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Joanna Weller has no disclosures to report. Robert Zivadinov received personal compensation from Bristol Myers Squibb, EMD Serono, Sanofi and Biogen for speaking and consultant fees. He received financial support for research activities from Bristol Myers Squibb, Genentech, Neurogenesis and Protembis GmbH, but no COI related to the present analyses. Bianca Weinstock-Guttman has no disclosures to report. Daniel Golan has no disclosures to report. Myassar Zarif has no disclosures to report. Fiona Costello has received compensation for consulting services from Amgen. Robert Sergott has received consulting fees from Heidelberg Engineering. Steven Galetta has no disclosures to report. Rachel Kenney has no disclosures to report. Laura J Balcer has no disclosures to report. Wim Van Hecke is an employee of Icometrix. Dirk Smeets is an employee of Icometrix. Bishal Dhakal has no disclosures to report. Sarah A Morrow has no disclosures to report. Thomas J Covey has received compensation for consulting services from Genentech and Biogen, but no COI related to the present analyses. Mark Gudesblatt has no disclosures to report.","order":1,"name":"Ethics","label":"Conflicts of interest","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"This retrospective analysis of de-identified clinical data was determined to meet exemption criteria by Solutions IRB (Protocol No. 2021\/07\/22; Registration No. IORG0007116; FWA No. IRB00008523) under federal regulation 45 CFR 46.104(d) (4). The study was conducted in accordance with the ethical principles of the Declaration of Helsinki and Good Clinical Practice (ICH E6) guidelines. A waiver of informed consent was granted because the study involved the retrospective analysis of de-identified clinical data.","order":2,"name":"Ethics","label":"Ethical approval","group":{"name":"EthicsHeading","label":"Declarations"}}],"article-number":"621"}}