{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,3]],"date-time":"2026-04-03T17:02:57Z","timestamp":1775235777281,"version":"3.50.1"},"reference-count":35,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2011,11,10]],"date-time":"2011-11-10T00:00:00Z","timestamp":1320883200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Graefes Arch Clin Exp Ophthalmol"],"published-print":{"date-parts":[[2012,2]]},"DOI":"10.1007\/s00417-011-1840-4","type":"journal-article","created":{"date-parts":[[2011,11,9]],"date-time":"2011-11-09T05:08:05Z","timestamp":1320815285000},"page":"231-238","source":"Crossref","is-referenced-by-count":11,"title":["Intravitreal treatment with antisense oligonucleotides targeting tumor necrosis factor-\u03b1 in murine herpes simplex virus type 1 retinitis"],"prefix":"10.1007","volume":"250","author":[{"given":"Rafael S.","family":"Grajewski","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jin","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Susanne","family":"Wasmuth","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maren","family":"Hennig","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dirk","family":"Bauer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arnd","family":"Heiligenhaus","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2011,11,10]]},"reference":[{"key":"1840_CR1","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1016\/S0002-9394(14)71046-3","volume":"123","author":"BE Silverstein","year":"1997","unstructured":"Silverstein BE, Conrad D, Margolis TP, Wong IG (1997) Cytomegalovirus-associated acute retinal necrosis syndrome. Am J Ophthalmol 123:257\u2013258","journal-title":"Am J Ophthalmol"},{"key":"1840_CR2","first-page":"69","volume":"8","author":"SS Atherton","year":"2001","unstructured":"Atherton SS (2001) Acute retinal necrosis: insights into pathogenesis from the mouse model. Herpes 8:69\u201373","journal-title":"Herpes"},{"key":"1840_CR3","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1016\/S0002-9394(99)00316-5","volume":"129","author":"JB Ganatra","year":"2000","unstructured":"Ganatra JB, Chandler D, Santos C, Kuppermann B, Margolis TP (2000) Viral causes of the acute retinal necrosis syndrome. Am J Ophthalmol 129:166\u2013172","journal-title":"Am J Ophthalmol"},{"key":"1840_CR4","first-page":"1065","volume":"25","author":"JA Whittum","year":"1984","unstructured":"Whittum JA, McCulley JP, Niederkorn JY, Streilein JW (1984) Ocular disease induced in mice by anterior chamber inoculation of herpes simplex virus. Invest Ophthalmol Vis Sci 25:1065\u20131073","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"1840_CR5","first-page":"1485","volume":"30","author":"SW Cousins","year":"1989","unstructured":"Cousins SW, Gonzalez A, Atherton SS (1989) Herpes simplex retinitis in the mouse. Clinicopathologic correlations. Invest Ophthalmol Vis Sci 30:1485\u20131494","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"1840_CR6","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1080\/13550280290049570","volume":"8","author":"NM Archin","year":"2002","unstructured":"Archin NM, Atherton SS (2002) Rapid spread of a neurovirulent strain of HSV-1 through the CNS of BALB\/c mice following anterior chamber inoculation. J Neurovirol 8:122\u2013135","journal-title":"J Neurovirol"},{"key":"1840_CR7","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/0090-1229(90)90094-7","volume":"55","author":"Y Fong","year":"1990","unstructured":"Fong Y, Lowry SF (1990) Tumor necrosis factor in the pathophysiology of infection and sepsis. Clin Immunol Immunopathol 55:157\u2013170","journal-title":"Clin Immunol Immunopathol"},{"key":"1840_CR8","first-page":"2211","volume":"37","author":"G Sartani","year":"1996","unstructured":"Sartani G, Silver PB, Rizzo LV, Chan CC, Wiggert B, Mastorakos G, Caspi RR (1996) Anti-tumor necrosis factor alpha therapy suppresses the induction of experimental autoimmune uveoretinitis in mice by inhibiting antigen priming. Invest Ophthalmol Vis Sci 37:2211\u20132218","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"1840_CR9","doi-asserted-by":"crossref","first-page":"1356","DOI":"10.1167\/iovs.04-1284","volume":"46","author":"M Zheng","year":"2005","unstructured":"Zheng M, Atherton SS (2005) Cytokine profiles and inflammatory cells during HSV-1-induced acute retinal necrosis. Invest Ophthalmol Vis Sci 46:1356\u20131363","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"1840_CR10","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1076\/ocii.11.3.187.17354","volume":"11","author":"M Zheng","year":"2003","unstructured":"Zheng M, Qian H, Joshi RM, Nechtman J, Atherton SS (2003) DNA microarray analysis of the uninoculated eye following anterior chamber inoculation of HSV-1. Ocul Immunol Inflamm 11:187\u2013195","journal-title":"Ocul Immunol Inflamm"},{"key":"1840_CR11","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1089\/10799900360708650","volume":"23","author":"C Oettinger","year":"2003","unstructured":"Oettinger C, D'Souza M (2003) Microencapsulation of tumor necrosis factor oligomers: a new approach to proinflammatory cytokine inhibition. J Interferon Cytokine Res 23:533\u2013543","journal-title":"J Interferon Cytokine Res"},{"key":"1840_CR12","doi-asserted-by":"crossref","first-page":"71","DOI":"10.2174\/0929867053363603","volume":"12","author":"T Ros Da","year":"2005","unstructured":"Da Ros T, Spalluto G, Prato M, Saison-Behmoaras T, Boutorine A, Cacciari B (2005) Oligonucleotides and oligonucleotide conjugates: a new approach for cancer treatment. Curr Med Chem 12:71\u201388","journal-title":"Curr Med Chem"},{"key":"1840_CR13","doi-asserted-by":"crossref","first-page":"1628","DOI":"10.1046\/j.1432-1033.2003.03555.x","volume":"270","author":"J Kurreck","year":"2003","unstructured":"Kurreck J (2003) Antisense technologies. Improvement through novel chemical modifications. Eur J Biochem 270:1628\u20131644","journal-title":"Eur J Biochem"},{"key":"1840_CR14","doi-asserted-by":"crossref","first-page":"5228","DOI":"10.1167\/iovs.03-0312","volume":"44","author":"S Wasmuth","year":"2003","unstructured":"Wasmuth S, Bauer D, Yang Y, Steuhl KP, Heiligenhaus A (2003) Topical treatment with antisense oligonucleotides targeting tumor necrosis factor-alpha in herpetic stromal keratitis. Invest Ophthalmol Vis Sci 44:5228\u20135234","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"1840_CR15","doi-asserted-by":"crossref","first-page":"1265","DOI":"10.1007\/s00417-008-0839-y","volume":"246","author":"J Li","year":"2008","unstructured":"Li J, Wasmuth S, Bauer D, Baehler H, Hennig M, Heiligenhaus A (2008) Subconjunctival antisense oligonucleotides targeting TNF-alpha influence immunopathology and viral replication in murine HSV-1 retinitis. Graefes Arch Clin Exp Ophthalmol 246:1265\u20131273","journal-title":"Graefes Arch Clin Exp Ophthalmol"},{"key":"1840_CR16","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1007\/s004170050251","volume":"237","author":"A Heiligenhaus","year":"1999","unstructured":"Heiligenhaus A, Bauer D, Zheng M, Mrzyk S, Steuhl KP (1999) CD4+ T-cell type 1 and type 2 cytokines in the HSV-1 infected cornea. Graefes Arch Clin Exp Ophthalmol 237:399\u2013406","journal-title":"Graefes Arch Clin Exp Ophthalmol"},{"issue":"Suppl 1","key":"1840_CR17","doi-asserted-by":"crossref","first-page":"S83","DOI":"10.1007\/BF02343053","volume":"234","author":"A Berra","year":"1996","unstructured":"Berra A, Heiligenhaus A, Foster CS (1996) T-cell subsets and T-cell receptor V beta utilization by Igh-1-congenic mice in herpetic retinal necrosis. Graefes Arch Clin Exp Ophthalmol 234(Suppl 1):S83\u2013S88","journal-title":"Graefes Arch Clin Exp Ophthalmol"},{"key":"1840_CR18","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1006\/exer.2000.0947","volume":"72","author":"D Bauer","year":"2001","unstructured":"Bauer D, Mrzyk S, Van Rooijen N, Steuhl KP, Heiligenhaus A (2001) Incidence and severity of herpetic stromal keratitis: impaired by the depletion of lymph node macrophages. Exp Eye Res 72:261\u2013269","journal-title":"Exp Eye Res"},{"key":"1840_CR19","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1046\/j.1365-2567.2002.01477.x","volume":"107","author":"D Bauer","year":"2002","unstructured":"Bauer D, Schmitz A, Van Rooijen N, Steuhl KP, Heiligenhaus A (2002) Conjunctival macrophage-mediated influence of the local and systemic immune response after corneal herpes simplex virus-1 infection. Immunology 107:118\u2013128","journal-title":"Immunology"},{"key":"1840_CR20","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1016\/S1357-4310(99)01638-X","volume":"6","author":"S Agrawal","year":"2000","unstructured":"Agrawal S, Kandimalla ER (2000) Antisense therapeutics: is it as simple as complementary base recognition? Mol Med Today 6:72\u201381","journal-title":"Mol Med Today"},{"key":"1840_CR21","doi-asserted-by":"crossref","first-page":"41","DOI":"10.2174\/1389557053402846","volume":"5","author":"TL Pierce","year":"2005","unstructured":"Pierce TL, White AR, Tregear GW, Sexton PM (2005) Peptide-oligonucleotide hybrids in antisense therapy. Mini Rev Med Chem 5:41\u201355","journal-title":"Mini Rev Med Chem"},{"key":"1840_CR22","doi-asserted-by":"crossref","first-page":"415","DOI":"10.2174\/1389201043376689","volume":"5","author":"KJ Scanlon","year":"2004","unstructured":"Scanlon KJ (2004) Anti-genes: siRNA, ribozymes and antisense. Curr Pharm Biotechnol 5:415\u2013420","journal-title":"Curr Pharm Biotechnol"},{"key":"1840_CR23","first-page":"2646","volume":"42","author":"SP Henry","year":"2001","unstructured":"Henry SP, Miner RC, Drew WL, Fitchett J, York-Defalco C, Rapp LM, Levin AA (2001) Antiviral activity and ocular kinetics of antisense oligonucleotides designed to inhibit CMV replication. Invest Ophthalmol Vis Sci 42:2646\u20132651","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"1840_CR24","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1001\/archopht.123.2.214","volume":"123","author":"RB Bhisitkul","year":"2005","unstructured":"Bhisitkul RB, Robinson GS, Moulton RS, Claffey KP, Gragoudas ES, Miller JW (2005) An antisense oligodeoxynucleotide against vascular endothelial growth factor in a nonhuman primate model of iris neovascularization. Arch Ophthalmol 123:214\u2013219","journal-title":"Arch Ophthalmol"},{"key":"1840_CR25","doi-asserted-by":"crossref","first-page":"840","DOI":"10.1111\/j.1582-4934.2005.tb00383.x","volume":"9","author":"FD Popescu","year":"2005","unstructured":"Popescu FD (2005) Antisense- and RNA interference-based therapeutic strategies in allergy. J Cell Mol Med 9:840\u2013853","journal-title":"J Cell Mol Med"},{"key":"1840_CR26","doi-asserted-by":"crossref","first-page":"299","DOI":"10.2165\/00003495-199856030-00001","volume":"56","author":"RA Hogezand van","year":"1998","unstructured":"van Hogezand RA, Verspaget HW (1998) The future role of anti-tumour necrosis factor-alpha products in the treatment of Crohn's disease. Drugs 56:299\u2013305","journal-title":"Drugs"},{"key":"1840_CR27","doi-asserted-by":"crossref","first-page":"698","DOI":"10.1136\/bjo.68.10.698","volume":"68","author":"PS Hiscott","year":"1984","unstructured":"Hiscott PS, Grierson I, Trombetta CJ, Rahi AH, Marshall J, McLeod D (1984) Retinal and epiretinal glia\u2013an immunohistochemical study. Br J Ophthalmol 68:698\u2013707","journal-title":"Br J Ophthalmol"},{"key":"1840_CR28","doi-asserted-by":"crossref","first-page":"1983","DOI":"10.4049\/jimmunol.161.4.1983","volume":"161","author":"LP Erwig","year":"1998","unstructured":"Erwig LP, Kluth DC, Walsh GM, Rees AJ (1998) Initial cytokine exposure determines function of macrophages and renders them unresponsive to other cytokines. J Immunol 161:1983\u20131988","journal-title":"J Immunol"},{"key":"1840_CR29","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1038\/nri910","volume":"2","author":"Q Li","year":"2002","unstructured":"Li Q, Verma IM (2002) NF-kappaB regulation in the immune system. Nat Rev Immunol 2:725\u2013734","journal-title":"Nat Rev Immunol"},{"key":"1840_CR30","first-page":"2250","volume":"43","author":"MJ Robertson","year":"2002","unstructured":"Robertson MJ, Erwig LP, Liversidge J, Forrester JV, Rees AJ, Dick AD (2002) Retinal microenvironment controls resident and infiltrating macrophage function during uveoretinitis. Invest Ophthalmol Vis Sci 43:2250\u20132257","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"1840_CR31","first-page":"78","volume":"39","author":"A Azumi","year":"1998","unstructured":"Azumi A, Atherton SS (1998) T cells in the uninjected eye after anterior chamber inoculation of herpes simplex virus type 1. Invest Ophthalmol Vis Sci 39:78\u201383","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"1840_CR32","doi-asserted-by":"crossref","first-page":"1907","DOI":"10.1002\/eji.1830220734","volume":"22","author":"FM Brennan","year":"1992","unstructured":"Brennan FM, Gibbons DL, Mitchell T, Cope AP, Maini RN, Feldmann M (1992) Enhanced expression of tumor necrosis factor receptor mRNA and protein in mononuclear cells isolated from rheumatoid arthritis synovial joints. Eur J Immunol 22:1907\u20131912","journal-title":"Eur J Immunol"},{"key":"1840_CR33","first-page":"21","volume":"84","author":"AP Cope","year":"1995","unstructured":"Cope AP, Aderka D, Wallach D, Kahan M, Chu NR, Brennan FM, Feldmann M (1995) Soluble TNF receptor production by activated T lymphocytes: differential effects of acute and chronic exposure to TNF. Immunology 84:21\u201330","journal-title":"Immunology"},{"key":"1840_CR34","doi-asserted-by":"crossref","first-page":"4229","DOI":"10.4049\/jimmunol.147.12.4229","volume":"147","author":"CF Ware","year":"1991","unstructured":"Ware CF, Crowe PD, Vanarsdale TL, Andrews JL, Grayson MH, Jerzy R, Smith CA, Goodwin RG (1991) Tumor necrosis factor (TNF) receptor expression in T lymphocytes. Differential regulation of the type I TNF receptor during activation of resting and effector T cells. J Immunol 147:4229\u20134238","journal-title":"J Immunol"},{"key":"1840_CR35","doi-asserted-by":"crossref","first-page":"2269","DOI":"10.1167\/iovs.08-2874","volume":"50","author":"HM Cathcart","year":"2009","unstructured":"Cathcart HM, Fields MA, Zheng M, Marshall B, Atherton SS (2009) Infiltrating cells and IFNgamma production in the injected eye after uniocular anterior chamber inoculation of HSV-1. Invest Ophthalmol Vis Sci 50:2269\u20132275","journal-title":"Invest Ophthalmol Vis Sci"}],"container-title":["Graefe's Archive for Clinical and Experimental Ophthalmology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00417-011-1840-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00417-011-1840-4\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00417-011-1840-4","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,6,11]],"date-time":"2023-06-11T00:47:44Z","timestamp":1686444464000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00417-011-1840-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,11,10]]},"references-count":35,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2012,2]]}},"alternative-id":["1840"],"URL":"https:\/\/doi.org\/10.1007\/s00417-011-1840-4","relation":{},"ISSN":["0721-832X","1435-702X"],"issn-type":[{"value":"0721-832X","type":"print"},{"value":"1435-702X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,11,10]]}}}