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Modelling of group effects found that bvFTD had greater symptoms than AD in most CBI-R domains. Notably, SDL and SDR compared differently with AD and bvFTD; whilst SDR did not differ significantly from bvFTD in any CBI-R domain, SDL had less severe symptoms than bvFTD in everyday skills, motivation, sleep and eating habits; whilst SDL had greater disturbances in abnormal behaviour and stereotypic behaviour than AD, SDR had greater disturbances in addition in motivation and eating habits. Motivation, eating habits, abnormal behaviour and stereotypic behaviour were the most frequently different behavioural domains between groups.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusion<\/jats:title>\n            <jats:p>We have shown that the combined, longitudinal use of existing behavioural and cognitive assessments could capture distinct clinical profiles of common and rare dementia syndromes. Our findings also highlight the importance of select behavioural domains such as motivation and the usefulness of\u00a0separate\u00a0clinical characterisations of SDL and SDR.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1007\/s00415-025-13025-z","type":"journal-article","created":{"date-parts":[[2025,3,22]],"date-time":"2025-03-22T21:24:04Z","timestamp":1742678644000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Behavioural and cognitive profiles in frontotemporal dementia and Alzheimer\u2019s disease: a longitudinal study"],"prefix":"10.1007","volume":"272","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5096-7194","authenticated-orcid":false,"given":"Xin","family":"Zhang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Muireann","family":"Irish","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Olivier","family":"Piguet","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rebekah M.","family":"Ahmed","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2025,3,21]]},"reference":[{"key":"13025_CR1","doi-asserted-by":"publisher","DOI":"10.1093\/braincomms\/fcac344","author":"S Ramanan","year":"2023","unstructured":"Ramanan S, El-Omar H, Roquet D, Ahmed RA-O, Hodges JR, Piguet OA-O et al (2023) Mapping behavioural, cognitive and affective transdiagnostic dimensions in frontotemporal dementia. 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Xin Zhang has no funding to disclose. Muireann Irish is supported by a Medical Research Future Fund Dementia, Aging, and Aged Care Grant from the Australian Government Department of Health and Aged Care (GNT2024329), and an NHMRC Investigator Grant (GNT2025228). Olivier Piguet is supported in part by an NHMRC Investigator Grant (GNT2008020). Rebekah Ahmed is supported by the National Health and Medical Research Council\u2019s early career fellowship.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflicts of interest"}},{"value":"Ethics approval for this study was granted by the University of New South Wales, the Southeastern Sydney Local Health District, and the University of Sydney human ethics committees. All participants or the person responsible provided written informed consent in accordance with the Declaration of Helsinki.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}}],"article-number":"279"}}