi.org\/10.1080\/21678421.2019.1587629","journal-title":"Amyotrop Lateral Scler Frontotemporal Degener"},{"issue":"7","key":"12743_CR35","doi-asserted-by":"publisher","first-page":"12408","DOI":"10.1038\/ncomms12408","volume":"11","author":"KC Arthur","year":"2016","unstructured":"Arthur KC, Calvo A, Price TR, Geiger JT, Chi\u00f2 A, Traynor BJ (2016) Projected increase in amyotrophic lateral sclerosis from 2015 to 2040. Nat Commun 11(7):12408. https:\/\/doi.org\/10.1038\/ncomms12408","journal-title":"Nat Commun"},{"key":"12743_CR36","doi-asserted-by":"publisher","first-page":"120697","DOI":"10.1016\/j.jns.2023.120697","volume":"451","author":"S Yamashita","year":"2023","unstructured":"Yamashita S, Tawara N, Hara K, Ueda M (2023) Gender differences in clinical features at the initial examination of late-onset amyotrophic lateral sclerosis. J Neurol Sci 451:120697. https:\/\/doi.org\/10.1016\/j.jns.2023.120697","journal-title":"J Neurol Sci"},{"issue":"3","key":"12743_CR37","doi-asserted-by":"publisher","first-page":"785","DOI":"10.1007\/s00415-012-6706-0","volume":"260","author":"P Jennum","year":"2013","unstructured":"Jennum P, Ibsen R, Pedersen SW, Kjellberg J (2013) Mortality, health, social and economic consequences of amyotrophic lateral sclerosis: a controlled national study. J Neurol 260(3):785\u2013793. https:\/\/doi.org\/10.1007\/s00415-012-6706-0","journal-title":"J Neurol"},{"issue":"5","key":"12743_CR38","doi-asserted-by":"publisher","first-page":"459","DOI":"10.1016\/s1474-4422(18)30499-x","volume":"18","author":"VL Feigin","year":"2019","unstructured":"Feigin VL, Nichols E, Alam T et al (2019) Global, regional, and national burden of neurological disorders, 1990\u20132016: a systematic analysis for the Global Burden of Disease Study 2016. Lancet Neurol 18(5):459\u2013480. https:\/\/doi.org\/10.1016\/s1474-4422(18)30499-x","journal-title":"Lancet Neurol"},{"issue":"1","key":"12743_CR39","doi-asserted-by":"publisher","first-page":"6","DOI":"10.1136\/jnnp.2006.104828","volume":"79","author":"G Logroscino","year":"2008","unstructured":"Logroscino G, Traynor BJ, Hardiman O et al (2008) Descriptive epidemiology of amyotrophic lateral sclerosis: new evidence and unsolved issues. J Neurol Neurosurg Psychiatry 79(1):6\u201311. https:\/\/doi.org\/10.1136\/jnnp.2006.104828","journal-title":"J Neurol Neurosurg Psychiatry"},{"issue":"2","key":"12743_CR40","doi-asserted-by":"publisher","first-page":"507","DOI":"10.1007\/s00415-012-6665-5","volume":"260","author":"S de Jong","year":"2013","unstructured":"de Jong S, Huisman M, Sutedja N et al (2013) Endogenous female reproductive hormones and the risk of amyotrophic lateral sclerosis. J Neurol 260(2):507\u2013512. https:\/\/doi.org\/10.1007\/s00415-012-6665-5","journal-title":"J Neurol"},{"issue":"6","key":"12743_CR41","doi-asserted-by":"publisher","first-page":"1407","DOI":"10.1007\/s00415-014-7564-8","volume":"262","author":"H Creemers","year":"2015","unstructured":"Creemers H, Grupstra H, Nollet F, van den Berg LH, Beelen A (2015) Prognostic factors for the course of functional status of patients with ALS: a systematic review. J Neurol 262(6):1407\u20131423. https:\/\/doi.org\/10.1007\/s00415-014-7564-8","journal-title":"J Neurol"},{"issue":"3\u20134","key":"12743_CR42","doi-asserted-by":"publisher","first-page":"230","DOI":"10.3109\/21678421.2014.990036","volume":"16","author":"H Watanabe","year":"2015","unstructured":"Watanabe H, Atsuta N, Nakamura R et al (2015) Factors affecting longitudinal functional decline and survival in amyotrophic lateral sclerosis patients. Amyotroph Lateral Scler Frontotemporal Degener 16(3\u20134):230\u2013236. https:\/\/doi.org\/10.3109\/21678421.2014.990036","journal-title":"Amyotroph Lateral Scler Frontotemporal Degener"},{"issue":"6","key":"12743_CR43","doi-asserted-by":"publisher","first-page":"1129","DOI":"10.1007\/s00415-016-8109-0","volume":"263","author":"D Yokoi","year":"2016","unstructured":"Yokoi D, Atsuta N, Watanabe H et al (2016) Age of onset differentially influences the progression of regional dysfunction in sporadic amyotrophic lateral sclerosis. J Neurol 263(6):1129\u20131136. https:\/\/doi.org\/10.1007\/s00415-016-8109-0","journal-title":"J Neurol"},{"issue":"2","key":"12743_CR44","doi-asserted-by":"publisher","first-page":"213","DOI":"10.1016\/0022-510x(77)90069-7","volume":"34","author":"BE Tomlinson","year":"1977","unstructured":"Tomlinson BE, Irving D (1977) The numbers of limb motor neurons in the human lumbosacral cord throughout life. J Neurol Sci 34(2):213\u2013219. https:\/\/doi.org\/10.1016\/0022-510x(77)90069-7","journal-title":"J Neurol Sci"},{"issue":"3","key":"12743_CR45","doi-asserted-by":"publisher","first-page":"391","DOI":"10.1093\/gerona\/60.3.391","volume":"60","author":"P Leslie","year":"2005","unstructured":"Leslie P, Drinnan MJ, Ford GA, Wilson JA (2005) Swallow respiratory patterns and aging: presbyphagia or dysphagia? J Gerontol A Biol Sci Med Sci 60(3):391\u2013395. https:\/\/doi.org\/10.1093\/gerona\/60.3.391","journal-title":"J Gerontol A Biol Sci Med Sci"},{"issue":"4","key":"12743_CR46","doi-asserted-by":"publisher","first-page":"432","DOI":"10.1249\/00005768-199404000-00006","volume":"26","author":"SV Brooks","year":"1994","unstructured":"Brooks SV, Faulkner JA (1994) Skeletal muscle weakness in old age: underlying mechanisms. Med Sci Sports Exerc 26(4):432\u2013439","journal-title":"Med Sci Sports Exerc"},{"issue":"3","key":"12743_CR47","doi-asserted-by":"publisher","first-page":"253","DOI":"10.2147\/ciia.2006.1.3.253","volume":"1","author":"G Sharma","year":"2006","unstructured":"Sharma G, Goodwin J (2006) Effect of aging on respiratory system physiology and immunology. Clin Interv Aging 1(3):253\u2013260. https:\/\/doi.org\/10.2147\/ciia.2006.1.3.253","journal-title":"Clin Interv Aging"},{"issue":"1\u20132","key":"12743_CR48","doi-asserted-by":"publisher","first-page":"62","DOI":"10.3109\/21678421.2013.837929","volume":"15","author":"P Dreyer","year":"2014","unstructured":"Dreyer P, Lorenzen CK, Schou L, Felding M (2014) Survival in ALS with home mechanical ventilation non-invasively and invasively: a 15-year cohort study in west Denmark. Amyotroph Lateral Scler Frontotemporal Degener 15(1\u20132):62\u201367. https:\/\/doi.org\/10.3109\/21678421.2013.837929","journal-title":"Amyotroph Lateral Scler Frontotemporal Degener"},{"issue":"6","key":"12743_CR49","doi-asserted-by":"publisher","first-page":"1516","DOI":"10.1007\/s00415-019-09290-4","volume":"266","author":"J Dorst","year":"2019","unstructured":"Dorst J, Chen L, Rosenbohm A et al (2019) Prognostic factors in ALS: a comparison between Germany and China. J Neurol 266(6):1516\u20131525. https:\/\/doi.org\/10.1007\/s00415-019-09290-4","journal-title":"J Neurol"},{"issue":"1","key":"12743_CR50","doi-asserted-by":"publisher","first-page":"205","DOI":"10.1186\/s12883-018-1208-z","volume":"18","author":"AG Karanevich","year":"2018","unstructured":"Karanevich AG, Weisbrod LJ, Jawdat O et al (2018) Using automated electronic medical record data extraction to model ALS survival and progression. BMC Neurol 18(1):205. https:\/\/doi.org\/10.1186\/s12883-018-1208-z","journal-title":"BMC Neurol"},{"issue":"1","key":"12743_CR51","doi-asserted-by":"publisher","first-page":"30","DOI":"10.1136\/jnnp.2007.117788","volume":"79","author":"O O'Toole","year":"2008","unstructured":"O\u2019Toole O, Traynor BJ, Brennan P et al (2008) Epidemiology and clinical features of amyotrophic lateral sclerosis in Ireland between 1995 and 2004. J Neurol Neurosurg Psychiatry 79(1):30\u201332. https:\/\/doi.org\/10.1136\/jnnp.2007.117788","journal-title":"J Neurol Neurosurg Psychiatry"},{"issue":"8","key":"12743_CR52","doi-asserted-by":"publisher","first-page":"725","DOI":"10.1212\/01.wnl.0000343008.26874.d1","volume":"72","author":"A Chi\u00f2","year":"2009","unstructured":"Chi\u00f2 A, Mora G, Calvo A, Mazzini L, Bottacchi E, Mutani R (2009) Epidemiology of ALS in Italy: a 10-year prospective population-based study. Neurology 72(8):725\u2013731. https:\/\/doi.org\/10.1212\/01.wnl.0000343008.26874.d1","journal-title":"Neurology"},{"issue":"7417","key":"12743_CR53","doi-asserted-by":"publisher","first-page":"716","DOI":"10.1136\/bmj.327.7417.716","volume":"327","author":"TW Loong","year":"2003","unstructured":"Loong TW (2003) Understanding sensitivity and specificity with the right side of the brain. BMJ 327(7417):716\u2013719. https:\/\/doi.org\/10.1136\/bmj.327.7417.716","journal-title":"BMJ"},{"key":"12743_CR54","unstructured":"Danish data protection legislation. https:\/\/www.datatilsynet.dk\/english\/legislation. Accessed Jan 4, 2024"}],"updated-by":[{"DOI":"10.1007\/s00415-025-13076-2","type":"correction","label":"Correction","source":"publisher","updated":{"date-parts":[[2025,4,29]],"date-time":"2025-04-29T00:00:00Z","timestamp":1745884800000}}],"container-title":["Journal of Neurology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00415-024-12743-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00415-024-12743-0\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00415-024-12743-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,29]],"date-time":"2025-04-29T12:58:16Z","timestamp":1745931496000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00415-024-12743-0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,12,12]]},"references-count":54,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2025,1]]}},"alternative-id":["12743"],"URL":"https:\/\/doi.org\/10.1007\/s00415-024-12743-0","relation":{"correction":[{"id-type":"doi","id":"10.1007\/s00415-025-13076-2","asserted-by":"object"}]},"ISSN":["0340-5354","1432-1459"],"issn-type":[{"value":"0340-5354","type":"print"},{"value":"1432-1459","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,12,12]]},"assertion":[{"value":"23 August 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"6 November 2024","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"7 November 2024","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"12 December 2024","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"29 April 2025","order":5,"name":"change_date","label":"Change Date","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"Correction","order":6,"name":"change_type","label":"Change Type","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"A Correction to this paper has been published:","order":7,"name":"change_details","label":"Change Details","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"https:\/\/doi.org\/10.1007\/s00415-025-13076-2","URL":"https:\/\/doi.org\/10.1007\/s00415-025-13076-2","order":8,"name":"change_details","label":"Change Details","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"On behalf of all authors, the corresponding author states that there is no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflicts of interest"}},{"value":"The study was approved by The Central Jutland Regional Committee on Health Research Ethics (record number 1\u201345\u201370\u201363\u201321). Approval from the Ethical Committee is not required to conduct registry-based studies in Denmark.54","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}}],"article-number":"44"}}