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The Mini-Linguistic State Examination (MLSE) is a short speech and language screening test used in the diagnostic process of PPA in English-speaking patients. We adapted the MLSE into Dutch (MLSE\u2013NL) and validated this new version as a diagnostic screening tool in Dutch-speaking patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methodology<\/jats:title>\n                    <jats:p>\n                      We assessed the MLSE\u2013NL in 90 Dutch-speaking patients with PPA (nonfluent variant PPA (nfvPPA)\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a023, logopenic variant PPA (lvPPA)\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a024, semantic variant PPA (svPPA)\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a032, PPA Not Otherwise Specified (PPA\u2013NOS)\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a011) (mean age: 68.3, 47.8% male) and 276 healthy volunteers (mean age: 56.3, 38.8% male). The MLSE\u2013NL includes subscores in motor speech, phonological structure, semantic knowledge, syntax, and working memory. Group differences were assessed using Kruskal\u2013Wallis tests, with linear models controlling for covariates as confirmatory analyses.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The MLSE\u2013NL shows significantly lower scores for all PPA variants for total score, ranging from 30 to 96\/100 in patients and 83 to 100\/100 in controls. The AUC for total score was 0.99 (subdomain AUCs ranged from 0.80 to 0.92). nfvPPA had more motor speech errors than controls, svPPA had more semantic errors, while lvPPA had the most working memory deficits. Syntax errors were frequent in all variants, while phonological deficits were greater in lvPPA and nfvPPA. PPA\u2013NOS had deficits in all domains aside from motor speech.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The MLSE\u2013NL can successfully discriminate the three canonical variants of PPA and PPA\u2013NOS from controls and captures domain-specific neurolinguistic profiles.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1007\/s00415-026-14203-3","type":"journal-article","created":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T13:16:47Z","timestamp":1792761407000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["The Dutch Mini-Linguistic State Examination (MLSE-NL): findings in Primary Progressive Aphasia (PPA)"],"prefix":"10.1007","volume":"273","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-7392-2618","authenticated-orcid":false,"given":"Rosie","family":"Coppieters","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4866-1954","authenticated-orcid":false,"given":"Nikki","family":"Janssen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8268-9718","authenticated-orcid":false,"given":"Peter","family":"Garrard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-8899-5999","authenticated-orcid":false,"given":"Fenna","family":"Hiemstra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0279-1806","authenticated-orcid":false,"given":"Annelien","family":"Duits","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5198-9275","authenticated-orcid":false,"given":"Mattias","family":"De Coninck","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-2396-3218","authenticated-orcid":false,"given":"St\u00e9phanie","family":"De Keulenaer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0952-0673","authenticated-orcid":false,"given":"Ian","family":"Storey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4860-5952","authenticated-orcid":false,"given":"Vit\u00f3ria","family":"Piai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2609-1102","authenticated-orcid":false,"given":"Johan","family":"Renssen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0801-8937","authenticated-orcid":false,"given":"Carla","family":"Ruis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1989-7527","authenticated-orcid":false,"given":"Harro","family":"Seelaar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8120-7366","authenticated-orcid":false,"given":"Esther","family":"van den Berg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4403-2958","authenticated-orcid":false,"given":"Sara","family":"Van Mossevelde","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2631-9234","authenticated-orcid":false,"given":"Rose","family":"Bruffaerts","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1120-1858","authenticated-orcid":false,"given":"Lize","family":"Jiskoot","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,10,23]]},"reference":[{"issue":"21","key":"14203_CR1","doi-asserted-by":"publisher","first-page":"1670","DOI":"10.1212\/WNL.0b013e3182574f79","volume":"78","author":"SA Sajjadi","year":"2012","unstructured":"Sajjadi SA, Patterson K, Arnold RJ, Watson PC, Nestor PJ (2012) Primary progressive aphasia. 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