{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,16]],"date-time":"2026-08-16T21:51:26Z","timestamp":1786917086185,"version":"build-2736575974"},"reference-count":34,"publisher":"Springer Science and Business Media LLC","issue":"7","license":[{"start":{"date-parts":[[2015,5,26]],"date-time":"2015-05-26T00:00:00Z","timestamp":1432598400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Graefes Arch Clin Exp Ophthalmol"],"published-print":{"date-parts":[[2015,7]]},"DOI":"10.1007\/s00417-015-3045-8","type":"journal-article","created":{"date-parts":[[2015,5,25]],"date-time":"2015-05-25T09:10:35Z","timestamp":1432545035000},"page":"1187-1194","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":40,"title":["Malignant optic glioma \u2013 the spectrum of disease in a case series"],"prefix":"10.1007","volume":"253","author":[{"given":"Ghislaine L.","family":"Traber","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Athina","family":"Pangalu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manuela","family":"Neumann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joao","family":"Costa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Weller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruth","family":"Huna-Baron","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Klara","family":"Landau","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2015,5,26]]},"reference":[{"key":"3045_CR1","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1093\/brain\/96.1.121","volume":"96","author":"WF Hoyt","year":"1973","unstructured":"Hoyt WF, Meshel LG, Lessell S, Schatz NJ, Suckling RD (1973) Malignant optic glioma of adulthood. Brain 96:121\u2013132","journal-title":"Brain"},{"key":"3045_CR2","volume-title":"WHO Classification of tumours of the central nervous system","author":"DN Louis","year":"2007","unstructured":"Louis DN, Ohgaki H, Wiestler OD, Cavenee WK (2007) WHO Classification of tumours of the central nervous system. IARC, Lyon"},{"key":"3045_CR3","volume-title":"Youmans Neurological Surgery","author":"HR Winn","year":"2011","unstructured":"Winn HR (2011) Youmans Neurological Surgery, 6th edn. Elsevier Saunders, Philadelphia","edition":"6"},{"key":"3045_CR4","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1007\/s00417-004-0905-z","volume":"242","author":"B Wabbels","year":"2004","unstructured":"Wabbels B, Demmler A, Seitz J, Woenckhaus M, Bloss HG, Lorenz B (2004) Unilateral adult malignant optic nerve glioma. Graefes Arch Clin Exp Ophthalmol 242:741\u2013748","journal-title":"Graefes Arch Clin Exp Ophthalmol"},{"key":"3045_CR5","first-page":"1700","volume":"176","author":"U Hahn","year":"2004","unstructured":"Hahn U, Ritz R, Ernemann U (2004) Glioblastoma multiforme des Nervus opticus. R\u00f6fo 176:1700\u20131701","journal-title":"R\u00f6fo"},{"key":"3045_CR6","doi-asserted-by":"crossref","first-page":"694","DOI":"10.1001\/archopht.123.5.694","volume":"123","author":"HV Danesh-Meyer","year":"2005","unstructured":"Danesh-Meyer HV, Savino PJ, Bilyk JR, Sergott RC (2005) Aggressive glioma of adulthood simulating ischemic optic neuropathy. Arch Ophthalmol 123:694\u2013700","journal-title":"Arch Ophthalmol"},{"key":"3045_CR7","first-page":"29","volume":"102","author":"PH Hartel","year":"2006","unstructured":"Hartel PH, Rosen C, Larzo C, Nestor S (2006) Malignant optic nerve glioma (glioblastoma multiforme): A case report and literature review. W V Med J 102:29\u201331","journal-title":"W V Med J"},{"key":"3045_CR8","doi-asserted-by":"crossref","first-page":"502","DOI":"10.1016\/j.jocn.2006.04.012","volume":"14","author":"TT Dinh","year":"2007","unstructured":"Dinh TT, Wang YY, Rosenfeld JV, Cherny M (2007) Glioblastoma of the optic chiasm. J Clin Neurosci 14:502\u2013505","journal-title":"J Clin Neurosci"},{"key":"3045_CR9","first-page":"389","volume":"22","author":"LM Romano","year":"2007","unstructured":"Romano LM, Gaspari M, Guagnini M (2007) Astrocitoma \u00f3ptico maligno bilateral del adulto. Neurologia 22:389\u2013390","journal-title":"Neurologia"},{"key":"3045_CR10","doi-asserted-by":"crossref","first-page":"772","DOI":"10.1080\/02688690802233372","volume":"22","author":"A Abou-Zeid","year":"2008","unstructured":"Abou-Zeid A, Duplessis D, Gnanalingham KK (2008) Blindness from multiple cerebral gliomas mimicking metastatic brain disease. Br J Neurosurg 22:772\u2013773","journal-title":"Br J Neurosurg"},{"issue":"782\u20133","key":"3045_CR11","first-page":"812","volume":"94","author":"JG Chacko","year":"2010","unstructured":"Chacko JG, Lam BL, Adusumilli J, Dubovy SR (2010) Multicentric malignant glioma of adulthood masquerading as optic neuritis. Br J Ophthalmol 94(782\u20133):812","journal-title":"Br J Ophthalmol"},{"key":"3045_CR12","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1016\/j.jfo.2010.06.014","volume":"33","author":"S Dumas-Stoeckel","year":"2010","unstructured":"Dumas-Stoeckel S, Gambrelle J, Cornut PL, El Chehab H, Vighetto A, Denis P (2010) Central retinal vein and artery occlusions related to intraocular involvement of an anaplastic optochiasmatic glioma. J Fr Ophtalmol 33:564\u2013567","journal-title":"J Fr Ophtalmol"},{"key":"3045_CR13","doi-asserted-by":"crossref","first-page":"974","DOI":"10.1016\/j.jocn.2010.12.010","volume":"18","author":"S Matloob","year":"2011","unstructured":"Matloob S, Fan JC, Danesh-Meyer HV (2011) Multifocal malignant optic glioma of adulthood presenting as acute anterior optic neuropathy. J Clin Neurosci 18:974\u2013977","journal-title":"J Clin Neurosci"},{"key":"3045_CR14","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1016\/j.survophthal.2010.11.003","volume":"56","author":"LM Simao","year":"2011","unstructured":"Simao LM, Dine Sultan EN, Hall JK, Reardon DA, Bhatti MT (2011) Knee deep in the nerve. Surv Ophthalmol 56:362\u2013370","journal-title":"Surv Ophthalmol"},{"key":"3045_CR15","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1097\/WNO.0b013e31824095d1","volume":"32","author":"NS Lincoff","year":"2012","unstructured":"Lincoff NS, Chung C, Balos L, Corbo JC, Sharma A (2012) Combing the globe for terrorism. J Neuroophthalmol 32:82\u201385","journal-title":"J Neuroophthalmol"},{"key":"3045_CR16","doi-asserted-by":"crossref","first-page":"59","DOI":"10.3109\/01658107.2012.658594","volume":"36","author":"JJ Kang","year":"2012","unstructured":"Kang JJ, Hou JH, Bui KM, Michals E, Valyi-Nagy T, Koshy M, Munson T, Charbel FT, Villano JL, Moss HE (2012) malignant optic chiasm glioma with initial clinical response to steroids. Neuroophthalmology 36:59\u201363","journal-title":"Neuroophthalmology"},{"key":"3045_CR17","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1097\/CAD.0b013e32835c7a47","volume":"24","author":"O Ashur-Fabian","year":"2013","unstructured":"Ashur-Fabian O, Blumenthal DT, Bakon M, Nass D, Davis PJ, Hercbergs A (2013) Long-term response in high-grade optic glioma treated with medically induced hypothyroidism and carboplatin: a case report and review of the literature. Anticancer Drugs 24:315\u2013323","journal-title":"Anticancer Drugs"},{"key":"3045_CR18","doi-asserted-by":"crossref","first-page":"548","DOI":"10.1016\/j.survophthal.2013.12.003","volume":"59","author":"AI Colpak","year":"2014","unstructured":"Colpak AI, Isikay I, Mut M, Soylemezoglu F, Kansu T, Foroozan R (2014) Acute visual loss: Just the beginning? Surv Ophthalmol 59:548\u2013552","journal-title":"Surv Ophthalmol"},{"key":"3045_CR19","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1080\/028418500127345505","volume":"41","author":"B Cirak","year":"2000","unstructured":"Cirak B, Unal O, Arslan H, Cinal A (2000) Chiasmatic glioblastoma of childhood. A case report. Acta Radiol 41:375\u2013376","journal-title":"Acta Radiol"},{"key":"3045_CR20","doi-asserted-by":"crossref","first-page":"1847","DOI":"10.1002\/1097-0142(19871015)60:8<1847::AID-CNCR2820600829>3.0.CO;2-E","volume":"60","author":"JY Wong","year":"1987","unstructured":"Wong JY, Uhl V, Wara WM, Sheline GE (1987) Optic gliomas. A reanalysis of the University of California, San Francisco experience. Cancer 60:1847\u20131855","journal-title":"Cancer"},{"key":"3045_CR21","doi-asserted-by":"crossref","first-page":"498","DOI":"10.1017\/S0317167100041706","volume":"19","author":"JR Safneck","year":"1992","unstructured":"Safneck JR, Napier LB, Halliday WC (1992) Malignant astrocytoma of the optic nerve in a child. Can J Neurol Sci 19:498\u2013503","journal-title":"Can J Neurol Sci"},{"key":"3045_CR22","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1177\/000992287601500610","volume":"15","author":"WH Brooks","year":"1976","unstructured":"Brooks WH, Parker JCJ, Young AB, Mortara RH (1976) Malignant gliomas of the optic chiasm in adolescents. Clin Pediatr (Phila) 15:557\u2013561","journal-title":"Clin Pediatr (Phila)"},{"key":"3045_CR23","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1212\/WNL.26.4.322","volume":"26","author":"WB Wilson","year":"1976","unstructured":"Wilson WB, Feinsod M, Hoyt WF, Nielsen SL (1976) Malignant evolution of childhood chiasmal pilocytic astrocytoma. Neurology 26:322\u2013325","journal-title":"Neurology"},{"key":"3045_CR24","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1016\/0002-9394(89)90868-4","volume":"108","author":"RJ Keizer de","year":"1989","unstructured":"de Keizer RJ, de Wolff-Rouendaal D, Bots GT, Thomeer RT, Brouwer OF, Vielvoye GJ (1989) Optic glioma with intraocular tumor and seeding in a child with neurofibromatosis. Am J Ophthalmol 108:717\u2013725","journal-title":"Am J Ophthalmol"},{"key":"3045_CR25","doi-asserted-by":"crossref","first-page":"507","DOI":"10.3171\/2009.12.PEDS09173","volume":"5","author":"GK Zoeller","year":"2010","unstructured":"Zoeller GK, Brathwaite CD, Sandberg DI (2010) Malignant transformation of an optic pathway glioma without prior radiation therapy. J Neurosurg Pediatr 5:507\u2013510","journal-title":"J Neurosurg Pediatr"},{"key":"3045_CR26","doi-asserted-by":"crossref","first-page":"1026","DOI":"10.1038\/sj.eye.6701592","volume":"18","author":"NR Miller","year":"2004","unstructured":"Miller NR (2004) Primary tumours of the optic nerve and its sheath. Eye (Lond) 18:1026\u20131037","journal-title":"Eye (Lond)"},{"key":"3045_CR27","doi-asserted-by":"crossref","first-page":"S27","DOI":"10.1102\/1470-7330.2006.9003","volume":"6","author":"VF Chong","year":"2006","unstructured":"Chong VF (2006) The orbits in cancer imaging. Cancer Imaging 6:S27\u2013S31","journal-title":"Cancer Imaging"},{"key":"3045_CR28","doi-asserted-by":"crossref","first-page":"1046","DOI":"10.1148\/radiographics.18.4.9672989","volume":"18","author":"DP Friedman","year":"1998","unstructured":"Friedman DP, Hollander MD (1998) Neuroradiology case of the day. Malignant optic glioma of adulthood. Radiographics 18:1046\u20131048","journal-title":"Radiographics"},{"key":"3045_CR29","doi-asserted-by":"crossref","first-page":"1071","DOI":"10.1212\/WNL.38.7.1071","volume":"38","author":"GW Albers","year":"1988","unstructured":"Albers GW, Hoyt WF, Forno LS, Shratter LA (1988) Treatment response in malignant optic glioma of adulthood. Neurology 38:1071\u20131074","journal-title":"Neurology"},{"key":"3045_CR30","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1016\/j.ejrad.2009.09.029","volume":"74","author":"M Becker","year":"2010","unstructured":"Becker M, Masterson K, Delavelle J, Viallon M, Vargas MI, Becker CD (2010) Imaging of the optic nerve. Eur J Radiol 74:299\u2013313","journal-title":"Eur J Radiol"},{"key":"3045_CR31","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1097\/PPO.0b013e318244d7c8","volume":"18","author":"JL Clarke","year":"2012","unstructured":"Clarke JL, Chang SM (2012) Neuroimaging: diagnosis and response assessment in glioblastoma. Cancer J 18:26\u201331","journal-title":"Cancer J"},{"key":"3045_CR32","doi-asserted-by":"crossref","first-page":"987","DOI":"10.1056\/NEJMoa043330","volume":"352","author":"R Stupp","year":"2005","unstructured":"Stupp R, Mason WP, van den Bent MJ, Weller M, Fisher B, Taphoorn MJ, Belanger K, Brandes AA, Marosi C, Bogdahn U, Curschmann J, Janzer RC, Ludwin SK, Gorlia T, Allgeier A, Lacombe D, Cairncross JG, Eisenhauer E, Mirimanoff RO (2005) Radiotherapy plus concomitant and adjuvant temozolomide for glioblastoma. N Engl J Med 352:987\u2013996","journal-title":"N Engl J Med"},{"key":"3045_CR33","doi-asserted-by":"crossref","first-page":"e395","DOI":"10.1016\/S1470-2045(14)70011-7","volume":"15","author":"M Weller","year":"2014","unstructured":"Weller M, van den Bent M, Hopkins K, Tonn JC, Stupp R, Falini A, Cohen-Jonathan-Moyal E, Frappaz D, Henriksson R, Balana C, Chinot O, Ram Z, Reifenberger G, Soffietti R, Wick W (2014) EANO guideline for the diagnosis and treatment of anaplastic gliomas and glioblastoma. Lancet Oncol 15:e395\u2013e403","journal-title":"Lancet Oncol"},{"key":"3045_CR34","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1097\/PPO.0b013e318243f6c9","volume":"18","author":"M Weller","year":"2012","unstructured":"Weller M, Stupp R, Hegi M, Wick W (2012) Individualized targeted therapy for glioblastoma: fact or fiction? Cancer J 18:40\u201344","journal-title":"Cancer J"}],"container-title":["Graefe's Archive for Clinical and Experimental Ophthalmology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00417-015-3045-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00417-015-3045-8\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00417-015-3045-8","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,8,25]],"date-time":"2019-08-25T09:57:29Z","timestamp":1566727049000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00417-015-3045-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,5,26]]},"references-count":34,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2015,7]]}},"alternative-id":["3045"],"URL":"https:\/\/doi.org\/10.1007\/s00417-015-3045-8","relation":{},"ISSN":["0721-832X","1435-702X"],"issn-type":[{"value":"0721-832X","type":"print"},{"value":"1435-702X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,5,26]]}}}