{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,13]],"date-time":"2025-11-13T07:00:06Z","timestamp":1763017206822},"reference-count":28,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2012,6,23]],"date-time":"2012-06-23T00:00:00Z","timestamp":1340409600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Graefes Arch Clin Exp Ophthalmol"],"published-print":{"date-parts":[[2013,2]]},"DOI":"10.1007\/s00417-012-2082-9","type":"journal-article","created":{"date-parts":[[2012,6,22]],"date-time":"2012-06-22T12:22:53Z","timestamp":1340367773000},"page":"543-547","source":"Crossref","is-referenced-by-count":19,"title":["In vitro effect of corneal collagen cross-linking on corneal hydration properties and stiffness"],"prefix":"10.1007","volume":"251","author":[{"given":"Georgios A.","family":"Kontadakis","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Harilaos","family":"Ginis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nikolaos","family":"Karyotakis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexandros","family":"Pennos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Iro","family":"Pentari","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"George D.","family":"Kymionis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ioannis G.","family":"Pallikaris","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2012,6,23]]},"reference":[{"key":"2082_CR1","doi-asserted-by":"crossref","first-page":"837","DOI":"10.3928\/1081597X-20090917-04","volume":"25","author":"RR Krueger","year":"2009","unstructured":"Krueger RR (2009) Biomechanical manipulation: the next frontier in corneal refractive surgery. J Refract Surg 25:837\u201340","journal-title":"J Refract Surg"},{"key":"2082_CR2","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1016\/j.jmbbm.2008.07.002","volume":"2","author":"A Gefen","year":"2009","unstructured":"Gefen A, Shalom R, Elad D, Mandel Y (2009) Biomechanical analysis of the keratoconic cornea. J Mech Behav Biomed Mater 2:224\u201336","journal-title":"J Mech Behav Biomed Mater"},{"key":"2082_CR3","doi-asserted-by":"crossref","first-page":"1530","DOI":"10.1016\/j.jcrs.2007.04.043","volume":"33","author":"PS Binder","year":"2007","unstructured":"Binder PS (2007) Analysis of ectasia after laser in situ keratomileusis: risk factors. J Cataract Refract Surg 33:1530\u20138","journal-title":"J Cataract Refract Surg"},{"key":"2082_CR4","doi-asserted-by":"crossref","first-page":"620","DOI":"10.1016\/S0002-9394(02)02220-1","volume":"135","author":"G Wollensak","year":"2003","unstructured":"Wollensak G, Spoerl E, Seiler T (2003) Riboflavin\/ultraviolet-a-induced collagen crosslinking for the treatment of keratoconus. Am J Ophthalmol 135:620\u20137","journal-title":"Am J Ophthalmol"},{"key":"2082_CR5","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1006\/exer.1997.0410","volume":"66","author":"E Spoerl","year":"1998","unstructured":"Spoerl E, Huhle M, Seiler T (1998) Induction of cross-links in corneal tissue. Exp Eye Res 66:97\u2013103","journal-title":"Exp Eye Res"},{"key":"2082_CR6","doi-asserted-by":"crossref","first-page":"1780","DOI":"10.1016\/S0886-3350(03)00407-3","volume":"29","author":"G Wollensak","year":"2003","unstructured":"Wollensak G, Spoerl E, Seiler T (2003) Stress-strain measurements of human and porcine corneas after riboflavin\u2013ultraviolet-A-induced cross-linking. J Cataract Refract Surg 29:1780\u20135","journal-title":"J Cataract Refract Surg"},{"key":"2082_CR7","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1016\/j.jcrs.2005.12.092","volume":"32","author":"M Kohlhaas","year":"2006","unstructured":"Kohlhaas M, Spoerl E, Schilde T, Unger G, Wittig C, Pillunat LE (2006) Biomechanical evidence of the distribution of cross-links in corneas treated with riboflavin and ultraviolet A light. J Cataract Refract Surg 32:279\u201383","journal-title":"J Cataract Refract Surg"},{"key":"2082_CR8","doi-asserted-by":"crossref","first-page":"3961","DOI":"10.1167\/iovs.09-4536","volume":"51","author":"S Kling","year":"2010","unstructured":"Kling S, Remon L, P\u00e9rez-Escudero A, Merayo-Lloves J, Marcos S (2010) Corneal biomechanical changes after collagen cross-linking from porcine eye inflation experiments. Investig Ophthalmol Vis Sci 51:3961\u20138","journal-title":"Investig Ophthalmol Vis Sci"},{"key":"2082_CR9","doi-asserted-by":"crossref","first-page":"796","DOI":"10.1016\/j.jcrs.2007.12.039","volume":"34","author":"F Raiskup-Wolf","year":"2008","unstructured":"Raiskup-Wolf F, Hoyer A, Spoerl E, Pillunat LE (2008) Collagen crosslinking with riboflavin and ultraviolet-A light in keratoconus: long-term results. J Cataract Refract Surg 34:796\u2013801","journal-title":"J Cataract Refract Surg"},{"key":"2082_CR10","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1016\/j.ajo.2009.10.021","volume":"149","author":"A Caporossi","year":"2010","unstructured":"Caporossi A, Mazzotta C, Baiocchi S, Caporossi T (2010) Long-term results of riboflavin ultraviolet a corneal collagen cross-linking for keratoconus in Italy: the Siena eye cross study. Am J Ophthalmol 149:585\u201393","journal-title":"Am J Ophthalmol"},{"key":"2082_CR11","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1111\/j.1600-0420.2007.01085.x","volume":"86","author":"N Ehlers","year":"2008","unstructured":"Ehlers N, Hjortdal J (2008) Riboflavin-ultraviolet light induced cross-linking in endothelial decompensation. Acta Ophthalmol 86:549\u201351","journal-title":"Acta Ophthalmol"},{"key":"2082_CR12","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1159\/000187630","volume":"41","author":"G Wollensak","year":"2009","unstructured":"Wollensak G, Aurich H, Wirbelauer C, Pham DT (2009) Potential use of riboflavin\/UVA cross-linking in bullous keratopathy. Ophthalmic Res 41:114\u20137","journal-title":"Ophthalmic Res"},{"key":"2082_CR13","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1016\/j.jcrs.2009.07.041","volume":"36","author":"RC Ghanem","year":"2010","unstructured":"Ghanem RC, Santhiago MR, Berti TB, Thomaz S, Netto MV (2010) Collagen crosslinking with riboflavin and ultraviolet-A in eyes with pseudophakic bullous keratopathy. J Cataract Refract Surg 36:273\u20136","journal-title":"J Cataract Refract Surg"},{"key":"2082_CR14","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1097\/ICO.0b013e3181c296c2","volume":"29","author":"MM Cordeiro Barbosa","year":"2010","unstructured":"Cordeiro Barbosa MM, Barbosa JB Jr, Hirai FE, Hofling-Lima AL (2010) Effect of cross-linking on corneal thickness in patients with corneal edema. Cornea 29:613\u20137","journal-title":"Cornea"},{"key":"2082_CR15","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1097\/ICO.0b013e3181bd9f12","volume":"29","author":"KM Bott\u00f3s","year":"2010","unstructured":"Bott\u00f3s KM, Hofling-Lima AL, Barbosa MC, Barbosa JB Jr, Dreyfuss JL, Schor P, Nader HB (2010) Effect of collagen cross-linking in stromal fibril organization in edematous human corneas. Cornea 29:789\u201393","journal-title":"Cornea"},{"key":"2082_CR16","doi-asserted-by":"crossref","first-page":"516","DOI":"10.1016\/j.jcrs.2006.11.015","volume":"33","author":"G Wollensak","year":"2007","unstructured":"Wollensak G, Aurich H, Pham DT, Wirbelauer C (2007) Hydration behavior of porcine cornea crosslinked with riboflavin and ultraviolet A. J Cataract Refract Surg 33:516\u201321","journal-title":"J Cataract Refract Surg"},{"key":"2082_CR17","doi-asserted-by":"crossref","first-page":"17","DOI":"10.3181\/00379727-196-43158C","volume":"196","author":"KM Reiser","year":"1991","unstructured":"Reiser KM (1991) Nonenzymatic glycation of collagen in aging and diabetes. Proc Soc Exp Biol Med 196:17\u201329","journal-title":"Proc Soc Exp Biol Med"},{"key":"2082_CR18","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1167\/iovs.09-3738","volume":"51","author":"AS McCall","year":"2010","unstructured":"McCall AS, Kraft S, Edelhauser HF, Kidder GW, Lundquist RR, Bradshaw HE, Dedeic Z, Dionne MJ, Clement EM, Conrad GW (2010) Mechanisms of corneal tissue cross-linking in response to treatment with topical riboflavin and long-wavelength ultraviolet radiation (UVA). Investig Ophthalmol Vis Sci 51:129\u201338","journal-title":"Investig Ophthalmol Vis Sci"},{"key":"2082_CR19","doi-asserted-by":"crossref","first-page":"13011","DOI":"10.1074\/jbc.M110.169813","volume":"286","author":"Y Zhang","year":"2011","unstructured":"Zhang Y, Conrad AH, Conrad GW (2011) Effects of ultraviolet-A and riboflavin on the interaction of collagen and proteoglycans during corneal cross-linking. J Biol Chem 286:13011\u201322","journal-title":"J Biol Chem"},{"key":"2082_CR20","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/S0002-9394(14)72896-X","volume":"118","author":"PJ Dougherty","year":"1994","unstructured":"Dougherty PJ, Wellish KL, Maloney RK (1994) Excimer laser ablation rate and corneal hydration. Am J Ophthalmol 118:169\u201376","journal-title":"Am J Ophthalmol"},{"key":"2082_CR21","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1111\/j.1600-0420.1995.tb00004.x","volume":"73","author":"JO Hjortdal","year":"1995","unstructured":"Hjortdal JO, Jensen PK (1995) In vitro measurement of corneal strain, thickness, and curvature using digital image processing. Acta Ophthalmol Scand 73:5\u201311","journal-title":"Acta Ophthalmol Scand"},{"key":"2082_CR22","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1111\/j.1600-0420.1995.tb00005.x","volume":"73","author":"JO Hjortdal","year":"1995","unstructured":"Hjortdal JO (1995) Extensibility of the normo-hydrated human cornea. Acta Ophthalmol Scand 73:12\u20137","journal-title":"Acta Ophthalmol Scand"},{"key":"2082_CR23","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1016\/j.ophtha.2008.09.048","volume":"116","author":"P Vinciguerra","year":"2009","unstructured":"Vinciguerra P, Alb\u00e8 E, Trazza S, Rosetta P, Vinciguerra R, Seiler T, Epstein D (2009) Refractive, topographic, tomographic, and aberrometric analysis of keratoconic eyes undergoing corneal cross-linking. Ophthalmology 116:369\u201378","journal-title":"Ophthalmology"},{"key":"2082_CR24","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1016\/S0014-4835(66)80010-6","volume":"5","author":"BO Hedbys","year":"1966","unstructured":"Hedbys BO, Mishima S (1966) The thickness-hydration relationship of the cornea. Exp Eye Res 5:221\u20138","journal-title":"Exp Eye Res"},{"key":"2082_CR25","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1097\/01.ico.0000105827.85025.7f","volume":"23","author":"G Wollensak","year":"2004","unstructured":"Wollensak G, Wilsch M, Spoerl E, Seiler T (2004) Collagen fiber diameter in the rabbit cornea after collagen crosslinking by riboflavin\/UVA. Cornea 23:503\u20137","journal-title":"Cornea"},{"key":"2082_CR26","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1111\/j.1442-9071.2010.02207.x","volume":"38","author":"R Mencucci","year":"2010","unstructured":"Mencucci R, Marini M, Paladini I, Sarchielli E, Sgambati E, Menchini U, Vannelli GB (2010) Effects of riboflavin\/UVA corneal cross-linking on keratocytes and collagen fibres in human cornea. Clin Exp Ophthalmol 38:49\u201356","journal-title":"Clin Exp Ophthalmol"},{"key":"2082_CR27","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1097\/01.icu.0000233954.86723.25","volume":"17","author":"G Wollensak","year":"2006","unstructured":"Wollensak G (2006) Crosslinking treatment of progressive keratoconus: new hope. Curr Opin Ophthalmol 17:356\u201360","journal-title":"Curr Opin Ophthalmol"},{"key":"2082_CR28","doi-asserted-by":"crossref","first-page":"876","DOI":"10.1136\/bjo.2010.190843","volume":"95","author":"G Wollensak","year":"2011","unstructured":"Wollensak G, Sp\u00f6rl E, Mazzotta C, Kalinski T, Sel S (2011) Interlamellar cohesion after corneal crosslinking using riboflavin and ultraviolet A light. Br J Ophthalmol 95:876\u201380","journal-title":"Br J Ophthalmol"}],"container-title":["Graefe's Archive for Clinical and Experimental Ophthalmology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00417-012-2082-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00417-012-2082-9\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00417-012-2082-9","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,5,28]],"date-time":"2019-05-28T15:48:19Z","timestamp":1559058499000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00417-012-2082-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,6,23]]},"references-count":28,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2013,2]]}},"alternative-id":["2082"],"URL":"https:\/\/doi.org\/10.1007\/s00417-012-2082-9","relation":{},"ISSN":["0721-832X","1435-702X"],"issn-type":[{"value":"0721-832X","type":"print"},{"value":"1435-702X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,6,23]]}}}