{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,23]],"date-time":"2025-09-23T13:22:46Z","timestamp":1758633766388},"reference-count":34,"publisher":"Springer Science and Business Media LLC","issue":"8","license":[{"start":{"date-parts":[[2013,4,28]],"date-time":"2013-04-28T00:00:00Z","timestamp":1367107200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Graefes Arch Clin Exp Ophthalmol"],"published-print":{"date-parts":[[2013,8]]},"DOI":"10.1007\/s00417-013-2345-0","type":"journal-article","created":{"date-parts":[[2013,5,1]],"date-time":"2013-05-01T11:36:24Z","timestamp":1367408184000},"page":"1919-1927","source":"Crossref","is-referenced-by-count":2,"title":["Short- and long-term corneal vascular effects of tafluprost eye drops"],"prefix":"10.1007","volume":"251","author":[{"given":"Deniz","family":"Hos","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Konrad R.","family":"Koch","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Felix","family":"Bock","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rafael S.","family":"Grajewski","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas S.","family":"Dietlein","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claus","family":"Cursiefen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ludwig M.","family":"Heindl","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2013,4,28]]},"reference":[{"key":"2345_CR1","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1080\/02713680902989337","volume":"34","author":"I Kaiserman","year":"2009","unstructured":"Kaiserman I, Fendyur A, Vinker S (2009) Topical beta blockers in asthmatic patients-is it safe? Curr Eye Res 34:517\u2013522","journal-title":"Curr Eye Res"},{"key":"2345_CR2","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1097\/00055735-199704000-00002","volume":"8","author":"DM Talluto","year":"1997","unstructured":"Talluto DM, Wyse TB, Krupin T (1997) Topical carbonic anhydrase inhibitors. Curr Opin Ophthalmol 8:2\u20136","journal-title":"Curr Opin Ophthalmol"},{"key":"2345_CR3","first-page":"7","volume":"7","author":"Y Liu","year":"2013","unstructured":"Liu Y, Mao W (2013) Tafluprost once daily for treatment of elevated intraocular pressure in patients with open-angle glaucoma. Clin Ophthalmol 7:7\u201314","journal-title":"Clin Ophthalmol"},{"key":"2345_CR4","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1016\/j.exer.2003.12.007","volume":"78","author":"Y Takagi","year":"2004","unstructured":"Takagi Y, Nakajima T, Shimazaki A, Kageyama M, Matsugi T, Matsumura Y, Gabelt BT, Kaufman PL, Hara H (2004) Pharmacological characteristics of AFP-168 (tafluprost), a new prostanoid FP receptor agonist, as an ocular hypotensive drug. Exp Eye Res 78:767\u2013776","journal-title":"Exp Eye Res"},{"key":"2345_CR5","doi-asserted-by":"crossref","first-page":"1814","DOI":"10.1016\/S0886-3350(02)01334-2","volume":"28","author":"PC Yeh","year":"2002","unstructured":"Yeh PC, Ramanathan S (2002) Latanoprost and clinically significant cystoid macular edema after uneventful phacoemulsification with intraocular lens implantation. J Cataract Refract Surg 28:1814\u20131818","journal-title":"J Cataract Refract Surg"},{"issue":"Suppl 1","key":"2345_CR6","doi-asserted-by":"crossref","first-page":"S219","DOI":"10.1016\/S0039-6257(02)00328-4","volume":"47","author":"RA Schumer","year":"2002","unstructured":"Schumer RA, Camras CB, Mandahl AK (2002) Putative side effects of prostaglandin analogs. Surv Ophthalmol 47(Suppl 1):S219","journal-title":"Surv Ophthalmol"},{"issue":"Suppl 1","key":"2345_CR7","doi-asserted-by":"crossref","first-page":"S203","DOI":"10.1016\/S0039-6257(02)00294-1","volume":"47","author":"K Miyake","year":"2002","unstructured":"Miyake K, Ibaraki N (2002) Prostaglandins and cystoid macular edema. Surv Ophthalmol 47(Suppl 1):S203\u2013S218","journal-title":"Surv Ophthalmol"},{"key":"2345_CR8","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/S0002-9394(98)00071-3","volume":"126","author":"RD Fechtner","year":"1998","unstructured":"Fechtner RD, Khouri AS, Zimmerman TJ, Bullock J, Feldman R, Kulkarni P, Michael AJ, Realini T, Warwar R (1998) Anterior uveitis associated with latanoprost. Am J Ophthalmol 126:37\u201341","journal-title":"Am J Ophthalmol"},{"key":"2345_CR9","doi-asserted-by":"crossref","first-page":"916","DOI":"10.1136\/bjo.2007.131037","volume":"92","author":"JH Chang","year":"2008","unstructured":"Chang JH, McCluskey P, Missotten T, Ferrante P, Jalaludin B, Lightman S (2008) Use of ocular hypotensive prostaglandin analogues in patients with uveitis: does their use increase anterior uveitis and cystoid macular oedema? Br J Ophthalmol 92:916\u2013921","journal-title":"Br J Ophthalmol"},{"key":"2345_CR10","doi-asserted-by":"crossref","first-page":"285","DOI":"10.3109\/08820538.2011.588650","volume":"26","author":"MB Horsley","year":"2011","unstructured":"Horsley MB, Chen TC (2011) The use of prostaglandin analogs in the uveitic patient. Semin Ophthalmol 26:285\u2013289","journal-title":"Semin Ophthalmol"},{"issue":"Suppl1","key":"2345_CR11","doi-asserted-by":"crossref","first-page":"S93","DOI":"10.1016\/j.survophthal.2008.08.004","volume":"53","author":"A Alm","year":"2008","unstructured":"Alm A, Grierson I, Shields MB (2008) Side effects associated with prostaglandin analog therapy. Surv Ophthalmol 53(Suppl1):S93\u2013S105","journal-title":"Surv Ophthalmol"},{"key":"2345_CR12","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1097\/00003226-200304000-00021","volume":"22","author":"C Cursiefen","year":"2003","unstructured":"Cursiefen C, Chen L, Dana MR, Streilein JW (2003) Corneal lymphangiogenesis: evidence, mechanisms, and implications for corneal transplant immunology. Cornea 22:273\u2013281","journal-title":"Cornea"},{"key":"2345_CR13","doi-asserted-by":"crossref","first-page":"993","DOI":"10.1038\/nature05249","volume":"443","author":"BK Ambati","year":"2006","unstructured":"Ambati BK, Nozaki M, Singh N, Takeda A, Jani PD, Suthar T, Albuquerque RJ, Richter E, Sakurai E, Newcomb MT, Kleinman ME, Caldwell RB, Lin Q, Ogura Y, Orecchia A, Samuelson DA, Agnew DW, St Leger J, Green WR, Mahasreshti PJ, Curiel DT, Kwan D, Marsh H, Ikeda S, Leiper LJ, Collinson JM, Bogdanovich S, Khurana TS, Shibuya M, Baldwin ME, Ferrara N, Gerber HP, De Falco S, Witta J, Baffi JZ, Raisler BJ, Ambati J (2006) Corneal avascularity is due to soluble VEGF receptor-1. Nature 443:993\u2013997","journal-title":"Nature"},{"key":"2345_CR14","doi-asserted-by":"crossref","first-page":"11405","DOI":"10.1073\/pnas.0506112103","volume":"103","author":"C Cursiefen","year":"2006","unstructured":"Cursiefen C, Chen L, Saint-Geniez M, Hamrah P, Jin Y, Rashid S, Pytowski B, Persaud K, Wu Y, Streilein JW, Dana R (2006) Nonvascular VEGF receptor 3 expression by corneal epithelium maintains avascularity and vision. Proc Natl Acad Sci U S A 103:11405\u201311410","journal-title":"Proc Natl Acad Sci U S A"},{"key":"2345_CR15","doi-asserted-by":"crossref","first-page":"2666","DOI":"10.1167\/iovs.03-1380","volume":"45","author":"C Cursiefen","year":"2004","unstructured":"Cursiefen C, Cao J, Chen L, Liu Y, Maruyama K, Jackson D, Kruse FE, Wiegand SJ, Dana MR, Streilein JW (2004) Inhibition of hemangiogenesis and lymphangiogenesis after normal-risk corneal transplantation by neutralizing VEGF promotes graft survival. Invest Ophthalmol Vis Sci 45:2666\u20132673","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"2345_CR16","doi-asserted-by":"crossref","first-page":"1836","DOI":"10.1167\/iovs.07-1314","volume":"49","author":"D Hos","year":"2008","unstructured":"Hos D, Bock F, Dietrich T, Onderka J, Kruse FE, Thierauch KH, Cursiefen C (2008) Inflammatory corneal (lymph)angiogenesis is blocked by VEGFR-tyrosine kinase inhibitor ZK 261991, resulting in improved graft survival after corneal transplantation. Invest Ophthalmol Vis Sci 49:1836\u20131842","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"2345_CR17","doi-asserted-by":"crossref","first-page":"535","DOI":"10.4049\/jimmunol.0903180","volume":"184","author":"T Dietrich","year":"2010","unstructured":"Dietrich T, Bock F, Yuen D, Hos D, Bachmann BO, Zahn G, Wiegand S, Chen L, Cursiefen C (2010) Cutting edge: lymphatic vessels, not blood vessels, primarily mediate immune rejections after transplantation. J Immunol 184:535\u2013539","journal-title":"J Immunol"},{"key":"2345_CR18","doi-asserted-by":"crossref","first-page":"5906","DOI":"10.1167\/iovs.12-10410","volume":"53","author":"SD Schoenberger","year":"2012","unstructured":"Schoenberger SD, Kim SJ, Sheng J, Rezaei KA, Lalezary M, Cherney E (2012) Increased prostaglandin E2 (PGE2) levels in proliferative diabetic retinopathy, and correlation with VEGF and inflammatory cytokines. Invest Ophthalmol Vis Sci 53:5906\u20135911","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"2345_CR19","first-page":"581","volume":"39","author":"T Cheng","year":"1998","unstructured":"Cheng T, Cao W, Wen R, Steinberg RH, LaVail MM (1998) Prostaglandin E2 induces vascular endothelial growth factor and basic fibroblast growth factor mRNA expression in cultured rat Muller cells. Invest Ophthalmol Vis Sci 39:581\u2013591","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"2345_CR20","doi-asserted-by":"crossref","first-page":"5778","DOI":"10.1167\/iovs.10-6816","volume":"52","author":"D Hos","year":"2011","unstructured":"Hos D, Regenfuss B, Bock F, Onderka J, Cursiefen C (2011) Blockade of insulin receptor substrate-1 inhibits corneal lymphangiogenesis. Invest Ophthalmol Vis Sci 52:5778\u20135785","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"2345_CR21","doi-asserted-by":"crossref","first-page":"1040","DOI":"10.1172\/JCI20465","volume":"113","author":"C Cursiefen","year":"2004","unstructured":"Cursiefen C, Chen L, Borges LP, Jackson D, Cao J, Radziejewski C, D\u2019Amore PA, Dana MR, Wiegand SJ, Streilein JW (2004) VEGF-A stimulates lymphangiogenesis and hemangiogenesis in inflammatory neovascularization via macrophage recruitment. J Clin Invest 113:1040\u20131050","journal-title":"J Clin Invest"},{"key":"2345_CR22","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1001\/archophthalmol.2011.42","volume":"129","author":"D Hos","year":"2011","unstructured":"Hos D, Saban DR, Bock F, Regenfuss B, Onderka J, Masli S, Cursiefen C (2011) Suppression of inflammatory corneal lymphangiogenesis by application of topical corticosteroids. Arch Ophthalmol 129:445\u2013452","journal-title":"Arch Ophthalmol"},{"key":"2345_CR23","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1097\/01.ico.0000183485.85636.ff","volume":"25","author":"C Cursiefen","year":"2006","unstructured":"Cursiefen C, Maruyama K, Jackson DG, Streilein JW, Kruse FE (2006) Time course of angiogenesis and lymphangiogenesis after brief corneal inflammation. Cornea 25:443\u2013447","journal-title":"Cornea"},{"key":"2345_CR24","doi-asserted-by":"crossref","first-page":"3545","DOI":"10.1167\/iovs.06-0695","volume":"48","author":"T Usui","year":"2007","unstructured":"Usui T, Yamagami S, Kishimoto S, Seiich Y, Nakayama T, Amano S (2007) Role of macrophage migration inhibitory factor in corneal neovascularization. Invest Ophthalmol Vis Sci 48:3545\u20133550","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"2345_CR25","doi-asserted-by":"crossref","first-page":"2545","DOI":"10.1167\/iovs.06-0570","volume":"48","author":"F Bock","year":"2007","unstructured":"Bock F, Onderka J, Dietrich T, Bachmann B, Kruse FE, Paschke M, Zahn G, Cursiefen C (2007) Bevacizumab as a potent inhibitor of inflammatory corneal angiogenesis and lymphangiogenesis. Invest Ophthalmol Vis Sci 48:2545\u20132552","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"2345_CR26","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1016\/j.exer.2008.07.013","volume":"87","author":"D Hos","year":"2008","unstructured":"Hos D, Bachmann B, Bock F, Onderka J, Cursiefen C (2008) Age-related changes in murine limbal lymphatic vessels and corneal lymphangiogenesis. Exp Eye Res 87:427\u2013432","journal-title":"Exp Eye Res"},{"key":"2345_CR27","doi-asserted-by":"crossref","first-page":"501","DOI":"10.2353\/ajpath.2010.090794","volume":"177","author":"B Regenfuss","year":"2010","unstructured":"Regenfuss B, Onderka J, Bock F, Hos D, Maruyama K, Cursiefen C (2010) Genetic heterogeneity of lymphangiogenesis in different mouse strains. Am J Pathol 177:501\u2013510","journal-title":"Am J Pathol"},{"key":"2345_CR28","doi-asserted-by":"crossref","first-page":"462","DOI":"10.1016\/j.exer.2008.08.007","volume":"87","author":"F Bock","year":"2008","unstructured":"Bock F, Onderka J, Hos D, Horn F, Martus P, Cursiefen C (2008) Improved semiautomatic method for morphometry of angiogenesis and lymphangiogenesis in corneal flatmounts. Exp Eye Res 87:462\u2013470","journal-title":"Exp Eye Res"},{"key":"2345_CR29","doi-asserted-by":"crossref","first-page":"2363","DOI":"10.1172\/JCI23874","volume":"115","author":"K Maruyama","year":"2005","unstructured":"Maruyama K, Ii M, Cursiefen C, Jackson DG, Keino H, Tomita M, Van Rooijen N, Takenaka H, D\u2019Amore PA, Stein-Streilein J, Losordo DW, Streilein JW (2005) Inflammation-induced lymphangiogenesis in the cornea arises from CD11b-positive macrophages. J Clin Invest 115:2363\u20132372","journal-title":"J Clin Invest"},{"key":"2345_CR30","doi-asserted-by":"crossref","first-page":"1297","DOI":"10.1016\/S0161-6420(93)31484-3","volume":"100","author":"CB Toris","year":"1993","unstructured":"Toris CB, Camras CB, Yablonski ME (1993) Effects of PhXA41, a new prostaglandin F2 alpha analog, on aqueous humor dynamics in human eyes. Ophthalmology 100:1297\u20131304","journal-title":"Ophthalmology"},{"key":"2345_CR31","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1001\/archopht.123.2.186","volume":"123","author":"ES Arcieri","year":"2005","unstructured":"Arcieri ES, Santana A, Rocha FN, Guapo GL, Costa VP (2005) Blood-aqueous barrier changes after the use of prostaglandin analogues in patients with pseudophakia and aphakia: a 6-month randomized trial. Arch Ophthalmol 123:186\u2013192","journal-title":"Arch Ophthalmol"},{"key":"2345_CR32","doi-asserted-by":"crossref","first-page":"2211","DOI":"10.1016\/j.ophtha.2012.05.038","volume":"119","author":"J Shim","year":"2012","unstructured":"Shim J, Park C, Lee HS, Park MS, Lim HT, Chauhan S, Dana R, Lee H, Lee HK (2012) Change in prostaglandin expression levels and synthesizing activities in dry eye disease. Ophthalmology 119:2211\u20132219","journal-title":"Ophthalmology"},{"key":"2345_CR33","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1167\/iovs.06-1337","volume":"49","author":"S Schwartz","year":"2008","unstructured":"Schwartz S, George J, Ben-Shoshan J, Luboshits G, Avni I, Levkovitch-Verbin H, Ziv H, Rosner M, Barak A (2008) Drug modification of angiogenesis in a rat cornea model. Invest Ophthalmol Vis Sci 49:250\u2013254","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"2345_CR34","doi-asserted-by":"crossref","first-page":"5473","DOI":"10.1167\/iovs.06-0728","volume":"48","author":"A Pauly","year":"2007","unstructured":"Pauly A, Brignole-Baudouin F, Labbe A, Liang H, Warnet JM, Baudouin C (2007) New tools for the evaluation of toxic ocular surface changes in the rat. Invest Ophthalmol Vis Sci 48:5473\u20135483","journal-title":"Invest Ophthalmol Vis Sci"}],"container-title":["Graefe's Archive for Clinical and Experimental Ophthalmology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00417-013-2345-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00417-013-2345-0\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00417-013-2345-0","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,5,28]],"date-time":"2019-05-28T19:48:26Z","timestamp":1559072906000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00417-013-2345-0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,4,28]]},"references-count":34,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2013,8]]}},"alternative-id":["2345"],"URL":"https:\/\/doi.org\/10.1007\/s00417-013-2345-0","relation":{},"ISSN":["0721-832X","1435-702X"],"issn-type":[{"value":"0721-832X","type":"print"},{"value":"1435-702X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,4,28]]}}}