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Grey matter (GM) changes are well documented in MS, and GM atrophy is common in older adults. The relationship between GM changes and mobility disability in OAMS is unknown. We sought to identify GM patterns associated with gait speed in OAMS and healthy older controls, using structural covariance network analysis. OAMS (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u2009102; 64.8\u2009\u00b1\u20094.4\u00a0years) and healthy controls (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u2009106; 68.2\u2009\u00b1\u20097.3\u00a0years) underwent brain MRI and gait assessments; structural covariance networks were constructed to elucidate brain regions with significant associations between GM volume and 25-foot walk gait speed. We used voxel-wise linear regression analyses to elucidate per-network subregions with significant correlations with gait speed. Voxel-wise moderation analysis tested for group differences in these associations. Across the entire cohort, the following networks demonstrated significant gait speed associations: bilateral hippocampus, bilateral caudate\/pallidum\/putamen, bilateral thalamus\/putamen, right middle temporal gyrus and multiple cerebellar regions. There were no significant group-by-network interaction effects. In summary, structural network analysis reveals unique brain patterns of gait speed in older adults, but these patterns are common amongst healthy older adults and OAMS and highlight the importance of cerebellar and subcortical networks in supporting gait speed.\n                  <\/jats:p>","DOI":"10.1007\/s00415-025-13373-w","type":"journal-article","created":{"date-parts":[[2025,9,26]],"date-time":"2025-09-26T18:11:32Z","timestamp":1758910292000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Grey matter atrophy patterns of mobility shared across older adults with and without multiple sclerosis"],"prefix":"10.1007","volume":"272","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2258-6933","authenticated-orcid":false,"given":"Mark E.","family":"Wagshul","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siddharth","family":"Nayak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frederick W.","family":"Foley","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert W.","family":"Motl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manuel E.","family":"Hernandez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meltem","family":"Izzetoglu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roee","family":"Holtzer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,9,26]]},"reference":[{"key":"13373_CR1","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1186\/s12877-025-05683-5","volume":"25","author":"JSR Alex","year":"2025","unstructured":"Alex JSR, Roshini R, Maneesha G, Aparajeeta J, Priyadarshini B, Lin CY, Lung CW (2025) Enhanced detection of mild cognitive impairment in Alzheimer\u2019s disease: a hybrid model integrating dual biomarkers and advanced machine learning. 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The funders had no role in the design of the study; in the collection, analyses, or interpretation of data; in the writing of the manuscript; or in the decision to publish the results.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"The work described in this manuscript has been executed in adherence with The Code of Ethics of the World Medical Association (Declaration of Helsinki)\n                      .\n                      The Albert Einstein College of Medicine Institutional Review Board approved this study (IRB #: 2019\u201310049). All participants signed written informed consents at the first in-person study visit.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}}],"article-number":"656"}}