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SMD has no conflicts of interest. LREM declares fees for lectures or assistance to congresses from Alter, Bristol Myers Squibb, Daiichi Sankyo, Merck, Novartis, and Roche. APS has received personal compensation from Merck Serono, Novartis, Roche, and Sandoz for serving on a scientific advisory board or speaking.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interests"}},{"value":"This study received ethical approval from the Ethics Committee for Medical Research (IRB) of the Health Department of Alicante\u2013General Hospital in Alicante, Spain (approval PI2024-014) on March 28, 2024. This is an IRB-approved retrospective study, all patient information was de-identified and patient consent was not required. 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