{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T06:31:44Z","timestamp":1791873104215,"version":"4.3.4"},"reference-count":54,"publisher":"Springer Science and Business Media LLC","issue":"7","license":[{"start":{"date-parts":[[2026,6,20]],"date-time":"2026-06-20T00:00:00Z","timestamp":1781913600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,6,20]],"date-time":"2026-06-20T00:00:00Z","timestamp":1781913600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82471199"],"award-info":[{"award-number":["82471199"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82171582"],"award-info":[{"award-number":["82171582"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Neurol"],"published-print":{"date-parts":[[2026,7]]},"DOI":"10.1007\/s00415-026-13954-3","type":"journal-article","created":{"date-parts":[[2026,6,20]],"date-time":"2026-06-20T15:29:49Z","timestamp":1781969389000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Plasma p-Tau217 and A\u03b242\/A\u03b240 mediate the association between minimal depressive symptoms and cognitive impairment"],"prefix":"10.1007","volume":"273","author":[{"given":"Yuhan","family":"Chen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhibo","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huan","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haoxuan","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zixuan","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huixian","family":"Cui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sha","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"for the Alzheimer\u2019s Disease Neuroimaging Initiative","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,6,20]]},"reference":[{"key":"13954_CR1","doi-asserted-by":"publisher","first-page":"3708","DOI":"10.1002\/alz.13809","volume":"20","author":"Alzheimer's disease facts and figures","year":"2024","unstructured":"Alzheimer\u2019s disease facts and figures (2024) Alzheimers Dement 20:3708\u20133821","journal-title":"Alzheimers Dement"},{"key":"13954_CR2","doi-asserted-by":"publisher","first-page":"312","DOI":"10.1016\/j.cell.2019.09.001","volume":"179","author":"JM Long","year":"2019","unstructured":"Long JM, Holtzman DM (2019) Alzheimer Disease: An Update on Pathobiology and Treatment Strategies. Cell 179:312\u2013339","journal-title":"Cell"},{"key":"13954_CR3","doi-asserted-by":"publisher","first-page":"1577","DOI":"10.1016\/S0140-6736(20)32205-4","volume":"397","author":"P Scheltens","year":"2021","unstructured":"Scheltens P, De Strooper B, Kivipelto M, Holstege H, Ch\u00e9telat G, Teunissen CE et al (2021) Alzheimer\u2019s disease. Lancet 397:1577\u20131590","journal-title":"Lancet"},{"key":"13954_CR4","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1038\/s41572-021-00269-y","volume":"7","author":"DS Knopman","year":"2021","unstructured":"Knopman DS, Amieva H, Petersen RC, Ch\u00e9telat G, Holtzman DM, Hyman BT et al (2021) Alzheimer disease Nat Rev Dis Primers 7:33","journal-title":"Alzheimer disease Nat Rev Dis Primers"},{"key":"13954_CR5","doi-asserted-by":"publisher","DOI":"10.1002\/alz.14434","volume":"21","author":"LL Gibson","year":"2025","unstructured":"Gibson LL, Gonzalez MC, Ashton NJ, Tovar-Rios D, Blanc F, Pilotto A et al (2025) Plasma phosphorylated tau and neuropsychiatric symptoms in dementia with Lewy bodies. Alzheimers Dement 21:e14434","journal-title":"Alzheimers Dement"},{"key":"13954_CR6","doi-asserted-by":"publisher","first-page":"179","DOI":"10.1186\/s13195-024-01550-4","volume":"16","author":"X Liu","year":"2024","unstructured":"Liu X, Yu GX, Xue M, Huang LY, Fu Y, Wang ZT et al (2024) The interrelationships of CSF sTREM2, AD pathology, minimal depressive symptoms, and cognition in non-demented adults. Alzheimers Res Ther 16:179","journal-title":"Alzheimers Res Ther"},{"key":"13954_CR7","doi-asserted-by":"publisher","DOI":"10.3389\/fnagi.2024.1301854","volume":"16","author":"YH Chen","year":"2024","unstructured":"Chen YH, Wang ZB, Liu XP, Xu JP, Mao ZQ (2024) Sex differences in the relationship between depression and Alzheimer\u2019s disease-mechanisms, genetics, and therapeutic opportunities. Front Aging Neurosci 16:1301854","journal-title":"Front Aging Neurosci"},{"key":"13954_CR8","doi-asserted-by":"publisher","first-page":"766","DOI":"10.1016\/j.biopsych.2020.07.004","volume":"89","author":"W Xu","year":"2021","unstructured":"Xu W, Feng W, Shen XN, Bi YL, Ma YH, Li JQ et al (2021) Amyloid Pathologies Modulate the Associations of Minimal Depressive Symptoms With Cognitive Impairments in Older Adults Without Dementia. Biol Psychiatry 89:766\u2013775","journal-title":"Biol Psychiatry"},{"key":"13954_CR9","doi-asserted-by":"publisher","first-page":"262","DOI":"10.1016\/j.jad.2020.05.097","volume":"274","author":"Z Zhang","year":"2020","unstructured":"Zhang Z, Wei F, Shen XN, Ma YH, Chen KL, Dong Q et al (2020) Associations of Subsyndromal Symptomatic Depression with Cognitive Decline and Brain Atrophy in Elderly Individuals without Dementia: A Longitudinal Study. J Affect Disord 274:262\u2013268","journal-title":"J Affect Disord"},{"key":"13954_CR10","doi-asserted-by":"publisher","first-page":"845","DOI":"10.1016\/j.jad.2024.08.204","volume":"367","author":"X Duan","year":"2024","unstructured":"Duan X, Zhang Y, Li W, Su N, Sun L (2024) Neutrophil activation and related disrupted frontolimbic circuit may contribute to cognitive progression of minimal depressive symptoms in non-dementia elderly. J Affect Disord 367:845\u2013853","journal-title":"J Affect Disord"},{"key":"13954_CR11","doi-asserted-by":"publisher","DOI":"10.1038\/s41398-022-01910-4","volume":"12","author":"ZB Wang","year":"2022","unstructured":"Wang ZB, Sun Y, Ma YH, Fu Y, Hu H, Xu W et al (2022) sTREM2 mediates the associations of minimal depressive symptoms with amyloid pathology in prodromal Alzheimer\u2019s disease: the CABLE study. Transl Psychiatry 12:140","journal-title":"Transl Psychiatry"},{"key":"13954_CR12","doi-asserted-by":"publisher","first-page":"525","DOI":"10.1001\/jamapsychiatry.2016.0004","volume":"73","author":"AR Kaup","year":"2016","unstructured":"Kaup AR, Byers AL, Falvey C, Simonsick EM, Satterfield S, Ayonayon HN et al (2016) Trajectories of depressive symptoms in older adults and risk of dementia. JAMA Psychiat 73:525\u2013531","journal-title":"JAMA Psychiat"},{"key":"13954_CR13","doi-asserted-by":"publisher","first-page":"116","DOI":"10.3390\/jpm10030116","volume":"10","author":"C d'Abramo","year":"2020","unstructured":"d\u2019Abramo C, D\u2019Adamio L, Giliberto L (2020) Significance of blood and cerebrospinal fluid biomarkers for Alzheimer\u2019s disease: sensitivity, specificity and potential for clinical use. J Pers Med 10:116","journal-title":"J Pers Med"},{"key":"13954_CR14","doi-asserted-by":"publisher","first-page":"834","DOI":"10.1001\/jamapsychiatry.2024.1389","volume":"81","author":"JJ Gomar","year":"2024","unstructured":"Gomar JJ, Koppel J (2024) Psychosis in Alzheimer disease and elevations in disease-relevant biomarkers. JAMA Psychiat 81:834\u2013839","journal-title":"JAMA Psychiat"},{"key":"13954_CR15","doi-asserted-by":"publisher","first-page":"5143","DOI":"10.1002\/alz.13859","volume":"20","author":"CR Jack Jr.","year":"2024","unstructured":"Jack CR Jr., Andrews JS, Beach TG, Buracchio T, Dunn B, Graf A et al (2024) Revised criteria for diagnosis and staging of Alzheimer\u2019s disease: Alzheimer\u2019s Association Workgroup. Alzheimers Dement 20:5143\u20135169","journal-title":"Alzheimers Dement"},{"key":"13954_CR16","doi-asserted-by":"publisher","first-page":"1085","DOI":"10.1038\/s41591-024-02869-z","volume":"30","author":"NR Barth\u00e9lemy","year":"2024","unstructured":"Barth\u00e9lemy NR, Salvad\u00f3 G, Schindler SE, He Y, Janelidze S, Collij LE et al (2024) Highly accurate blood test for Alzheimer\u2019s disease is similar or superior to clinical cerebrospinal fluid tests. Nat Med 30:1085\u20131095","journal-title":"Nat Med"},{"key":"13954_CR17","doi-asserted-by":"publisher","first-page":"1601","DOI":"10.1038\/s43587-025-00904-3","volume":"5","author":"G Lan","year":"2025","unstructured":"Lan G, Wang M, Gonzalez-Ortiz F, Zhang L, Li A, Li B et al (2025) Comprehensive evaluation of plasma tau biomarkers for detecting and monitoring Alzheimer\u2019s disease in a multicenter and multiethnic aging population. Nat Aging 5:1601\u20131618","journal-title":"Nat Aging"},{"key":"13954_CR18","doi-asserted-by":"publisher","first-page":"1214","DOI":"10.1002\/alz.13542","volume":"20","author":"RA Rissman","year":"2024","unstructured":"Rissman RA, Langford O, Raman R, Donohue MC, Abdel-Latif S, Meyer MR et al (2024) Plasma A\u03b242\/A\u03b240 and phospho-tau217 concentration ratios increase the accuracy of amyloid PET classification in preclinical Alzheimer\u2019s disease. Alzheimers Dement 20:1214\u20131224","journal-title":"Alzheimers Dement"},{"key":"13954_CR19","doi-asserted-by":"publisher","first-page":"3505","DOI":"10.1093\/brain\/awab223","volume":"144","author":"JB Pereira","year":"2021","unstructured":"Pereira JB, Janelidze S, Smith R, Mattsson-Carlgren N, Palmqvist S, Teunissen CE et al (2021) Plasma GFAP is an early marker of amyloid-\u03b2 but not tau pathology in Alzheimer\u2019s disease. Brain 144:3505\u20133516","journal-title":"Brain"},{"key":"13954_CR20","first-page":"441","volume":"80","author":"C Delaby","year":"2022","unstructured":"Delaby C, Bousiges O, Bouvier D, Fill\u00e9e C, Fourier A, Mond\u00e9sert \u00c9 et al (2022) Neurofilaments: a key new biomarker for clinicians Part 2: Neurofilaments, an asset beyond neurodegenerative diseases. Ann Biol Clin (Paris). 80:441\u2013450","journal-title":"Ann Biol Clin (Paris)."},{"key":"13954_CR21","doi-asserted-by":"publisher","first-page":"523","DOI":"10.1176\/appi.ajp.2011.11081153","volume":"169","author":"N Pomara","year":"2012","unstructured":"Pomara N, Bruno D, Sarreal AS, Hernando RT, Nierenberg J, Petkova E et al (2012) Lower CSF amyloid beta peptides and higher F2-isoprostanes in cognitively intact elderly individuals with major depressive disorder. Am J Psychiatry 169:523\u2013530","journal-title":"Am J Psychiatry"},{"issue":"3","key":"13954_CR22","doi-asserted-by":"publisher","first-page":"508","DOI":"10.1002\/ana.27285","volume":"98","author":"M Mil\u00e0-Alom\u00e0","year":"2025","unstructured":"Mil\u00e0-Alom\u00e0 M, Tosun D, Schindler SE, Hausle I, Petersen KK, Li Y et al (2025) Timing of changes in alzheimer\u2019s disease plasma biomarkers as assessed by Amyloid and Tau PET Clocks. Ann Neurol 98(3):508\u2013523","journal-title":"Ann Neurol"},{"key":"13954_CR23","doi-asserted-by":"publisher","first-page":"202","DOI":"10.1016\/j.jalz.2010.03.007","volume":"6","author":"MW Weiner","year":"2010","unstructured":"Weiner MW, Aisen PS, Jack CR Jr., Jagust WJ, Trojanowski JQ, Shaw L et al (2010) The Alzheimer\u2019s disease neuroimaging initiative: progress report and future plans. Alzheimers Dement 6:202\u201311.e7","journal-title":"Alzheimers Dement"},{"key":"13954_CR24","doi-asserted-by":"publisher","first-page":"316","DOI":"10.1186\/s12974-022-02679-5","volume":"19","author":"ZB Wang","year":"2022","unstructured":"Wang ZB, Ma YH, Sun Y, Tan L, Wang HF, Yu JT (2022) Interleukin-3 is associated with sTREM2 and mediates the correlation between amyloid-\u03b2 and tau pathology in Alzheimer\u2019s disease. J Neuroinflammation 19:316","journal-title":"J Neuroinflammation"},{"key":"13954_CR25","doi-asserted-by":"publisher","first-page":"629","DOI":"10.1038\/s41598-024-51334-x","volume":"14","author":"P Kivis\u00e4kk","year":"2024","unstructured":"Kivis\u00e4kk P, Fatima HA, Cahoon DS, Otieno B, Chacko L, Minooei F et al (2024) Clinical evaluation of a novel plasma pTau217 electrochemiluminescence immunoassay in Alzheimer\u2019s disease. Sci Rep 14:629","journal-title":"Sci Rep"},{"key":"13954_CR26","doi-asserted-by":"publisher","first-page":"595","DOI":"10.1038\/nbt.1641","volume":"28","author":"DM Rissin","year":"2010","unstructured":"Rissin DM, Kan CW, Campbell TG, Howes SC, Fournier DR, Song L et al (2010) Single-molecule enzyme-linked immunosorbent assay detects serum proteins at subfemtomolar concentrations. Nat Biotechnol 28:595\u2013599","journal-title":"Nat Biotechnol"},{"issue":"9","key":"13954_CR27","doi-asserted-by":"publisher","first-page":"12060","DOI":"10.1007\/s12035-025-05007-z","volume":"62","author":"YH Chen","year":"2025","unstructured":"Chen YH, Wang ZB, Liu XP, Mao ZQ (2025) Cerebrospinal fluid CCL25 as a Biomarker for Alzheimer\u2019s Disease: associations with pathology, neurodegeneration, and cognitive decline. Mol Neurobiol 62(9):12060\u201312077","journal-title":"Mol Neurobiol"},{"issue":"1","key":"13954_CR28","doi-asserted-by":"publisher","first-page":"216","DOI":"10.1177\/13872877251326286","volume":"105","author":"YH Chen","year":"2025","unstructured":"Chen YH, Wang ZB, Liu XP, Mao ZQ (2025) Cerebrospinal fluid LMO4 as a synaptic biomarker linked to Alzheimer\u2019s disease pathology and cognitive decline. J Alzheimers Dis 105(1):216\u2013227","journal-title":"J Alzheimers Dis"},{"key":"13954_CR29","doi-asserted-by":"publisher","first-page":"1173","DOI":"10.1037\/0022-3514.51.6.1173","volume":"51","author":"RM Baron","year":"1986","unstructured":"Baron RM, Kenny DA (1986) The moderator-mediator variable distinction in social psychological research: conceptual, strategic, and statistical considerations. J Pers Soc Psychol 51:1173\u20131182","journal-title":"J Pers Soc Psychol"},{"key":"13954_CR30","first-page":"1797","volume":"28","author":"M Mil\u00e0-Alom\u00e0","year":"2022","unstructured":"Mil\u00e0-Alom\u00e0 M, Ashton NJ, Shekari M, Salvad\u00f3 G, Ortiz-Romero P, Montoliu-Gaya L et al (2022) Plasma p-tau231 and p-tau217 as state markers of amyloid-\u03b2 pathology in preclinical Alzheimer\u2019s disease. Nat Med 28:1797\u20131801","journal-title":"Nat Med"},{"key":"13954_CR31","doi-asserted-by":"publisher","first-page":"1298","DOI":"10.3390\/brainsci11101298","volume":"11","author":"J Mikulska","year":"2021","unstructured":"Mikulska J, Juszczyk G, Gawro\u0144ska-Grzywacz M, Herbet M (2021) HPA Axis in the Pathomechanism of Depression and Schizophrenia: New Therapeutic Strategies Based on Its Participation. Brain Sci 11:1298","journal-title":"Brain Sci"},{"key":"13954_CR32","doi-asserted-by":"publisher","first-page":"459","DOI":"10.3233\/JAD-2009-1152","volume":"18","author":"H Dong","year":"2009","unstructured":"Dong H, Csernansky JG (2009) Effects of stress and stress hormones on amyloid-beta protein and plaque deposition. J Alzheimers Dis 18:459\u2013469","journal-title":"J Alzheimers Dis"},{"key":"13954_CR33","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2022.105926","volume":"175","author":"EM Medina-Rodriguez","year":"2022","unstructured":"Medina-Rodriguez EM, Beurel E (2022) Blood brain barrier and inflammation in depression. Neurobiol Dis 175:105926","journal-title":"Neurobiol Dis"},{"key":"13954_CR34","doi-asserted-by":"publisher","DOI":"10.3390\/ijms242216288","author":"AE Alkhalifa","year":"2023","unstructured":"Alkhalifa AE, Al-Ghraiybah NF, Odum J, Shunnarah JG, Austin N, Kaddoumi A (2023) Blood-brain barrier breakdown in Alzheimer\u2019s disease: mechanisms and targeted strategies. Int J Mol Sci. https:\/\/doi.org\/10.3390\/ijms242216288","journal-title":"Int J Mol Sci"},{"key":"13954_CR35","doi-asserted-by":"publisher","first-page":"1141","DOI":"10.1016\/j.jagp.2024.03.004","volume":"32","author":"EL Twait","year":"2024","unstructured":"Twait EL, Kamarioti M, Verberk IMW, Teunissen CE, Nooyens ACJ, Monique Verschuren WM et al (2024) Depressive Symptoms and Plasma Markers of Alzheimer\u2019s disease and neurodegeneration: a coordinated meta-analysis of 8 cohort studies. Am J Geriatr Psychiatry 32:1141\u20131153","journal-title":"Am J Geriatr Psychiatry"},{"key":"13954_CR36","doi-asserted-by":"publisher","first-page":"97","DOI":"10.1111\/pcn.13608","volume":"78","author":"IK Schuurmans","year":"2024","unstructured":"Schuurmans IK, Ghanbari M, Cecil CAM, Ikram MA, Luik AI (2024) Plasma neurofilament light chain in association to late-life depression in the general population. Psychiatry Clin Neurosci 78:97\u2013103","journal-title":"Psychiatry Clin Neurosci"},{"key":"13954_CR37","doi-asserted-by":"publisher","DOI":"10.1186\/s12888-024-06051-0","volume":"24","author":"A Habibzadeh","year":"2024","unstructured":"Habibzadeh A, Ostovan VR, Ghezel MA, Kavari K, Kardeh S, Tabrizi R (2024) Neurofilament light chain as a promising biomarker for depression diagnosis: a systematic review and meta-analysis. BMC Psychiatry 24:617","journal-title":"BMC Psychiatry"},{"key":"13954_CR38","doi-asserted-by":"publisher","first-page":"379","DOI":"10.1111\/bdi.70029","volume":"27","author":"MJY Kang","year":"2025","unstructured":"Kang MJY, Eratne D, Dean O, Berk M, Walker AJ, Wannan C et al (2025) Plasma glial fibrillary acidic protein and neurofilament light are elevated in bipolar depression: evidence for neuroprogression and astrogliosis. Bipolar Disord 27:379\u2013388","journal-title":"Bipolar Disord"},{"key":"13954_CR39","doi-asserted-by":"publisher","DOI":"10.1186\/s12888-024-06143-x","volume":"24","author":"Y He","year":"2024","unstructured":"He Y, Cheng S, Yang L, Ding L, Chen Y, Lu J et al (2024) Associations between plasma markers and symptoms of anxiety and depression in patients with breast cancer. BMC Psychiatry 24:678","journal-title":"BMC Psychiatry"},{"key":"13954_CR40","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1016\/j.neurobiolaging.2023.04.011","volume":"128","author":"A Terracciano","year":"2023","unstructured":"Terracciano A, Walker K, An Y, Luchetti M, Stephan Y, Moghekar AR et al (2023) The association between personality and plasma biomarkers of astrogliosis and neuronal injury. Neurobiol Aging 128:65\u201373","journal-title":"Neurobiol Aging"},{"key":"13954_CR41","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.ade1474","volume":"9","author":"JP Ferrari-Souza","year":"2023","unstructured":"Ferrari-Souza JP, Lussier FZ, Leffa DT, Therriault J, Tissot C, Bellaver B et al (2023) APOE\u03b54 associates with microglial activation independently of A\u03b2 plaques and tau tangles. Sci Adv 9:eade1474","journal-title":"Sci Adv"},{"key":"13954_CR42","doi-asserted-by":"publisher","first-page":"22","DOI":"10.1038\/nri.2015.5","volume":"16","author":"AH Miller","year":"2016","unstructured":"Miller AH, Raison CL (2016) The role of inflammation in depression: from evolutionary imperative to modern treatment target. Nat Rev Immunol 16:22\u201334","journal-title":"Nat Rev Immunol"},{"key":"13954_CR43","doi-asserted-by":"publisher","first-page":"3029","DOI":"10.1038\/s41380-025-02908-2","volume":"30","author":"M Bocharova","year":"2025","unstructured":"Bocharova M, Borza T, Watne LO, Engedal K, O\u2019Brien JT, Selb\u00e6k G et al (2025) The role of plasma inflammatory markers in late-life depression and conversion to dementia: a 3-year follow-up study. Mol Psychiatry 30:3029\u20133038","journal-title":"Mol Psychiatry"},{"key":"13954_CR44","doi-asserted-by":"publisher","first-page":"963","DOI":"10.1038\/mp.2013.20","volume":"18","author":"WD Taylor","year":"2013","unstructured":"Taylor WD, Aizenstein HJ, Alexopoulos GS (2013) The vascular depression hypothesis: mechanisms linking vascular disease with depression. Mol Psychiatry 18:963\u2013974","journal-title":"Mol Psychiatry"},{"key":"13954_CR45","doi-asserted-by":"publisher","DOI":"10.1002\/alz.70195","volume":"21","author":"S Kurose","year":"2025","unstructured":"Kurose S, Moriguchi S, Kubota M, Tagai K, Momota Y, Ichihashi M et al (2025) Diverse tau pathologies in late-life mood disorders revealed by PET and autopsy assays. Alzheimers Dement 21:e70195","journal-title":"Alzheimers Dement"},{"key":"13954_CR46","doi-asserted-by":"publisher","DOI":"10.1186\/s12974-024-03152-1","volume":"21","author":"Y Zhang","year":"2024","unstructured":"Zhang Y, Tan X, Tang C (2024) Estrogen-immuno-neuromodulation disorders in menopausal depression. J Neuroinflammation 21:159","journal-title":"J Neuroinflammation"},{"key":"13954_CR47","volume":"17","author":"S Mohammadi","year":"2025","unstructured":"Mohammadi S, Rahmani F, Dolatshahi M, Schindler SE, Raji CA (2025) Effects of obesity on plasma biomarker and amyloid PET trajectories in Alzheimer\u2019s disease. Alzheimers Dement Diagn Assess Dis Monit 17:e70143","journal-title":"Alzheimers Dement Diagn Assess Dis Monit"},{"key":"13954_CR48","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000210287","volume":"104","author":"JA Bornhorst","year":"2025","unstructured":"Bornhorst JA, Lundgreen CS, Weigand SD, Figdore DJ, Wiste H, Griswold M et al (2025) Quantitative assessment of the effect of chronic kidney disease on plasma P-Tau217 concentrations. Neurology 104:e210287","journal-title":"Neurology"},{"key":"13954_CR49","doi-asserted-by":"publisher","DOI":"10.1002\/alz.70411","volume":"21","author":"A Marengoni","year":"2025","unstructured":"Marengoni A, Grande G, Valletta M, Gregorio C, Calder\u00f3n-Larra\u00f1aga A, Dale M et al (2025) Multimorbidity patterns and blood biomarkers of Alzheimer\u2019s disease in community-dwelling cognitively unimpaired older adults. Alzheimers Dement 21:e70411","journal-title":"Alzheimers Dement"},{"key":"13954_CR50","doi-asserted-by":"publisher","first-page":"4115","DOI":"10.1002\/alz.13860","volume":"20","author":"M Valletta","year":"2024","unstructured":"Valletta M, Vetrano DL, Rizzuto D, Winblad B, Canevelli M, Andersson S et al (2024) Blood biomarkers of Alzheimer\u2019s disease in the community: Variation by chronic diseases and inflammatory status. Alzheimers Dement 20:4115\u20134125","journal-title":"Alzheimers Dement"},{"key":"13954_CR51","doi-asserted-by":"publisher","first-page":"344","DOI":"10.1001\/jamaneurol.2024.5017","volume":"82","author":"L VandeVrede","year":"2025","unstructured":"VandeVrede L, Cho H, Sanderson-Cimino M, Wekselman F, Cobigo Y, Gorno-Tempini ML et al (2025) Detection of Alzheimer Neuropathology in Alzheimer and Non-Alzheimer Clinical Syndromes With Blood-Based Biomarkers. JAMA Neurol 82:344\u2013354","journal-title":"JAMA Neurol"},{"key":"13954_CR52","doi-asserted-by":"publisher","DOI":"10.3390\/biomedicines12040786","author":"DJ Jarek","year":"2024","unstructured":"Jarek DJ, Mizerka H, Nuszkiewicz J, Szewczyk-Golec K (2024) Evaluating p-tau217 and p-tau231 as biomarkers for early diagnosis and differentiation of Alzheimer\u2019s disease: a narrative review. Biomedicines. https:\/\/doi.org\/10.3390\/biomedicines12040786","journal-title":"Biomedicines"},{"key":"13954_CR53","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-024-02988-7","author":"CR Jack Jr.","year":"2024","unstructured":"Jack CR Jr., Andrews SJ, Beach TG, Buracchio T, Dunn B, Graf A et al (2024) Revised criteria for the diagnosis and staging of Alzheimer\u2019s disease. Nat Med. https:\/\/doi.org\/10.1038\/s41591-024-02988-7","journal-title":"Nat Med"},{"key":"13954_CR54","doi-asserted-by":"publisher","first-page":"2044","DOI":"10.1038\/s41591-025-03617-7","volume":"31","author":"K Horie","year":"2025","unstructured":"Horie K, Salvad\u00f3 G, Koppisetti RK, Janelidze S, Barth\u00e9lemy NR, He Y et al (2025) Plasma MTBR-tau243 biomarker identifies tau tangle pathology in Alzheimer\u2019s disease. Nat Med 31:2044\u20132053","journal-title":"Nat Med"}],"container-title":["Journal of Neurology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00415-026-13954-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00415-026-13954-3","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00415-026-13954-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T08:02:07Z","timestamp":1783497727000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00415-026-13954-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6,20]]},"references-count":54,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2026,7]]}},"alternative-id":["13954"],"URL":"https:\/\/doi.org\/10.1007\/s00415-026-13954-3","relation":{},"ISSN":["0340-5354","1432-1459"],"issn-type":[{"value":"0340-5354","type":"print"},{"value":"1432-1459","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,6,20]]},"assertion":[{"value":"2 March 2026","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"8 June 2026","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"10 June 2026","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"20 June 2026","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Written informed consent was obtained from all ADNI participants, and ADNI received approval from the institutional review boards at all participating institutions.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval and consent to participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no conflicts of interest.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflicts of interest"}}],"article-number":"409"}}