{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,23]],"date-time":"2026-03-23T04:32:50Z","timestamp":1774240370448,"version":"3.50.1"},"reference-count":45,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"name":"Baasch medicus Foundation"},{"DOI":"10.13039\/501100007673","name":"Fondation Centre de Recherches M\u00e9dicales Carlos et Elsie de Reuter","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007673","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Neurol"],"published-print":{"date-parts":[[2025,3]]},"DOI":"10.1007\/s00415-025-12973-w","type":"journal-article","created":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T09:23:20Z","timestamp":1740821000000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Reflexive and voluntary saccades as a proxy for bradykinesia and apathy in Parkinson\u2019s disease"],"prefix":"10.1007","volume":"272","author":[{"given":"Fabian","family":"Rey","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Damien","family":"Benis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Radek","family":"Ptak","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Diego","family":"Kaski","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matthieu","family":"B\u00e9reau","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ren\u00e9 M.","family":"M\u00fcri","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paul","family":"Krack","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3011-4792","authenticated-orcid":false,"given":"Andr\u00e9","family":"Zacharia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2025,3,1]]},"reference":[{"issue":"9996","key":"12973_CR1","doi-asserted-by":"crossref","first-page":"896","DOI":"10.1016\/S0140-6736(14)61393-3","volume":"386","author":"LV Kalia","year":"2015","unstructured":"Kalia LV, Lang AE (2015) Parkinson\u2019s disease. Lancet 386(9996):896\u2013912","journal-title":"Lancet"},{"issue":"7","key":"12973_CR2","doi-asserted-by":"crossref","first-page":"916","DOI":"10.1093\/cercor\/bhj043","volume":"16","author":"R Levy","year":"2006","unstructured":"Levy R, Dubois B (2006) Apathy and the functional anatomy of the prefrontal cortex-basal ganglia circuits. Cereb Cortex 16(7):916\u2013928","journal-title":"Cereb Cortex"},{"issue":"8\u20139","key":"12973_CR3","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1016\/j.neurol.2012.05.003","volume":"168","author":"R Levy","year":"2012","unstructured":"Levy R (2012) Apathy: a pathology of goal-directed behaviour. A new concept of the clinic and pathophysiology of apathy. Rev Neurol (Paris) 168(8\u20139):585\u2013597","journal-title":"Rev Neurol (Paris)"},{"issue":"2","key":"12973_CR4","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1002\/mds.23872","volume":"27","author":"J Benito-Le\u00f3n","year":"2012","unstructured":"Benito-Le\u00f3n J, Cubo E, Coronell C, Rodr\u00edguez-Fern\u00e1ndez R, Pego-Reigosa R, Paz-Gonz\u00e1lez JM et al (2012) Impact of apathy on health-related quality of life in recently diagnosed Parkinson\u2019s disease: the ANIMO study. Mov Disord 27(2):211\u2013218","journal-title":"Mov Disord"},{"issue":"15","key":"12973_CR5","doi-asserted-by":"crossref","first-page":"2175","DOI":"10.1002\/mds.22589","volume":"24","author":"D Aarsland","year":"2009","unstructured":"Aarsland D, Marsh L, Schrag A (2009) Neuropsychiatric symptoms in Parkinson\u2019s disease. Mov Disord 24(15):2175\u20132186","journal-title":"Mov Disord"},{"issue":"2","key":"12973_CR6","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1176\/jnp.4.2.134","volume":"4","author":"SE Starkstein","year":"1992","unstructured":"Starkstein SE, Mayberg HS, Preziosi T, Andrezejewski P, Leiguarda R, Robinson RG (1992) Reliability, validity, and clinical correlates of apathy in Parkinson\u2019s disease. J Neuropsychiatry Clin Neurosci 4(2):134\u2013139","journal-title":"J Neuropsychiatry Clin Neurosci"},{"issue":"12","key":"12973_CR7","doi-asserted-by":"crossref","first-page":"1892","DOI":"10.1002\/alz.12358","volume":"17","author":"DS Miller","year":"2021","unstructured":"Miller DS, Robert P, Ereshefsky L, Adler L, Bateman D, Cummings J et al (2021) Diagnostic criteria for apathy in neurocognitive disorders. Alzheimers Dement 17(12):1892\u20131904","journal-title":"Alzheimers Dement"},{"issue":"12","key":"12973_CR8","doi-asserted-by":"crossref","first-page":"1599","DOI":"10.3390\/cells12121599","volume":"12","author":"M B\u00e9reau","year":"2023","unstructured":"B\u00e9reau M, Van Waes V, Servant M, Magnin E, Tatu L, Anheim M (2023) Apathy in Parkinson\u2019s disease: clinical patterns and neurobiological basis. Cells 12(12):1599","journal-title":"Cells"},{"issue":"4","key":"12973_CR9","first-page":"1329","volume":"12","author":"M B\u00e9reau","year":"2022","unstructured":"B\u00e9reau M, Castrioto A, Lhomm\u00e9e E, Maillet A, G\u00e9razime A, Bichon A et al (2022) Fatigue in de novo Parkinson\u2019s disease: expanding the neuropsychiatric triad? J Park Dis 12(4):1329\u20131337","journal-title":"J Park Dis"},{"issue":"3","key":"12973_CR10","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1093\/brain\/awz344","volume":"143","author":"M Bologna","year":"2020","unstructured":"Bologna M, Paparella G, Fasano A, Hallett M, Berardelli A (2020) Evolving concepts on bradykinesia. Brain 143(3):727\u2013750","journal-title":"Brain"},{"issue":"2","key":"12973_CR11","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1093\/brain\/103.2.301","volume":"103","author":"M Hallett","year":"1980","unstructured":"Hallett M, Khoshbin S (1980) A physiological mechanism of bradykinesia. Brain 103(2):301\u2013314","journal-title":"Brain"},{"key":"12973_CR12","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2016.00083\/abstract","author":"S Tinaz","year":"2016","unstructured":"Tinaz S, Pillai AS, Hallett M (2016) Sequence effect in Parkinson\u2019s disease is related to motor energetic cost. Front Neurol. https:\/\/doi.org\/10.3389\/fneur.2016.00083\/abstract","journal-title":"Front Neurol"},{"issue":"27","key":"12973_CR13","doi-asserted-by":"crossref","first-page":"7105","DOI":"10.1523\/JNEUROSCI.0264-07.2007","volume":"27","author":"P Mazzoni","year":"2007","unstructured":"Mazzoni P, Hristova A, Krakauer JW (2007) Why don\u2019t we move faster? Parkinson\u2019s disease, movement vigor, and implicit motivation. J Neurosci 27(27):7105\u20137116","journal-title":"J Neurosci"},{"issue":"1","key":"12973_CR14","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1212\/WNL.9.1.65","volume":"9","author":"RS Schwab","year":"1959","unstructured":"Schwab RS, England AC, Peterson E (1959) Akinesia in Parkinson\u2019s disease. Neurology 9(1):65\u201372","journal-title":"Neurology"},{"issue":"11","key":"12973_CR15","doi-asserted-by":"crossref","first-page":"2131","DOI":"10.1093\/brain\/124.11.2131","volume":"124","author":"A Berardelli","year":"2001","unstructured":"Berardelli A, Rothwell JC, Thompson PD, Hallett M (2001) Pathophysiology of bradykinesia in parkinson\u2019s disease. Brain 124(11):2131\u20132146","journal-title":"Brain"},{"issue":"5","key":"12973_CR16","doi-asserted-by":"crossref","first-page":"646","DOI":"10.1002\/mds.870120505","volume":"12","author":"A Curr\u00e0","year":"1997","unstructured":"Curr\u00e0 A, Berardelli A, Agostino R, Modugno N, Puorger CC, Accornero N, Manfredi M (1997) Performance of sequential arm movements with and without advance knowledge of motor pathways in Parkinson's disease. Move Disord: Official j Move Disord Soc 12(5):646\u2013654","journal-title":"Move Disord: Official j Move Disord Soc"},{"issue":"4","key":"12973_CR17","doi-asserted-by":"crossref","first-page":"935","DOI":"10.1093\/brain\/118.4.935","volume":"118","author":"R Cunnington","year":"1995","unstructured":"Cunnington R, Iansek R, Bradshaw JL, Phillips JG (1995) Movement-related potentials in Parkinson\u2019s disease: presence and predictability of temporal and spatial cues. Brain 118(4):935\u2013950","journal-title":"Brain"},{"issue":"3","key":"12973_CR18","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1136\/jnnp.57.3.368","volume":"57","author":"N Georgiou","year":"1994","unstructured":"Georgiou N, Bradshaw JL, Iansek R, Phillips JG, Mattingley JB, Bradshaw JA (1994) Reduction in external cues and movement sequencing in Parkinson\u2019s disease. J Neurol Neurosurg Psychiatry 57(3):368\u2013370","journal-title":"J Neurol Neurosurg Psychiatry"},{"issue":"5","key":"12973_CR19","doi-asserted-by":"crossref","first-page":"518","DOI":"10.1016\/S1474-4422(15)00019-8","volume":"14","author":"J Pagonabarraga","year":"2015","unstructured":"Pagonabarraga J, Kulisevsky J, Strafella AP, Krack P (2015) Apathy in Parkinson\u2019s disease: clinical features, neural substrates, diagnosis, and treatment. Lancet Neurol 14(5):518\u2013531","journal-title":"Lancet Neurol"},{"issue":"2","key":"12973_CR20","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1038\/nrneurol.2012.273","volume":"9","author":"TJ Anderson","year":"2013","unstructured":"Anderson TJ, MacAskill MR (2013) Eye movements in patients with neurodegenerative disorders. Nat Rev Neurol 9(2):74\u201385","journal-title":"Nat Rev Neurol"},{"issue":"5","key":"12973_CR21","doi-asserted-by":"crossref","first-page":"1193","DOI":"10.1093\/brain\/112.5.1193","volume":"112","author":"O Rascol","year":"1989","unstructured":"Rascol O, Clanet M, Montastruc JL, Simonetta M, Soulier-Esteve MJ, Doyon B et al (1989) Abnormal ocular movements in Parkinson\u2019s disease: evidence for involvement of dopaminergic systems. Brain 112(5):1193\u20131214","journal-title":"Brain"},{"issue":"7","key":"12973_CR22","doi-asserted-by":"crossref","first-page":"1729","DOI":"10.1002\/mds.28609","volume":"36","author":"N Koohi","year":"2021","unstructured":"Koohi N, Bancroft MJ, Patel J, Castro P, Akram H, Warner TT et al (2021) Saccadic bradykinesia in Parkinson\u2019s disease: preliminary observations. Mov Disord 36(7):1729\u20131731","journal-title":"Mov Disord"},{"issue":"1","key":"12973_CR23","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1016\/0014-4886(71)90165-8","volume":"32","author":"JD DeJong","year":"1971","unstructured":"DeJong JD, Jones GM (1971) Akinesia, hypokinesia, and bradykinesia in the oculomotor system of patients with Parkinson\u2019s disease. Exp Neurol 32(1):58\u201368","journal-title":"Exp Neurol"},{"issue":"6","key":"12973_CR24","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1001\/archneur.1979.00500420070009","volume":"36","author":"H Shibasaki","year":"1979","unstructured":"Shibasaki H, Tsuji S, Kuroiwa Y (1979) Oculomotor abnormalities in Parkinson\u2019s disease. Arch Neurol 36(6):360\u2013364","journal-title":"Arch Neurol"},{"issue":"1","key":"12973_CR25","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/0014-4886(71)90173-7","volume":"31","author":"GM Jones","year":"1971","unstructured":"Jones GM, DeJong JD (1971) Dynamic characteristics of saccadic eye movements in Parkinson\u2019s disease. Exp Neurol 31(1):17\u201331","journal-title":"Exp Neurol"},{"issue":"15","key":"12973_CR26","doi-asserted-by":"crossref","first-page":"2129","DOI":"10.1002\/mds.22340","volume":"23","author":"CG Goetz","year":"2008","unstructured":"Goetz CG, Tilley BC, Shaftman SR, Stebbins GT, Fahn S, Martinez-Martin P et al (2008) Movement disorder society-sponsored revision of the unified Parkinson\u2019s disease rating scale (MDS-UPDRS): scale presentation and clinimetric testing results. Mov Disord 23(15):2129\u20132170","journal-title":"Mov Disord"},{"issue":"3","key":"12973_CR27","doi-asserted-by":"crossref","first-page":"658","DOI":"10.1016\/j.psychres.2014.06.010","volume":"219","author":"R Radakovic","year":"2014","unstructured":"Radakovic R, Abrahams S (2014) Developing a new apathy measurement scale: dimensional apathy scale. Psychiatry Res 219(3):658\u2013663","journal-title":"Psychiatry Res"},{"issue":"1","key":"12973_CR28","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1002\/gps.4697","volume":"33","author":"R Radakovic","year":"2018","unstructured":"Radakovic R, Davenport R, Starr JM, Abrahams S (2018) Apathy dimensions in Parkinson\u2019s disease. Int J Geriatr Psychiatry 33(1):151\u2013158","journal-title":"Int J Geriatr Psychiatry"},{"issue":"9","key":"12973_CR29","doi-asserted-by":"crossref","first-page":"2533","DOI":"10.1007\/s11136-017-1569-6","volume":"26","author":"G Santangelo","year":"2017","unstructured":"Santangelo G, D\u2019Iorio A, Piscopo F, Cuoco S, Longo K, Amboni M et al (2017) Assessment of apathy minimising the effect of motor dysfunctions in Parkinson\u2019s disease: a validation study of the dimensional apathy scale. Qual Life Res 26(9):2533\u20132540","journal-title":"Qual Life Res"},{"issue":"6","key":"12973_CR30","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1136\/jnnp.51.6.745","volume":"51","author":"WR Gibb","year":"1988","unstructured":"Gibb WR, Lees A (1988) The relevance of the Lewy body to the pathogenesis of idiopathic Parkinson's disease. J Neurol Neurosurg Psychiatry 51(6):745\u2013752","journal-title":"J Neurol Neurosurg Psychiatry"},{"issue":"4","key":"12973_CR31","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1111\/j.1532-5415.2005.53221.x","volume":"53","author":"ZS Nasreddine","year":"2005","unstructured":"Nasreddine ZS, Phillips NA, B\u00c3\u00a9dirian V, Charbonneau S, Whitehead V, Collin I et al (2005) The montreal cognitive assessment, MoCA: a brief screening tool for mild cognitive impairment: MOCA: a brief screening tool for MCI. J Am Geriatr Soc 53(4):695\u2013699","journal-title":"J Am Geriatr Soc"},{"issue":"21","key":"12973_CR32","doi-asserted-by":"crossref","first-page":"1738","DOI":"10.1212\/WNL.0b013e3181c34b47","volume":"73","author":"S Hoops","year":"2009","unstructured":"Hoops S, Nazem S, Siderowf AD, Duda JE, Xie SX, Stern MB, Weintraub D (2009) Validity of the MoCA and MMSE in the detection of MCI and dementia in Parkinson disease. Neurology 73(21):1738\u20131745","journal-title":"Neurology"},{"key":"12973_CR33","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1136\/jnnp.23.1.56","volume":"23","author":"MAX Hamilton","year":"1960","unstructured":"Hamilton MAX (1960) A rating scale for depression. J Neurol Neurosurg Psychiatry 23:56\u201362","journal-title":"J Neurol Neurosurg Psychiatry"},{"issue":"10","key":"12973_CR34","doi-asserted-by":"crossref","first-page":"1103","DOI":"10.1136\/jnnp.2010.232793","volume":"82","author":"C Hubsch","year":"2011","unstructured":"Hubsch C, Vidailhet M, Rivaud-P\u00e9choux S, Pouget P, Brochard V, Degos B et al (2011) Impaired saccadic adaptation in DYT11 dystonia. J Neurol Neurosurg Psychiatry 82(10):1103\u20131106","journal-title":"J Neurol Neurosurg Psychiatry"},{"issue":"2","key":"12973_CR35","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1177\/1362361316667057","volume":"22","author":"T Zalla","year":"2018","unstructured":"Zalla T, Seassau M, Cazalis F, Gras D, Leboyer M (2018) Saccadic eye movements in adults with high-functioning autism spectrum disorder. Autism 22(2):195\u2013204","journal-title":"Autism"},{"key":"12973_CR36","first-page":"271","volume-title":"Progress in brain research","author":"DA Robinson","year":"2022","unstructured":"Robinson DA (2022) Properties of rapid eye movements. Progress in brain research. Elsevier, pp 271\u2013286"},{"issue":"5","key":"12973_CR37","doi-asserted-by":"crossref","first-page":"848","DOI":"10.1162\/jocn.2009.21227","volume":"22","author":"R Cools","year":"2010","unstructured":"Cools R, Rogers R, Barker RA, Robbins TW (2010) Top-down attentional control in Parkinson\u02bcs disease: salient considerations. J Cogn Neurosci 22(5):848\u2013859","journal-title":"J Cogn Neurosci"},{"issue":"8","key":"12973_CR38","doi-asserted-by":"crossref","first-page":"2432","DOI":"10.1093\/brain\/awy155","volume":"141","author":"M Bologna","year":"2018","unstructured":"Bologna M, Guerra A, Paparella G, Giordo L, Alunni Fegatelli D, Vestri AR et al (2018) Neurophysiological correlates of bradykinesia in Parkinson\u2019s disease. Brain 141(8):2432\u20132444","journal-title":"Brain"},{"issue":"4","key":"12973_CR39","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1002\/ana.410350419","volume":"35","author":"A Vermersch","year":"1994","unstructured":"Vermersch A, Rivaud S, Vidailhet M, Bonnet A, Gaymard B, Agid Y et al (1994) Sequences of memory-guided saccades in Parkinson\u2019s disease. Ann Neurol 35(4):487\u2013490","journal-title":"Ann Neurol"},{"issue":"6","key":"12973_CR40","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1136\/jnnp.2006.099754","volume":"78","author":"AJ Hood","year":"2007","unstructured":"Hood AJ, Amador SC, Cain AE, Briand KA, Al-Refai AH, Schiess MC et al (2007) Levodopa slows prosaccades and improves antisaccades: an eye movement study in Parkinson\u2019s disease. J Neurol Neurosurg Psychiatry 78(6):565\u2013570","journal-title":"J Neurol Neurosurg Psychiatry"},{"issue":"1","key":"12973_CR41","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1007\/s00221-006-0412-z","volume":"174","author":"AW Michell","year":"2006","unstructured":"Michell AW, Xu Z, Fritz D, Lewis SJG, Foltynie T, Williams-Gray CH et al (2006) Saccadic latency distributions in Parkinson\u2019s disease and the effects of l-dopa. Exp Brain Res 174(1):7\u201318","journal-title":"Exp Brain Res"},{"issue":"4","key":"12973_CR42","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1159\/000026694","volume":"42","author":"L Crevits","year":"2000","unstructured":"Crevits L, Versijpt J, Hanse M, De Ridder K (2000) Antisaccadic effects of a dopamine agonist as add-on therapy in advanced Parkinson\u2019s patients. Neuropsychobiology 42(4):202\u2013206","journal-title":"Neuropsychobiology"},{"issue":"9092","key":"12973_CR43","doi-asserted-by":"crossref","first-page":"1675","DOI":"10.1016\/S0140-6736(97)24049-3","volume":"350","author":"P Krack","year":"1997","unstructured":"Krack P, Pollak P, Limousin P, Benazzouz A, Benabid A (1997) Stimulation of subthalamic nucleus alleviates tremor in Parkinson\u2019s disease. Lancet 350(9092):1675","journal-title":"Lancet"},{"issue":"8942","key":"12973_CR44","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/S0140-6736(95)90062-4","volume":"345","author":"P Limousin","year":"1995","unstructured":"Limousin P, Pollak P, Benazzouz A, Hoffmann D, Le Bas JF, Perret JE et al (1995) Effect on parkinsonian signs and symptoms of bilateral subthalamic nucleus stimulation. Lancet 345(8942):91\u201395","journal-title":"Lancet"},{"key":"12973_CR45","first-page":"S248","volume":"30","author":"A Zacharia","year":"2015","unstructured":"Zacharia A, Sastre I, Georgiev D, Hariz M, Zrinzo L, Foltynie T et al (2015) Role of the frequency of Stn stimulation on bradykinesia in Parkinsonian patients. Mov Disord 30:S248","journal-title":"Mov Disord"}],"container-title":["Journal of Neurology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00415-025-12973-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00415-025-12973-w\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00415-025-12973-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,17]],"date-time":"2025-03-17T17:43:36Z","timestamp":1742233416000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00415-025-12973-w"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,3]]},"references-count":45,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2025,3]]}},"alternative-id":["12973"],"URL":"https:\/\/doi.org\/10.1007\/s00415-025-12973-w","relation":{},"ISSN":["0340-5354","1432-1459"],"issn-type":[{"value":"0340-5354","type":"print"},{"value":"1432-1459","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,3]]},"assertion":[{"value":"27 September 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"21 January 2025","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"12 February 2025","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"1 March 2025","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors have no conflict of interest to report.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflicts of interest"}},{"value":"This study protocol was reviewed and approved by the local ethical committee of the Canton of Geneva (Project-ID 2019-01039). All the participants signed informed consent. We confirm that we have read the Journal\u2019s position on issues involved in ethical publication and affirm that this work is consistent with those guidelines.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}}],"article-number":"236"}}