{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T01:08:07Z","timestamp":1789520887400,"version":"build-2803163510"},"reference-count":116,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2025,3,19]],"date-time":"2025-03-19T00:00:00Z","timestamp":1742342400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,3,19]],"date-time":"2025-03-19T00:00:00Z","timestamp":1742342400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/501100012165","name":"Key Technologies Research and Development Program","doi-asserted-by":"publisher","award":["No. 2022YFC2009901\/2022YFC2009900"],"award-info":[{"award-number":["No. 2022YFC2009901\/2022YFC2009900"]}],"id":[{"id":"10.13039\/501100012165","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Neurol"],"published-print":{"date-parts":[[2025,4]]},"DOI":"10.1007\/s00415-025-12934-3","type":"journal-article","created":{"date-parts":[[2025,3,19]],"date-time":"2025-03-19T15:18:21Z","timestamp":1742397501000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Gray matter structural and functional brain abnormalities in Parkinson\u2019s disease: a meta-analysis of VBM and ALFF data"],"prefix":"10.1007","volume":"272","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-4236-9486","authenticated-orcid":false,"given":"Lu","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Xiong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junqi","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruishan","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan","family":"Liao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fan","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shangxiong","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weiwei","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lihua","family":"Zhuo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongwei","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,3,19]]},"reference":[{"key":"12934_CR1","doi-asserted-by":"publisher","first-page":"384","DOI":"10.1212\/01.wnl.0000247740.47667.03","volume":"68","author":"ER Dorsey","year":"2007","unstructured":"Dorsey ER, Constantinescu R, Thompson JP, Biglan KM, Holloway RG, Kieburtz K, Marshall FJ, Ravina BM, Schifitto G, Siderowf A, Tanner CM (2007) Projected number of people with Parkinson disease in the most populous nations, 2005 through 2030. Neurology 68:384\u2013386","journal-title":"Neurology"},{"key":"12934_CR2","doi-asserted-by":"publisher","first-page":"150","DOI":"10.1038\/s41531-023-00592-z","volume":"9","author":"K Yang","year":"2023","unstructured":"Yang K, Wu Z, Long J, Li W, Wang X, Hu N, Zhao X, Sun T (2023) White matter changes in Parkinson\u2019s disease. NPJ Parkinson Dis 9:150","journal-title":"NPJ Parkinson Dis"},{"key":"12934_CR3","doi-asserted-by":"publisher","first-page":"17013","DOI":"10.1038\/nrdp.2017.13","volume":"3","author":"W Poewe","year":"2017","unstructured":"Poewe W, Seppi K, Tanner CM, Halliday GM, Brundin P, Volkmann J, Schrag A-E, Lang AE (2017) Parkinson disease. Nat Rev Dis Primers 3:17013","journal-title":"Nat Rev Dis Primers"},{"key":"12934_CR4","doi-asserted-by":"publisher","first-page":"1465758","DOI":"10.3389\/fpsyt.2024.1465758","volume":"15","author":"L Wang","year":"2024","unstructured":"Wang L, Liu R, Liao J, Xiong X, Xia L, Wang W, Liu J, Zhao F, Zhuo L, Li H (2024) Meta-analysis of structural and functional brain abnormalities in early-onset schizophrenia. Front Psych 15:1465758","journal-title":"Front Psych"},{"key":"12934_CR5","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1016\/j.braindev.2006.07.002","volume":"29","author":"YF Zang","year":"2007","unstructured":"Zang YF, He Y, Zhu CZ, Cao QJ, Sui MQ, Liang M, Tian LX, Jiang TZ, Wang YF (2007) Altered baseline brain activity in children with ADHD revealed by resting-state functional MRI. Brain Develop 29:83\u201391","journal-title":"Brain Develop"},{"key":"12934_CR6","first-page":"1390","volume":"39","author":"H Lv","year":"2018","unstructured":"Lv H, Wang Z, Tong E, Williams LM, Zaharchuk G, Zeineh M, Goldstein-Piekarski AN, Ball TM, Liao C, Wintermark M (2018) Resting-state functional MRI: everything that nonexperts have always wanted to know. AJNR Am J Neuroradiol 39:1390\u20131399","journal-title":"AJNR Am J Neuroradiol"},{"key":"12934_CR7","doi-asserted-by":"publisher","first-page":"249","DOI":"10.1016\/j.neuroimage.2011.06.056","volume":"75","author":"FM Skidmore","year":"2013","unstructured":"Skidmore FM, Yang M, Baxter L, von Deneen KM, Collingwood J, He G, White K, Korenkevych D, Savenkov A, Heilman KM, Gold M, Liu Y (2013) Reliability analysis of the resting state can sensitively and specifically identify the presence of Parkinson disease. Neuroimage 75:249\u2013261","journal-title":"Neuroimage"},{"key":"12934_CR8","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.neulet.2017.02.056","volume":"645","author":"Y Tang","year":"2017","unstructured":"Tang Y, Meng L, Wan CM, Liu ZH, Liao WH, Yan XX, Wang XY, Tang BS, Guo JF (2017) Identifying the presence of Parkinson\u2019s disease using low-frequency fluctuations in BOLD signals. Neurosci Lett 645:1\u20136","journal-title":"Neurosci Lett"},{"key":"12934_CR9","doi-asserted-by":"publisher","first-page":"1669","DOI":"10.1177\/02841851211055401","volume":"63","author":"Y Zhang","year":"2022","unstructured":"Zhang Y, Wang X, Li Y (2022) Disrupted dynamic pattern of regional neural activity in early-stage cognitively normal Parkinson\u2019s disease. Acta Radiol 63:1669\u20131677","journal-title":"Acta Radiol"},{"key":"12934_CR10","doi-asserted-by":"publisher","first-page":"5815","DOI":"10.1002\/hbm.22587","volume":"35","author":"Y Hou","year":"2014","unstructured":"Hou Y, Wu X, Hallett M, Chan P, Wu T (2014) Frequency-dependent neural activity in Parkinson\u2019s disease. Hum Brain Mapp 35:5815\u20135833","journal-title":"Hum Brain Mapp"},{"key":"12934_CR11","doi-asserted-by":"publisher","DOI":"10.1016\/j.nicl.2023.103430","volume":"38","author":"B Yang","year":"2023","unstructured":"Yang B, Wang X, Mo J, Li Z, Hu W, Zhang C, Zhao B, Gao D, Zhang X, Zou L, Zhao X, Guo Z, Zhang J, Zhang K (2023) The altered spontaneous neural activity in patients with Parkinson\u2019s disease and its predictive value for the motor improvement of deep brain stimulation. NeuroImage Clin 38:103430","journal-title":"NeuroImage Clin"},{"key":"12934_CR12","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1016\/j.bbr.2013.05.039","volume":"252","author":"J Zhang","year":"2013","unstructured":"Zhang J, Wei L, Hu X, Zhang Y, Zhou D, Li C, Wang X, Feng H, Yin X, Xie B, Wang J (2013) Specific frequency band of amplitude low-frequency fluctuation predicts Parkinson\u2019s disease. Behav Brain Res 252:18\u201323","journal-title":"Behav Brain Res"},{"key":"12934_CR13","doi-asserted-by":"publisher","first-page":"241","DOI":"10.1111\/cns.12666","volume":"23","author":"JJ Zhang","year":"2017","unstructured":"Zhang JJ, Ding J, Li JY, Wang M, Yuan YS, Zhang L, Jiang SM, Wang XX, Zhu L, Zhang KZ (2017) Abnormal resting-state neural activity and connectivity of fatigue in Parkinson\u2019s disease. CNS Neurosci Ther 23:241\u2013247","journal-title":"CNS Neurosci Ther"},{"key":"12934_CR14","doi-asserted-by":"publisher","DOI":"10.1007\/s11434-016-1205-9","author":"L Gao","year":"2016","unstructured":"Gao L, Xuemin W, Zhang J, Chan P, Bulletin Tao WJS (2016) Brain activity in Parkinson\u2019s disease patients with mild cognitive impairment. Sci Bull. https:\/\/doi.org\/10.1007\/s11434-016-1205-9","journal-title":"Sci Bull"},{"key":"12934_CR15","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2022.975189","volume":"16","author":"H Xu","year":"2022","unstructured":"Xu H, Zhang M, Wang Z, Yang Y, Chang Y, Liu L (2022) Abnormal brain activities in multiple frequency bands in Parkinson\u2019s disease with apathy. Front Neurosci 16:975189","journal-title":"Front Neurosci"},{"key":"12934_CR16","doi-asserted-by":"publisher","first-page":"1052","DOI":"10.3389\/fneur.2019.01052","volume":"10","author":"C Zhang","year":"2019","unstructured":"Zhang C, Dou B, Wang J, Xu K, Zhang H, Sami MU, Hu C, Rong Y, Xiao Q, Chen N, Li K (2019) Dynamic alterations of spontaneous neural activity in parkinson\u2019s disease: a resting-state fMRI study. Front Neurol 10:1052","journal-title":"Front Neurol"},{"key":"12934_CR17","doi-asserted-by":"publisher","first-page":"1289934","DOI":"10.3389\/fneur.2023.1289934","volume":"14","author":"H Xie","year":"2023","unstructured":"Xie H, Yang Y, Sun Q, Li ZY, Ni MH, Chen ZH, Li SN, Dai P, Cui YY, Cao XY, Jiang N, Du LJ, Yu Y, Yan LF, Cui GB (2023) Abnormalities of cerebral blood flow and the regional brain function in Parkinson\u2019s disease: a systematic review and multimodal neuroimaging meta-analysis. Front Neurol 14:1289934","journal-title":"Front Neurol"},{"key":"12934_CR18","doi-asserted-by":"publisher","first-page":"805","DOI":"10.1006\/nimg.2000.0582","volume":"11","author":"J Ashburner","year":"2000","unstructured":"Ashburner J, Friston KJ (2000) Voxel-based morphometry\u2013the methods. Neuroimage 11:805\u2013821","journal-title":"Neuroimage"},{"key":"12934_CR19","doi-asserted-by":"publisher","first-page":"10240","DOI":"10.1073\/pnas.0701519104","volume":"104","author":"CJ Honey","year":"2007","unstructured":"Honey CJ, K\u00f6tter R, Breakspear M, Sporns O (2007) Network structure of cerebral cortex shapes functional connectivity on multiple time scales. Proc Natl Acad Sci USA 104:10240\u201310245","journal-title":"Proc Natl Acad Sci USA"},{"key":"12934_CR20","doi-asserted-by":"publisher","first-page":"4415","DOI":"10.21037\/qims-22-1403","volume":"13","author":"X Wang","year":"2023","unstructured":"Wang X, Wang S, Lin J, Zhang D, Lu H, Xiong Y, Deng L, Zhang D, Bian X, Zhou J, Pan L, Lou X (2023) Gray matter alterations in tremor-dominant Parkinson\u2019s disease after MRgFUS thalamotomy are correlated with tremor improvement: a pilot study. Quant Imaging Med Surg 13:4415\u20134428","journal-title":"Quant Imaging Med Surg"},{"key":"12934_CR21","doi-asserted-by":"publisher","first-page":"1910","DOI":"10.1007\/s00415-023-12136-9","volume":"271","author":"A Quattrone","year":"2024","unstructured":"Quattrone A, Calomino C, Sarica A, Caligiuri ME, Bianco MG, Vescio B, Arcuri PP, Buonocore J, De Maria M, Vaccaro MG, Quattrone A (2024) Neuroimaging correlates of postural instability in Parkinson\u2019s disease. J Neurol 271:1910\u20131920","journal-title":"J Neurol"},{"key":"12934_CR22","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2022.136835","volume":"788","author":"JH Zheng","year":"2022","unstructured":"Zheng JH, Sun WH, Ma JJ, Wang ZD, Chang QQ, Dong LR, Shi XX, Li MJ, Gu Q, Chen SY (2022) Structural and functional abnormalities in Parkinson\u2019s disease based on voxel-based morphometry and resting-state functional magnetic resonance imaging. Neurosci Lett 788:136835","journal-title":"Neurosci Lett"},{"key":"12934_CR23","doi-asserted-by":"publisher","first-page":"70","DOI":"10.1038\/s41531-022-00332-9","volume":"8","author":"SJ Lin","year":"2022","unstructured":"Lin SJ, Rodriguez-Rojas R, Baumeister TR, Lenglos C, Pineda-Pardo JA, M\u00e1\u00f1ez-Mir\u00f3 JU, Del Alamo M, Martinez-Fernandez R, Obeso JA, Iturria-Medina Y (2022) Neuroimaging signatures predicting motor improvement to focused ultrasound subthalamotomy in Parkinson\u2019s disease. NPJ Parkinson Dis 8:70","journal-title":"NPJ Parkinson Dis"},{"key":"12934_CR24","doi-asserted-by":"publisher","first-page":"1178","DOI":"10.1007\/s00415-016-8122-3","volume":"263","author":"Y Xu","year":"2016","unstructured":"Xu Y, Yang J, Hu X, Shang H (2016) Voxel-based meta-analysis of gray matter volume reductions associated with cognitive impairment in Parkinson\u2019s disease. J Neurol 263:1178\u20131187","journal-title":"J Neurol"},{"key":"12934_CR25","first-page":"318","volume":"139","author":"I Beheshti","year":"2024","unstructured":"Beheshti I, Perron J, Ko JH (2024) Neuroanatomical signature of the transition from normal cognition to MCI in Parkinson\u2019s disease. Aging Dis 139:318","journal-title":"Aging Dis"},{"key":"12934_CR26","doi-asserted-by":"publisher","first-page":"199","DOI":"10.1111\/j.1468-1331.2011.03474.x","volume":"19","author":"PL Pan","year":"2012","unstructured":"Pan PL, Song W, Shang HF (2012) Voxel-wise meta-analysis of gray matter abnormalities in idiopathic Parkinson\u2019s disease. Eur J Neurol 19:199\u2013206","journal-title":"Eur J Neurol"},{"key":"12934_CR27","doi-asserted-by":"publisher","first-page":"653","DOI":"10.1111\/ene.14132","volume":"27","author":"X Xu","year":"2020","unstructured":"Xu X, Han Q, Lin J, Wang L, Wu F, Shang H (2020) Grey matter abnormalities in Parkinson\u2019s disease: a voxel-wise meta-analysis. Eur J Neurol 27:653\u2013659","journal-title":"Eur J Neurol"},{"key":"12934_CR28","doi-asserted-by":"publisher","first-page":"1221","DOI":"10.14336\/AD.2018.1116","volume":"10","author":"X Jia","year":"2019","unstructured":"Jia X, Wang Z, Yang T, Li Y, Gao S, Wu G, Jiang T, Liang P (2019) Entorhinal cortex Atrophy in early, drug-naive Parkinson\u2019s disease with mild cognitive impairment. Aging Dis 10:1221\u20131232","journal-title":"Aging Dis"},{"key":"12934_CR29","doi-asserted-by":"publisher","first-page":"1644","DOI":"10.1002\/mds.27793","volume":"34","author":"S Prange","year":"2019","unstructured":"Prange S, Metereau E, Maillet A, Lhomm\u00e9e E, Klinger H, Pelissier P, Ibarrola D, Heckemann RA, Castrioto A, Tremblay L, Sgambato V, Broussolle E, Krack P, Thobois S (2019) Early limbic microstructural alterations in apathy and depression in de novo Parkinson\u2019s disease. Movement Dis 34:1644\u20131654","journal-title":"Movement Dis"},{"key":"12934_CR30","doi-asserted-by":"publisher","first-page":"124","DOI":"10.1016\/j.parkreldis.2019.02.022","volume":"63","author":"A Quattrone","year":"2019","unstructured":"Quattrone A, Caligiuri ME, Morelli M, Nigro S, Vescio B, Arabia G, Nicoletti G, Nistic\u00f2 R, Salsone M, Novellino F, Barbagallo G, Vaccaro MG, Sabatini U, Vescio V, Stan\u00e0 C, Rocca F, Caracciolo M, Quattrone A (2019) Imaging counterpart of postural instability and vertical ocular dysfunction in patients with PSP: a multimodal MRI study. Parkinsonism Relat Disord 63:124\u2013130","journal-title":"Parkinsonism Relat Disord"},{"key":"12934_CR31","doi-asserted-by":"publisher","first-page":"1133","DOI":"10.1007\/s00702-020-02219-6","volume":"127","author":"M Siciliano","year":"2020","unstructured":"Siciliano M, De Micco R, Giordano A, Di Nardo F, Russo A, Caiazzo G, De Mase A, Cirillo M, Tedeschi G, Trojano L, Tessitore A (2020) Supplementary motor area functional connectivity in \u201cdrug-na\u00efve\u201d Parkinson\u2019s disease patients with fatigue. J Neural Trans 127:1133\u20131142","journal-title":"J Neural Trans"},{"key":"12934_CR32","doi-asserted-by":"publisher","first-page":"2591248","DOI":"10.1155\/2020\/2591248","volume":"2020","author":"CC Yu","year":"2020","unstructured":"Yu CC, Chen HL, Chen MH, Lu CH, Tsai NW, Huang CC, Chang YY, Li SH, Chen YS, Chiang PL, Lin WC (2020) Vascular inflammation is a risk factor associated with brain atrophy and disease severity in Parkinson\u2019s disease: a case-control study. Oxid Med Cell Longev 2020:2591248","journal-title":"Oxid Med Cell Longev"},{"key":"12934_CR33","doi-asserted-by":"publisher","DOI":"10.3389\/fnagi.2022.923560","volume":"14","author":"M Zhong","year":"2022","unstructured":"Zhong M, Li C, Lu H, Xue D, Wang Y, Jiang Y, Zhu S, Gu R, Jiang X, Shen B, Zhu J, Zhang W, Pan Y, Yan J, Zhang L (2022) Aberrant gray matter volume and functional connectivity in Parkinson\u2019s disease with minor hallucination. Front Aging Neurosci 14:923560","journal-title":"Front Aging Neurosci"},{"key":"12934_CR34","doi-asserted-by":"publisher","DOI":"10.3389\/fnhum.2022.919081","volume":"16","author":"K Cao","year":"2022","unstructured":"Cao K, Pang H, Yu H, Li Y, Guo M, Liu Y, Fan G (2022) Identifying and validating subtypes of Parkinson\u2019s disease based on multimodal MRI data via hierarchical clustering analysis. Front Hum Neurosci 16:919081","journal-title":"Front Hum Neurosci"},{"key":"12934_CR35","doi-asserted-by":"publisher","first-page":"1116516","DOI":"10.3389\/fnagi.2023.1116516","volume":"15","author":"K Chen","year":"2023","unstructured":"Chen K, Zhang L, Mao H, Chen K, Shi Y, Meng X, Wang F, Hu X, Fang X (2023) The impact of iron deposition on the fear circuit of the brain in patients with Parkinson\u2019s disease and anxiety. Front Aging Neurosci 15:1116516","journal-title":"Front Aging Neurosci"},{"key":"12934_CR36","doi-asserted-by":"publisher","first-page":"725","DOI":"10.1007\/s11682-023-00793-3","volume":"17","author":"H Zhai","year":"2023","unstructured":"Zhai H, Fan W, Xiao Y, Zhu Z, Ding Y, He C, Zhang W, Xu Y, Zhang Y (2023) Voxel-based morphometry of grey matter structures in Parkinson\u2019s disease with wearing-off. Brain Imaging Behav 17:725\u2013737","journal-title":"Brain Imaging Behav"},{"key":"12934_CR37","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1007\/s11682-023-00815-0","volume":"18","author":"G Donzuso","year":"2024","unstructured":"Donzuso G, Cicero CE, Giuliano L, Squillaci R, Luca A, Palmucci S, Basile A, Lanza G, Ferri R, Zappia M, Nicoletti A (2024) Neuroanatomical findings in isolated REM sleep behavior disorder and early Parkinson\u2019s disease: a Voxel-based morphometry study. Brain Imaging Behav 18:83\u201391","journal-title":"Brain Imaging Behav"},{"key":"12934_CR38","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.b2535","volume":"339","author":"D Moher","year":"2009","unstructured":"Moher D, Liberati A, Tetzlaff J, Altman DG (2009) Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. BMJ 339:b2535","journal-title":"BMJ"},{"key":"12934_CR39","doi-asserted-by":"publisher","first-page":"775","DOI":"10.1016\/j.biopsych.2012.04.020","volume":"72","author":"AM Shepherd","year":"2012","unstructured":"Shepherd AM, Matheson SL, Laurens KR, Carr VJ, Green MJ (2012) Systematic meta-analysis of insula volume in schizophrenia. Biol Psychiat 72:775\u2013784","journal-title":"Biol Psychiat"},{"key":"12934_CR40","doi-asserted-by":"publisher","first-page":"401","DOI":"10.1503\/jpn.140119","volume":"40","author":"ZQ Chen","year":"2015","unstructured":"Chen ZQ, Du MY, Zhao YJ, Huang XQ, Li J, Lui S, Hu JM, Sun HQ, Liu J, Kemp GJ, Gong QY (2015) Voxel-wise meta-analyses of brain blood flow and local synchrony abnormalities in medication-free patients with major depressive disorder. J Psychiatry Neurosci 40:401\u2013411","journal-title":"J Psychiatry Neurosci"},{"key":"12934_CR41","doi-asserted-by":"publisher","first-page":"605","DOI":"10.1016\/j.eurpsy.2011.04.001","volume":"27","author":"J Radua","year":"2012","unstructured":"Radua J, Mataix-Cols D, Phillips ML, El-Hage W, Kronhaus DM, Cardoner N, Surguladze S (2012) A new meta-analytic method for neuroimaging studies that combines reported peak coordinates and statistical parametric maps. Eur Psychiatry 27:605\u2013611","journal-title":"Eur Psychiatry"},{"key":"12934_CR42","doi-asserted-by":"publisher","DOI":"10.3791\/59841","author":"A Albajes-Eizagirre","year":"2019","unstructured":"Albajes-Eizagirre A, Solanes A, Fullana MA, Ioannidis JPA, Fusar-Poli P, Torrent C, Sol\u00e9 B, Bonn\u00edn CM, Vieta E, Mataix-Cols D, Radua J (2019) Meta-analysis of voxel-based neuroimaging studies using seed-based d mapping with permutation of subject images (SDM-PSI). J Vis Exp. https:\/\/doi.org\/10.3791\/59841","journal-title":"J Vis Exp"},{"key":"12934_CR43","doi-asserted-by":"publisher","first-page":"153","DOI":"10.1016\/j.jpsychires.2022.08.010","volume":"155","author":"S Xiao","year":"2022","unstructured":"Xiao S, Yang Z, Su T, Gong J, Huang L, Wang Y (2022) Functional and structural brain abnormalities in posttraumatic stress disorder: a multimodal meta-analysis of neuroimaging studies. J Psychiatr Res 155:153\u2013162","journal-title":"J Psychiatr Res"},{"key":"12934_CR44","first-page":"1","volume":"43","author":"X Gao","year":"2017","unstructured":"Gao X, Zhang W, Yao L, Xiao Y, Liu L, Liu J, Li S, Tao B, Shah C, Gong Q, Sweeney J, Lui S (2017) Association between structural and functional brain alterations in drug-free patients with schizophrenia: a multimodal meta-analysis. J Psychiatry Neurosci 43:1\u201312","journal-title":"J Psychiatry Neurosci"},{"key":"12934_CR45","doi-asserted-by":"publisher","first-page":"2325","DOI":"10.1016\/j.neubiorev.2012.07.012","volume":"36","author":"J Radua","year":"2012","unstructured":"Radua J, Borgwardt S, Crescini A, Mataix-Cols D, Meyer-Lindenberg A, McGuire PK, Fusar-Poli P (2012) Multimodal meta-analysis of structural and functional brain changes in first episode psychosis and the effects of antipsychotic medication. Neurosci Biobehav Rev 36:2325\u20132333","journal-title":"Neurosci Biobehav Rev"},{"key":"12934_CR46","doi-asserted-by":"publisher","first-page":"629","DOI":"10.1136\/bmj.315.7109.629","volume":"315","author":"M Egger","year":"1997","unstructured":"Egger M, Davey Smith G, Schneider M, Minder C (1997) Bias in meta-analysis detected by a simple, graphical test. BMJ 315:629\u2013634","journal-title":"BMJ"},{"key":"12934_CR47","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.d4002","volume":"343","author":"JA Sterne","year":"2011","unstructured":"Sterne JA, Sutton AJ, Ioannidis JP, Terrin N, Jones DR, Lau J, Carpenter J, R\u00fccker G, Harbord RM, Schmid CH, Tetzlaff J, Deeks JJ, Peters J, Macaskill P, Schwarzer G, Duval S, Altman DG, Moher D, Higgins JP (2011) Recommendations for examining and interpreting funnel plot asymmetry in meta-analyses of randomised controlled trials. BMJ 343:d4002","journal-title":"BMJ"},{"key":"12934_CR48","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1186\/s13229-024-00593-6","volume":"15","author":"Z Guo","year":"2024","unstructured":"Guo Z, Tang X, Xiao S, Yan H, Sun S, Yang Z, Huang L, Chen Z, Wang Y (2024) Systematic review and meta-analysis: multimodal functional and anatomical neural alterations in autism spectrum disorder. Molecular autism 15:16","journal-title":"Molecular autism"},{"key":"12934_CR49","doi-asserted-by":"publisher","first-page":"223","DOI":"10.1016\/j.neubiorev.2016.11.018","volume":"72","author":"P Pan","year":"2017","unstructured":"Pan P, Zhan H, Xia M, Zhang Y, Guan D, Xu Y (2017) Aberrant regional homogeneity in Parkinson\u2019s disease: a voxel-wise meta-analysis of resting-state functional magnetic resonance imaging studies. Neurosci Biobehav Rev 72:223\u2013231","journal-title":"Neurosci Biobehav Rev"},{"key":"12934_CR50","doi-asserted-by":"publisher","first-page":"50","DOI":"10.1038\/s41582-023-00905-z","volume":"20","author":"S Citro","year":"2024","unstructured":"Citro S, Lazzaro GD, Cimmino AT, Giuffr\u00e8 GM, Marra C, Calabresi P (2024) A multiple hits hypothesis for memory dysfunction in Parkinson disease. Nat Rev Neurol 20:50\u201361","journal-title":"Nat Rev Neurol"},{"key":"12934_CR51","doi-asserted-by":"publisher","first-page":"449","DOI":"10.1007\/s00702-017-1744-5","volume":"125","author":"G Beck","year":"2018","unstructured":"Beck G, Singh A, Papa SM (2018) Dysregulation of striatal projection neurons in Parkinson\u2019s disease. J Neural Trans 125:449\u2013460","journal-title":"J Neural Trans"},{"key":"12934_CR52","doi-asserted-by":"publisher","first-page":"1131","DOI":"10.3390\/ijms25021131","volume":"25","author":"MF Salvatore","year":"2024","unstructured":"Salvatore MF (2024) Dopamine signaling in Substantia Nigra and its impact on locomotor function-not a new concept, but neglected reality. Int J Mol Sci 25:1131","journal-title":"Int J Mol Sci"},{"issue":"Suppl 2","key":"12934_CR53","first-page":"S30","volume":"64","author":"JA Obeso","year":"2008","unstructured":"Obeso JA, Marin C, Rodriguez-Oroz C, Blesa J, Benitez-Temi\u00f1o B, Mena-Segovia J, Rodr\u00edguez M, Olanow CW (2008) The basal ganglia in Parkinson\u2019s disease: current concepts and unexplained observations. Ann Neurol 64(Suppl 2):S30-46","journal-title":"Ann Neurol"},{"key":"12934_CR54","doi-asserted-by":"publisher","first-page":"109","DOI":"10.1016\/j.conb.2014.07.008","volume":"29","author":"DJ Surmeier","year":"2014","unstructured":"Surmeier DJ, Graves SM, Shen W (2014) Dopaminergic modulation of striatal networks in health and Parkinson\u2019s disease. Curr Opin Neurobiol 29:109\u2013117","journal-title":"Curr Opin Neurobiol"},{"key":"12934_CR55","doi-asserted-by":"publisher","first-page":"622","DOI":"10.1038\/nature09159","volume":"466","author":"AV Kravitz","year":"2010","unstructured":"Kravitz AV, Freeze BS, Parker PR, Kay K, Thwin MT, Deisseroth K, Kreitzer AC (2010) Regulation of parkinsonian motor behaviours by optogenetic control of basal ganglia circuitry. Nature 466:622\u2013626","journal-title":"Nature"},{"key":"12934_CR56","doi-asserted-by":"publisher","first-page":"226","DOI":"10.1016\/j.expneurol.2008.04.001","volume":"212","author":"H Braak","year":"2008","unstructured":"Braak H, Del Tredici K (2008) Cortico-basal ganglia-cortical circuitry in Parkinson\u2019s disease reconsidered. Exp Neurol 212:226\u2013229","journal-title":"Exp Neurol"},{"key":"12934_CR57","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1016\/j.conb.2017.08.004","volume":"48","author":"S Zhai","year":"2018","unstructured":"Zhai S, Tanimura A, Graves SM, Shen W, Surmeier DJ (2018) Striatal synapses, circuits, and Parkinson\u2019s disease. Curr Opin Neurobiol 48:9\u201316","journal-title":"Curr Opin Neurobiol"},{"key":"12934_CR58","doi-asserted-by":"publisher","first-page":"1567","DOI":"10.1002\/hbm.22724","volume":"36","author":"KH Chou","year":"2015","unstructured":"Chou KH, Lin WC, Lee PL, Tsai NW, Huang YC, Chen HL, Cheng KY, Chen PC, Wang HC, Lin TK, Li SH, Lin WM, Lu CH, Lin CP (2015) Structural covariance networks of striatum subdivision in patients with Parkinson\u2019s disease. Hum Brain Mapp 36:1567\u20131584","journal-title":"Hum Brain Mapp"},{"key":"12934_CR59","doi-asserted-by":"publisher","first-page":"427","DOI":"10.3389\/fnagi.2018.00427","volume":"10","author":"X Jia","year":"2018","unstructured":"Jia X, Li Y, Li K, Liang P, Fu X (2018) Precuneus dysfunction in Parkinson\u2019s disease with mild cognitive impairment. Front Aging Neurosci 10:427","journal-title":"Front Aging Neurosci"},{"key":"12934_CR60","doi-asserted-by":"publisher","first-page":"645","DOI":"10.1016\/j.parkreldis.2010.08.014","volume":"16","author":"TM Ellmore","year":"2010","unstructured":"Ellmore TM, Hood AJ, Castriotta RJ, Stimming EF, Bick RJ, Schiess MC (2010) Reduced volume of the putamen in REM sleep behavior disorder patients. Parkinsonism Relat Disord 16:645\u2013649","journal-title":"Parkinsonism Relat Disord"},{"key":"12934_CR61","doi-asserted-by":"publisher","first-page":"1356","DOI":"10.5498\/wjp.v12.i12.1356","volume":"12","author":"JH Deng","year":"2022","unstructured":"Deng JH, Zhang HW, Liu XL, Deng HZ, Lin F (2022) Morphological changes in Parkinson\u2019s disease based on magnetic resonance imaging: a mini-review of subcortical structures segmentation and shape analysis. World J Psychiatry 12:1356\u20131366","journal-title":"World J Psychiatry"},{"key":"12934_CR62","doi-asserted-by":"publisher","DOI":"10.1016\/j.nicl.2019.101730","volume":"22","author":"BM Kluger","year":"2019","unstructured":"Kluger BM, Zhao Q, Tanner JJ, Schwab NA, Levy SA, Burke SE, Huang H, Ding M, Price C (2019) Structural brain correlates of fatigue in older adults with and without Parkinson\u2019s disease. NeuroImage Clin 22:101730","journal-title":"NeuroImage Clin"},{"key":"12934_CR63","doi-asserted-by":"publisher","first-page":"1352","DOI":"10.1007\/s11682-018-9939-4","volume":"13","author":"S Kamps","year":"2019","unstructured":"Kamps S, van den Heuvel OA, van der Werf YD, Berendse HW, Weintraub D, Vriend C (2019) Smaller subcortical volume in Parkinson patients with rapid eye movement sleep behavior disorder. Brain Imaging Behav 13:1352\u20131360","journal-title":"Brain Imaging Behav"},{"key":"12934_CR64","doi-asserted-by":"publisher","first-page":"1447","DOI":"10.1002\/mds.27106","volume":"32","author":"SJ Chung","year":"2017","unstructured":"Chung SJ, Shin JH, Cho KH, Lee Y, Sohn YH, Seong JK, Lee PH (2017) Subcortical shape analysis of progressive mild cognitive impairment in Parkinson\u2019s disease. Movement Disord 32:1447\u20131456","journal-title":"Movement Disord"},{"key":"12934_CR65","doi-asserted-by":"publisher","DOI":"10.1038\/cddis.2012.194","volume":"4","author":"A Vaarmann","year":"2013","unstructured":"Vaarmann A, Kovac S, Holmstr\u00f6m KM, Gandhi S, Abramov AY (2013) Dopamine protects neurons against glutamate-induced excitotoxicity. Cell Death Dis 4:e455","journal-title":"Cell Death Dis"},{"key":"12934_CR66","doi-asserted-by":"publisher","first-page":"2441","DOI":"10.3390\/cells9112441","volume":"9","author":"VS Witzig","year":"2020","unstructured":"Witzig VS, Komnig D, Falkenburger BH (2020) Changes in striatal medium spiny neuron morphology resulting from dopamine depletion are reversible. Cells 9:2441","journal-title":"Cells"},{"key":"12934_CR67","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2023.106096","volume":"181","author":"M Zhong","year":"2023","unstructured":"Zhong M, Wang Y, Lin G, Liao FF, Zhou FM (2023) Dopamine-independent development and maintenance of mouse striatal medium spiny neuron dendritic spines. Neurobiol Dis 181:106096","journal-title":"Neurobiol Dis"},{"key":"12934_CR68","doi-asserted-by":"publisher","first-page":"1921","DOI":"10.1002\/mds.26418","volume":"30","author":"JH Ham","year":"2015","unstructured":"Ham JH, Lee JJ, Kim JS, Lee PH, Sohn YH (2015) Is dominant-side onset associated with a better motor compensation in Parkinson\u2019s disease? Movement Disord 30:1921\u20131925","journal-title":"Movement Disord"},{"key":"12934_CR69","doi-asserted-by":"publisher","first-page":"1282","DOI":"10.1016\/j.neuroscience.2010.07.030","volume":"170","author":"CA Haaxma","year":"2010","unstructured":"Haaxma CA, Helmich RC, Borm GF, Kappelle AC, Horstink MW, Bloem BR (2010) Side of symptom onset affects motor dysfunction in Parkinson\u2019s disease. Neuroscience 170:1282\u20131285","journal-title":"Neuroscience"},{"key":"12934_CR70","doi-asserted-by":"publisher","first-page":"727","DOI":"10.3389\/fneur.2020.00727","volume":"11","author":"K Li","year":"2020","unstructured":"Li K, Su W, Chen M, Li CM, Ma XX, Wang R, Lou BH, Zhao H, Chen HB, Yan CZ (2020) Abnormal spontaneous brain activity in left-onset parkinson disease: a resting-state functional MRI study. Front Neurol 11:727","journal-title":"Front Neurol"},{"key":"12934_CR71","doi-asserted-by":"publisher","first-page":"72","DOI":"10.1136\/jnnp.52.1.72","volume":"52","author":"PA Kempster","year":"1989","unstructured":"Kempster PA, Gibb WR, Stern GM, Lees AJ (1989) Asymmetry of substantia nigra neuronal loss in Parkinson\u2019s disease and its relevance to the mechanism of levodopa related motor fluctuations. J Neurol Neurosurg Psychiatry 52:72\u201376","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"12934_CR72","doi-asserted-by":"publisher","first-page":"796","DOI":"10.1016\/S1474-4422(06)70549-X","volume":"5","author":"R Djaldetti","year":"2006","unstructured":"Djaldetti R, Ziv I, Melamed E (2006) The mystery of motor asymmetry in Parkinson\u2019s disease. Lancet Neurol 5:796\u2013802","journal-title":"Lancet Neurol"},{"key":"12934_CR73","doi-asserted-by":"publisher","first-page":"2583","DOI":"10.1002\/mds.28706","volume":"36","author":"MA Laansma","year":"2021","unstructured":"Laansma MA, Bright JK, Al-Bachari S, Anderson TJ, Ard T, Assogna F, Baquero KA, Berendse HW, Blair J, Cendes F, Dalrymple-Alford JC, de Bie RMA, Debove I, Dirkx MF, Druzgal J, Emsley HCA, Garraux G, Guimar\u00e3es RP, Gutman BA, Helmich RC, Klein JC, Mackay CE, McMillan CT, Melzer TR, Parkes LM, Piras F, Pitcher TL, Poston KL, Rango M, Ribeiro LF, Rocha CS, Rummel C, Santos LSR, Schmidt R, Schwingenschuh P, Spalletta G, Squarcina L, van den Heuvel OA, Vriend C, Wang JJ, Weintraub D, Wiest R, Yasuda CL, Jahanshad N, Thompson PM, van der Werf YD (2021) International multicenter analysis of brain structure across clinical stages of Parkinson\u2019s disease. Movement Disord 36:2583\u20132594","journal-title":"Movement Disord"},{"key":"12934_CR74","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3390\/brainsci12091248","volume":"12","author":"M Banwinkler","year":"2022","unstructured":"Banwinkler M, Theis H, Prange S, van Eimeren T (2022) Imaging the limbic system in Parkinson\u2019s disease-a review of limbic pathology and clinical symptoms. Brain Sci 12:1","journal-title":"Brain Sci"},{"key":"12934_CR75","doi-asserted-by":"publisher","first-page":"284","DOI":"10.1038\/nature14188","volume":"517","author":"PH Janak","year":"2015","unstructured":"Janak PH, Tye KM (2015) From circuits to behaviour in the amygdala. Nature 517:284\u2013292","journal-title":"Nature"},{"key":"12934_CR76","doi-asserted-by":"publisher","first-page":"317","DOI":"10.1006\/nimg.2002.1179","volume":"17","author":"AR Hariri","year":"2002","unstructured":"Hariri AR, Tessitore A, Mattay VS, Fera F, Weinberger DR (2002) The amygdala response to emotional stimuli: a comparison of faces and scenes. Neuroimage 17:317\u2013323","journal-title":"Neuroimage"},{"key":"12934_CR77","doi-asserted-by":"publisher","first-page":"540","DOI":"10.1002\/mds.20371","volume":"20","author":"C Junqu\u00e9","year":"2005","unstructured":"Junqu\u00e9 C, Ram\u00edrez-Ruiz B, Tolosa E, Summerfield C, Mart\u00ed MJ, Pastor P, G\u00f3mez-Ans\u00f3n B, Mercader JM (2005) Amygdalar and hippocampal MRI volumetric reductions in Parkinson\u2019s disease with dementia. Movement Disord 20:540\u2013544","journal-title":"Movement Disord"},{"key":"12934_CR78","doi-asserted-by":"publisher","first-page":"521","DOI":"10.1017\/S135561770410413X","volume":"10","author":"G Simons","year":"2004","unstructured":"Simons G, Pasqualini MC, Reddy V, Wood J (2004) Emotional and nonemotional facial expressions in people with Parkinson\u2019s disease. J Int Neuropsychol Soc 10:521\u2013535","journal-title":"J Int Neuropsychol Soc"},{"key":"12934_CR79","doi-asserted-by":"publisher","first-page":"189","DOI":"10.1007\/s11682-017-9754-3","volume":"13","author":"PT Bell","year":"2019","unstructured":"Bell PT, Gilat M, Shine JM, McMahon KL, Lewis SJG, Copland DA (2019) Neural correlates of emotional valence processing in Parkinson\u2019s disease: dysfunction in the subcortex. Brain Imaging Behav 13:189\u2013199","journal-title":"Brain Imaging Behav"},{"key":"12934_CR80","doi-asserted-by":"publisher","first-page":"9099","DOI":"10.1523\/JNEUROSCI.22-20-09099.2002","volume":"22","author":"A Tessitore","year":"2002","unstructured":"Tessitore A, Hariri AR, Fera F, Smith WG, Chase TN, Hyde TM, Weinberger DR, Mattay VS (2002) Dopamine modulates the response of the human amygdala: a study in Parkinson\u2019s disease. J Neurosci 22:9099\u20139103","journal-title":"J Neurosci"},{"key":"12934_CR81","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2020.147235","volume":"1753","author":"M Criaud","year":"2021","unstructured":"Criaud M, Kim JH, Zurowski M, Lobaugh N, Chavez S, Houle S, Strafella AP (2021) Anxiety in Parkinson\u2019s disease: abnormal resting activity and connectivity. Brain Res 1753:147235","journal-title":"Brain Res"},{"key":"12934_CR82","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropsychologia.2018.03.019","volume":"145","author":"CS Inman","year":"2020","unstructured":"Inman CS, Bijanki KR, Bass DI, Gross RE, Hamann S, Willie JT (2020) Human amygdala stimulation effects on emotion physiology and emotional experience. Neuropsychologia 145:106722","journal-title":"Neuropsychologia"},{"key":"12934_CR83","doi-asserted-by":"publisher","first-page":"493","DOI":"10.1136\/jnnp-2015-310383","volume":"87","author":"C Vriend","year":"2016","unstructured":"Vriend C, Boedhoe PS, Rutten S, Berendse HW, van der Werf YD, van den Heuvel OA (2016) A smaller amygdala is associated with anxiety in Parkinson\u2019s disease: a combined FreeSurfer-VBM study. J Neurol Neurosurg Psychiatry 87:493\u2013500","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"12934_CR84","doi-asserted-by":"publisher","first-page":"809","DOI":"10.1016\/j.parkreldis.2012.03.008","volume":"18","author":"I Surdhar","year":"2012","unstructured":"Surdhar I, Gee M, Bouchard T, Coupland N, Malykhin N, Camicioli R (2012) Intact limbic-prefrontal connections and reduced amygdala volumes in Parkinson\u2019s disease with mild depressive symptoms. Parkinsonism Relat Disord 18:809\u2013813","journal-title":"Parkinsonism Relat Disord"},{"key":"12934_CR85","doi-asserted-by":"publisher","first-page":"333","DOI":"10.1038\/s41582-023-00802-5","volume":"19","author":"K Ray Chaudhuri","year":"2023","unstructured":"Ray Chaudhuri K, Leta V, Bannister K, Brooks DJ, Svenningsson P (2023) The noradrenergic subtype of Parkinson disease: from animal models to clinical practice. Nat Rev Neurol 19:333\u2013345","journal-title":"Nat Rev Neurol"},{"key":"12934_CR86","doi-asserted-by":"publisher","first-page":"493","DOI":"10.1007\/BF00296485","volume":"88","author":"H Braak","year":"1994","unstructured":"Braak H, Braak E, Yilmazer D, de Vos RA, Jansen EN, Bohl J, Jellinger K (1994) Amygdala pathology in Parkinson\u2019s disease. Acta Neuropathol 88:493\u2013500","journal-title":"Acta Neuropathol"},{"key":"12934_CR87","doi-asserted-by":"publisher","first-page":"28","DOI":"10.1038\/s41531-023-00469-1","volume":"9","author":"J Wang","year":"2023","unstructured":"Wang J, Sun L, Chen L, Sun J, Xie Y, Tian D, Gao L, Zhang D, Xia M, Wu T (2023) Common and distinct roles of amygdala subregional functional connectivity in non-motor symptoms of Parkinson\u2019s disease. NPJ Parkinson Dis 9:28","journal-title":"NPJ Parkinson Dis"},{"key":"12934_CR88","doi-asserted-by":"publisher","first-page":"188","DOI":"10.1136\/jnnp-2011-300828","volume":"83","author":"TR Melzer","year":"2012","unstructured":"Melzer TR, Watts R, MacAskill MR, Pitcher TL, Livingston L, Keenan RJ, Dalrymple-Alford JC, Anderson TJ (2012) Grey matter atrophy in cognitively impaired Parkinson\u2019s disease. J Neurol Neurosurg Psychiatry 83:188\u2013194","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"12934_CR89","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000003086","volume":"95","author":"MH Chen","year":"2016","unstructured":"Chen MH, Lu CH, Chen PC, Tsai NW, Huang CC, Chen HL, Yang IH, Yu CC, Lin WC (2016) Association between autonomic impairment and structural deficit in Parkinson disease. Medicine 95:e3086","journal-title":"Medicine"},{"key":"12934_CR90","doi-asserted-by":"publisher","first-page":"1375","DOI":"10.1002\/hbm.23109","volume":"37","author":"M Criaud","year":"2016","unstructured":"Criaud M, Christopher L, Boulinguez P, Ballanger B, Lang AE, Cho SS, Houle S, Strafella AP (2016) Contribution of insula in Parkinson\u2019s disease: a quantitative meta-analysis study. Hum Brain Mapp 37:1375\u20131392","journal-title":"Hum Brain Mapp"},{"key":"12934_CR91","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbr.2019.111973","volume":"371","author":"D Zheng","year":"2019","unstructured":"Zheng D, Chen C, Song W, Yi Z, Zhao P, Zhong J, Dai Z, Shi H, Pan P (2019) Regional gray matter reductions associated with mild cognitive impairment in Parkinson\u2019s disease: a meta-analysis of voxel-based morphometry studies. Behav Brain Res 371:111973","journal-title":"Behav Brain Res"},{"key":"12934_CR92","doi-asserted-by":"publisher","first-page":"2318","DOI":"10.1002\/mds.23268","volume":"25","author":"JS Reijnders","year":"2010","unstructured":"Reijnders JS, Scholtissen B, Weber WE, Aalten P, Verhey FR, Leentjens AF (2010) Neuroanatomical correlates of apathy in Parkinson\u2019s disease: a magnetic resonance imaging study using voxel-based morphometry. Movement Disord 25:2318\u20132325","journal-title":"Movement Disord"},{"key":"12934_CR93","doi-asserted-by":"publisher","first-page":"2143","DOI":"10.1093\/brain\/awu084","volume":"137","author":"L Christopher","year":"2014","unstructured":"Christopher L, Koshimori Y, Lang AE, Criaud M, Strafella AP (2014) Uncovering the role of the insula in non-motor symptoms of Parkinson\u2019s disease. Brain 137:2143\u20132154","journal-title":"Brain"},{"key":"12934_CR94","doi-asserted-by":"publisher","first-page":"702","DOI":"10.1523\/JNEUROSCI.4860-03.2004","volume":"24","author":"O Monchi","year":"2004","unstructured":"Monchi O, Petrides M, Doyon J, Postuma RB, Worsley K, Dagher A (2004) Neural bases of set-shifting deficits in Parkinson\u2019s disease. J Neurosci 24:702\u2013710","journal-title":"J Neurosci"},{"key":"12934_CR95","doi-asserted-by":"publisher","first-page":"2187","DOI":"10.1093\/cercor\/bhaa354","volume":"31","author":"I Espadas","year":"2021","unstructured":"Espadas I, Ortiz O, Garc\u00eda-Sanz P, Sanz-Magro A, Alberquilla S, Solis O, Delgado-Garc\u00eda JM, Gruart A, Moratalla R (2021) Dopamine D2R is required for hippocampal-dependent memory and plasticity at the CA3-CA1 synapse. Cerebral Cortex 31:2187\u20132204","journal-title":"Cerebral Cortex"},{"key":"12934_CR96","doi-asserted-by":"publisher","first-page":"347","DOI":"10.1080\/17470910902934400","volume":"4","author":"JA Weller","year":"2009","unstructured":"Weller JA, Levin IP, Shiv B, Bechara A (2009) The effects of insula damage on decision-making for risky gains and losses. Soc Neurosci 4:347\u2013358","journal-title":"Soc Neurosci"},{"key":"12934_CR97","doi-asserted-by":"publisher","first-page":"1443","DOI":"10.1002\/hbm.21118","volume":"32","author":"T Wu","year":"2011","unstructured":"Wu T, Long X, Wang L, Hallett M, Zang Y, Li K, Chan P (2011) Functional connectivity of cortical motor areas in the resting state in Parkinson\u2019s disease. Hum Brain Mapp 32:1443\u20131457","journal-title":"Hum Brain Mapp"},{"key":"12934_CR98","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1016\/j.biopsych.2012.06.003","volume":"73","author":"V Baur","year":"2013","unstructured":"Baur V, H\u00e4nggi J, Langer N, J\u00e4ncke L (2013) Resting-state functional and structural connectivity within an insula-amygdala route specifically index state and trait anxiety. Biol Psychiat 73:85\u201392","journal-title":"Biol Psychiat"},{"key":"12934_CR99","doi-asserted-by":"publisher","first-page":"225","DOI":"10.1002\/mds.23480","volume":"26","author":"R Cilia","year":"2011","unstructured":"Cilia R, Cho SS, van Eimeren T, Marotta G, Siri C, Ko JH, Pellecchia G, Pezzoli G, Antonini A, Strafella AP (2011) Pathological gambling in patients with Parkinson\u2019s disease is associated with fronto-striatal disconnection: a path modeling analysis. Movement Disord 26:225\u2013233","journal-title":"Movement Disord"},{"key":"12934_CR100","doi-asserted-by":"publisher","first-page":"245","DOI":"10.1002\/mds.26112","volume":"30","author":"TJ van Mierlo","year":"2015","unstructured":"van Mierlo TJ, Chung C, Foncke EM, Berendse HW, van den Heuvel OA (2015) Depressive symptoms in Parkinson\u2019s disease are related to decreased hippocampus and amygdala volume. Movement Disord 30:245\u2013252","journal-title":"Movement Disord"},{"key":"12934_CR101","doi-asserted-by":"publisher","first-page":"1324","DOI":"10.1007\/s00415-008-0885-8","volume":"255","author":"N Ibarretxe-Bilbao","year":"2008","unstructured":"Ibarretxe-Bilbao N, Ram\u00edrez-Ruiz B, Tolosa E, Mart\u00ed MJ, Valldeoriola F, Bargall\u00f3 N, Junqu\u00e9 C (2008) Hippocampal head atrophy predominance in Parkinson\u2019s disease with hallucinations and with dementia. J Neurol 255:1324\u20131331","journal-title":"J Neurol"},{"key":"12934_CR102","doi-asserted-by":"publisher","first-page":"1508","DOI":"10.1016\/j.neuroimage.2008.06.026","volume":"42","author":"J Janzen","year":"2008","unstructured":"Janzen J, Schlindwein P, Bense S, Bauermann T, Vucurevic G, Stoeter P, Dieterich M (2008) Neural correlates of hemispheric dominance and ipsilaterality within the vestibular system. Neuroimage 42:1508\u20131518","journal-title":"Neuroimage"},{"key":"12934_CR103","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1002\/mds.22818","volume":"25","author":"ME Bodden","year":"2010","unstructured":"Bodden ME, Dodel R, Kalbe E (2010) Theory of mind in Parkinson\u2019s disease and related basal ganglia disorders: a systematic review. Movement Disord 25:13\u201327","journal-title":"Movement Disord"},{"key":"12934_CR104","doi-asserted-by":"publisher","first-page":"169","DOI":"10.1016\/j.parkreldis.2019.04.007","volume":"64","author":"H Otomune","year":"2019","unstructured":"Otomune H, Mihara M, Hattori N, Fujimoto H, Kajiyama Y, Konaka K, Mitani Y, Watanabe Y, Mochizuki H (2019) Involvement of cortical dysfunction in frequent falls in patients with Parkinson\u2019s disease. Parkinsonism Relat Disord 64:169\u2013174","journal-title":"Parkinsonism Relat Disord"},{"key":"12934_CR105","doi-asserted-by":"publisher","first-page":"821","DOI":"10.3233\/JPD-160809","volume":"6","author":"H Alzahrani","year":"2016","unstructured":"Alzahrani H, Antonini A, Venneri A (2016) Apathy in mild Parkinson\u2019s disease: neuropsychological and neuroimaging evidence. J Parkinsons Dis 6:821\u2013832","journal-title":"J Parkinsons Dis"},{"key":"12934_CR106","doi-asserted-by":"publisher","first-page":"42","DOI":"10.1002\/mds.21765","volume":"23","author":"A Feldmann","year":"2008","unstructured":"Feldmann A, Illes Z, Kosztolanyi P, Illes E, Mike A, Kover F, Balas I, Kovacs N, Nagy F (2008) Morphometric changes of gray matter in Parkinson\u2019s disease with depression: a voxel-based morphometry study. Movement Disord 23:42\u201346","journal-title":"Movement Disord"},{"key":"12934_CR107","doi-asserted-by":"publisher","first-page":"213","DOI":"10.3389\/fnagi.2020.00213","volume":"12","author":"C Yang","year":"2020","unstructured":"Yang C, Chang J, Liang X, Bao X, Wang R (2020) Gray matter alterations in Parkinson\u2019s disease with rapid eye movement sleep behavior disorder: a meta-analysis of voxel-based morphometry studies. Front Aging Neurosci 12:213","journal-title":"Front Aging Neurosci"},{"key":"12934_CR108","doi-asserted-by":"publisher","DOI":"10.1002\/brb3.2103","volume":"11","author":"X Zhang","year":"2021","unstructured":"Zhang X, Cao X, Xue C, Zheng J, Zhang S, Huang Q, Liu W (2021) Aberrant functional connectivity and activity in Parkinson\u2019s disease and comorbidity with depression based on radiomic analysis. Brain and behavior 11:e02103","journal-title":"Brain and behavior"},{"key":"12934_CR109","doi-asserted-by":"publisher","first-page":"1777","DOI":"10.1002\/mds.26321","volume":"30","author":"Y Lou","year":"2015","unstructured":"Lou Y, Huang P, Li D, Cen Z, Wang B, Gao J, Xuan M, Yu H, Zhang M, Luo W (2015) Altered brain network centrality in depressed Parkinson\u2019s disease patients. Movement Disord 30:1777\u20131784","journal-title":"Movement Disord"},{"key":"12934_CR110","doi-asserted-by":"publisher","first-page":"401","DOI":"10.1016\/j.cortex.2020.06.012","volume":"130","author":"B Orso","year":"2020","unstructured":"Orso B, Arnaldi D, Fam\u00e0 F, Girtler N, Brugnolo A, Doglione E, Filippi L, Massa F, Peira E, Bauckneht M, Morbelli S, Nobili F, Pardini M (2020) Anatomical and neurochemical bases of theory of mind in de novo Parkinson\u2019s disease. Cortex 130:401\u2013412","journal-title":"Cortex"},{"key":"12934_CR111","first-page":"100308","volume":"3","author":"M Jiang","year":"2022","unstructured":"Jiang M (2022) Neural circuits underlying motor and non-motor defects of Parkinson\u2019s disease. Innovation 3:100308","journal-title":"Innovation"},{"key":"12934_CR112","doi-asserted-by":"publisher","first-page":"321","DOI":"10.1038\/s41586-022-04806-x","volume":"607","author":"Y Zhang","year":"2022","unstructured":"Zhang Y, Roy DS, Zhu Y, Chen Y, Aida T, Hou Y, Shen C, Lea NE, Schroeder ME, Skaggs KM, Sullivan HA, Fischer KB, Callaway EM, Wickersham IR, Dai J, Li XM, Lu Z, Feng G (2022) Targeting thalamic circuits rescues motor and mood deficits in PD mice. Nature 607:321\u2013329","journal-title":"Nature"},{"key":"12934_CR113","doi-asserted-by":"publisher","first-page":"5246021","DOI":"10.1155\/2016\/5246021","volume":"2016","author":"J Xiang","year":"2016","unstructured":"Xiang J, Jia X, Li H, Qin J, Liang P, Li K (2016) Altered spontaneous brain activity in cortical and subcortical regions in Parkinson\u2019s disease. Parkinson\u2019s disease 2016:5246021","journal-title":"Parkinson's disease"},{"key":"12934_CR114","doi-asserted-by":"publisher","first-page":"16711","DOI":"10.1038\/s41598-017-16922-0","volume":"7","author":"TM Mi","year":"2017","unstructured":"Mi TM, Mei SS, Liang PP, Gao LL, Li KC, Wu T, Chan P (2017) Altered resting-state brain activity in Parkinson\u2019s disease patients with freezing of gait. Sci Rep 7:16711","journal-title":"Sci Rep"},{"key":"12934_CR115","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0063691","volume":"8","author":"X Wen","year":"2013","unstructured":"Wen X, Wu X, Liu J, Li K, Yao L (2013) Abnormal baseline brain activity in non-depressed Parkinson\u2019s disease and depressed Parkinson\u2019s disease: a resting-state functional magnetic resonance imaging study. PLoS ONE 8:e63691","journal-title":"PLoS ONE"},{"key":"12934_CR116","doi-asserted-by":"publisher","first-page":"393","DOI":"10.1192\/bjp.bp.108.055046","volume":"195","author":"J Radua","year":"2009","unstructured":"Radua J, Mataix-Cols D (2009) Voxel-wise meta-analysis of grey matter changes in obsessive-compulsive disorder. Br J Psychiatry 195:393\u2013402","journal-title":"Br J Psychiatry"}],"container-title":["Journal of Neurology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00415-025-12934-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00415-025-12934-3\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00415-025-12934-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,18]],"date-time":"2025-04-18T11:02:10Z","timestamp":1744974130000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00415-025-12934-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,3,19]]},"references-count":116,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2025,4]]}},"alternative-id":["12934"],"URL":"https:\/\/doi.org\/10.1007\/s00415-025-12934-3","relation":{},"ISSN":["0340-5354","1432-1459"],"issn-type":[{"value":"0340-5354","type":"print"},{"value":"1432-1459","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,3,19]]},"assertion":[{"value":"10 December 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"21 January 2025","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"22 January 2025","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"19 March 2025","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare that there are no financial or personal relationships with other people showing conflict of interest in this paper.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"All studies included in this meta-analysis have been approved by the appropriate ethics committee and have therefore been performed in accordance with the ethical standards laid down in the 1964 Declaration of Helsinki and its later amendments.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}}],"article-number":"276"}}