{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T15:26:58Z","timestamp":1759937218077},"reference-count":41,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2011,9,6]],"date-time":"2011-09-06T00:00:00Z","timestamp":1315267200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Graefes Arch Clin Exp Ophthalmol"],"published-print":{"date-parts":[[2012,2]]},"DOI":"10.1007\/s00417-011-1801-y","type":"journal-article","created":{"date-parts":[[2011,9,6]],"date-time":"2011-09-06T18:22:55Z","timestamp":1315333375000},"page":"211-222","source":"Crossref","is-referenced-by-count":5,"title":["Polyunsaturated fatty acids induce modification in the lipid composition and the prostaglandin production of the conjunctival epithelium cells"],"prefix":"10.1007","volume":"250","author":[{"given":"Sabrina","family":"Viau","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laurent","family":"Lecl\u00e8re","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B\u00e9n\u00e9dicte","family":"Buteau","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"St\u00e9phane","family":"Gr\u00e9goire","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Niyazi","family":"Acar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alain","family":"Bron","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Catherine P.","family":"Creuzot-Garcher","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lionel","family":"Bretillon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Corinne","family":"Joffre","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2011,9,6]]},"reference":[{"key":"1801_CR1","first-page":"386","volume":"10","author":"JM Bourre","year":"2006","unstructured":"Bourre JM (2006) Effects of nutrients (in food) on the structure and function of the nervous system: update on dietary requirements for brain. Part 2: macronutrients. J Nutr Health Aging 10:386\u201399","journal-title":"J Nutr Health Aging"},{"key":"1801_CR2","doi-asserted-by":"crossref","unstructured":"Schnebelen C, Pasquis B, Salinas-Navarro M, Joffre C, Creuzot-Garcher CP, Vidal-Sanz M, Bron AM, Bretillon L, Acar N (2009) A dietary combination of omega-3 and omega-6 polyunsaturated fatty acids is more efficient than single supplementations in the prevention of retinal damage induced by elevation of intraocular pressure in rats. Graefes Arch Clin Exp Ophthalmol","DOI":"10.1007\/s00417-009-1094-6"},{"key":"1801_CR3","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1159\/000217726","volume":"41","author":"C Schnebelen","year":"2009","unstructured":"Schnebelen C, Viau S, Gregoire S, Joffre C, Creuzot-Garcher CP, Bron AM, Bretillon L, Acar N (2009) Nutrition for the eye: different susceptibility of the retina and the lacrimal gland to dietary omega-6 and omega-3 polyunsaturated fatty acid incorporation. Ophthalmic Res 41:216\u201324","journal-title":"Ophthalmic Res"},{"key":"1801_CR4","doi-asserted-by":"crossref","first-page":"1039","DOI":"10.1007\/s00417-009-1080-z","volume":"247","author":"S Viau","year":"2009","unstructured":"Viau S, Maire MA, Pasquis B, Gregoire S, Acar N, Bron AM, Bretillon L, Creuzot-Garcher CP, Joffre C (2009) Efficacy of a 2-month dietary supplementation with polyunsaturated fatty acids in dry eye induced by scopolamine in a rat model. Graefes Arch Clin Exp Ophthalmol 247:1039\u201350","journal-title":"Graefes Arch Clin Exp Ophthalmol"},{"key":"1801_CR5","doi-asserted-by":"crossref","first-page":"1925","DOI":"10.1093\/jn\/130.8.1925","volume":"130","author":"JB Barham","year":"2000","unstructured":"Barham JB, Edens MB, Fonteh AN, Johnson MM, Easter L, Chilton FH (2000) Addition of eicosapentaenoic acid to gamma-linolenic acid-supplemented diets prevents serum arachidonic acid accumulation in humans. J Nutr 130:1925\u201331","journal-title":"J Nutr"},{"key":"1801_CR6","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1016\/j.plefa.2003.11.008","volume":"70","author":"EA Miles","year":"2004","unstructured":"Miles EA, Banerjee T, Calder PC (2004) The influence of different combinations of gamma-linolenic, stearidonic and eicosapentaenoic acids on the fatty acid composition of blood lipids and mononuclear cells in human volunteers. Prostaglandins, Leukot Essent Fatty Acids 70:529\u201338","journal-title":"Prostaglandins, Leukot Essent Fatty Acids"},{"key":"1801_CR7","doi-asserted-by":"crossref","first-page":"1505S","DOI":"10.1093\/ajcn\/83.6.1505S","volume":"83","author":"PC Calder","year":"2006","unstructured":"Calder PC (2006) n-3 polyunsaturated fatty acids, inflammation, and inflammatory diseases. Am J Clin Nutr 83:1505S\u20131519S","journal-title":"Am J Clin Nutr"},{"key":"1801_CR8","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1016\/0161-4630(79)90068-5","volume":"3","author":"BR Culp","year":"1979","unstructured":"Culp BR, Titus BG, Lands WE (1979) Inhibition of prostaglandin biosynthesis by eicosapentaenoic acid. Prostaglandins Med 3:269\u201378","journal-title":"Prostaglandins Med"},{"key":"1801_CR9","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1007\/s11745-009-3289-3","volume":"44","author":"C Schnebelen","year":"2009","unstructured":"Schnebelen C, Gregoire S, Pasquis B, Joffre C, Creuzot-Garcher CP, Bron AM, Bretillon L, Acar N (2009) Dietary n-3 and n-6 PUFA enhance DHA incorporation in retinal phospholipids without affecting PGE(1) and PGE (2) levels. Lipids 44:465\u201370","journal-title":"Lipids"},{"key":"1801_CR10","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1016\/S1542-0124(12)70148-9","volume":"2","author":"ME Stern","year":"2004","unstructured":"Stern ME, Pflugfelder SC (2004) Inflammation in dry eye. Ocul Surf 2:124\u201330","journal-title":"Ocul Surf"},{"key":"1801_CR11","doi-asserted-by":"crossref","first-page":"4474","DOI":"10.1167\/iovs.04-1394","volume":"46","author":"P Aragona","year":"2005","unstructured":"Aragona P, Bucolo C, Spinella R, Giuffrida S, Ferreri G (2005) Systemic omega-6 essential fatty acid treatment and pge1 tear content in Sj\u00f6gren's syndrome patients. Invest Ophthalmol Vis Sci 46:4474\u20139","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"1801_CR12","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1097\/00003226-200303000-00002","volume":"22","author":"S Barabino","year":"2003","unstructured":"Barabino S, Rolando M, Camicione P, Ravera G, Zanardi S, Giuffrida S, Calabria G (2003) Systemic linoleic and gamma-linolenic acid therapy in dry eye syndrome with an inflammatory component. Cornea 22:97\u2013101","journal-title":"Cornea"},{"key":"1801_CR13","doi-asserted-by":"crossref","first-page":"1053","DOI":"10.1016\/S0181-5512(06)73900-6","volume":"29","author":"C Creuzot-Garcher","year":"2006","unstructured":"Creuzot-Garcher C (2006) Lacrimal film and the ocular surface. J Fr Ophtalmol 29:1053\u20139","journal-title":"J Fr Ophtalmol"},{"key":"1801_CR14","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1007\/s00417-003-0685-x","volume":"241","author":"A Macri","year":"2003","unstructured":"Macri A, Giuffrida S, Amico V, Iester M, Traverso CE (2003) Effect of linoleic acid and gamma-linolenic acid on tear production, tear clearance and on the ocular surface after photorefractive keratectomy. Graefes Arch Clin Exp Ophthalmol 241:561\u20136","journal-title":"Graefes Arch Clin Exp Ophthalmol"},{"key":"1801_CR15","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1097\/ICO.0b013e3181f22e03","volume":"30","author":"JC Wojtowicz","year":"2011","unstructured":"Wojtowicz JC, Butovich I, Uchiyama E, Aronowicz J, Agee S, McCulley JP (2011) Pilot, prospective, randomized, double-masked, placebo-controlled clinical trial of an omega-3 supplement for dry eye. Cornea 30:308\u201314","journal-title":"Cornea"},{"key":"1801_CR16","doi-asserted-by":"crossref","first-page":"887","DOI":"10.1093\/ajcn\/82.4.887","volume":"82","author":"B Miljanovic","year":"2005","unstructured":"Miljanovic B, Trivedi KA, Dana MR, Gilbard JP, Buring JE, Schaumberg DA (2005) Relation between dietary n-3 and n-6 fatty acids and clinically diagnosed dry eye syndrome in women. Am J Clin Nutr 82:887\u201393","journal-title":"Am J Clin Nutr"},{"key":"1801_CR17","doi-asserted-by":"crossref","first-page":"867","DOI":"10.7326\/0003-4819-119-9-199311010-00001","volume":"119","author":"LJ Leventhal","year":"1993","unstructured":"Leventhal LJ, Boyce EG, Zurier RB (1993) Treatment of rheumatoid arthritis with gammalinolenic acid. Ann Intern Med 119:867\u201373","journal-title":"Ann Intern Med"},{"key":"1801_CR18","first-page":"39","volume":"312","author":"PS Kulkarni","year":"1989","unstructured":"Kulkarni PS, Srinivasan BD (1989) Cyclooxygenase and lipoxygenase pathways in anterior uvea and conjunctiva. Prog Clin Biol Res 312:39\u201352","journal-title":"Prog Clin Biol Res"},{"key":"1801_CR19","doi-asserted-by":"crossref","first-page":"678","DOI":"10.1002\/(SICI)1097-4547(20000601)60:5<678::AID-JNR13>3.0.CO;2-T","volume":"60","author":"B Goustard-Langelier","year":"2000","unstructured":"Goustard-Langelier B, Alessandri JM, Raguenez G, Durand G, Courtois Y (2000) Phospholipid incorporation and metabolic conversion of n-3 polyunsaturated fatty acids in the Y79 retinoblastoma cell line. J Neurosci Res 60:678\u201385","journal-title":"J Neurosci Res"},{"key":"1801_CR20","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1016\/S0021-9258(18)64849-5","volume":"226","author":"J Folch","year":"1957","unstructured":"Folch J, Lees M, Sloane-Stanley G (1957) A simple method for the isolation and purification of total lipids from animal tissues. J Biol Chem 226:497\u2013509","journal-title":"J Biol Chem"},{"key":"1801_CR21","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1007\/BF02534360","volume":"20","author":"P Juaneda","year":"1985","unstructured":"Juaneda P, Rocquelin G (1985) Rapid and convenient separation of phospholipids and non-phosphorus lipids from rat heart using silica cartridges. Lipids 20:40\u201341","journal-title":"Lipids"},{"key":"1801_CR22","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1136\/bjo.2007.126144","volume":"92","author":"C Joffre","year":"2008","unstructured":"Joffre C, Souchier M, Gregoire S, Viau S, Bretillon L, Acar N, Bron AM, Creuzot-Garcher C (2008) Differences in meibomian fatty acid composition in patients with meibomian gland dysfunction and aqueous-deficient dry eye. Br J Ophthalmol 92:116\u20139","journal-title":"Br J Ophthalmol."},{"key":"1801_CR23","doi-asserted-by":"crossref","first-page":"2028","DOI":"10.1194\/jlr.M600177-JLR200","volume":"47","author":"Y Wang","year":"2006","unstructured":"Wang Y, Botolin D, Xu J, Christian B, Mitchell E, Jayaprakasam B, Nair MG, Peters JM, Busik JV, Olson LK, Jump DB (2006) Regulation of hepatic fatty acid elongase and desaturase expression in diabetes and obesity. J Lipid Res 47:2028\u201341","journal-title":"J Lipid Res."},{"key":"1801_CR24","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.bbalip.2005.01.006","volume":"1734","author":"X Zheng","year":"2005","unstructured":"Zheng X, Torstensen BE, Tocher DR, Dick JR, Henderson RJ, Bell JG (2005) Environmental and dietary influences on highly unsaturated fatty acid biosynthesis and expression of fatty acyl desaturase and elongase genes in liver of Atlantic salmon (Salmo salar). Biochim Biophys Acta 1734:13\u201324","journal-title":"Biochim Biophys Acta."},{"key":"1801_CR25","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1146\/annurev.nutr.24.121803.063211","volume":"24","author":"MT Nakamura","year":"2004","unstructured":"Nakamura MT, Nara TY (2004) Structure, function, and dietary regulation of delta6, delta5, and delta9 desaturases. Annu Rev Nutr 24:345\u201376","journal-title":"Annu Rev Nutr."},{"key":"1801_CR26","doi-asserted-by":"crossref","first-page":"978","DOI":"10.1016\/S0022-2275(20)33865-7","volume":"39","author":"DE Williard","year":"1998","unstructured":"Williard DE, Kaduce TL, Harmon SD, Spector AA (1998) Conversion of eicosapentaenoic acid to chain-shortened omega-3 fatty acid metabolites by peroxisomal oxidation. J Lipid Res 39:978\u201386","journal-title":"J Lipid Res."},{"key":"1801_CR27","doi-asserted-by":"crossref","first-page":"2471","DOI":"10.1016\/S0022-2275(20)41084-3","volume":"36","author":"H Sprecher","year":"1995","unstructured":"Sprecher H, Luthria DL, Mohammed BS, Baykousheva SP (1995) Reevaluation of the pathways for the biosynthesis of polyunsaturated fatty acids. J Lipid Res 36:2471\u20137","journal-title":"J Lipid Res."},{"key":"1801_CR28","doi-asserted-by":"crossref","first-page":"1129","DOI":"10.1046\/j.1365-2222.1999.00604.x","volume":"29","author":"T Obata","year":"1999","unstructured":"Obata T, Nagakura T, Masaki T, Maekawa K, Yamashita K (1999) Eicosapentaenoic acid inhibits prostaglandin D2 generation by inhibiting cyclo-oxygenase-2 in cultured human mast cells. Clin Exp Allergy 29:1129\u201335","journal-title":"Clin Exp Allergy."},{"key":"1801_CR29","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1016\/S0021-9673(01)94187-1","volume":"394","author":"CA Herman","year":"1987","unstructured":"Herman CA, Hamberg M, Granstrom E (1987) Quantitative determination of prostaglandins E1, E2 and E3 in frog tissue. J Chromatogr 394:353\u201362","journal-title":"J Chromatogr."},{"key":"1801_CR30","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1016\/0090-6980(89)90076-2","volume":"37","author":"LG Raisz","year":"1989","unstructured":"Raisz LG, Alander CB, Simmons HA (1989) Effects of prostaglandin E3 and eicosapentaenoic acid on rat bone in organ culture. Prostaglandins 37:615\u201325","journal-title":"Prostaglandins."},{"key":"1801_CR31","doi-asserted-by":"crossref","first-page":"23618","DOI":"10.1016\/S0021-9258(18)54328-3","volume":"266","author":"D Rubin","year":"1991","unstructured":"Rubin D, Laposata M (1991) Regulation of agonist-induced prostaglandin E1 versus prostaglandin E2 production. A mass analysis J Biol Chem 266:23618\u201323","journal-title":"A mass analysis. J Biol Chem."},{"key":"1801_CR32","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1016\/j.plefa.2010.02.004","volume":"82","author":"J He","year":"2010","unstructured":"He J, Bazan HE (2010) Omega-3 fatty acids in dry eye and corneal nerve regeneration after refractive surgery. Prostaglandins Leukot Essent Fatty Acids 82:319\u201325","journal-title":"Prostaglandins Leukot Essent Fatty Acids."},{"key":"1801_CR33","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1016\/j.plefa.2007.10.022","volume":"77","author":"PK Mukherjee","year":"2007","unstructured":"Mukherjee PK, Chawla A, Loayza MS, Bazan NG (2007) Docosanoids are multifunctional regulators of neural cell integrity and fate: significance in aging and disease. Prostaglandins Leukot Essent Fatty Acids 77:233\u20138","journal-title":"Prostaglandins Leukot Essent Fatty Acids."},{"issue":"Suppl 1","key":"1801_CR34","doi-asserted-by":"crossref","first-page":"S200","DOI":"10.1038\/sj.bjp.0707489","volume":"153","author":"CN Serhan","year":"2008","unstructured":"Serhan CN, Chiang N (2008) Endogenous pro-resolving and anti-inflammatory lipid mediators: a new pharmacologic genus. Br J Pharmacol 153(Suppl 1):S200\u201315","journal-title":"Br J Pharmacol."},{"key":"1801_CR35","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1089\/jop.2010.0019","volume":"26","author":"N Li","year":"2010","unstructured":"Li N, He J, Schwartz CE, Gjorstrup P, Bazan HE (2010) Resolvin E1 improves tear production and decreases inflammation in a dry eye mouse model. J Ocul Pharmacol Ther 26:431\u20139","journal-title":"J Ocul Pharmacol Ther."},{"key":"1801_CR36","doi-asserted-by":"crossref","first-page":"1131","DOI":"10.1007\/s001340050735","volume":"24","author":"JW Christman","year":"1998","unstructured":"Christman JW, Lancaster LH, Blackwell TS (1998) Nuclear factor kappa B: a pivotal role in the systemic inflammatory response syndrome and new target for therapy. Intensive Care Med 24:1131\u20138","journal-title":"Intensive Care Med."},{"key":"1801_CR37","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1080\/07315724.2004.10719345","volume":"23","author":"Y Zhao","year":"2004","unstructured":"Zhao Y, Joshi-Barve S, Barve S, Chen LH (2004) Eicosapentaenoic acid prevents LPS-induced TNF-alpha expression by preventing NF-kappaB activation. J Am Coll Nutr 23:71\u20138","journal-title":"J Am Coll Nutr."},{"key":"1801_CR38","first-page":"28","volume":"40","author":"K Tsubota","year":"1999","unstructured":"Tsubota K, Fukagawa K, Fujihara T, Shimmura S, Saito I, Saito K, Takeuchi T (1999) Regulation of human leukocyte antigen expression in human conjunctival epithelium. Invest Ophthalmol Vis Sci 40:28\u201334","journal-title":"Invest Ophthalmol Vis Sci."},{"key":"1801_CR39","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1038\/259211a0","volume":"259","author":"KS Lavappa","year":"1976","unstructured":"Lavappa KS, Macy ML, Shannon JE (1976) Examination of ATCC stocks for HeLa marker chromosomes in human cell lines. Nature 259:211\u20133","journal-title":"Nature."},{"key":"1801_CR40","doi-asserted-by":"crossref","first-page":"4594","DOI":"10.1167\/iovs.05-0776","volume":"46","author":"JM Guenoun","year":"2005","unstructured":"Guenoun JM, Baudouin C, Rat P, Pauly A, Warnet JM, Brignole-Baudouin F (2005) In vitro comparison of cytoprotective and antioxidative effects of latanoprost, travoprost, and bimatoprost on conjunctiva-derived epithelial cells. Invest Ophthalmol Vis Sci 46:4594\u20139","journal-title":"Invest Ophthalmol Vis Sci."},{"key":"1801_CR41","doi-asserted-by":"crossref","first-page":"4263","DOI":"10.1167\/iovs.03-0560","volume":"44","author":"Y Diebold","year":"2003","unstructured":"Diebold Y, Calonge M, Enriquez de Salamanca A, Callejo S, Corrales RM, Saez V, Siemasko KF, Stern ME (2003) Characterization of a spontaneously immortalized cell line (IOBA-NHC) from normal human conjunctiva. Invest Ophthalmol Vis Sci 44:4263\u201374","journal-title":"Invest Ophthalmol Vis Sci."}],"container-title":["Graefe's Archive for Clinical and Experimental Ophthalmology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00417-011-1801-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00417-011-1801-y\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00417-011-1801-y","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,6,9]],"date-time":"2023-06-09T06:48:21Z","timestamp":1686293301000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00417-011-1801-y"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,9,6]]},"references-count":41,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2012,2]]}},"alternative-id":["1801"],"URL":"https:\/\/doi.org\/10.1007\/s00417-011-1801-y","relation":{},"ISSN":["0721-832X","1435-702X"],"issn-type":[{"value":"0721-832X","type":"print"},{"value":"1435-702X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,9,6]]}}}