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However, growing evidence shows that balance and gait problems may occur early in the disease.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Objective<\/jats:title>\n            <jats:p>To describe balance, gait, and falls\/near falls in persons with newly diagnosed, untreated PD (\u201cde novo\u201d), and to compare this with persons with mild-moderate PD (Later PD). In addition, we evaluated differences relative to PD subtypes in de novo PD.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods<\/jats:title>\n            <jats:p>De novo (<jats:italic>n<\/jats:italic>\u2009=\u200954) and Later (<jats:italic>n<\/jats:italic>\u2009=\u200958) PD were assessed regarding motor symptoms, balance, gait, and falls\/near falls.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results<\/jats:title>\n            <jats:p>At least 25% of de novo PD had impaired reactive balance and\/or comfortable gait speed\u2009\u2264\u20091.0\u00a0m\/s. At least 50% had abnormal dynamic balance. A third reported balance problems during dual-tasking. Five persons (9%) reported falls\/near falls. The median (<jats:italic>q<\/jats:italic>1\u2013<jats:italic>q<\/jats:italic>3) motor symptom score was 21 (14\u201328) in de novo PD and 13.5 (9\u201320) in Later PD (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001). Later PD performed worse on more balance-demanding tests and a higher percentage of individuals reported falls\/near falls (<jats:italic>p<\/jats:italic>\u2009\u2264\u20090.048). De novo PIGD PD (<jats:italic>n<\/jats:italic>\u2009=\u200910) exhibited worse motor symptoms, reactive and dynamic balance, gait speed, mobility, and freezing of gait as compared to the non-PIGD de novo PD (<jats:italic>n<\/jats:italic>\u2009=\u200937) (<jats:italic>p<\/jats:italic>\u2009\u2264\u20090.049).<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusion<\/jats:title>\n            <jats:p>Balance and gait were impaired in de novo PD and most pronounced in PIGD subtype. In addition, balance difficulties during dual-tasking and falls\/near falls were evident during this early stage. The lower scores of motor symptoms in Later PD did not result in better mobility, balance, or less falls\/near falls indicating that medications have less effect on these symptoms.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1007\/s00415-024-12804-4","type":"journal-article","created":{"date-parts":[[2024,12,12]],"date-time":"2024-12-12T12:06:40Z","timestamp":1734005200000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Balance and gait disorders in de novo Parkinson\u2019s disease: support for early rehabilitation"],"prefix":"10.1007","volume":"272","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9021-9847","authenticated-orcid":false,"given":"Beata","family":"Lindholm","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Hagell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Per","family":"Odin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oskar","family":"Hansson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arkadiusz","family":"Siennicki-Lantz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S\u00f6lve","family":"Elmst\u00e5hl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lars B.","family":"Dahlin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erika","family":"Franz\u00e9n","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,12,12]]},"reference":[{"key":"12804_CR1","doi-asserted-by":"crossref","first-page":"1436","DOI":"10.1212\/01.wnl.0000183359.50822.f2","volume":"65","author":"G Alves","year":"2005","unstructured":"Alves G, Wentzel-Larsen T, Aarsland D, Larsen JP (2005) Progression of motor impairment and disability in Parkinson disease: a population-based study. 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