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Cinnante, Claudia Morelli, Stefano Messina, Joana Braga Pereira, O. Hardiman, Federico Verde report no disclosure. Barabara Poletti received compensation for consulting services and\/or speaking activities from Liquidweb S.r.l. and she is associated Editor for Frontiers in Neuroscience. Vincenzo Silani received compensation for consulting services and\/or speaking activities from AveXis, Cytokinetics, Italfarmaco, LiquidWeb, Srl and Novartis Pharma AG. He receives or he has received research support from the Italian Ministry of Health, AriSla, and E-Rare Joint Translational Call. He is on. The Editorial Board of Amyotrophic Lateral Sclerosis and Frontotemproal Degeneration, European Neurology, American Journal of Neurodegenerative Disease and Frontiers in Neurology. Nicola Ticozzi received compensation for consulting services from Amylyx Pharmaceutical, Biogen, Italfarmaco and Zambon Biotech SA. 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