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B.S. de Vries: reports no disclosures relevant to the manuscript. W. van Hecke: reports no disclosures relevant to the manuscript. A. M\u00fchlebner: reports no disclosures relevant to the manuscript. K.L. Vincken: reports no disclosures relevant to the manuscript. C.P. Mol: reports no disclosures relevant to the manuscript. W. van Rheenen: reports no disclosures relevant to the manuscript. H-J Westeneng: reports no disclosures relevant to the manuscript. J.H. Veldink: reports to have sponsored research agreements with Biogen and Astra Zeneca. This project has received funding from the European Research Council (ERC) under the European Union\u2019s Horizon 2020 research and innovation programme (grant agreement n\u00b0 772376 \u2013 EScORIAL. G.U. H\u00f6glinger: reports no disclosures relevant to the manuscript. H.R. Morris: reports no disclosures relevant to the manuscript. I. Litvan: reports no disclosures relevant to the manuscript. J. Raaphorst: reports no disclosures relevant to the manuscript. N. Ticozzi: reports no disclosures relevant to the manuscript. P. Corcia: reports no disclosures relevant to the manuscript. W. Vandenberghe: reports no disclosures relevant to the manuscript. Y.A.L. Pijnenburg: reports no disclosures relevant to the manuscript. H. Seelaar: reports no disclosures relevant to the manuscript. C. Ingre: reports no disclosures relevant to the manuscript. P. Van Damme: reports no disclosures relevant to the manuscript. L.H. van den Berg: declares fees to his institution from Biogen, Wave, Amylyx, Ferrer, and Cytokinetics for being on a scientific advisory board; fees to his institution from Amylyx for a lecture; an unrestricted educational grant from Takeda; and is the Chair of ENCALS and TRICALS. B.P.C. van de Warrenburg: reports no disclosures relevant to the manuscript. M.A. van Es: has consulted for Biogen, and has received travel grants from Shire (formerly Baxalta), performed work as a medical monitor for Ferrer (NCT05178810) with fees going to his institution. MAvE receives funding support from the Netherlands Organization for Health Research and Development (Vidi scheme), The Thierry Latran Foundation, the Motor Neurone Disease Association, FIGHT-MND and the ALS Foundation Netherlands. He is also a member of the European Reference Network for Rare Neuromuscular Diseases (ERN-NMD).","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflicts of interest"}}],"article-number":"46"}}