{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T04:36:39Z","timestamp":1790742999432,"version":"4.1.0"},"reference-count":30,"publisher":"Springer Science and Business Media LLC","issue":"12","license":[{"start":{"date-parts":[[2014,8,30]],"date-time":"2014-08-30T00:00:00Z","timestamp":1409356800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Graefes Arch Clin Exp Ophthalmol"],"published-print":{"date-parts":[[2014,12]]},"DOI":"10.1007\/s00417-014-2785-1","type":"journal-article","created":{"date-parts":[[2014,8,29]],"date-time":"2014-08-29T04:06:10Z","timestamp":1409285170000},"page":"1977-1984","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["CCL20\/MIP-3 alpha mRNA expression in the conjunctival epithelium of normal individuals and patients with vernal keratoconjunctivitis"],"prefix":"10.1007","volume":"252","author":[{"given":"Noriko","family":"Inada","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akiko","family":"Ishimori","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Shoji","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2014,8,30]]},"reference":[{"key":"2785_CR1","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1006\/exer.1998.0528","volume":"67","author":"M Hingorani","year":"1998","unstructured":"Hingorani M, Calder VL, Buckley RJ, Lightman SL (1998) The role of conjunctival epithelial cells in chronic ocular allergic disease. Exp Eye Res 67:491\u2013500","journal-title":"Exp Eye Res"},{"key":"2785_CR2","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1097\/01.all.0000182545.75842.77","volume":"5","author":"M Calonge","year":"2005","unstructured":"Calonge M, Enriquez-de-Salamanca A (2005) The role of the conjunctival epithelium in ocular allergy. Curr Opin Allergy Clin Immunol 5:441\u2013445","journal-title":"Curr Opin Allergy Clin Immunol"},{"key":"2785_CR3","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1007\/s10384-008-0628-5","volume":"53","author":"J Shoji","year":"2009","unstructured":"Shoji J, Inada N, Sawa M (2009) Evaluation of eotaxin-1, \u22122, and \u22123 protein production and messenger RNA expression in patients with vernal keratoconjunctivitis. Jpn J Ophthalmol 53:92\u201399","journal-title":"Jpn J Ophthalmol"},{"key":"2785_CR4","doi-asserted-by":"crossref","first-page":"117","DOI":"10.3109\/09273949709085060","volume":"5","author":"DA Gamache","year":"1997","unstructured":"Gamache DA, Dimitrijevich SD, Weimer LK, Lang LS, Spellman JM, Graff G, Yanni JM (1997) Secretion of proinflammatory cytokines by human conjunctival epithelial cells. Ocul Immunol Inflamm 5:117\u2013128","journal-title":"Ocul Immunol Inflamm"},{"key":"2785_CR5","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1167\/iovs.06-0081","volume":"48","author":"I Venza","year":"2007","unstructured":"Venza I, Cucinotta M, Caristi S, Mancuso G, Teti D (2007) Transcriptional regulation of IL-8 by Staphylococcus aureus in human conjunctival cells involves activation of AP-1. Invest Ophthalmol Vis Sci 48:270\u2013276","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"2785_CR6","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1159\/000093068","volume":"38","author":"M Fodor","year":"2006","unstructured":"Fodor M, Facsko A, Rajna\u00f6lgyi E, Harsfalvi J, Bessenyei E, Kardos L, Berta A (2006) Enhanced release of IL-6 and IL-8 into tears in various anterior segmenta eye disease. Ophthalmic Res 38:182\u2013188","journal-title":"Ophthalmic Res"},{"key":"2785_CR7","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1002\/1521-4141(200201)32:1<104::AID-IMMU104>3.0.CO;2-C","volume":"32","author":"T Kucharzik","year":"2002","unstructured":"Kucharzik T, Hudson JT 3rd, Waikel RL, Martin WD, Williams IR (2002) CCR6 expression distinguishes mouse myeloid and lymphoid dendritic cell subsets: demonstration using a CCR6 EGFP knock-in mouse. Eur J Immunol 32:104\u2013112","journal-title":"Eur J Immunol"},{"key":"2785_CR8","doi-asserted-by":"crossref","first-page":"2338","DOI":"10.1182\/blood.V96.7.2338","volume":"96","author":"R Krzysiek","year":"2000","unstructured":"Krzysiek R, Lefevre EA, Bernard J, Foussat A, Galanaud P, Louache F, Richard Y (2000) Regulation of CCR6 chemokine receptor expression and responsiveness to macrophage inflammatory protein-3alpha\/CCL20 in human B cells. Blood 96:2338\u20132345","journal-title":"Blood"},{"key":"2785_CR9","doi-asserted-by":"crossref","first-page":"4871","DOI":"10.4049\/jimmunol.168.10.4871","volume":"168","author":"F Liao","year":"2002","unstructured":"Liao F, Shirakawa AK, Foley JF, Rabin RL, Farber JM (2002) Human B cells become highly responsive to macrophage-inflammatory protein-3 alpha\/CC chemokine ligand-20 after cellular activation without changes in CCR6 expression or ligand binding. J Immunol 168:4871\u20134880","journal-title":"J Immunol"},{"key":"2785_CR10","doi-asserted-by":"crossref","first-page":"186","DOI":"10.4049\/jimmunol.162.1.186","volume":"162","author":"F Liao","year":"1999","unstructured":"Liao F, Rabin RL, Smith CS, Sharma G, Nutman TB, Farber JM (1999) CC-chemokine receptor 6 is expressed on diverse memory subsets of T cells and determines responsiveness to macrophage inflammatory protein 3 alpha. J Immunol 162:186\u2013194","journal-title":"J Immunol"},{"key":"2785_CR11","doi-asserted-by":"crossref","first-page":"2803","DOI":"10.1084\/jem.20071397","volume":"204","author":"K Hirota","year":"2007","unstructured":"Hirota K, Yoshitomi H, Hashimoto M, Maeda S, Teradaira S, Sugimoto N, Yamaguchi T, Nomura T, Ito H, Nakamura T, Sakaguchi N, Sakaguchi N (2007) Preferential recruitment of CCR6-expressing Th17 cells to inflamed joints via CCL20 in rheumatoid arthritis and its animal model. J Exp Med 204:2803\u20132812","journal-title":"J Exp Med"},{"issue":"12","key":"2785_CR12","doi-asserted-by":"crossref","first-page":"1755","DOI":"10.1084\/jem.190.12.1755","volume":"190","author":"AS Charbonnier","year":"1999","unstructured":"Charbonnier AS, Kohrgruber N, Kriehuber E, Stingl G, Rot A, Maurer D (1999) Macrophage inflammatory protein 3alpha is involved in the constitutive trafficking of epidermal Langerhans cells. J Exp Med 190(12):1755\u20131768","journal-title":"J Exp Med"},{"key":"2785_CR13","doi-asserted-by":"crossref","first-page":"686","DOI":"10.1016\/S0091-6749(96)70103-3","volume":"98","author":"DP Metz","year":"1996","unstructured":"Metz DP, Bacon AS, Holgate S, Lightman SL (1996) Phenotypic characterization of T cells infiltrating the conjunctiva in chronic allergic eye disease. J Allergy Clin Immunol 98:686\u2013696","journal-title":"J Allergy Clin Immunol"},{"key":"2785_CR14","doi-asserted-by":"crossref","first-page":"4081","DOI":"10.1167\/iovs.12-11216","volume":"54","author":"TH Dohlman","year":"2013","unstructured":"Dohlman TH, Chauhan SK, Kodati S, Hua J, Chen Y, Omoto M, Sadrai Z, Dana R (2013) The CCR6\/CCL20 axis mediates Th17 cell migration to the ocular surface in dry eye disease. Invest Ophthalmol Vis Sci 54:4081\u20134091","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"2785_CR15","doi-asserted-by":"crossref","first-page":"191","DOI":"10.2332\/allergolint.11-RAI-0335","volume":"60","author":"E Takamura","year":"2011","unstructured":"Takamura E, Uchio E, Ebihara N, Ohno S, Ohashi Y, Okamoto S, Kumagai N, Satake Y, Shoji J, Nakagawa Y, Namba K, Fukagawa K, Fukushima A, Fujishima H (2011) Japanese guideline for allergic conjunctival diseases. Allergol Int 60:191\u2013203","journal-title":"Allergol Int"},{"key":"2785_CR16","doi-asserted-by":"crossref","first-page":"591","DOI":"10.2332\/allergolint.09-OA-0100","volume":"58","author":"J Shoji","year":"2009","unstructured":"Shoji J, Inada N, Sawa M (2009) Evaluation of novel scoring system using 5-5-5 exacerbation grading scale for allergic conjunctivitis disease. Allergol Int 58:591\u2013597","journal-title":"Allergol Int"},{"key":"2785_CR17","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1196\/annals.1326.036","volume":"1072","author":"Williams IR: CCR6 and CCL20","year":"2006","unstructured":"Williams IR: CCR6 and CCL20 (2006) partners in interstinal immunity and lymphorganogenesis. Ann N Y Acad Sci 1072:52\u201361","journal-title":"Ann N Y Acad Sci"},{"key":"2785_CR18","doi-asserted-by":"crossref","first-page":"4357","DOI":"10.1128\/IAI.01660-06","volume":"75","author":"YY Wu","year":"2007","unstructured":"Wu YY, Tsai HF, Lin WC, Hsu PI, Shun CT, Wu MS, Hsu PN (2007) Upregulation of CCL20 and recruitment of CCR6+ gastric infiltrating lymphocytes in Hericobacter pylori gastritis. Infect Immun 75:4357\u20134363","journal-title":"Infect Immun"},{"key":"2785_CR19","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1016\/j.yexcr.2010.12.018","volume":"317","author":"T Ito","year":"2011","unstructured":"Ito T, Carson WF 4th, Cavassani KA, Connett JM, Kunkel SL (2011) CCR6 as a mediator of immunity in the lung and gut. Exp Cell Res 317:613\u2013619","journal-title":"Exp Cell Res"},{"key":"2785_CR20","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1053\/j.gastro.2004.04.018","volume":"127","author":"M Rumbo","year":"2004","unstructured":"Rumbo M, Sierro F, Debard N, Kraehenbuhl JP, Finke D (2004) Lymphotoxin beta receptor signaling induces the chemokine CCL20 in intestinal epithelium. Gastroenterology 127:213\u2013223","journal-title":"Gastroenterology"},{"key":"2785_CR21","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0021-5155(97)00100-7","volume":"42","author":"J Shoji","year":"1998","unstructured":"Shoji J, Inada N, Saito K, Takaura N, Iwasaki Y, Sawa M (1998) Immunohistochemical study on follicular dendritic cell of conjunctiva-associated lymphoid tissue. Jpn J Ophthalmol 42:1\u20137","journal-title":"Jpn J Ophthalmol"},{"key":"2785_CR22","first-page":"1270","volume":"41","author":"N Knop","year":"2000","unstructured":"Knop N, Knop E (2000) Conjunctiva-associated lymphoid tissue in the human eye. Invest Ophthalmol Vis Sci 41:1270\u20131279","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"2785_CR23","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1007\/s00417-002-0429-3","volume":"240","author":"EA Giuliano","year":"2002","unstructured":"Giuliano EA, Moore CP, Phillips TE (2002) Morphological evidence of M cells in healthy canine conjunctiva-associated lymphoid tissue. Graefes Arch Clin Exp Ophthalmol 240:220\u2013226","journal-title":"Graefes Arch Clin Exp Ophthalmol"},{"key":"2785_CR24","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1016\/S0021-5155(02)00503-8","volume":"46","author":"T Sakimoto","year":"2002","unstructured":"Sakimoto T, Shoji J, Inada N, Saito K, Iwasaki Y, Sawa M (2002) Histological study of conjunctiva-associated lymphoid tissue in mouse. Jpn J Ophthalmol 46:364\u2013369","journal-title":"Jpn J Ophthalmol"},{"key":"2785_CR25","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1111\/j.1365-2249.2008.03657.x","volume":"152","author":"JN Francis","year":"2008","unstructured":"Francis JN, Sabroe I, Lloyd CM, Durham SR, Till SJ (2008) Elevated CCR6+ CD4+ T lymphocytes in tissue compared with blood and induction of CCL20 during the asthmatic late response. Clin Exp Immunol 152:440\u2013447","journal-title":"Clin Exp Immunol"},{"key":"2785_CR26","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1084\/jem.194.4.551","volume":"194","author":"NW Lukacs","year":"2001","unstructured":"Lukacs NW, Prosser DM, Wiekowski M, Lira SA, Cook DN (2001) Requirement for the chemokine receptor CCR6 in allergic pulmonary inflammation. J Exp Med 194:551\u2013555","journal-title":"J Exp Med"},{"key":"2785_CR27","doi-asserted-by":"crossref","first-page":"648","DOI":"10.1165\/rcmb.2002-0095OC","volume":"28","author":"J Reibman","year":"2003","unstructured":"Reibman J, Hsu Y, Chen LC, Bleck B, Gordon T (2003) Airway epithelial cells release MIP-3alpha\/CCL20 in response to cytokines and ambient particulate matter. Am J Respir Cell Mol Biol 28:648\u2013654","journal-title":"Am J Respir Cell Mol Biol"},{"key":"2785_CR28","doi-asserted-by":"crossref","first-page":"1028","DOI":"10.1016\/j.jaci.2010.02.008","volume":"125","author":"AT Hastie","year":"2010","unstructured":"Hastie AT, Moore WC, Meyers DA, Vestal PL, Li H, Peters SP, Bleecker ER, National Heart, Lung, and Blood institute Severe Asthma Research Program (2010) Analyses of asthma severity phenotypes and inflammatory proteins in subjects stratified by sputum granulocytes. J Allergy Clin Immunol 125:1028\u20131036","journal-title":"J Allergy Clin Immunol"},{"key":"2785_CR29","doi-asserted-by":"crossref","first-page":"2175","DOI":"10.1038\/jid.2009.65","volume":"129","author":"EG Harper","year":"2009","unstructured":"Harper EG, Guo C, Rizzo H, Lillis JV, Kurtz SE, Skorcheva I, Purdy D, Fitch E, Iordanov M, Blauvelt A (2009) Th17 cytokines stimulate CCL20 expression in keratinocytes in vitro and in vivo: implications for psoriasis pathogenesis. J Invest Dermatol 129:2175\u20132183","journal-title":"J Invest Dermatol"},{"key":"2785_CR30","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1002\/(SICI)1521-4141(199902)29:02<633::AID-IMMU633>3.0.CO;2-I","volume":"29","author":"Y Tanaka","year":"1999","unstructured":"Tanaka Y, Imai T, BabaM II, Uehira M, Nomiyama H, Yoshie O (1999) Selective expression of liver and activation-regulated chemokine (LARC) in intestinal epithelium in mice and humans. Eur J Immunol 29:633\u2013642","journal-title":"Eur J Immunol"}],"container-title":["Graefe's Archive for Clinical and Experimental Ophthalmology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00417-014-2785-1\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00417-014-2785-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00417-014-2785-1","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,7,16]],"date-time":"2023-07-16T08:34:18Z","timestamp":1689496458000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00417-014-2785-1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,8,30]]},"references-count":30,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2014,12]]}},"alternative-id":["2785"],"URL":"https:\/\/doi.org\/10.1007\/s00417-014-2785-1","relation":{},"ISSN":["0721-832X","1435-702X"],"issn-type":[{"value":"0721-832X","type":"print"},{"value":"1435-702X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,8,30]]}}}