{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T00:21:02Z","timestamp":1789604462511,"version":"build-2803163510"},"reference-count":33,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2010,8,26]],"date-time":"2010-08-26T00:00:00Z","timestamp":1282780800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Graefes Arch Clin Exp Ophthalmol"],"published-print":{"date-parts":[[2011,3]]},"DOI":"10.1007\/s00417-010-1487-6","type":"journal-article","created":{"date-parts":[[2010,8,25]],"date-time":"2010-08-25T09:28:11Z","timestamp":1282728491000},"page":"443-448","source":"Crossref","is-referenced-by-count":34,"title":["Levels of plasma homocysteine in pseudoexfoliation glaucoma"],"prefix":"10.1007","volume":"249","author":[{"given":"Laura","family":"Tranchina","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco","family":"Centofanti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Oddone","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucia","family":"Tanga","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gloria","family":"Roberti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Liberatoscioli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudio","family":"Cortese","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gianluca","family":"Manni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2010,8,26]]},"reference":[{"key":"1487_CR1","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1034\/j.1600-0420.2001.079002213.x","volume":"79","author":"R Ritch","year":"2001","unstructured":"Ritch R, Schlotzer-Schrehardt U (2001) Exfoliation syndrome: toward a new understanding: proceedings of the First International Think Tank. Acta Ophthalmol Scand 79:213\u2013217","journal-title":"Acta Ophthalmol Scand."},{"key":"1487_CR2","first-page":"176","volume":"3","author":"R Ritch","year":"1994","unstructured":"Ritch R (1994) Exfoliation syndrome: the most common identifiable cause of open-angle glaucoma. J Glaucoma 3:176\u2013178","journal-title":"J Glaucoma"},{"key":"1487_CR3","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/S0039-6257(00)00196-X","volume":"45","author":"R Ritch","year":"2001","unstructured":"Ritch R, Schlotzer-Schrehardt U (2001) Exfoliation syndrome. Surv Ophthalmol 45:265\u2013315","journal-title":"Surv Ophthalmol"},{"key":"1487_CR4","doi-asserted-by":"crossref","first-page":"921","DOI":"10.1016\/j.ajo.2006.01.047","volume":"141","author":"U Schlotzer-Schrehardt","year":"2006","unstructured":"Schlotzer-Schrehardt U, Naumann GO (2006) Ocular and systemic pseudoexfoliation syndrome. Am J Ophthalmol 141:921\u2013937","journal-title":"Am J Ophthalmol"},{"key":"1487_CR5","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1016\/S1350-9462(01)00005-2","volume":"20","author":"SS Hayreh","year":"2001","unstructured":"Hayreh SS (2001) Blood flow in the optic nerve head and factors that may influence it. Prog Retin Eye Res 20:595\u2013624","journal-title":"Prog Retin Eye Res"},{"key":"1487_CR6","first-page":"59","volume-title":"100 Years of Progress in Glaucoma","author":"RN Weinreb","year":"1997","unstructured":"Weinreb RN, Cioffi GA, Harris A (1997) Optic nerve blood flow. In: Van Buskirk EM, Shields B (eds) 100 Years of Progress in Glaucoma. Lippincott-Raven, Philadelphia, pp 59\u201378"},{"key":"1487_CR7","doi-asserted-by":"crossref","first-page":"1476","DOI":"10.1016\/S0161-6420(03)00408-1","volume":"110","author":"DJ Lee","year":"2003","unstructured":"Lee DJ, Gomez-Marin O, Lam BL (2003) Glaucoma and survival: the national health interview survey 1986-1994. Ophthalmology 110:1476\u20131483","journal-title":"Ophthalmology"},{"key":"1487_CR8","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1016\/S1350-9462(02)00008-3","volume":"21","author":"J Flammer","year":"2002","unstructured":"Flammer J, Orgul S, Costa VP, Orzalesi N, Krieglstein GK, Serra LM, Renard JP, Stef\u00e1nsson E (2002) The impact of ocular blood flow in glaucoma. Prog Retin Eye Res 21:359\u2013393","journal-title":"Prog Retin Eye Res"},{"key":"1487_CR9","doi-asserted-by":"crossref","first-page":"1499","DOI":"10.1007\/s007020200097","volume":"109","author":"S Bleich","year":"2002","unstructured":"Bleich S, Naumann GOH, Kornhuber J (2002) Homocysteine and risk of open angle glaucoma. J Neural Transm 109:1499\u20131504","journal-title":"J Neural Transm"},{"key":"1487_CR10","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1007\/PL00014300","volume":"157","author":"JD Finklestein","year":"1998","unstructured":"Finklestein JD (1998) The metabolism of homocysteine: pathways and regulation. Eur J Pediatr 157:40\u201344","journal-title":"Eur J Pediatr"},{"key":"1487_CR11","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1016\/S0002-9394(14)70908-0","volume":"124","author":"P Mitchell","year":"1997","unstructured":"Mitchell P, Wang JJ, Smith W (1997) Association of pseudoexfoliation with increased vascular risk. Am J Ophthalmol 124:685\u2013687","journal-title":"Am J Ophthalmol"},{"key":"1487_CR12","doi-asserted-by":"crossref","first-page":"877","DOI":"10.1001\/jama.268.7.877","volume":"268","author":"MJ Stampfer","year":"1992","unstructured":"Stampfer MJ, Willet WC (1992) A prospective study of plasma homocysteine and risk of myocardial infarction in US physicians. JAMA 268:877\u2013881","journal-title":"JAMA"},{"key":"1487_CR13","doi-asserted-by":"crossref","first-page":"1395","DOI":"10.1016\/S0140-6736(95)92407-8","volume":"346","author":"IJ Perry","year":"1995","unstructured":"Perry IJ, Morris RW (1995) Prospective study of serum total homocysteine concentration and risk of stroke in middle-aged British men. Lancet 346:1395\u20131398","journal-title":"Lancet"},{"key":"1487_CR14","doi-asserted-by":"crossref","first-page":"640","DOI":"10.1016\/S0002-9394(99)00476-6","volume":"129","author":"AK Vine","year":"2000","unstructured":"Vine AK (2000) Hyperhomocysteinemia: a risk factor for central retinal vein occlusion. Am J Ophthalmol 129:640\u2013644","journal-title":"Am J Ophthalmol"},{"key":"1487_CR15","doi-asserted-by":"crossref","first-page":"1588","DOI":"10.1016\/S0161-6420(00)00181-0","volume":"107","author":"P Pianka","year":"2000","unstructured":"Pianka P, Almog Y, Man O, Goldstein M, Sela BA, Loewenstein A (2000) Hyperhomocysteinemia in patients with nonarteritic anterior ischemic optic neuropathy, central retinal artery occlusion, and central retinal vein occlusion. Ophthalmology 107:1588\u20131592","journal-title":"Ophthalmology"},{"key":"1487_CR16","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1016\/j.ajo.2004.02.027","volume":"138","author":"S Bleich","year":"2004","unstructured":"Bleich S, Roedl J, Von Ahsen N, Schl\u00f6tzer-Schrehardt U, Reulbach U, Beck G, Kruse FE, Naumann GO, Kornhuber J, J\u00fcnemann AG (2004) Elevated homocysteine in aqueous humor of patients with pseudoexfoliation glaucoma. Am J Ophthalmol 138:162\u2013164","journal-title":"Am J Ophthalmol"},{"key":"1487_CR17","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1097\/00061198-200302000-00007","volume":"12","author":"I Leibovitch","year":"2003","unstructured":"Leibovitch I, Kurtz S, Shemesh G, Goldstein M, Sela BA, Lazar M, Loewenstein A (2003) Hyperhomocysteinemia in pseudoexfoliation glaucoma. J Glaucoma 12:36\u201339","journal-title":"J Glaucoma"},{"key":"1487_CR18","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/S0002-9394(03)00077-1","volume":"136","author":"RM Vessani","year":"2003","unstructured":"Vessani RM, Ritch R, Liebmann JM, Jofe M (2003) Plasma homocysteine is elevated in patients with exfoliation syndrome. Am J Ophthalmol 136:41\u201346","journal-title":"Am J Ophthalmol"},{"key":"1487_CR19","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1097\/IJG.0b013e31816f7631","volume":"18","author":"CI Clement","year":"2009","unstructured":"Clement CI, Goldberg I, Healey PR, Graham SL (2009) Plasma homocysteine, MTHFR gene mutation, and open-angle glaucoma. J Glaucoma 18:73\u201378","journal-title":"J Glaucoma"},{"key":"1487_CR20","first-page":"1090","volume":"15","author":"S Michael","year":"2009","unstructured":"Michael S, Qamar R, Akhtar F, Khan WA, Ahmed A (2009) MTHFR gene C677T and A1298C polymorphisms and homocysteine levels in primary open angle and primary closed angle glaucoma. Molecular Vision 15:1090","journal-title":"Molecular Vision"},{"key":"1487_CR21","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1373\/clinchem.2003.021634","volume":"50","author":"H Refsum","year":"2004","unstructured":"Refsum H, Smith AD, Ueland PM, Nexo E, Clarke R, McPartlin J, Johnston C, Engbaek F, Schneede J, McPartlin C, Scott JM (2004) Facts and recommendations about total homocysteine determinations: an expert opinion. Clin Chem 50:3\u201332","journal-title":"Clin Chem"},{"issue":"1\u20132","key":"1487_CR22","first-page":"113","volume":"349","author":"K Demuth","year":"2004","unstructured":"Demuth K, Ducros V, Michelsohn S, Paul JL (2004) Evaluation of Advia Centaur automated chemiluminescence immunoassay for determining total homocysteine in plasma Clin Chim Acta 349(1\u20132):113\u2013120","journal-title":"Evaluation of Advia Centaur automated chemiluminescence immunoassay for determining total homocysteine in plasma Clin Chim Acta."},{"key":"1487_CR23","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1186\/1471-2415-6-6","volume":"6","author":"T Cumurcu","year":"2006","unstructured":"Cumurcu T, Sahin S, Aydin E (2006) Serum homocysteine, vitamin B12 and folic acid levels in different types of glaucoma. BMC Ophthalmol 6:6","journal-title":"BMC Ophthalmol"},{"key":"1487_CR24","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1038\/ng0595-111","volume":"10","author":"P Frosst","year":"1995","unstructured":"Frosst P, Blom HJ, Milos R, Goyette P, Sheppard CA, Matthews RG, Boers GJ, den Heijer M, Kluijtmans LA, van den Heuvel LP (1995) A candidate genetic risk factor for vascular disease: a common mutation in methylenetetrahydrofolate reductase. Nat Genetics 10:111\u2013113","journal-title":"Nat Genetics"},{"key":"1487_CR25","doi-asserted-by":"crossref","first-page":"749","DOI":"10.1007\/s00417-004-0918-7","volume":"242","author":"T Puustj\u00e4rvi","year":"2004","unstructured":"Puustj\u00e4rvi T, Blomster H, Kontkanen M, Punnonen K, Ter\u00e4svirta M (2004) Plasma and aqueous humour levels of homocysteine in exfoliation syndrome. Graefes Arch Clin Exp Ophthalmol 242:749\u2013754","journal-title":"Graefes Arch Clin Exp Ophthalmol"},{"issue":"7","key":"1487_CR26","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1007\/s00417-004-1097-2","volume":"243","author":"O Altinta\u015f","year":"2005","unstructured":"Altinta\u015f O, Maral H, Y\u00fcksel N, Karaba\u015f VL, Dillio\u011flugil MO, Ca\u011flar Y (2005) Homocysteine and nitric oxide levels in plasma of patients with pseudoexfoliation syndrome, pseudoexfoliation glaucoma, and primary open-angle glaucoma. Graefes Arch Clin Exp Ophthalmol 243(7):677\u2013683","journal-title":"Graefes Arch Clin Exp Ophthalmol"},{"issue":"5","key":"1487_CR27","doi-asserted-by":"crossref","first-page":"133","DOI":"10.2147\/CIA.S9918","volume":"26","author":"B Turgut","year":"2010","unstructured":"Turgut B, Kaya M, Arslan S, Demir T, G\u00fcler M, Kaya MK (2010) Levels of circulating homocysteine, vitamin B6, vitamin B12, and folate in different types of open-angle glaucoma. Clin Interv Aging 26(5):133\u2013139","journal-title":"Clin Interv Aging"},{"issue":"5","key":"1487_CR28","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1111\/j.1442-9071.2005.01070.x","volume":"33","author":"ME Tura\u00e7li","year":"2005","unstructured":"Tura\u00e7li ME, Tekeli O, Ozdemir F, Akar N (2005) Methylenetetrahydrofolate reductase 677 C-T and homocysteine levels in Turkish patients with pseudoexfoliation. Clin Experiment Ophthalmol 33(5):505\u20138","journal-title":"Clin Experiment Ophthalmol"},{"key":"1487_CR29","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1006\/exer.2001.1009","volume":"73","author":"P Moore","year":"2001","unstructured":"Moore P, El-sherbeny A, Roon P, Schoenlein PV, Ganapathy V, Smith SB (2001) Apoptotic cell death in the mouse retinal ganglion cell layer is induced in vivo by the excitatory amino acid homocysteine. Exp Eye Res 73:45\u201357","journal-title":"Exp Eye Res"},{"key":"1487_CR30","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1385\/CBB:43:1:037","volume":"43","author":"SC Tyagi","year":"2005","unstructured":"Tyagi SC, Lominadze D, Roberts AM (2005) Homocysteine in microvascular endothelial cell barrier permeability. Cell Biochem Biophys 43:37\u201344","journal-title":"Cell Biochem Biophys"},{"key":"1487_CR31","doi-asserted-by":"crossref","first-page":"951","DOI":"10.1016\/S0161-6420(98)96020-1","volume":"105","author":"GO Naumann","year":"1998","unstructured":"Naumann GO, Schlotzer-Schrehardt U, Kuchle M (1998) Pseudoexfoliation syndrome for the comprehensive ophthalmologist. Intraocular and systemic manifestations. Ophthalmology 105:951\u2013968","journal-title":"Ophthalmology"},{"key":"1487_CR32","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1067\/mva.2000.107563","volume":"32","author":"T Brunelli","year":"2000","unstructured":"Brunelli T, Prisco D, Fedi S, Rogolino A, Farsi A, Marcucci R, Giusti B, Pratesi C, Pulli R, Gensini GF, Abbate R, Pepe G (2000) High prevalence of mild hyperhomocysteinemia in patients with abdominal aortic aneurysm. J Vasc Surg 32:531\u2013536","journal-title":"J Vasc Surg"},{"key":"1487_CR33","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1016\/S0140-6736(98)11058-9","volume":"357","author":"GJ Hankey","year":"1999","unstructured":"Hankey GJ, Eikelboom JW (1999) Homocysteine and vascular disease. Lancet 357:407\u2013413","journal-title":"Lancet"}],"container-title":["Graefe's Archive for Clinical and Experimental Ophthalmology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00417-010-1487-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00417-010-1487-6\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00417-010-1487-6","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,5,28]],"date-time":"2019-05-28T19:48:03Z","timestamp":1559072883000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00417-010-1487-6"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,8,26]]},"references-count":33,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2011,3]]}},"alternative-id":["1487"],"URL":"https:\/\/doi.org\/10.1007\/s00417-010-1487-6","relation":{},"ISSN":["0721-832X","1435-702X"],"issn-type":[{"value":"0721-832X","type":"print"},{"value":"1435-702X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,8,26]]}}}