{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,2]],"date-time":"2025-12-02T03:14:54Z","timestamp":1764645294168},"reference-count":30,"publisher":"Springer Science and Business Media LLC","issue":"12","license":[{"start":{"date-parts":[[2016,6,8]],"date-time":"2016-06-08T00:00:00Z","timestamp":1465344000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Graefes Arch Clin Exp Ophthalmol"],"published-print":{"date-parts":[[2016,12]]},"DOI":"10.1007\/s00417-016-3398-7","type":"journal-article","created":{"date-parts":[[2016,6,8]],"date-time":"2016-06-08T02:50:08Z","timestamp":1465354208000},"page":"2333-2338","update-policy":"http:\/\/dx.doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Rhegmatogenous retinal detachment following intravitreal ocriplasmin"],"prefix":"10.1007","volume":"254","author":[{"given":"Haifa A.","family":"Madi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Richard J.","family":"Haynes","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Diana","family":"Depla","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Morten D.","family":"de la Cour","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sarit","family":"Lesnik-Oberstein","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mahi M. K.","family":"Muqit","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Niall","family":"Patton","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nick","family":"Price","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David H.W.","family":"Steel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2016,6,8]]},"reference":[{"key":"3398_CR1","doi-asserted-by":"crossref","first-page":"606","DOI":"10.1056\/NEJMoa1110823","volume":"367","author":"P Stalmans","year":"2012","unstructured":"Stalmans P, Benz MS, Gandorfer A, Kampik A, Girach A, Pakola S, Haller JA (2012) Enzymatic vitreolysis with ocriplasmin for vitreomacular traction and macular holes. N Engl J Med 367:606\u2013615","journal-title":"N Engl J Med"},{"key":"3398_CR2","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1167\/iovs.03-0930","volume":"45","author":"A Gandorfer","year":"2004","unstructured":"Gandorfer A, Rohleder M, Sethi C, Eckle D, Welge-L\u00fcssen U, Kampik A, Luthert P, Charteris D (2004) Posterior vitreous detachment induced by microplasmin. Invest Ophthalmol Vis Sci 45:641\u2013647","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"3398_CR3","doi-asserted-by":"crossref","first-page":"1349.e2","DOI":"10.1016\/j.ophtha.2009.03.051","volume":"116","author":"MD Smet de","year":"2009","unstructured":"de Smet MD, Gandorfer A, Stalmans P, Veckeneer M, Feron E, Pakola S, Kampik A (2009) Microplasmin intravitreal administration in patients with vitreomacular traction scheduled for vitrectomy: the MIVI I trial. Ophthalmology 116:1349.e2\u20131355.e2","journal-title":"Ophthalmology"},{"key":"3398_CR4","doi-asserted-by":"crossref","first-page":"654","DOI":"10.1016\/j.ajo.2005.04.017","volume":"140","author":"A Takano","year":"2005","unstructured":"Takano A, Hirata A, Inomata Y, Kawaji T, Nakagawa K, Nagata S, Tanihara H (2005) Intravitreal plasmin injection activates endogenous matrix metalloproteinase-2 in rabbit and human vitreous. Am J Ophthalmol 140:654\u2013660","journal-title":"Am J Ophthalmol"},{"key":"3398_CR5","doi-asserted-by":"crossref","first-page":"1111","DOI":"10.1097\/IAE.0000000000000448","volume":"35","author":"PK Kaiser","year":"2015","unstructured":"Kaiser PK, Kampik A, Kuppermann BD, Girach A, Rizzo S, Sergott RC (2015) Safety profile of ocriplasmin for the pharmacologic treatment of symptomatic vitreomacular adhesion\/traction. Retina 35:1111\u20131127","journal-title":"Retina"},{"key":"3398_CR6","first-page":"1591","volume":"8","author":"RA Silva","year":"2014","unstructured":"Silva RA, Moshfeghi DM, Leng T (2014) Retinal breaks due to intravitreal ocriplasmin. Clin Ophthalmol 8:1591\u20131594","journal-title":"Clin Ophthalmol"},{"key":"3398_CR7","doi-asserted-by":"crossref","first-page":"1135","DOI":"10.1097\/IAE.0000000000000507","volume":"35","author":"K Willekens","year":"2015","unstructured":"Willekens K, Abeg\u00e3o Pinto L, Vandewalle E, Stalmans I, Stalmans P (2015) Improved efficacy of ocriplasmin for vitreomacular traction release and transient changes in optic disk morphology. Retina 35:1135\u20131143","journal-title":"Retina"},{"key":"3398_CR8","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/j.ajo.2014.09.015","volume":"159","author":"DJ Warrow","year":"2015","unstructured":"Warrow DJ, Lai MM, Patel A, Raevis J, Berinstein DM (2015) Treatment outcomes and spectral-domain optical coherence tomography findings of eyes with symptomatic vitreomacular adhesion treated with intravitreal ocriplasmin. Am J Ophthalmol 159:20\u201330","journal-title":"Am J Ophthalmol"},{"issue":"2","key":"3398_CR9","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1007\/s00417-015-3031-1","volume":"254","author":"I Chatziralli","year":"2016","unstructured":"Chatziralli I, Theodossiadis G, Parikakis E, Datseris I, Theodossiadis P (2016) Real-life experience after intravitreal ocriplasmin for vitreomacular traction and macular hole: a spectral-domain optical coherence tomography prospective study. Graefes Arch Clin Exp Ophthalmol 254(2): 223\u2013233","journal-title":"Graefes Arch Clin Exp Ophthalmol"},{"key":"3398_CR10","doi-asserted-by":"crossref","first-page":"861","DOI":"10.1016\/j.ajo.2015.01.034","volume":"159","author":"P Sharma","year":"2015","unstructured":"Sharma P, Juhn A, Houston SK, Fineman M, Chiang A, Ho A, Regillo C (2015) Efficacy of intravitreal ocriplasmin on vitreomacular traction and full-thickness macular holes. Am J Ophthalmol 159:861\u2013867","journal-title":"Am J Ophthalmol"},{"key":"3398_CR11","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1159\/000370024","volume":"5","author":"EK Chin","year":"2014","unstructured":"Chin EK, Almeida DRP, Sohn EH, Boldt HC, Mahajan VB, Gehrs KM, Russell SR, Folk JC (2014) Incomplete vitreomacular traction release using intravitreal ocriplasmin. Case Rep Ophthalmol 5:455\u2013462","journal-title":"Case Rep Ophthalmol"},{"key":"3398_CR12","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1136\/bjophthalmol-2014-305620","volume":"99","author":"A Hager","year":"2014","unstructured":"Hager A, Seibel I, Riechardt A, Rehak M, Joussen AM (2014) Does ocriplasmin affect the RPE-photoreceptor adhesion in macular holes? Br J Ophthalmol 99:635\u2013638","journal-title":"Br J Ophthalmol"},{"key":"3398_CR13","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1136\/bjophthalmol-2013-304219","volume":"98","author":"RP Singh","year":"2014","unstructured":"Singh RP, Li A, Bedi R, Srivastava S, Sears JE, Ehlers JP, Schachat AP, Kaiser PK (2014) Anatomical and visual outcomes following ocriplasmin treatment for symptomatic vitreomacular traction syndrome. Br J Ophthalmol 98:356\u2013360","journal-title":"Br J Ophthalmol"},{"key":"3398_CR14","doi-asserted-by":"crossref","first-page":"293","DOI":"10.3928\/23258160-20140709-05","volume":"45","author":"JB Miller","year":"2014","unstructured":"Miller JB, Kim LA, Wu DM, Vavvas DG, Eliott D, Husain D (2014) Ocriplasmin for treatment of stage 2 macular holes: early clinical results. Ophthalmic Surg Lasers Imaging Retina 45:293\u2013297","journal-title":"Ophthalmic Surg Lasers Imaging Retina"},{"key":"3398_CR15","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1016\/j.ophtha.2009.11.005","volume":"117","author":"MS Benz","year":"2010","unstructured":"Benz MS, Packo KH, Gonzalez V, Pakola S, Bezner D, Haller JA, Schwartz SD (2010) A placebo-controlled trial of microplasmin intravitreous injection to facilitate posterior vitreous detachment before vitrectomy. Ophthalmology 117:791\u2013797","journal-title":"Ophthalmology"},{"key":"3398_CR16","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/j.ajo.2012.10.016","volume":"155","author":"MW Johnson","year":"2013","unstructured":"Johnson MW (2013) How should we release vitreomacular traction: surgically, pharmacologically, or pneumatically? Am J Ophthalmol 155:203\u2013205","journal-title":"Am J Ophthalmol"},{"issue":"Suppl 2","key":"3398_CR17","doi-asserted-by":"crossref","first-page":"S221","DOI":"10.1097\/IAE.0b013e31825bc4df","volume":"32","author":"A Gandorfer","year":"2012","unstructured":"Gandorfer A (2012) Pharmacologic vitreolysis: rationale, potential indications, and promising agents. Retina 32(Suppl 2):S221\u2013S224","journal-title":"Retina"},{"key":"3398_CR18","doi-asserted-by":"crossref","first-page":"814","DOI":"10.1167\/iovs.08-2185","volume":"50","author":"MD Smet de","year":"2009","unstructured":"de Smet MD, Valmaggia C, Zarranz-Ventura J, Willekens B (2009) Microplasmin: ex vivo characterization of its activity in porcine vitreous. Invest Ophthalmol Vis Sci 50:814\u2013819","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"3398_CR19","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/j.bpc.2012.03.002","volume":"165\u2013166","author":"F Aerts","year":"2012","unstructured":"Aerts F, Noppen B, Fonteyn L, Derua R, Waelkens E, de Smet MD, Vanhove M (2012) Mechanism of inactivation of ocriplasmin in porcine vitreous. Biophys Chem 165\u2013166:30\u201338","journal-title":"Biophys Chem"},{"key":"3398_CR20","doi-asserted-by":"crossref","first-page":"221.e1","DOI":"10.1016\/j.ajo.2013.09.011","volume":"157","author":"M Shunmugam","year":"2014","unstructured":"Shunmugam M, Shah AN, Hysi PG, Williamson TH (2014) The pattern and distribution of retinal breaks in eyes with rhegmatogenous retinal detachment. Am J Ophthalmol 157:221.e1\u2013226.e1","journal-title":"Am J Ophthalmol"},{"key":"3398_CR21","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1016\/S0002-9394(02)01944-X","volume":"135","author":"Y Ito","year":"2003","unstructured":"Ito Y, Terasaki H, Suzuki T, Kojima T, Mori M, Ishikawa K, Miyake Y (2003) Mapping posterior vitreous detachment by optical coherence tomography in eyes with idiopathic macular hole. Am J Ophthalmol 135:351\u2013355","journal-title":"Am J Ophthalmol"},{"key":"3398_CR22","doi-asserted-by":"crossref","first-page":"1012","DOI":"10.1016\/j.ajo.2009.01.013","volume":"147","author":"SE Chung","year":"2009","unstructured":"Chung SE, Kim K-H, Kang SW (2009) Retinal breaks associated with the induction of posterior vitreous detachment. Am J Ophthalmol 147:1012\u20131016","journal-title":"Am J Ophthalmol"},{"key":"3398_CR23","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1097\/00006982-199902000-00004","volume":"19","author":"JS Heier","year":"1999","unstructured":"Heier JS, Topping TM, Frederick AR, Morley MG, Millay R, Pesavento RD (1999) Visual and surgical outcomes of retinal detachment following macular hole repair. Retina 19:110\u2013115","journal-title":"Retina"},{"key":"3398_CR24","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1097\/00006982-199919040-00003","volume":"19","author":"H Tabandeh","year":"1999","unstructured":"Tabandeh H, Chaudhry NA, Smiddy WE (1999) Retinal detachment associated with macular hole surgery: characteristics, mechanism, and outcomes. Retina 19:281\u2013286","journal-title":"Retina"},{"key":"3398_CR25","doi-asserted-by":"crossref","first-page":"295","DOI":"10.3109\/08820538.2010.518865","volume":"25","author":"M-A Rh\u00e9aume","year":"2010","unstructured":"Rh\u00e9aume M-A, Vavvas D (2010) Pharmacologic vitreolysis. Semin Ophthalmol 25:295\u2013302","journal-title":"Semin Ophthalmol"},{"key":"3398_CR26","first-page":"0710","volume":"2010","author":"S Fraser","year":"2010","unstructured":"Fraser S, Steel D (2010) Retinal detachment. BMJ Clin Evid 2010:0710","journal-title":"BMJ Clin Evid"},{"key":"3398_CR27","doi-asserted-by":"crossref","first-page":"4038","DOI":"10.1167\/iovs.15-16409","volume":"56","author":"DHW Steel","year":"2015","unstructured":"Steel DHW, Sandinha MT, White K (2015) The plane of vitreoretinal separation and results of vitrectomy surgery in patients given ocriplasmin for idiopathic macular hole. Invest Opthalmol Vis Sci 56:4038\u20134044","journal-title":"Invest Opthalmol Vis Sci"},{"key":"3398_CR28","doi-asserted-by":"crossref","first-page":"1055","DOI":"10.1097\/IAE.0000000000000667","volume":"35","author":"MW Johnson","year":"2015","unstructured":"Johnson MW, Fahim AT, Rao RC (2015) Acute ocriplasmin retinopathy. Retina 35:1055\u20131058","journal-title":"Retina"},{"key":"3398_CR29","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1001\/archopht.1995.01100050123041","volume":"113","author":"GS Hageman","year":"1995","unstructured":"Hageman GS, Marmor MF, Yao XY, Johnson LV (1995) The interphotoreceptor matrix mediates primate retinal adhesion. Arch Ophthalmol 113:655\u2013660","journal-title":"Arch Ophthalmol"},{"key":"3398_CR30","doi-asserted-by":"crossref","first-page":"602","DOI":"10.1016\/j.ajo.2008.05.039","volume":"146","author":"C Bredrup","year":"2008","unstructured":"Bredrup C, Matejas V, Barrow M, Bl\u00e1hov\u00e1 K, Bockenhauer D, Fowler DJ, Gregson RM, Maruniak-Chudek I, Medeira A, Mendon\u00e7a EL, Kagan M, Koenig J, Krastel H, Kroes HY, Saggar A, Sawyer T, Schittkowski M, Swietli\u0144ski J, Thompson D, VanDeVoorde RG, Wittebol-Post D, Woodruff G, Zurowska A, Hennekam RC, Zenker M, Russell-Eggitt I (2008) Ophthalmological aspects of Pierson syndrome. Am J Ophthalmol 146:602\u2013611","journal-title":"Am J Ophthalmol"}],"container-title":["Graefe's Archive for Clinical and Experimental Ophthalmology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00417-016-3398-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00417-016-3398-7\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00417-016-3398-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2017,6,24]],"date-time":"2017-06-24T11:56:32Z","timestamp":1498305392000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00417-016-3398-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,6,8]]},"references-count":30,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2016,12]]}},"alternative-id":["3398"],"URL":"https:\/\/doi.org\/10.1007\/s00417-016-3398-7","relation":{},"ISSN":["0721-832X","1435-702X"],"issn-type":[{"value":"0721-832X","type":"print"},{"value":"1435-702X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,6,8]]}}}