{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,11]],"date-time":"2026-02-11T15:22:24Z","timestamp":1770823344146,"version":"3.50.1"},"reference-count":44,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2003,12,18]],"date-time":"2003-12-18T00:00:00Z","timestamp":1071705600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Graefe's Arch Clin Exp Ophthalmol"],"published-print":{"date-parts":[[2004,2]]},"DOI":"10.1007\/s00417-003-0831-5","type":"journal-article","created":{"date-parts":[[2004,3,3]],"date-time":"2004-03-03T23:12:14Z","timestamp":1078355534000},"page":"130-145","source":"Crossref","is-referenced-by-count":90,"title":["Prognostic value of cell-cycle markers in ocular adnexal lymphoma: an assessment of 230 cases"],"prefix":"10.1007","volume":"242","author":[{"given":"Sarah E.","family":"Coupland","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martin","family":"Hellmich","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claudia","family":"Auw-Haedrich","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"William R.","family":"Lee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Harald","family":"Stein","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2003,12,18]]},"reference":[{"key":"831_CR1","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1093\/oxfordjournals.jjco.a039079","volume":"15","author":"A","year":"1985","unstructured":"A Malignancy Study Group of T-and B-Cells (1985) Statistical analyses of clinico-pathological, virological and epidemiological data on lymphoid malignancies with special reference to adult T-cell leukemia\/lymphoma: a report of the second nationwide study of Japan. Jpn J Clin Oncol 15:517\u2013535","journal-title":"Jpn J Clin Oncol"},{"key":"831_CR2","doi-asserted-by":"publisher","first-page":"178","DOI":"10.1007\/s002920050384","volume":"21","author":"Anagnostopoulos","year":"2000","unstructured":"Anagnostopoulos I, Stein H (2000) Large B-cell lymphomas: variants and entities. Pathologe 21:178\u2013189","journal-title":"Pathologe"},{"key":"831_CR3","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1136\/bjo.85.1.63","volume":"85","author":"Auw-Haedrich","year":"2001","unstructured":"Auw-Haedrich C, Coupland SE, Kapp A, et al (2001) Long term outcome of ocular adnexal lymphoma subtyped according to the REAL classification. Br J Ophthalmol 85:63\u201369","journal-title":"Br J Ophthalmol"},{"key":"831_CR4","doi-asserted-by":"publisher","first-page":"779","DOI":"10.1023\/A:1008327301372","volume":"9","author":"Baldini","year":"1998","unstructured":"Baldini L, Blini M, Guffanti A, et al (1998) Treatment and prognosis in a series of primary extranodal lymphomas of the ocular adnexa. Ann Oncol 9:779\u2013781","journal-title":"Ann Oncol"},{"key":"831_CR5","doi-asserted-by":"crossref","first-page":"2423","DOI":"10.1182\/blood.V83.9.2423.2423","volume":"83","author":"Bastard","year":"1994","unstructured":"Bastard C, Deweindt C, Kerckaert JP, et al (1994) LAZ3 rearrangements in non-Hodgkin\u2019s lymphoma: correlation with histology, immunophenotype, karyotype, and clinical outcome in 217 patients. Blood 83:2423\u20132427","journal-title":"Blood"},{"key":"831_CR6","doi-asserted-by":"publisher","first-page":"1204","DOI":"10.1002\/1097-0142(19860315)57:6<1204::AID-CNCR2820570624>3.0.CO;2-2","volume":"57","author":"Bennett","year":"1986","unstructured":"Bennett CL, Putterman A, Bitran JD, et al (1986) Staging and therapy of orbital lymphomas. Cancer 57:1204\u20131208","journal-title":"Cancer"},{"key":"831_CR7","doi-asserted-by":"publisher","first-page":"237","DOI":"10.1016\/0167-8140(88)90218-6","volume":"13","author":"Bessell","year":"1988","unstructured":"Bessell EM, Henk JM, Wright JE, Whitelocke RA (1988) Orbital and conjunctival lymphoma treatment and prognosis. Radiother Oncol 13:237\u2013244","journal-title":"Radiother Oncol"},{"key":"831_CR8","doi-asserted-by":"publisher","first-page":"219","DOI":"10.1177\/32.2.6198355","volume":"32","author":"Cordell","year":"1984","unstructured":"Cordell JL, Falini B, Erber WN, et al (1984) Immunoenzymatic labeling of monoclonal antibodies using immune complexes of alkaline phosphatase and monoclonal anti-alkaline phosphatase (APAAP complexes). J Histochem Cytochem 32:219\u2013229","journal-title":"J Histochem Cytochem"},{"key":"831_CR9","doi-asserted-by":"publisher","first-page":"1430","DOI":"10.1016\/S0161-6420(98)98024-1","volume":"105","author":"Coupland","year":"1998","unstructured":"Coupland SE, Krause L, Delecluse HJ, et al. (1998) Lymphoproliferative lesions of the ocular adnexa. Analysis of 112 cases. Ophthalmology 105:1430\u20131441","journal-title":"Ophthalmology"},{"key":"831_CR10","doi-asserted-by":"publisher","first-page":"2109","DOI":"10.1016\/S0161-6420(99)90492-X","volume":"106","author":"Coupland","year":"1999","unstructured":"Coupland SE, Foss HD, Assaf C, et al (1999) T-cell and T\/natural killer-cell lymphomas involving ocular and ocular adnexal tissues: a clinicopathologic, immunohistochemical, and molecular study of seven cases. Ophthalmology 106:2109\u20132120","journal-title":"Ophthalmology"},{"key":"831_CR11","doi-asserted-by":"publisher","first-page":"470","DOI":"10.1016\/S0039-6257(02)00337-5","volume":"47","author":"Coupland","year":"2002","unstructured":"Coupland SE, Hummel M, Stein H (2002) Ocular adnexal lymphomas: five case presentations and a review of the literature. Surv Ophthalmol 47:470\u2013490","journal-title":"Surv Ophthalmol"},{"key":"831_CR12","doi-asserted-by":"publisher","first-page":"719","DOI":"10.1046\/j.1365-2141.1997.2703087.x","volume":"98","author":"Dierlamm","year":"1997","unstructured":"Dierlamm J, Pittaluga S, Stul M, et al (1997) BCL6 gene rearrangements also occur in marginal zone B-cell lymphoma. Br J Haematol 98:719\u2013725","journal-title":"Br J Haematol"},{"key":"831_CR13","doi-asserted-by":"crossref","first-page":"2084","DOI":"10.1182\/blood.V95.6.2084","volume":"95","author":"Falini","year":"2000","unstructured":"Falini B, Fizzotti M, Pucciarini A, et al (2000) A monoclonal antibody (MUM1p) detects expression of the MUM1\/IRF4 protein in a subset of germinal center B cells, plasma cells, and activated T cells. Blood 95:2084\u20132092","journal-title":"Blood"},{"key":"831_CR14","doi-asserted-by":"publisher","first-page":"1207","DOI":"10.1001\/archopht.1994.01090210091021","volume":"112","author":"Hardman","year":"1994","unstructured":"Hardman Lea S, Kerr Muir M, Wotherspoon AC, et al. (1994) Mucosal-associated lymphoid tissue lymphoma of the conjunctiva. Arch Ophthalmol 112:1207\u20131212","journal-title":"Arch Ophthalmol"},{"key":"831_CR15","first-page":"S126","volume":"111","author":"Harris","year":"1999","unstructured":"Harris NL, Isaacson PG (1999) What are the criteria for distinguishing MALT from non-MALT lymphoma at extranodal sites? Am J Clin Pathol 111:S126\u2013S132","journal-title":"Am J Clin Pathol"},{"key":"831_CR16","doi-asserted-by":"crossref","first-page":"1361","DOI":"10.1182\/blood.V84.5.1361.1361","volume":"84","author":"Harris","year":"1994","unstructured":"Harris NL, Jaffe ES, Stein H, et al (1994) A revised European-American classification of lymphoid neoplasms: a proposal from the International Lymphoma Study Group (see comments). Blood 84:1361\u20131392","journal-title":"Blood"},{"key":"831_CR17","doi-asserted-by":"crossref","unstructured":"Harris NL, Stein H, Coupland SE, et al (2001) New approaches to lymphoma diagnosis. Hematology (Am Soc Hematol Educ Program):194\u2013220","DOI":"10.1182\/asheducation-2001.1.194"},{"key":"831_CR18","doi-asserted-by":"publisher","first-page":"577","DOI":"10.1177\/29.4.6166661","volume":"29","author":"Hsu","year":"1981","unstructured":"Hsu SM, Raine L, Fanger H (1981) Use of avidin-biotin-peroxidase complex (ABC) in immunoperoxidase techniques: a comparison between ABC and unlabeled antibody (PAP) procedures. J Histochem Cytochem 29:577\u2013580","journal-title":"J Histochem Cytochem"},{"key":"831_CR19","doi-asserted-by":"publisher","first-page":"1410","DOI":"10.1002\/1097-0142(19831015)52:8<1410::AID-CNCR2820520813>3.0.CO;2-3","volume":"52","author":"Isaacson","year":"1983","unstructured":"Isaacson P, Wright DH (1983) Malignant lymphoma of mucosa-associated lymphoid tissue: a distinctive type of B-cell lymphoma. Cancer 52:1410\u20131416","journal-title":"Cancer"},{"key":"831_CR20","unstructured":"Jaffe ES, Harris NL, Stein H, Vardiman JW (2001) World Health Organization classification of tumours. Tumours of haematopoietic and lymphoid tissues. Pathology and genetics. IARC Press, Lyon"},{"key":"831_CR21","first-page":"420","volume":"87","author":"Jakobiec","year":"1989","unstructured":"Jakobiec FA, Knowles DM (1989) An overview of ocular adnexal lymphoid tumors. Trans Am Ophthalmol Soc 87:420\u2013444","journal-title":"Trans Am Ophthalmol Soc"},{"key":"831_CR22","doi-asserted-by":"publisher","first-page":"907","DOI":"10.1136\/bjo.84.8.907","volume":"84","author":"Jenkins","year":"2000","unstructured":"Jenkins C, Rose GE, Bunce C, et al (2000) Histological features of ocular adnexal lymphoma (REAL classification) and their association with patient morbidity and survival. Br J Ophthalmol 84:907\u2013913","journal-title":"Br J Ophthalmol"},{"key":"831_CR23","doi-asserted-by":"publisher","first-page":"171","DOI":"10.1097\/00002341-199905000-00006","volume":"15","author":"Johnson","year":"1999","unstructured":"Johnson TE, Tse DT, Byrne GE, Jr., et al (1999) Ocular-adnexal lymphoid tumors: a clinicopathologic and molecular genetic study of 77 patients. Ophthal Plast Reconstr Surg 15:171\u2013179","journal-title":"Ophthal Plast Reconstr Surg"},{"key":"831_CR24","unstructured":"Knowles DM (ed) (2001) Neoplastic hematopathology, 2nd edn. Lippincott, Williams and Wilkins, Philadelphia"},{"key":"831_CR25","doi-asserted-by":"publisher","first-page":"959","DOI":"10.1016\/0046-8177(90)90181-4","volume":"21","author":"Knowles","year":"1990","unstructured":"Knowles DM, Jakobiec FA, McNally L, Burke JS (1990) Lymphoid hyperplasia and malignant lymphoma occurring in the ocular adnexa (orbit, conjunctiva, and eyelids): a prospective multiparametric analysis of 108 cases during 1977 to 1987. Hum Pathol 21:959\u2013973","journal-title":"Hum Pathol"},{"key":"831_CR26","doi-asserted-by":"publisher","first-page":"647","DOI":"10.3109\/10428190109097662","volume":"40","author":"Korkolopoulou","year":"2001","unstructured":"Korkolopoulou PA, Angelopoulou MK, Kontopidou FN, et al (2001) Retinoblastoma gene product and P21 (WAF1, CIP1) protein expression in non Hodgkin\u2019s lymphomas: a multivariate survival analysis. Leuk Lymphoma 40:647\u2013658","journal-title":"Leuk Lymphoma"},{"key":"831_CR27","doi-asserted-by":"publisher","first-page":"641","DOI":"10.1038\/modpathol.3880366","volume":"14","author":"Mannami","year":"2001","unstructured":"Mannami T, Yoshino T, Oshima K, et al (2001) Clinical, histopathological, and immunogenetic analysis of ocular adnexal lymphoproliferative disorders: characterization of malt lymphoma and reactive lymphoid hyperplasia. Mod Pathol 14:641\u2013649","journal-title":"Mod Pathol"},{"key":"831_CR28","doi-asserted-by":"publisher","first-page":"405","DOI":"10.1002\/path.1711690404","volume":"169","author":"Martinez","year":"1993","unstructured":"Martinez JC, Piris MA, Sanchez-Beato M, et al (1993) Retinoblastoma (Rb) gene product expression in lymphomas. Correlation with Ki67 growth fraction. J Pathol 169:405\u2013412","journal-title":"J Pathol"},{"key":"831_CR29","doi-asserted-by":"publisher","first-page":"387","DOI":"10.1046\/j.1442-9071.2001.d01-18.x","volume":"29","author":"McKelvie","year":"2001","unstructured":"McKelvie PA, McNab A, Francis IC, et al (2001) Ocular adnexal lymphoproliferative disease: a series of 73 cases. Clin Experiment Ophthalmol 29:387\u2013393","journal-title":"Clin Experiment Ophthalmol"},{"key":"831_CR30","doi-asserted-by":"publisher","first-page":"459","DOI":"10.1097\/00000478-198906000-00002","volume":"13","author":"Medeiros","year":"1989","unstructured":"Medeiros LJ, Harris NL (1989) Lymphoid infiltrates of the orbit and conjunctiva. A morphologic and immunophenotypic study of 99 cases. Am J Surg Pathol 13:459\u2013471","journal-title":"Am J Surg Pathol"},{"key":"831_CR31","doi-asserted-by":"publisher","first-page":"533","DOI":"10.3109\/10428199909058411","volume":"32","author":"Nakata","year":"1999","unstructured":"Nakata M, Matsuno Y, Katsumata N, et al (1999) Histology according to the Revised European-American Lymphoma Classification significantly predicts the prognosis of ocular adnexal lymphoma. Leuk Lymphoma 32:533\u2013543","journal-title":"Leuk Lymphoma"},{"key":"831_CR32","doi-asserted-by":"publisher","first-page":"371","DOI":"10.1002\/path.1711730413","volume":"173","author":"Norton","year":"1994","unstructured":"Norton AJ, Jordan S, Yeomans P (1994) Brief, high-temperature heat denaturation (pressure cooking): a simple and effective method of antigen retrieval for routinely processed tissues. J Pathol 173:371\u2013379","journal-title":"J Pathol"},{"key":"831_CR33","first-page":"181","volume":"11","author":"Omonishi","year":"1998","unstructured":"Omonishi K, Yoshino T, Sakuma I, et al. (1998) bcl-6 protein is identified in high-grade but not low-grade mucosa-associated lymphoid tissue lymphomas of the stomach. Mod Pathol 11:181\u2013185","journal-title":"Mod Pathol"},{"key":"831_CR34","doi-asserted-by":"publisher","first-page":"485","DOI":"10.1080\/028418601750288217","volume":"40","author":"Sasai","year":"2001","unstructured":"Sasai K, Yamabe H, Dodo Y, et al (2001) Non-Hodgkin\u2019s lymphoma of the ocular adnexa. Acta Oncol 40:485\u2013490","journal-title":"Acta Oncol"},{"key":"831_CR35","doi-asserted-by":"publisher","first-page":"979","DOI":"10.1016\/S0161-6420(01)00547-4","volume":"108","author":"Shields","year":"2001","unstructured":"Shields CL, Shields JA, Carvalho C, et al (2001) Conjunctival lymphoid tumors: clinical analysis of 117 cases and relationship to systemic lymphoma. Ophthalmology 108:979\u2013984","journal-title":"Ophthalmology"},{"key":"831_CR36","doi-asserted-by":"crossref","first-page":"983","DOI":"10.1016\/S0889-8588(18)30396-4","volume":"5","author":"Shih","year":"1991","unstructured":"Shih LY, Liang DC (1991) Non-Hodgkin\u2019s lymphomas in Asia. Hematol Oncol Clin North Am 5:983\u20131001","journal-title":"Hematol Oncol Clin North Am"},{"key":"831_CR37","doi-asserted-by":"publisher","first-page":"818","DOI":"10.1016\/S0161-6420(78)35620-7","volume":"85","author":"Sigelman","year":"1978","unstructured":"Sigelman J, Jakobiec FA (1978) Lymphoid lesions of the conjunctiva: relation of histopathology to clinical outcome. Ophthalmology 85:818\u2013843","journal-title":"Ophthalmology"},{"key":"831_CR38","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1016\/0360-3016(93)90173-S","volume":"26","author":"Smitt","year":"1993","unstructured":"Smitt MC, Donaldson SS (1993) Radiotherapy is successful treatment for orbital lymphoma. Int J Radiat Oncol Biol Phys 26:59\u201366","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"831_CR39","first-page":"2403","volume":"18","author":"Stefanaki","year":"1998","unstructured":"Stefanaki K, Tzardi M, Kouvidou C, et al (1998) Expression of p53, p21, mdm2, Rb, bax and Ki67 proteins in lymphomas of the mucosa-associated lymphoid (MALT) tissue. Anticancer Res 18:2403\u20132408","journal-title":"Anticancer Res"},{"key":"831_CR40","doi-asserted-by":"publisher","first-page":"1641","DOI":"10.1097\/00000478-200012000-00008","volume":"24","author":"Takeshita","year":"2000","unstructured":"Takeshita M, Iwashita A, Kurihara K, et al (2000) Histologic and immunohistologic findings and prognosis of 40 cases of gastric large B-cell lymphoma. Am J Surg Pathol 24:1641\u20131649","journal-title":"Am J Surg Pathol"},{"key":"831_CR41","doi-asserted-by":"publisher","first-page":"887","DOI":"10.1016\/S0002-9440(10)65630-1","volume":"153","author":"Villuendas","year":"1998","unstructured":"Villuendas R, Sanchez-Beato M, Martinez JC, et al (1998) Loss of p16\/INK4A protein expression in non-Hodgkin\u2019s lymphomas is a frequent finding associated with tumor progression. Am J Pathol 153:887\u2013897","journal-title":"Am J Pathol"},{"key":"831_CR42","doi-asserted-by":"publisher","first-page":"1994","DOI":"10.1016\/S0161-6420(95)30764-6","volume":"102","author":"White","year":"1995","unstructured":"White WA, Ferry JA, Harris NL, Grove AS (1995) Ocular adnexal lymphoma. A clinicopathologic study with identification of lymphomas of mucosa-associated lymphoid tissue type. Ophthalmology 102:1994\u20132006","journal-title":"Ophthalmology"},{"key":"831_CR43","doi-asserted-by":"publisher","first-page":"417","DOI":"10.1111\/j.1365-2559.1993.tb00489.x","volume":"23","author":"Wotherspoon","year":"1993","unstructured":"Wotherspoon AC, Diss TC, Pan LX, et al (1993) Primary low-grade B-cell lymphoma of the conjunctiva: a mucosa-associated lymphoid tissue type lymphoma. Histopathology 23:417\u2013424","journal-title":"Histopathology"},{"key":"831_CR44","doi-asserted-by":"publisher","first-page":"747","DOI":"10.1126\/science.8235596","volume":"262","author":"Ye","year":"1993","unstructured":"Ye BH, Lista F, Lo Coco F, et al (1993) Alterations of a zinc finger-encoding gene, BCL-6, in diffuse large-cell lymphoma. Science 262:747\u2013750","journal-title":"Science"}],"container-title":["Graefe's Archive for Clinical and Experimental Ophthalmology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00417-003-0831-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00417-003-0831-5\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00417-003-0831-5","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00417-003-0831-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,3,31]],"date-time":"2020-03-31T10:20:08Z","timestamp":1585650008000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00417-003-0831-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2003,12,18]]},"references-count":44,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2004,2]]}},"alternative-id":["831"],"URL":"https:\/\/doi.org\/10.1007\/s00417-003-0831-5","relation":{},"ISSN":["0721-832X","1435-702X"],"issn-type":[{"value":"0721-832X","type":"print"},{"value":"1435-702X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2003,12,18]]}}}