{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T11:49:31Z","timestamp":1784202571219,"version":"3.55.0"},"reference-count":41,"publisher":"Springer Science and Business Media LLC","issue":"9","license":[{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"name":"National High Level Hospital Clinical Research Funding","award":["2022--PUMCH-B-120"],"award-info":[{"award-number":["2022--PUMCH-B-120"]}]},{"name":"National High Level Hospital Clinical Research Funding","award":["2022--PUMCH-B-018"],"award-info":[{"award-number":["2022--PUMCH-B-018"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Neurol"],"published-print":{"date-parts":[[2025,9]]},"DOI":"10.1007\/s00415-025-13355-y","type":"journal-article","created":{"date-parts":[[2025,9,7]],"date-time":"2025-09-07T15:54:49Z","timestamp":1757260489000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Initiation of tocilizumab within 24\u00a0hours in acute necrotizing encephalopathy is related to a good outcome: a systematic review"],"prefix":"10.1007","volume":"272","author":[{"given":"Yalin","family":"Ju","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chang","family":"Geng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3903-5078","authenticated-orcid":false,"given":"Hongzhi","family":"Guan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,9,7]]},"reference":[{"issue":"5","key":"13355_CR1","doi-asserted-by":"publisher","first-page":"555","DOI":"10.1136\/jnnp.58.5.555","volume":"58","author":"M Mizuguchi","year":"1995","unstructured":"Mizuguchi M, Abe J, Mikkaichi K et al (1995) Acute necrotising encephalopathy of childhood: a new syndrome presenting with multifocal, symmetric brain lesions. J Neurol Neurosurg Psychiatry 58(5):555\u2013561","journal-title":"J Neurol Neurosurg Psychiatry"},{"issue":"9","key":"13355_CR2","doi-asserted-by":"publisher","first-page":"1552","DOI":"10.1212\/01.WNL.0000058757.52327.17","volume":"60","author":"AG Bassuk","year":"2003","unstructured":"Bassuk AG, Burrowes DM, McRae W (2003) Acute necrotizing encephalopathy of childhood with radiographic progression over 10 hours. Neurology 60(9):1552\u20131553","journal-title":"Neurology"},{"issue":"2","key":"13355_CR3","doi-asserted-by":"publisher","first-page":"81","DOI":"10.1016\/S0387-7604(96)00063-0","volume":"19","author":"M Mizuguchi","year":"1997","unstructured":"Mizuguchi M (1997) Acute necrotizing encephalopathy of childhood: a novel form of acute encephalopathy prevalent in Japan and Taiwan. Brain Dev 19(2):81\u201392","journal-title":"Brain Dev"},{"issue":"7","key":"13355_CR4","doi-asserted-by":"publisher","first-page":"641","DOI":"10.1080\/14737175.2023.2224503","volume":"23","author":"N Qin","year":"2023","unstructured":"Qin N, Wang J, Peng X et al (2023) Pathogenesis and management of acute necrotizing encephalopathy. Expert Rev Neurother 23(7):641\u2013650. https:\/\/doi.org\/10.1080\/14737175.2023.2224503","journal-title":"Expert Rev Neurother"},{"key":"13355_CR5","doi-asserted-by":"publisher","DOI":"10.1155\/2015\/792578","volume":"2015","author":"X Wu","year":"2015","unstructured":"Wu X, Wu W, Pan W et al (2015) Acute necrotizing encephalopathy: an underrecognized clinicoradiologic disorder. Mediators Inflamm 2015:792578. https:\/\/doi.org\/10.1155\/2015\/792578","journal-title":"Mediators Inflamm"},{"issue":"11","key":"13355_CR6","doi-asserted-by":"publisher","first-page":"5171","DOI":"10.1007\/s00415-023-11915-8","volume":"270","author":"C Geng","year":"2023","unstructured":"Geng C, Zhao W, Wang Z et al (2023) Acute necrotizing encephalopathy associated with COVID-19: case series and systematic review. J Neurol 270(11):5171\u20135181. https:\/\/doi.org\/10.1007\/s00415-023-11915-8","journal-title":"J Neurol"},{"key":"13355_CR7","doi-asserted-by":"publisher","DOI":"10.1016\/j.braindev.2020.08.001","author":"M Mizuguchi","year":"2021","unstructured":"Mizuguchi M, Ichiyama T, Imataka G et al (2021) Guidelines for the diagnosis and treatment of acute encephalopathy in childhood. Brain Dev. https:\/\/doi.org\/10.1016\/j.braindev.2020.08.001","journal-title":"Brain Dev"},{"issue":"4","key":"13355_CR8","doi-asserted-by":"publisher","first-page":"336","DOI":"10.3760\/cma.j.cn112140-20190812-00507","volume":"58","author":"KC Li","year":"2020","unstructured":"Li KC, Hao CJ, Qian SY et al (2020) Progress in the genetics of acute necrotizing encephalopathy in children. Zhonghua Er Ke Za Zhi = Chinese Journal of Pediatrics 58(4):336\u2013338. https:\/\/doi.org\/10.3760\/cma.j.cn112140-20190812-00507","journal-title":"Zhonghua Er Ke Za Zhi = Chinese Journal of Pediatrics"},{"key":"13355_CR9","doi-asserted-by":"publisher","DOI":"10.1016\/j.msard.2020.102194","volume":"43","author":"JM Levine","year":"2020","unstructured":"Levine JM, Ahsan N, Ho E et al (2020) Genetic acute necrotizing encephalopathy associated with RANBP2: clinical and therapeutic implications in pediatrics. Mult Scler Relat Disord 43:102194. https:\/\/doi.org\/10.1016\/j.msard.2020.102194","journal-title":"Mult Scler Relat Disord"},{"issue":"6","key":"13355_CR10","doi-asserted-by":"publisher","first-page":"400","DOI":"10.1016\/j.pediatrneurol.2011.09.007","volume":"45","author":"SM Kansagra","year":"2011","unstructured":"Kansagra SM, Gallentine WB (2011) Cytokine storm of acute necrotizing encephalopathy. Pediatr Neurol 45(6):400\u2013402. https:\/\/doi.org\/10.1016\/j.pediatrneurol.2011.09.007","journal-title":"Pediatr Neurol"},{"key":"13355_CR11","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2021.628811","volume":"12","author":"P Shukla","year":"2021","unstructured":"Shukla P, Mandalla A, Elrick MJ et al (2021) Clinical manifestations and pathogenesis of acute necrotizing encephalopathy: the interface between systemic infection and neurologic injury. Front Neurol 12:628811. https:\/\/doi.org\/10.3389\/fneur.2021.628811","journal-title":"Front Neurol"},{"issue":"10","key":"13355_CR12","doi-asserted-by":"publisher","first-page":"921","DOI":"10.1016\/j.braindev.2012.11.011","volume":"35","author":"T Yoshida","year":"2013","unstructured":"Yoshida T, Tamura T, Nagai Y et al (2013) MRI gadolinium enhancement precedes neuroradiological findings in acute necrotizing encephalopathy. Brain Dev 35(10):921\u2013924. https:\/\/doi.org\/10.1016\/j.braindev.2012.11.011","journal-title":"Brain Dev"},{"issue":"2","key":"13355_CR13","doi-asserted-by":"publisher","DOI":"10.4110\/in.2024.24.e18","volume":"24","author":"S Wang","year":"2024","unstructured":"Wang S, Wang D, Wang X et al (2024) Cytokine storm related to CD4+ T cells in influenza virus-associated acute necrotizing encephalopathy. Immune Netw 24(2):e18. https:\/\/doi.org\/10.4110\/in.2024.24.e18","journal-title":"Immune Netw"},{"issue":"3","key":"13355_CR14","doi-asserted-by":"publisher","first-page":"178","DOI":"10.1016\/j.bj.2019.01.008","volume":"42","author":"Y-Y Lin","year":"2019","unstructured":"Lin Y-Y, Lee K-Y, Ro L-S et al (2019) Clinical and cytokine profile of adult acute necrotizing encephalopathy. Biomed J 42(3):178\u2013186. https:\/\/doi.org\/10.1016\/j.bj.2019.01.008","journal-title":"Biomed J"},{"key":"13355_CR15","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1016\/j.ejpn.2024.07.009","volume":"52","author":"Y Ma","year":"2024","unstructured":"Ma Y, Liu L, Chen F et al (2024) Acute necrotizing encephalopathy infected with the SARS-CoV-2 in children: case series and literature review of clinical outcomes with the use of Tocilizumab. Eur J Paediatr Neurol 52:67\u201375. https:\/\/doi.org\/10.1016\/j.ejpn.2024.07.009","journal-title":"Eur J Paediatr Neurol"},{"issue":"5","key":"13355_CR16","doi-asserted-by":"publisher","first-page":"972","DOI":"10.1007\/s10165-012-0780-0","volume":"23","author":"J-I Kawada","year":"2013","unstructured":"Kawada J-I, Kitagawa Y, Iwata N et al (2013) Clinical characteristics of influenza virus infection in juvenile idiopathic arthritis patients treated with tocilizumab. Mod Rheumatol 23(5):972\u2013976. https:\/\/doi.org\/10.1007\/s10165-012-0780-0","journal-title":"Mod Rheumatol"},{"key":"13355_CR17","doi-asserted-by":"publisher","first-page":"80","DOI":"10.1016\/j.pediatrneurol.2019.04.009","volume":"98","author":"JC Koh","year":"2019","unstructured":"Koh JC, Murugasu A, Krishnappa J et al (2019) Favorable outcomes with early interleukin 6 receptor blockade in severe acute necrotizing encephalopathy of childhood. Pediatr Neurol 98:80\u201384. https:\/\/doi.org\/10.1016\/j.pediatrneurol.2019.04.009","journal-title":"Pediatr Neurol"},{"issue":"2","key":"13355_CR18","doi-asserted-by":"publisher","first-page":"116","DOI":"10.36519\/idcm.2022.116","volume":"4","author":"LN Altunal","year":"2022","unstructured":"Altunal LN, Ayd\u0131n M, \u00d6zel AS et al (2022) Appropriate use of Tocilizumab in COVID-19: early use is beneficial. Infect Dis Clin Microbiol 4(2):116\u2013121. https:\/\/doi.org\/10.36519\/idcm.2022.116","journal-title":"Infect Dis Clin Microbiol"},{"issue":"10","key":"13355_CR19","doi-asserted-by":"publisher","first-page":"547","DOI":"10.1016\/j.braindev.2023.06.004","volume":"45","author":"MA Anuar","year":"2023","unstructured":"Anuar MA, Lee JX, Musa H et al (2023) Severe and rare neurological manifestations following COVID-19 infection in children: a Malaysian tertiary centre experience. Brain Dev 45(10):547\u2013553. https:\/\/doi.org\/10.1016\/j.braindev.2023.06.004","journal-title":"Brain Dev"},{"issue":"7","key":"13355_CR20","doi-asserted-by":"publisher","first-page":"401","DOI":"10.1016\/j.braindev.2023.03.002","volume":"45","author":"PH Hosie","year":"2023","unstructured":"Hosie PH, Lim C, Scott TRD et al (2023) Treatment of severe acute necrotizing encephalopathy of childhood with interleukin-6 receptor blockade in the first 24 h as add-on immunotherapy shows favorable long-term outcome at 2 years. Brain Dev 45(7):401\u2013407. https:\/\/doi.org\/10.1016\/j.braindev.2023.03.002","journal-title":"Brain Dev"},{"issue":"1","key":"13355_CR21","doi-asserted-by":"publisher","DOI":"10.1212\/NXI.0000000000200186","volume":"11","author":"VW Lee","year":"2024","unstructured":"Lee VW, Kam KQ, Mohamed AR et al (2024) Defining the clinicoradiologic syndrome of SARS-CoV-2 acute necrotizing encephalopathy: a systematic review and 3 new pediatric cases. Neurology(R) Neuroimmunol Neuroinflamm 11(1):e200186. https:\/\/doi.org\/10.1212\/NXI.0000000000200186","journal-title":"Neurology(R) Neuroimmunol Neuroinflamm"},{"key":"13355_CR22","doi-asserted-by":"publisher","first-page":"160","DOI":"10.1016\/j.jpeds.2022.04.031","volume":"247","author":"M Khan","year":"2022","unstructured":"Khan M, Bhattarai S, Boyce TG et al (2022) Acute necrotizing encephalopathy associated with coronavirus disease 2019 in an infant. J Pediatr 247:160\u2013162. https:\/\/doi.org\/10.1016\/j.jpeds.2022.04.031","journal-title":"J Pediatr"},{"issue":"9","key":"13355_CR23","doi-asserted-by":"publisher","first-page":"1256","DOI":"10.1111\/dmcn.15536","volume":"65","author":"VWM Lee","year":"2023","unstructured":"Lee VWM, Khoo TB, Teh CM et al (2023) Factors associated with outcomes of severe acute necrotizing encephalopathy: a multicentre experience in Malaysia. Dev Med Child Neurol 65(9):1256\u20131263. https:\/\/doi.org\/10.1111\/dmcn.15536","journal-title":"Dev Med Child Neurol"},{"key":"13355_CR24","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1016\/j.pediatrneurol.2022.11.010","volume":"139","author":"JHY Ho","year":"2023","unstructured":"Ho JHY, Lee CYM, Chiong YK et al (2023) SARS-CoV-2-related acute necrotizing encephalopathy of childhood with good response to Tocilizumab in an adolescent. Pediatr Neurol 139:65\u201369. https:\/\/doi.org\/10.1016\/j.pediatrneurol.2022.11.010","journal-title":"Pediatr Neurol"},{"issue":"7","key":"13355_CR25","doi-asserted-by":"publisher","first-page":"517","DOI":"10.1177\/0883073820984063","volume":"36","author":"B Appavu","year":"2021","unstructured":"Appavu B, Foldes S, Fox J et al (2021) Treatment timing, EEG, neuroimaging, and outcomes after acute necrotizing encephalopathy in children. J Child Neurol 36(7):517\u2013524. https:\/\/doi.org\/10.1177\/0883073820984063","journal-title":"J Child Neurol"},{"key":"13355_CR26","doi-asserted-by":"publisher","DOI":"10.3389\/fped.2023.1209772","author":"YC Chao","year":"2023","unstructured":"Chao YC, Yang HW, Chang L et al (2023) Case report: presentations and cytokine profiles of inflammatory non-pulmonary COVID-19 and related diseases in children. Front Pediatr. https:\/\/doi.org\/10.3389\/fped.2023.1209772","journal-title":"Front Pediatr"},{"key":"13355_CR27","doi-asserted-by":"publisher","DOI":"10.3389\/fped.2024.1351478","author":"Y Huang","year":"2024","unstructured":"Huang Y, Zhou B, Hong S et al (2024) A case report and literature review on tocilizumab-cured acute necrotizing encephalopathy caused by influenza A virus. Front Pediatr. https:\/\/doi.org\/10.3389\/fped.2024.1351478","journal-title":"Front Pediatr"},{"issue":"1","key":"13355_CR28","doi-asserted-by":"publisher","first-page":"28","DOI":"10.1111\/jpc.16506","volume":"60","author":"JW Tang","year":"2024","unstructured":"Tang JW, Ritchie B, Taranath A et al (2024) Case of acute necrotising encephalopathy of childhood secondary to severe acute respiratory syndrome coronavirus 2 infection. J Paediatr Child Health 60(1):28\u201330. https:\/\/doi.org\/10.1111\/jpc.16506","journal-title":"J Paediatr Child Health"},{"issue":"4","key":"13355_CR29","doi-asserted-by":"publisher","first-page":"290","DOI":"10.1002\/ped4.12406","volume":"7","author":"J Li","year":"2023","unstructured":"Li J, Huo F, Wang S et al (2023) Recurrent infection triggered encephalopathy syndrome in a pediatric patient with RANBP2 mutation and severe acute respiratory syndrome coronavirus 2 infection. Pediatr Investig 7(4):290\u2013296. https:\/\/doi.org\/10.1002\/ped4.12406","journal-title":"Pediatr Investig"},{"key":"13355_CR30","doi-asserted-by":"publisher","DOI":"10.12659\/MSM.928374","volume":"27","author":"Y Song","year":"2021","unstructured":"Song Y, Li S, Xiao W et al (2021) Influenza-associated encephalopathy and acute necrotizing encephalopathy in children: a retrospective single-center study. Med Sci Monit 27:e928374. https:\/\/doi.org\/10.12659\/MSM.928374","journal-title":"Med Sci Monit"},{"issue":"19","key":"13355_CR31","doi-asserted-by":"publisher","DOI":"10.3346\/jkms.2019.34.e143","volume":"34","author":"YJ Lee","year":"2019","unstructured":"Lee YJ, Hwang SK, Kwon S (2019) Acute necrotizing encephalopathy in children: a long way to go. J Korean Med Sci 34(19):e143. https:\/\/doi.org\/10.3346\/jkms.2019.34.e143","journal-title":"J Korean Med Sci"},{"issue":"6","key":"13355_CR32","doi-asserted-by":"publisher","first-page":"1545","DOI":"10.1007\/s00415-012-6825-7","volume":"260","author":"K Wolf","year":"2013","unstructured":"Wolf K, Schmitt-Mechelke T, Kollias S et al (2013) Acute necrotizing encephalopathy (ANE1): rare autosomal-dominant disorder presenting as acute transverse myelitis. J Neurol 260(6):1545\u20131553. https:\/\/doi.org\/10.1007\/s00415-012-6825-7","journal-title":"J Neurol"},{"issue":"12","key":"13355_CR33","doi-asserted-by":"publisher","first-page":"1539","DOI":"10.1177\/0883073810374877","volume":"25","author":"W-C Weng","year":"2010","unstructured":"Weng W-C, Peng SS-F, Lee W-T (2010) Acute necrotizing encephalopathy of childhood with spinal cord involvement: a case report. J Child Neurol 25(12):1539\u20131541. https:\/\/doi.org\/10.1177\/0883073810374877","journal-title":"J Child Neurol"},{"issue":"12","key":"13355_CR34","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000025171","volume":"100","author":"Y-J Park","year":"2021","unstructured":"Park Y-J, Hwang J-Y, Kim Y-W et al (2021) Radiological manifestation of familial acute necrotizing encephalopathy with RANBP2 mutation in a far-East Asian family: case report. Medicine (Baltimore) 100(12):e25171. https:\/\/doi.org\/10.1097\/MD.0000000000025171","journal-title":"Medicine (Baltimore)"},{"key":"13355_CR35","doi-asserted-by":"publisher","first-page":"6695119","DOI":"10.1155\/2021\/6695119","volume":"2021","author":"M Paktinat","year":"2021","unstructured":"Paktinat M, Hessami K, Inaloo S et al (2021) Case Report of RANBP2 Mutation and Familial Acute Necrotizing Encephalopathy. Int J Pediatr 2021:6695119. https:\/\/doi.org\/10.1155\/2021\/6695119","journal-title":"Int J Pediatr"},{"issue":"1","key":"13355_CR36","doi-asserted-by":"publisher","first-page":"44","DOI":"10.1016\/j.ajhg.2008.12.009","volume":"84","author":"DE Neilson","year":"2009","unstructured":"Neilson DE, Adams MD, Orr CMD et al (2009) Infection-triggered familial or recurrent cases of acute necrotizing encephalopathy caused by mutations in a component of the nuclear pore, RANBP2. Am J Hum Genet 84(1):44\u201351. https:\/\/doi.org\/10.1016\/j.ajhg.2008.12.009","journal-title":"Am J Hum Genet"},{"key":"13355_CR37","doi-asserted-by":"publisher","DOI":"10.3389\/fped.2022.947693","volume":"10","author":"X Fan","year":"2022","unstructured":"Fan X, Huang L, Li S et al (2022) Clinical evaluation of acute necrotizing encephalopathy in children. Front Pediatr 10:947693. https:\/\/doi.org\/10.3389\/fped.2022.947693","journal-title":"Front Pediatr"},{"issue":"3","key":"13355_CR38","doi-asserted-by":"publisher","first-page":"639","DOI":"10.1007\/s10072-018-3623-8","volume":"40","author":"V Stevanovi\u0107","year":"2019","unstructured":"Stevanovi\u0107 V, Baru\u0161i\u0107 Z, Vi\u0161kovi\u0107 K et al (2019) Acute necrotizing encephalopathy of childhood associated with human herpes virus 6 in Croatia. Neurol Sci 40(3):639\u2013641. https:\/\/doi.org\/10.1007\/s10072-018-3623-8","journal-title":"Neurol Sci"},{"issue":"3","key":"13355_CR39","doi-asserted-by":"publisher","first-page":"221","DOI":"10.1016\/j.braindev.2008.03.005","volume":"31","author":"A Okumura","year":"2009","unstructured":"Okumura A, Mizuguchi M, Kidokoro H et al (2009) Outcome of acute necrotizing encephalopathy in relation to treatment with corticosteroids and gammaglobulin. Brain Dev 31(3):221\u2013227. https:\/\/doi.org\/10.1016\/j.braindev.2008.03.005","journal-title":"Brain Dev"},{"issue":"10","key":"13355_CR40","doi-asserted-by":"publisher","first-page":"7042","DOI":"10.1007\/s00415-024-12661-1","volume":"271","author":"A Balck","year":"2024","unstructured":"Balck A, Lange LM, Neumann A et al (2024) Highly beneficial outcome in severe acute necrotizing encephalopathy with tocilizumab treatment. J Neurol 271(10):7042\u20137045. https:\/\/doi.org\/10.1007\/s00415-024-12661-1","journal-title":"J Neurol"},{"issue":"8","key":"13355_CR41","doi-asserted-by":"publisher","first-page":"764","DOI":"10.3760\/cma.j.cn112140-20240226-00124","volume":"62","author":"YP Zhou","year":"2024","unstructured":"Zhou YP, Chen WM, Zhu XD et al (2024) Primary observational study of tocilizumab in children with severe acute necrotizing encephalopathy. Zhonghua Er Ke Za Zhi Chin J Pediatrics 62(8):764\u2013769. https:\/\/doi.org\/10.3760\/cma.j.cn112140-20240226-00124","journal-title":"Zhonghua Er Ke Za Zhi Chin J Pediatrics"}],"container-title":["Journal of Neurology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00415-025-13355-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00415-025-13355-y\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00415-025-13355-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,15]],"date-time":"2025-10-15T10:35:03Z","timestamp":1760524503000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00415-025-13355-y"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9]]},"references-count":41,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2025,9]]}},"alternative-id":["13355"],"URL":"https:\/\/doi.org\/10.1007\/s00415-025-13355-y","relation":{},"ISSN":["0340-5354","1432-1459"],"issn-type":[{"value":"0340-5354","type":"print"},{"value":"1432-1459","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,9]]},"assertion":[{"value":"20 July 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"12 August 2025","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"23 August 2025","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"7 September 2025","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"On behalf of all authors, the corresponding author states that there is no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflicts of interest"}}],"article-number":"618"}}