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The primary objective was adherence to guideline-recommended diagnostic and treatment interventions; the secondary was guideline memorability.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and methods<\/jats:title>\n                    <jats:p>A randomized controlled trial was conducted, randomizing physicians from various specialties at the University Hospital Basel, a Swiss academic care center into three groups: (1) without guidelines (controls), (2) with access to NCS guidelines, (3) provided with a condensed single-page guideline incorporating symbols to facilitate information assimilation and evaluation. Each group performed an identical simulated SE scenario. Primary endpoints included vital sign checks, therapeutic interventions, and timing. Secondary endpoints assessed questionnaire-based aftermath self-evaluation and guideline memorability.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Among 124 participating physicians, 35% were controls, 34% provided with NCS guideline, and 31% with the condensed single-page guideline. Participants using the condensed guideline showed higher adherence to key interventions, with significantly improved rates of side positioning for airway protection (63% with condensed guideline vs. 25% in controls and 26% in the full guideline group; p&lt;0.001) and second-line antiseizure drug administration (97% vs. 70% and 86%; p=0.003). No significant differences were observed in vital sign checks or other interventions. The condensed guideline was rated as more memorable compared to the original guidelines (\n                      <jats:italic>p<\/jats:italic>\n                      =0.001).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Condensed SE guidelines improved adherence to selected emergency interventions compared with both full NCS guidelines and no guideline support. Guideline usability may represent a modifiable target for improving time-critical neurological emergencies.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Trial Registration<\/jats:title>\n                    <jats:p>Clinicaltrials.gov ID NCT03883516 2019-03-12.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1007\/s00415-026-14058-8","type":"journal-article","created":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T16:34:03Z","timestamp":1787157243000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Improving emergency management of status epilepticus: a randomized high-fidelity simulator-based trial"],"prefix":"10.1007","volume":"273","clinical-trial-number":[{"clinical-trial-number":"nct03883516","registry":"10.18810\/clinical-trials-gov"}],"author":[{"given":"Paulina S. 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Kliem reports no disclosures. Kai Tisljar reports no disclosures. Sira M. Baumann reports no disclosures. Pascale Grzonka reports no disclosures. Gian Marco De Marchis was or is supported by the Swiss National Science Foundation; Science Funds [Wissenschaftsfonds] of the University Hospital Basel and University of Basel, the\u00a0Bangerter-Rhyner-Stiftung, the\u00a0Swisslife Jubil\u00e4umsstiftung for Medical Research, the\u00a0Swiss Neurological Society, the\u00a0Fondazione Dr. Ettore Balli the\u00a0De Quervain research grant,and the Thermo Fisher GmbH. He received travel honoraria by Bayer and speaker honoraria by Medtronic and BMS\/Pfizer. Sabina Hunziker is supported by the Swiss National Foundation (SNF) (Ref 10001C_192850\/1 and 10531C_182422), the Bangerter-Rhyner Foundation (8472\/HEG-DSV), and the Swiss Society of General Internal Medicine (SSGIM). Stefano Bassetti reports no disclosures. Roland Bingisser is the editor of medstandards.com, a symptom-based medical decision-support tool licensed to 150 European hospitals, owned by the University Hospital Basel. Sabina Hunziker reports no disclosures. Stephan Marsch reports no disclosures. Raoul Sutter received research grants from the Swiss National Foundation (No 320030_169379), the Research Fund of the University Basel, the Scientific Society Basel, and the Bangerter-Rhyner Foundation. He received personal grants from UCB-pharma and holds stocks from Alcon, Johnson & Johnson, Novartis, Roche and Sandoz.","order":1,"name":"Ethics","label":"Conflicts of interest","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The study was approved by the local ethics committee (EKNZRequ_2019-00168), who ascertained that this study complies with the general ethical principles for research involving human subjects (according to the article 51(2) of the Human Research Act). Consent was received from the volunteering physicians for the anonymized analyses of the video- and audio recordings of their performances. The Reporting Guidelines for Health Care Simulation Research\u2014and extensions to the CONSORT (CONsolidated Standards Of Reporting Trials) and STROBE (Strengthening The Reporting of OBservational studies in Epidemiology) Statements\u2014for randomized trials were followed.","order":2,"name":"Ethics","label":"Ethical approval and consent to participate","group":{"name":"EthicsHeading","label":"Declarations"}}],"article-number":"533"}}