{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T08:14:18Z","timestamp":1783498458920,"version":"3.55.0"},"reference-count":24,"publisher":"Springer Science and Business Media LLC","issue":"7","license":[{"start":{"date-parts":[[2026,6,8]],"date-time":"2026-06-08T00:00:00Z","timestamp":1780876800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2026,6,8]],"date-time":"2026-06-08T00:00:00Z","timestamp":1780876800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100004434","name":"Universit\u00e0 degli Studi di Firenze","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100004434","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Neurol"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>We investigated the etiology, safety and efficacy of endovascular treatment with and without stent placement as rescue treatment in patients with acute ischemic stroke due to basilar artery occlusion (BAO).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A Single-center retrospective observational study in consecutive patients with BAO treated with endovascular procedures, divided into stent and non-stent groups. Outcomes of interest were: stroke etiology; recanalization of the basilar artery defined as mTICI\u2009\u2265\u20092b; any intracranial hemorrhage; poor functional outcome (mRS 4\u20136) at 3\u00a0months. Independent associations were investigated with multivariable logistic and ordinal regression analyses adjusted for age, sex, NIHSS, rt-PA use and time-to-groin.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The analysis included 121 patients with a mean age of 70 (\u00b1\u200914) years; 48 (40%) were female. The median NIHSS score was 14 (IQR 6\u201336). Stent placement was performed in 28 patients (23%), mainly in those with atherosclerosis and artery dissection. Recanalization occurred in 110 (91%) patients, 79% in the stent group patients and 94% in the non-stent group. Ordinal analysis demonstrated higher risk of worse outcome in the stent group (OR\u2009=\u20093.73; 95%CI\u2009=\u20091.46\u20139.57); however, all patients without vessel recanalization had poor functional outcome. Periprocedural complications, particularly vessel perforation (14% vs 2%,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001), were more frequent in the stent group, whereas intracranial hemorrhage was similar between groups (7% vs 2%,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.200).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Stent placement was more frequent in patients with stroke due to atherosclerosis or artery dissection and was associated with higher rates of procedural complications and poor functional outcome. However, stenting represents an acceptable option for rescue therapy in BAO due to the high burden of disease in patients who did not achieve vessel recanalization.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1007\/s00415-026-13922-x","type":"journal-article","created":{"date-parts":[[2026,6,8]],"date-time":"2026-06-08T05:31:56Z","timestamp":1780896716000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Stent placement as rescue treatment in acute basilar artery occlusion"],"prefix":"10.1007","volume":"273","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-8196-9915","authenticated-orcid":false,"given":"Susanna","family":"Sammali","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danilo","family":"Caimano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Capasso","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leonardo","family":"Renieri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Poggesi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristina","family":"Sarti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesca","family":"Pescini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Lamassa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benedetta","family":"Piccardi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vanessa","family":"Palumbo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mascia","family":"Nesi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicola","family":"Limbucci","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio","family":"Laiso","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giorgio","family":"Busto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Enrico","family":"Fainardi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrizia","family":"Nencini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Arba","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,6,8]]},"reference":[{"key":"13922_CR1","doi-asserted-by":"publisher","first-page":"1002","DOI":"10.1016\/S1474-4422(11)70229-0","volume":"10","author":"HP Mattle","year":"2011","unstructured":"Mattle HP, Arnold M, Lindsberg PJ et al (2011) Basilar artery occlusion. Lancet Neurol 10:1002\u20131014. https:\/\/doi.org\/10.1016\/S1474-4422(11)70229-0","journal-title":"Lancet Neurol"},{"key":"13922_CR2","doi-asserted-by":"publisher","DOI":"10.1016\/j.inat.2023.101811","volume":"34","author":"DD Thuan","year":"2023","unstructured":"Thuan DD, Duc DP, Ha PT et al (2023) Misdiagnosis of acute basilar artery occlusion (BAOs) in the emergency department in Vietnam: a single-center, retrospective, cross-sectional study. Interdiscip Neurosurg 34:101811. https:\/\/doi.org\/10.1016\/j.inat.2023.101811","journal-title":"Interdiscip Neurosurg"},{"key":"13922_CR3","doi-asserted-by":"publisher","first-page":"561","DOI":"10.1001\/jamaneurol.2020.0156","volume":"77","author":"W Zi","year":"2020","unstructured":"Zi W, Qiu Z, Wu D et al (2020) Assessment of endovascular treatment for acute basilar artery occlusion via a Nationwide Prospective Registry. JAMA Neurol 77:561\u2013573. https:\/\/doi.org\/10.1001\/jamaneurol.2020.0156","journal-title":"JAMA Neurol"},{"key":"13922_CR4","doi-asserted-by":"publisher","first-page":"2296","DOI":"10.1056\/NEJMoa1503780","volume":"372","author":"TG Jovin","year":"2015","unstructured":"Jovin TG, Chamorro A, Cobo E et al (2015) Thrombectomy within 8 h after symptom onset in ischemic stroke. N Engl J Med 372:2296\u20132306. https:\/\/doi.org\/10.1056\/NEJMoa1503780","journal-title":"N Engl J Med"},{"key":"13922_CR5","doi-asserted-by":"publisher","first-page":"1361","DOI":"10.1056\/NEJMoa2206317","volume":"387","author":"C Tao","year":"2022","unstructured":"Tao C, Nogueira RG, Zhu Y et al (2022) Trial of endovascular treatment of acute basilar-artery occlusion. N Engl J Med 387:1361\u20131372. https:\/\/doi.org\/10.1056\/NEJMoa2206317","journal-title":"N Engl J Med"},{"key":"13922_CR6","doi-asserted-by":"publisher","first-page":"579","DOI":"10.1111\/ene.14126","volume":"27","author":"MA Hawkes","year":"2020","unstructured":"Hawkes MA, Blaginykh E, Ruff MW et al (2020) Long-term mortality, disability and stroke recurrence in patients with basilar artery occlusion. Eur J Neurol 27:579\u2013585. https:\/\/doi.org\/10.1111\/ene.14126","journal-title":"Eur J Neurol"},{"key":"13922_CR7","doi-asserted-by":"publisher","first-page":"724","DOI":"10.1016\/S1474-4422(09)70173-5","volume":"8","author":"WJ Schonewille","year":"2009","unstructured":"Schonewille WJ, Wijman CAC, Michel P et al (2009) Treatment and outcomes of acute basilar artery occlusion in the Basilar Artery International Cooperation Study (BASICS): a prospective registry study. Lancet Neurol 8:724\u2013730. https:\/\/doi.org\/10.1016\/S1474-4422(09)70173-5","journal-title":"Lancet Neurol"},{"key":"13922_CR8","doi-asserted-by":"publisher","first-page":"2360","DOI":"10.1161\/STROKEAHA.116.014073","volume":"47","author":"JH Baek","year":"2016","unstructured":"Baek JH, Kim BM, Kim DJ et al (2016) Stenting as a rescue treatment after failure of mechanical thrombectomy for anterior circulation large artery occlusion. Stroke 47:2360\u20132363. https:\/\/doi.org\/10.1161\/STROKEAHA.116.014073","journal-title":"Stroke"},{"key":"13922_CR9","doi-asserted-by":"publisher","first-page":"1009","DOI":"10.1056\/NEJMoa1414792","volume":"372","author":"BCV Campbell","year":"2015","unstructured":"Campbell BCV, Mitchell PJ, Kleinig TJ et al (2015) Endovascular therapy for ischemic stroke with perfusion-imaging selection. N Engl J Med 372:1009\u20131018. https:\/\/doi.org\/10.1056\/NEJMoa1414792","journal-title":"N Engl J Med"},{"key":"13922_CR10","doi-asserted-by":"publisher","first-page":"1019","DOI":"10.1056\/NEJMoa1414905","volume":"372","author":"M Goyal","year":"2015","unstructured":"Goyal M, Demchuk AM, Menon BK et al (2015) Randomized assessment of rapid endovascular treatment of ischemic stroke. N Engl J Med 372:1019\u20131030. https:\/\/doi.org\/10.1056\/NEJMoa1414905","journal-title":"N Engl J Med"},{"key":"13922_CR11","doi-asserted-by":"publisher","first-page":"2285","DOI":"10.1056\/NEJMoa1415061","volume":"372","author":"JL Saver","year":"2015","unstructured":"Saver JL, Goyal M, Bonafe A, Diener H et al (2015) Stent-retriever thrombectomy after intravenous t-PA vs. t-PA alone in stroke. N Engl J Med 372:2285\u20132295. https:\/\/doi.org\/10.1056\/NEJMoa1415061","journal-title":"N Engl J Med"},{"key":"13922_CR12","doi-asserted-by":"publisher","first-page":"1373","DOI":"10.1056\/NEJMoa2207576","volume":"387","author":"TG Jovin","year":"2022","unstructured":"Jovin TG, Li C, Wu L et al (2022) Trial of thrombectomy 6 to 24 hours after stroke due to basilar-artery occlusion. N Engl J Med 387:1373\u20131384. https:\/\/doi.org\/10.1056\/NEJMoa2207576","journal-title":"N Engl J Med"},{"key":"13922_CR13","doi-asserted-by":"publisher","DOI":"10.1161\/SVIN.123.000885","volume":"3","author":"KS Asif","year":"2023","unstructured":"Asif KS, Novakovic R, Nguyen TN et al (2023) Endovascular treatment in acute basilar artery occlusion stroke: A brief practice update from the Society of Vascular and Interventional Neurology. Stroke Vasc Interv Neurol 3:e000885. https:\/\/doi.org\/10.1161\/SVIN.123.000885","journal-title":"Stroke Vasc Interv Neurol"},{"key":"13922_CR14","doi-asserted-by":"publisher","first-page":"95","DOI":"10.1161\/01.STR.31.1.95","volume":"31","author":"CR Gomez","year":"2000","unstructured":"Gomez CR, Misra VK, Liu MW et al (2000) Elective stenting of symptomatic basilar artery stenosis. Stroke 31:95\u201399. https:\/\/doi.org\/10.1161\/01.STR.31.1.95","journal-title":"Stroke"},{"key":"13922_CR15","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2021.739213","volume":"12","author":"G Luo","year":"2021","unstructured":"Luo G, Gao F, Zhang X et al (2021) Intracranial stenting as rescue therapy after failure of mechanical thrombectomy for basilar artery occlusion: data from the ANGEL-ACT Registry. Front Neurol 12:739213. https:\/\/doi.org\/10.3389\/fneur.2021.739213","journal-title":"Front Neurol"},{"key":"13922_CR16","doi-asserted-by":"publisher","first-page":"577","DOI":"10.1001\/jamasurg.2021.0528","volume":"156","author":"AA Ghaferi","year":"2021","unstructured":"Ghaferi AA, Schwartz TA, Pawlik TM (2021) STROBE reporting guidelines for observational studies. JAMA Surg 156:577\u2013578. https:\/\/doi.org\/10.1001\/jamasurg.2021.0528","journal-title":"JAMA Surg"},{"key":"13922_CR17","doi-asserted-by":"publisher","first-page":"2650","DOI":"10.1161\/STROKEAHA.113.001972","volume":"44","author":"O Zaidat","year":"2013","unstructured":"Zaidat O, Yoo A, Khatri P et al (2013) Recommendations on angiographic revascularization grading standards for acute ischemic stroke: a consensus statement. Stroke 44:2650\u20132663. https:\/\/doi.org\/10.1161\/STROKEAHA.113.001972","journal-title":"Stroke"},{"key":"13922_CR18","doi-asserted-by":"publisher","first-page":"1127","DOI":"10.1161\/STROKEAHA.122.040807","volume":"54","author":"F Alemseged","year":"2023","unstructured":"Alemseged F, Nguyen TN, Alverne FM et al (2023) Endovascular therapy for basilar artery occlusion. Stroke 54:1127\u20131137. https:\/\/doi.org\/10.1161\/STROKEAHA.122.040807","journal-title":"Stroke"},{"key":"13922_CR19","doi-asserted-by":"publisher","first-page":"816","DOI":"10.1111\/ene.14628","volume":"28","author":"J Ritvonen","year":"2021","unstructured":"Ritvonen J, Sairanen T, Silvennoinen H et al (2021) Outcomes and long-term mortality after basilar artery occlusion\u2014a cohort with up to 20 years\u2019 follow-up. Eur J Neurol 28:816\u2013822. https:\/\/doi.org\/10.1111\/ene.14628","journal-title":"Eur J Neurol"},{"key":"13922_CR20","doi-asserted-by":"publisher","first-page":"967","DOI":"10.1161\/01.STR.0000258112.14918.24","volume":"38","author":"JH Rha","year":"2007","unstructured":"Rha JH, Saver JL (2007) The impact of recanalization on ischemic stroke outcome: a meta-analysis. Stroke 38:967\u2013973. https:\/\/doi.org\/10.1161\/01.STR.0000258112.14918.24","journal-title":"Stroke"},{"key":"13922_CR21","doi-asserted-by":"publisher","first-page":"835","DOI":"10.1177\/23969873241257223","volume":"9","author":"D Strbian","year":"2024","unstructured":"Strbian D, Tsivgoulis G, Ospel J et al (2024) European Stroke Organisation (ESO) and European Society for Minimally Invasive Neurological Therapy (ESMINT) guideline on acute management of basilar artery occlusion. Eur Stroke J 9:835\u2013884. https:\/\/doi.org\/10.1177\/23969873241257223","journal-title":"Eur Stroke J"},{"key":"13922_CR22","doi-asserted-by":"publisher","first-page":"1","DOI":"10.7461\/jcen.2025.E2024.11.003","volume":"27","author":"S Choi","year":"2025","unstructured":"Choi S, Kang CH, Kim JG et al (2025) Rescue angioplasty and stenting in refractory acute vertebrobasilar occlusion after mechanical thrombectomy: a single center experience. J Cerebrovasc Endovasc Neurosurg 27:1\u201379. https:\/\/doi.org\/10.7461\/jcen.2025.E2024.11.003","journal-title":"J Cerebrovasc Endovasc Neurosurg"},{"key":"13922_CR23","doi-asserted-by":"publisher","first-page":"129","DOI":"10.3988\/jcn.2016.12.2.129","volume":"12","author":"OY Bang","year":"2016","unstructured":"Bang OY (2016) Considerations when subtyping ischemic stroke in Asian patients. J Clin Neurol 12:129\u2013136. https:\/\/doi.org\/10.3988\/jcn.2016.12.2.129","journal-title":"J Clin Neurol"},{"key":"13922_CR24","doi-asserted-by":"publisher","first-page":"219","DOI":"10.7861\/clinmed.2022-0499","volume":"23","author":"AM Schneider","year":"2023","unstructured":"Schneider AM, Neuhaus AA, Hadley G et al (2023) Posterior circulation ischaemic stroke diagnosis and management. Clin Med 23:219\u2013227. https:\/\/doi.org\/10.7861\/clinmed.2022-0499","journal-title":"Clin Med"}],"container-title":["Journal of Neurology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00415-026-13922-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00415-026-13922-x","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00415-026-13922-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T07:22:01Z","timestamp":1783495321000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00415-026-13922-x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6,8]]},"references-count":24,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2026,7]]}},"alternative-id":["13922"],"URL":"https:\/\/doi.org\/10.1007\/s00415-026-13922-x","relation":{},"ISSN":["0340-5354","1432-1459"],"issn-type":[{"value":"0340-5354","type":"print"},{"value":"1432-1459","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,6,8]]},"assertion":[{"value":"6 January 2026","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"26 March 2026","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"28 May 2026","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"8 June 2026","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"None declared.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflicts of interest"}},{"value":"The study was conducted in accordance with European ethical guidelines, and informed consent was obtained from all patients.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}}],"article-number":"376"}}