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However, systematic descriptions of apraxic deficits in AD patients remain scarce. Here, we comprehensively investigate apraxia profiles and their link with cognitive impairment in patients with biomarker-verified Alzheimer\u2019s pathology. We characterised the frequency and patterns of apraxic deficits in patients with biomarker-verified Alzheimer\u2019s pathology using a battery of standardised apraxia tests. Demographic variables and apraxia scores were related to patients\u2019 general cognitive impairment using hierarchical regression analysis. Apraxic deficits were found in 67% of patients with biomarker-verified Alzheimer\u2019s pathology (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u200963). Patients with Alzheimer\u2019s pathology were more impaired in imitating finger gestures (than hand gestures: 89.2% vs. 80.0%,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.001) and imitating complex hand movements (than single hand movements: 97.4% vs. 78.5%,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.001), even when controlling for general cognitive impairment. Apraxia assessments explained about 60% of the variance in dementia severity, with performance in the KAS subtest of pantomiming object use (beta coefficient: 0.47,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.001) and the DATE subtest for limb apraxia (beta coefficient: 0.37,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.005) constituting significant predictors of general cognitive impairment. These findings emphasise the relevance of apraxia in patients with biomarker-verified Alzheimer\u2019s pathology, revealing that praxis deficits predict general cognitive impairment in AD. Further research is warranted into the role of apraxia as a potential early diagnostic criterion in AD.\n                  <\/jats:p>","DOI":"10.1007\/s00415-025-13401-9","type":"journal-article","created":{"date-parts":[[2025,9,25]],"date-time":"2025-09-25T19:58:46Z","timestamp":1758830326000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Apraxic deficits predict general cognitive impairment in patients with biomarker-verified Alzheimer\u2019s pathology"],"prefix":"10.1007","volume":"272","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1296-577X","authenticated-orcid":false,"given":"Claudia C.","family":"Schmidt","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michella M.","family":"Bardakan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elena","family":"Jaeger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nils","family":"Richter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G\u00e9rard N.","family":"Bischof","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathrin","family":"Giehl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oezguer A.","family":"Onur","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frank","family":"Jessen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gereon R.","family":"Fink","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander","family":"Drzezga","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter H.","family":"Weiss","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,9,25]]},"reference":[{"key":"13401_CR1","doi-asserted-by":"publisher","first-page":"1019","DOI":"10.1016\/S0140-6736(10)61349-9","volume":"377","author":"C Ballard","year":"2011","unstructured":"Ballard C, Gauthier S, Corbett A, Brayne C, Aarsland D, Jones E (2011) Alzheimer\u2019s disease. 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