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This study evaluated a smartphone-based intervention to enhance Conscientiousness in people with multiple sclerosis (PwMS) and healthy aging (HA) adults. Initially, 38 PwMS and 22 HA participants completed baseline assessments (cognitive, personality, depression, and anxiety measures). Attrition and disease factors left 24 PwMS and 20 HA adults at the 12-week follow-up. Participants randomly assigned to the intervention arm received the \u201cConscientiousness Coach\u201d app, which combined value identification, SMART goal development, smartphone-based tracking, and scheduled telehealth coaching sessions, whereas controls were wait-listed. ANCOVA for baseline scores showed a significant treatment effect on NEO-FFI Conscientiousness (p\u2009=\u20090.015) that remained after substituting age for diagnosis (p\u2009=\u20090.029). A lack of significant effects for group (PwMS vs. HA) and age indicated that treatment impact was consistent across both samples. Within the intervention group, paired-sample t-tests revealed large gains in the Conscientiousness domain (<jats:italic>d<\/jats:italic>\u2009=\u20090.93, p\u2009&lt;\u20090.001) and moderate improvements in the Orderliness (<jats:italic>d<\/jats:italic>\u2009=\u20090.67, p\u2009=\u20090.007) and Dependability (<jats:italic>d<\/jats:italic>\u2009=\u20090.52, p\u2009=\u20090.030) facets, with no change in wait-list controls. No treatment effects emerged for Neuroticism, depression, or anxiety, underscoring the trait-specific nature of the intervention. Results suggest that targeted digital interventions can favorably impact personality and enhance quality of life. Future study will examine use of AI to replace the behavioral coaching component of this intervention and its long-term impact on personality.<\/jats:p>","DOI":"10.1007\/s00415-025-13320-9","type":"journal-article","created":{"date-parts":[[2025,8,15]],"date-time":"2025-08-15T18:27:38Z","timestamp":1755282458000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Improving conscientiousness through a smartphone app and telecoaching intervention: insights from multiple sclerosis and healthy aging samples"],"prefix":"10.1007","volume":"272","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8184-4456","authenticated-orcid":false,"suffix":"III","given":"Michael","family":"Jaworski","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacob","family":"Balconi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Celeste","family":"Santivasci","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Margaret","family":"Youngs","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Morgan","family":"Woodbeck","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nathan","family":"Zak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara","family":"Cruz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bianca","family":"Weinstock-Guttman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ralph H. 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He has also received royalties from Psychological Assessment Resources, Inc. Author BWG served as a consultant for Biogen, EMD Serono, Novartis, Genentech, Celgene\/Bristol Meyers Squibb, Sanofi Genzyme, Bayer, Janssen, Labcorp, and Horizon. She served in the speaker bureau for Biogen. She has also received grant\/research support from the agencies listed in the previous sentence. She serves on the editorial board for BMJ Neurology, Children, CNS Drugs, MS International, and Frontiers Epidemiology. All other authors declare no financial or non-financial competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflicts of interest"}},{"value":"The dataset generated and analyzed during the current study is not publicly available but may be made available upon reasonable request and approval by the University at Buffalo institutional review board. 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