{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T00:31:54Z","timestamp":1790641914191,"version":"4.1.0"},"reference-count":20,"publisher":"Springer Science and Business Media LLC","issue":"7","license":[{"start":{"date-parts":[[2012,4,18]],"date-time":"2012-04-18T00:00:00Z","timestamp":1334707200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Graefes Arch Clin Exp Ophthalmol"],"published-print":{"date-parts":[[2012,7]]},"DOI":"10.1007\/s00417-012-1944-5","type":"journal-article","created":{"date-parts":[[2012,4,17]],"date-time":"2012-04-17T02:42:37Z","timestamp":1334630557000},"page":"999-1007","source":"Crossref","is-referenced-by-count":7,"title":["Growth inhibition of human lens epithelial cells by short hairpin RNA in transcription factor forkhead box E3 (FOXE3)"],"prefix":"10.1007","volume":"250","author":[{"given":"Ye","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenfeng","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yao","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yusen","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2012,4,18]]},"reference":[{"key":"1944_CR1","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1097\/00055735-200002000-00009","volume":"11","author":"DS Clark","year":"2000","unstructured":"Clark DS (2000) Posterior capsule opacification. Curr Opin Ophthalmol 11:56\u201364","journal-title":"Curr Opin Ophthalmol"},{"key":"1944_CR2","doi-asserted-by":"crossref","first-page":"1024","DOI":"10.1136\/bjo.2008.154633","volume":"94","author":"Y Huang","year":"2010","unstructured":"Huang Y, Xie L (2010) Short-term outcomes of dry pars plana posterior capsulotomy and anterior vitrectomy in paediatric cataract surgery using 25-gauge instruments. Br J Ophthalmol 94:1024\u20131027","journal-title":"Br J Ophthalmol"},{"key":"1944_CR3","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1016\/S0886-3350(99)00352-1","volume":"26","author":"Q Peng","year":"2000","unstructured":"Peng Q, Visessook N, Apple DJ, Pandey SK, Werner L, Escobar-Gomez M, Schoderbek R, Solomon KD, Guindi A (2000) Surgical prevention of posterior capsule opacification. Part 3: intraocular lens optic barrier effect as a second line of defense. J Cataract Refract Surg 26:198\u2013213","journal-title":"J Cataract Refract Surg"},{"key":"1944_CR4","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/0039-6257(92)90073-3","volume":"37","author":"DJ Apple","year":"1992","unstructured":"Apple DJ, Solomon KD, Tetz MR, Assia EI, Holland EY, Legler UF, Tsai JC, Castaneda VE, Hoggatt JP, Kostick AM (1992) Posterior capsule opacification. Surv Ophthalmol 37:73\u2013116","journal-title":"Surv Ophthalmol"},{"key":"1944_CR5","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1101\/gad.14.2.245","volume":"14","author":"A Blixt","year":"2000","unstructured":"Blixt A, Mahlapuu M, Aitola M, Pelto-Huikko M, Enerback S, Carlsson P (2000) A forkhead gene, FoxE3, is essential for lens epithelial proliferation and closure of the lens vesicle. Genes Dev 14:245\u2013254","journal-title":"Genes Dev"},{"key":"1944_CR6","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1002\/1526-968X(200006)27:2<81::AID-GENE50>3.0.CO;2-N","volume":"27","author":"I Brownell","year":"2000","unstructured":"Brownell I, Dirksen M, Jamrich M (2000) Forkhead Foxe3 maps to the dysgenetic lens locus and is critical in lens development and differentiation. Genesis 27:81\u201393","journal-title":"Genesis"},{"key":"1944_CR7","doi-asserted-by":"crossref","first-page":"582","DOI":"10.1002\/ajmg.a.33257","volume":"152A","author":"LM Reis","year":"2010","unstructured":"Reis LM, Tyler RC, Schneider A, Bardakjian T, Stoler JM, Melancon SB, Semina EV (2010) FOXE3 plays a significant role in autosomal recessive microphthalmia. Am J Med Genet A 152A:582\u2013590","journal-title":"Am J Med Genet A"},{"key":"1944_CR8","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1016\/j.mod.2006.07.004","volume":"123","author":"X Shi","year":"2006","unstructured":"Shi X, Luo Y, Howley S, Dzialo A, Foley S, Hyde DR, Vihtelic TS (2006) Zebrafish foxe3: roles in ocular lens morphogenesis through interaction with pitx3. Mech Dev 123:761\u2013782","journal-title":"Mech Dev"},{"key":"1944_CR9","doi-asserted-by":"crossref","first-page":"1378","DOI":"10.1002\/humu.21079","volume":"30","author":"SU Iseri","year":"2009","unstructured":"Iseri SU, Osborne RJ, Farrall M, Wyatt AW, Mirza G, Nurnberg G, Kluck C, Herbert H, Martin A, Hussain MS, Collin JR, Lathrop M, Nurnberg P, Ragoussis J, Ragge NK (2009) Seeing clearly: the dominant and recessive nature of FOXE3 in eye developmental anomalies. Hum Mutat 30:1378\u20131386","journal-title":"Hum Mutat"},{"key":"1944_CR10","doi-asserted-by":"crossref","first-page":"8854","DOI":"10.1128\/MCB.25.20.8854-8863.2005","volume":"25","author":"O Medina-Martinez","year":"2005","unstructured":"Medina-Martinez O, Brownell I, Amaya-Manzanares F, Hu Q, Behringer RR, Jamrich M (2005) Severe defects in proliferation and differentiation of lens cells in Foxe3 null mice. Mol Cell Biol 25:8854\u20138863","journal-title":"Mol Cell Biol"},{"key":"1944_CR11","doi-asserted-by":"crossref","first-page":"4269","DOI":"10.1167\/iovs.08-2243","volume":"49","author":"H Landgren","year":"2008","unstructured":"Landgren H, Blixt A, Carlsson P (2008) Persistent FoxE3 expression blocks cytoskeletal remodeling and organelle degradation during lens fiber differentiation. Invest Ophthalmol Vis Sci 49:4269\u20134277","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"1944_CR12","first-page":"341","volume":"16","author":"Y Huang","year":"2010","unstructured":"Huang Y, Xie L (2010) Expression of transcription factors and crystallin proteins during rat lens regeneration. Mol Vis 16:341\u2013352","journal-title":"Mol Vis"},{"key":"1944_CR13","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1002\/dvg.20380","volume":"46","author":"EC Swindell","year":"2008","unstructured":"Swindell EC, Zilinski CA, Hashimoto R, Shah R, Lane ME, Jamrich M (2008) Regulation and function of foxe3 during early zebrafish development. Genesis 46:177\u2013183","journal-title":"Genesis"},{"key":"1944_CR14","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1007\/s00424-008-0514-5","volume":"457","author":"A Meissner","year":"2008","unstructured":"Meissner A, Noack T (2008) Proliferation of human lens epithelial cells (HLE-B3) is inhibited by blocking of voltage-gated calcium channels. Pflugers Arch 457:47\u201359","journal-title":"Pflugers Arch"},{"key":"1944_CR15","first-page":"3094","volume":"35","author":"UP Andley","year":"1994","unstructured":"Andley UP, Rhim JS, Chylack LT Jr, Fleming TP (1994) Propagation and immortalization of human lens epithelial cells in culture. Invest Ophthalmol Vis Sci 35:3094\u20133102","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"1944_CR16","first-page":"1387","volume":"39","author":"TP Fleming","year":"1998","unstructured":"Fleming TP, Song Z, Andley UP (1998) Expression of growth control and differentiation genes in human lens epithelial cells with extended life span. Invest Ophthalmol Vis Sci 39:1387\u20131398","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"1944_CR17","first-page":"105","volume":"40","author":"P Mukhopadhyay","year":"1999","unstructured":"Mukhopadhyay P, Bhattacherjee P, Andom T, Geoghegan TE, Andley UP, Paterson CA (1999) Expression of prostaglandin receptors EP4 and FP in human lens epithelial cells. Invest Ophthalmol Vis Sci 40:105\u2013112","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"1944_CR18","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1124\/mol.109.063107","volume":"16","author":"J Yang","year":"2010","unstructured":"Yang J, Luo L, Liu X, Rosenblatt MI, Qu B, Liu Y (2010) Down regulation of the PEDF gene in human lens epithelium cells changed the expression of proteins vimentin and alphaB-crystallin. Mol Vis 16:105\u2013112","journal-title":"Mol Vis"},{"key":"1944_CR19","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1038\/nbt831","volume":"21","author":"AL Jackson","year":"2003","unstructured":"Jackson AL, Bartz SR, Schelter J, Kobayashi SV, Burchard J, Mao M, Li B, Cavet G, Linsley PS (2003) Expression profiling reveals off-target gene regulation by RNAi. Nat Biotechnol 21:635\u2013637","journal-title":"Nat Biotechnol"},{"key":"1944_CR20","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1016\/j.ydbio.2006.09.021","volume":"302","author":"A Blixt","year":"2007","unstructured":"Blixt A, Landgren H, Johansson BR, Carlsson P (2007) Foxe3 is required for morphogenesis and differentiation of the anterior segment of the eye and is sensitive to Pax6 gene dosage. Dev Biol 302:218\u2013229","journal-title":"Dev Biol"}],"container-title":["Graefe's Archive for Clinical and Experimental Ophthalmology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00417-012-1944-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00417-012-1944-5\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00417-012-1944-5","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,1,13]],"date-time":"2022-01-13T01:42:31Z","timestamp":1642038151000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00417-012-1944-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,4,18]]},"references-count":20,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2012,7]]}},"alternative-id":["1944"],"URL":"https:\/\/doi.org\/10.1007\/s00417-012-1944-5","relation":{},"ISSN":["0721-832X","1435-702X"],"issn-type":[{"value":"0721-832X","type":"print"},{"value":"1435-702X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,4,18]]}}}