{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,17]],"date-time":"2026-02-17T19:20:50Z","timestamp":1771356050049,"version":"3.50.1"},"reference-count":30,"publisher":"Springer Science and Business Media LLC","issue":"12","license":[{"start":{"date-parts":[[2013,5,16]],"date-time":"2013-05-16T00:00:00Z","timestamp":1368662400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Graefes Arch Clin Exp Ophthalmol"],"published-print":{"date-parts":[[2013,12]]},"DOI":"10.1007\/s00417-013-2363-y","type":"journal-article","created":{"date-parts":[[2013,5,15]],"date-time":"2013-05-15T05:23:25Z","timestamp":1368595405000},"page":"1-9","source":"Crossref","is-referenced-by-count":8,"title":["Characteristics of fundus autofluorescence and drusen in the fellow eyes of Japanese patients with exudative age-related macular degeneration"],"prefix":"10.1007","volume":"251","author":[{"given":"Shigeto","family":"Fujimura","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takashi","family":"Ueta","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hidenori","family":"Takahashi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ryo","family":"Obata","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R. Theodore","family":"Smith","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasuo","family":"Yanagi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2013,5,16]]},"reference":[{"key":"2363_CR1","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.ajo.2007.03.047","volume":"144","author":"I Maruko","year":"2007","unstructured":"Maruko I, Iida T, Saito M, Nagayama D, Saito K (2007) Clinical characteristics of exudative age-related macular degeneration in Japanese patients. Am J Ophthalmol 144:15\u201322","journal-title":"Am J Ophthalmol"},{"key":"2363_CR2","doi-asserted-by":"crossref","first-page":"1503","DOI":"10.1001\/archopht.117.11.1503","volume":"117","author":"LA Yannuzzi","year":"1999","unstructured":"Yannuzzi LA, Wong DW, Sforzolini BS, Goldbaum M, Tang KC, Spaide RF, Freund KB, Slakter JS, Guyer DR, Sorenson JA, Fisher Y, Maberley D, Orlock DA (1999) Polypoidal choroidal vasculopathy and neovascularized age-related macular degeneration. Arch Ophthalmol 117:1503\u20131510","journal-title":"Arch Ophthalmol"},{"key":"2363_CR3","doi-asserted-by":"crossref","first-page":"416","DOI":"10.1097\/00006982-200110000-00003","volume":"21","author":"LA Yannuzzi","year":"2001","unstructured":"Yannuzzi LA, Negrao S, Iida T, Carvalho C, Rodriguez-Coleman H, Slakter J, Freund KB, Sorenson J, Orlock D, Borodoker N (2001) Retinal angiomatous proliferation in age-related macular degeneration. Retina 21:416\u2013434","journal-title":"Retina"},{"key":"2363_CR4","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1016\/S0002-9394(02)01404-6","volume":"133","author":"M Uyama","year":"2002","unstructured":"Uyama M, Wada M, Nagai Y, Matsubara T, Matsunaga H, Fukushima I, Takahashi K, Matsumura M (2002) Polypoidal choroidal vasculopathy: natural history. Am J Ophthalmol 133:639\u2013648","journal-title":"Am J Ophthalmol"},{"key":"2363_CR5","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1016\/j.ajo.2008.03.002","volume":"146","author":"T Ueta","year":"2008","unstructured":"Ueta T, Iriyama A, Francis J, Takahashi H, Adachi T, Obata R, Inoue Y, Tamaki Y, Yanagi Y (2008) Development of typical age-related macular degeneration and polypoidal choroidal vasculopathy in fellow eyes of Japanese patients with exudative age-related macular degeneration. Am J Ophthalmol 146:96\u2013101","journal-title":"Am J Ophthalmol"},{"key":"2363_CR6","first-page":"718","volume":"36","author":"FC Delori","year":"1995","unstructured":"Delori FC, Dorey CK, Staurenghi G, Arend O, Goger DG, Weiter JJ (1995) In vivo fluorescence of the ocular fundus exhibits retinal pigment epithelium lipofuscin characteristics. Investig Ophthalmol Vis Sci 36:718\u2013729","journal-title":"Investig Ophthalmol Vis Sci"},{"key":"2363_CR7","first-page":"145","volume":"27","author":"JJ Weiter","year":"1986","unstructured":"Weiter JJ, Delori FC, Wing GL, Fitch KA (1986) Retinal pigment epithelial lipofuscin and melanin and choroidal melanin in human eyes. Invest Ophthalmol Vis Sci 27:145\u2013152","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"2363_CR8","first-page":"1691","volume":"30","author":"CK Dorey","year":"1989","unstructured":"Dorey CK, Wu G, Ebenstein D, Garsd A, Weiter JJ (1989) Cell loss in the aging retina. Relationship to lipofuscin accumulation and macular degeneration. Invest Ophthalmol Vis Sci 30:1691\u20131699","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"2363_CR9","doi-asserted-by":"crossref","first-page":"1229","DOI":"10.1007\/s00417-008-0854-z","volume":"246","author":"B Heimes","year":"2008","unstructured":"Heimes B, Lommatzsch A, Zeimer M, Gutfleisch M, Spital G, Bird AC, Pauleikhoff D (2008) Foveal RPE autofluorescence as a prognostic factor for anti-VEGF therapy in exudative AMD. Graefes Arch Clin Exp Ophthalmol 246:1229\u20131234","journal-title":"Graefes Arch Clin Exp Ophthalmol"},{"key":"2363_CR10","doi-asserted-by":"crossref","first-page":"2655","DOI":"10.1167\/iovs.05-1027","volume":"47","author":"JC Hwang","year":"2006","unstructured":"Hwang JC, Chan JW, Chang S, Smith RT (2006) Predictive value of fundus autofluorescence for development of geographic atrophy in age-related macular degeneration. Invest Ophthalmol Vis Sci 47:2655\u20132661","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"2363_CR11","doi-asserted-by":"crossref","first-page":"3309","DOI":"10.1167\/iovs.04-0430","volume":"46","author":"A Bindewald","year":"2005","unstructured":"Bindewald A, Bird AC, Dandekar SS, Dolar-Szczasny J, Dreyhaupt J, Fitzke FW, Einbock W, Holz FG, Jorzik JJ, Keilhauer C, Lois N, Mlynski J, Pauleikhoff D, Staurenghi G, Wolf S (2005) Classification of fundus autofluorescence patterns in early age-related macular disease. Invest Ophthalmol Vis Sci 46:3309\u20133314","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"2363_CR12","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1016\/S0161-6420(02)01756-6","volume":"110","author":"RF Spaide","year":"2003","unstructured":"Spaide RF (2003) Fundus autofluorescence and age-related macular degeneration. Ophthalmology 110:392\u2013399","journal-title":"Ophthalmology"},{"key":"2363_CR13","first-page":"496","volume":"41","author":"FC Delori","year":"2000","unstructured":"Delori FC, Fleckner MR, Goger DG, Weiter JJ, Dorey CK (2000) Autofluorescence distribution associated with drusen in age-related macular degeneration. Invest Ophthalmol Vis Sci 41:496\u2013504","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"2363_CR14","doi-asserted-by":"crossref","first-page":"1499","DOI":"10.1136\/bjo.2007.119685","volume":"91","author":"E Midena","year":"2007","unstructured":"Midena E, Vujosevic S, Convento E, Manfre A, Cavarzeran F, Pilotto E (2007) Microperimetry and fundus autofluorescence in patients with early age-related macular degeneration. Br J Ophthalmol 91:1499\u20131503","journal-title":"Br J Ophthalmol"},{"key":"2363_CR15","doi-asserted-by":"crossref","first-page":"5495","DOI":"10.1167\/iovs.05-1318","volume":"47","author":"RT Smith","year":"2006","unstructured":"Smith RT, Chan JK, Busuoic M, Sivagnanavel V, Bird AC, Chong NV (2006) Autofluorescence characteristics of early, atrophic, and high-risk fellow eyes in age-related macular degeneration. Invest Ophthalmol Vis Sci 47:5495\u20135504","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"2363_CR16","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1016\/S0002-9394(01)01404-0","volume":"133","author":"N Lois","year":"2002","unstructured":"Lois N, Owens SL, Coco R, Hopkins J, Fitzke FW, Bird AC (2002) Fundus autofluorescence in patients with age-related macular degeneration and high risk of visual loss. Am J Ophthalmol 133:341\u2013349","journal-title":"Am J Ophthalmol"},{"key":"2363_CR17","first-page":"478","volume":"38","author":"A Ruckmann von","year":"1997","unstructured":"von Ruckmann A, Fitzke FW, Bird AC (1997) Fundus autofluorescence in age-related macular disease imaged with a laser scanning ophthalmoscope. Invest Ophthalmol Vis Sci 38:478\u2013486","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"2363_CR18","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1007\/s10384-005-0337-2","volume":"50","author":"R Obata","year":"2006","unstructured":"Obata R, Yanagi Y, Kami J, Takahashi H, Inoue Y, Tamaki Y (2006) Polypoidal choroidal vasculopathy and retinochoroidal anastomosis in Japanese patients eligible for photodynamic therapy for exudative age-related macular degeneration. Jpn J Ophthalmol 50:354\u2013360","journal-title":"Jpn J Ophthalmol"},{"key":"2363_CR19","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1097\/00006982-200506000-00003","volume":"25","author":"JJ Jorzik","year":"2005","unstructured":"Jorzik JJ, Bindewald A, Dithmar S, Holz FG (2005) Digital simultaneous fluorescein and indocyanine green angiography, autofluorescence, and red-free imaging with a solid-state laser-based confocal scanning laser ophthalmoscope. Retina 25:405\u2013416","journal-title":"Retina"},{"key":"2363_CR20","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1007\/s00417-004-1027-3","volume":"243","author":"W Einbock","year":"2005","unstructured":"Einbock W, Moessner A, Schnurrbusch UE, Holz FG, Wolf S (2005) Changes in fundus autofluorescence in patients with age-related maculopathy. Correlation to visual function: a prospective study. Graefes Arch Clin Exp Ophthalmol 243:300\u2013305","journal-title":"Graefes Arch Clin Exp Ophthalmol"},{"key":"2363_CR21","doi-asserted-by":"crossref","first-page":"1707","DOI":"10.1109\/TBME.2010.2042169","volume":"57","author":"J Chen","year":"2010","unstructured":"Chen J, Tian J, Lee N, Zheng J, Smith RT, Laine AF (2010) A partial intensity invariant feature descriptor for multimodal retinal image registration. IEEE Trans Biomed Eng 57: 1707\u20131718","journal-title":"IEEE Trans Biomed Eng"},{"key":"2363_CR22","doi-asserted-by":"crossref","first-page":"1018","DOI":"10.1136\/bjo.84.9.1018","volume":"84","author":"M Uyama","year":"2000","unstructured":"Uyama M, Takahashi K, Ida N, Miyashiro M, Ando A, Takahashi A, Yamada E, Shirasu J, Nagai Y, Takeuchi M (2000) The second eye of Japanese patients with unilateral exudative age related macular degeneration. Br J Ophthalmol 84:1018\u20131023","journal-title":"Br J Ophthalmol"},{"key":"2363_CR23","doi-asserted-by":"crossref","first-page":"1484","DOI":"10.1001\/archopht.123.11.1484","volume":"123","author":"MD Davis","year":"2005","unstructured":"Davis MD, Gangnon RE, Lee LY, Hubbard LD, Klein BE, Klein R, Ferris FL, Bressler SB, Milton RC (2005) The Age-Related Eye Disease Study severity scale for age-related macular degeneration: AREDS Report No. 17. Arch Ophthalmol 123:1484\u20131498","journal-title":"Arch Ophthalmol"},{"key":"2363_CR24","doi-asserted-by":"crossref","first-page":"2165","DOI":"10.1016\/S0161-6420(02)01227-7","volume":"109","author":"S Ishiko","year":"2002","unstructured":"Ishiko S, Akiba J, Horikawa Y, Yoshida A (2002) Detection of drusen in the fellow eye of Japanese patients with age-related macular degeneration using scanning laser ophthalmoscopy. Ophthalmology 109:2165\u20132169","journal-title":"Ophthalmology"},{"key":"2363_CR25","doi-asserted-by":"crossref","first-page":"923","DOI":"10.1038\/sj.eye.6702056","volume":"20","author":"S Sivaprasad","year":"2006","unstructured":"Sivaprasad S, Membrey WL, Sivagnanavel V, Gonzalez JG, Liu DT, Chan WM, Lam DS, Jackson H, Chong NV (2006) Second eye of patients with unilateral neovascular age-related macular degeneration: Caucasians vs Chinese. Eye 20:923\u2013926","journal-title":"Eye"},{"key":"2363_CR26","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1136\/bjo.2006.095109","volume":"91","author":"VA McBain","year":"2007","unstructured":"McBain VA, Townend J, Lois N (2007) Fundus autofluorescence in exudative age-related macular degeneration. Br J Ophthalmol 91:491\u2013496","journal-title":"Br J Ophthalmol"},{"key":"2363_CR27","doi-asserted-by":"crossref","unstructured":"Cachulo L, Silva R, Fonseca P, Pires I, Carvajal-Gonzalez S, Bernardes R, Cunha-Vaz JG (2011) Early markers of choroidal neovascularization in the fellow eye of patients with unilateral exudative age-related macular degeneration. Ophthalmologica 225: 144\u2013149","DOI":"10.1159\/000321064"},{"key":"2363_CR28","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1016\/j.exer.2003.10.011","volume":"78","author":"DH Anderson","year":"2004","unstructured":"Anderson DH, Talaga KC, Rivest AJ, Barron E, Hageman GS, Johnson LV (2004) Characterization of beta amyloid assemblies in drusen: the deposits associated with aging and age-related macular degeneration. Exp Eye Res 78:243\u2013256","journal-title":"Exp Eye Res"},{"key":"2363_CR29","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1016\/j.exer.2007.04.002","volume":"85","author":"CM Li","year":"2007","unstructured":"Li CM, Clark ME, Rudolf M, Curcio CA (2007) Distribution and composition of esterified and unesterified cholesterol in extra-macular drusen. Exp Eye Res 85:192\u2013201","journal-title":"Exp Eye Res"},{"key":"2363_CR30","doi-asserted-by":"crossref","first-page":"835","DOI":"10.1096\/fasebj.14.7.835","volume":"14","author":"RF Mullins","year":"2000","unstructured":"Mullins RF, Russell SR, Anderson DH, Hageman GS (2000) Drusen associated with aging and age-related macular degeneration contain proteins common to extracellular deposits associated with atherosclerosis, elastosis, amyloidosis, and dense deposit disease. FASEB J 14:835\u2013846","journal-title":"FASEB J"}],"container-title":["Graefe's Archive for Clinical and Experimental Ophthalmology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00417-013-2363-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00417-013-2363-y\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00417-013-2363-y","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,7,13]],"date-time":"2019-07-13T20:48:39Z","timestamp":1563050919000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00417-013-2363-y"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,5,16]]},"references-count":30,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2013,12]]}},"alternative-id":["2363"],"URL":"https:\/\/doi.org\/10.1007\/s00417-013-2363-y","relation":{},"ISSN":["0721-832X","1435-702X"],"issn-type":[{"value":"0721-832X","type":"print"},{"value":"1435-702X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,5,16]]}}}